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Items: 11


NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.

Charych DH, Hoch U, Langowski JL, Lee SR, Addepalli MK, Kirk PB, Sheng D, Liu X, Sims PW, VanderVeen LA, Ali CF, Chang TK, Konakova M, Pena RL, Kanhere RS, Kirksey YM, Ji C, Wang Y, Huang J, Sweeney TD, Kantak SS, Doberstein SK.

Clin Cancer Res. 2016 Feb 1;22(3):680-90. doi: 10.1158/1078-0432.CCR-15-1631.


Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Burger MT, Nishiguchi G, Han W, Lan J, Simmons R, Atallah G, Ding Y, Tamez V, Zhang Y, Mathur M, Muller K, Bellamacina C, Lindvall MK, Zang R, Huh K, Feucht P, Zavorotinskaya T, Dai Y, Basham S, Chan J, Ginn E, Aycinena A, Holash J, Castillo J, Langowski JL, Wang Y, Chen MY, Lambert A, Fritsch C, Kauffmann A, Pfister E, Vanasse KG, Garcia PD.

J Med Chem. 2015 Nov 12;58(21):8373-86. doi: 10.1021/acs.jmedchem.5b01275. Epub 2015 Oct 27.


Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.

Garcia PD, Langowski JL, Wang Y, Chen M, Castillo J, Fanton C, Ison M, Zavorotinskaya T, Dai Y, Lu J, Niu XH, Basham S, Chan J, Yu J, Doyle M, Feucht P, Warne R, Narberes J, Tsang T, Fritsch C, Kauffmann A, Pfister E, Drueckes P, Trappe J, Wilson C, Han W, Lan J, Nishiguchi G, Lindvall M, Bellamacina C, Aycinena JA, Zang R, Holash J, Burger MT.

Clin Cancer Res. 2014 Apr 1;20(7):1834-45. doi: 10.1158/1078-0432.CCR-13-2062. Epub 2014 Jan 28.


Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.

Lu J, Zavorotinskaya T, Dai Y, Niu XH, Castillo J, Sim J, Yu J, Wang Y, Langowski JL, Holash J, Shannon K, Garcia PD.

Blood. 2013 Aug 29;122(9):1610-20. doi: 10.1182/blood-2013-01-481457. Epub 2013 Jul 1.


S179D prolactin diminishes the effects of UV light on epidermal gamma delta T cells.

Guzmán EA, Langowski JL, De Guzman A, Muller HK, Walker AM, Owen LB.

Mol Cell Endocrinol. 2008 Jan 2;280(1-2):6-12. Epub 2007 Sep 11.


Swords into plowshares: IL-23 repurposes tumor immune surveillance.

Langowski JL, Kastelein RA, Oft M.

Trends Immunol. 2007 May;28(5):207-12. Epub 2007 Mar 28.


IL-23 promotes tumour incidence and growth.

Langowski JL, Zhang X, Wu L, Mattson JD, Chen T, Smith K, Basham B, McClanahan T, Kastelein RA, Oft M.

Nature. 2006 Jul 27;442(7101):461-5. Epub 2006 May 10.


Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin.

Guzmán EA, Chen YH, Langowski JL, De Guzman A, Lo HL, Walter B, Muller HK, Walker AM, Owen LB.

J Neuroimmunol. 2005 Dec 30;170(1-2):31-40. Epub 2005 Sep 19.


Mad dogs, Englishmen and apoptosis: the role of cell death in UV-induced skin cancer.

Guzman E, Langowski JL, Owen-Schaub L.

Apoptosis. 2003 Aug;8(4):315-25. Review.


Nucleotide sequences of three distinct clones coding for rat heavy chain class I major histocompatibility antigens.

Wang M, Stepkowski SM, Tian L, Langowski JL, Yu J, Kahan BD.

Immunogenetics. 1996;43(5):318-20. No abstract available.


Nucleotide sequences of three distinct cDNA clones coding for the rat class I heavy chain RT1n antigen.

Wang M, Stepkowski SM, Tian L, Langowski JL, Hebert JS, Kloc M, Yu J, Kahan BD.

Immunogenetics. 1996;45(1):73-5. No abstract available.


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