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Comparative and functional analysis of the digital mucus glands and secretions of tree frogs.

Langowski JKA, Singla S, Nyarko A, Schipper H, van den Berg FT, Kaur S, Astley HC, Gussekloo SWS, Dhinojwala A, van Leeuwen JL.

Front Zool. 2019 Jun 13;16:19. doi: 10.1186/s12983-019-0315-z. eCollection 2019.


Estimating the maximum attachment performance of tree frogs on rough substrates.

Langowski JKA, Rummenie A, Pieters RPM, Kovalev A, Gorb SN, van Leeuwen JL.

Bioinspir Biomim. 2019 Feb 1;14(2):025001. doi: 10.1088/1748-3190/aafc37.


Pull-off and friction forces of micropatterned elastomers on soft substrates: the effects of pattern length scale and stiffness.

van Assenbergh P, Fokker M, Langowski J, van Esch J, Kamperman M, Dodou D.

Beilstein J Nanotechnol. 2019 Jan 8;10:79-94. doi: 10.3762/bjnano.10.8. eCollection 2019.


High precision FRET studies reveal reversible transitions in nucleosomes between microseconds and minutes.

Gansen A, Felekyan S, Kühnemuth R, Lehmann K, Tóth K, Seidel CAM, Langowski J.

Nat Commun. 2018 Nov 6;9(1):4628. doi: 10.1038/s41467-018-06758-1.


Tree frog attachment: mechanisms, challenges, and perspectives.

Langowski JKA, Dodou D, Kamperman M, van Leeuwen JL.

Front Zool. 2018 Aug 23;15:32. doi: 10.1186/s12983-018-0273-x. eCollection 2018. Review.


Force-transmitting structures in the digital pads of the tree frog Hyla cinerea: a functional interpretation.

Langowski JKA, Schipper H, Blij A, van den Berg FT, Gussekloo SWS, van Leeuwen JL.

J Anat. 2018 Oct;233(4):478-495. doi: 10.1111/joa.12860. Epub 2018 Aug 19.


Random Motion of Chromatin Is Influenced by Lamin A Interconnections.

Taheri F, Isbilir B, Müller G, Krieger JW, Chirico G, Langowski J, Tóth K.

Biophys J. 2018 May 22;114(10):2465-2472. doi: 10.1016/j.bpj.2018.04.037. Epub 2018 May 11.


Assembly Kinetics of Vimentin Tetramers to Unit-Length Filaments: A Stopped-Flow Study.

Mücke N, Kämmerer L, Winheim S, Kirmse R, Krieger J, Mildenberger M, Baßler J, Hurt E, Goldmann WH, Aebi U, Toth K, Langowski J, Herrmann H.

Biophys J. 2018 May 22;114(10):2408-2418. doi: 10.1016/j.bpj.2018.04.032. Epub 2018 May 10.


Widefield High Frame Rate Single-Photon SPAD Imagers for SPIM-FCS.

Buchholz J, Krieger J, Bruschini C, Burri S, Ardelean A, Charbon E, Langowski J.

Biophys J. 2018 May 22;114(10):2455-2464. doi: 10.1016/j.bpj.2018.04.029. Epub 2018 May 10.


Protein Flexibility and Synergy of HMG Domains Underlie U-Turn Bending of DNA by TFAM in Solution.

Rubio-Cosials A, Battistini F, Gansen A, Cuppari A, Bernadó P, Orozco M, Langowski J, Tóth K, Solà M.

Biophys J. 2018 May 22;114(10):2386-2396. doi: 10.1016/j.bpj.2017.11.3743. Epub 2017 Dec 13.


Effects of charge-modifying mutations in histone H2A α3-domain on nucleosome stability assessed by single-pair FRET and MD simulations.

Lehmann K, Zhang R, Schwarz N, Gansen A, Mücke N, Langowski J, Toth K.

Sci Rep. 2017 Oct 16;7(1):13303. doi: 10.1038/s41598-017-13416-x.


Defining the epichromatin epitope.

Gould TJ, Tóth K, Mücke N, Langowski J, Hakusui AS, Olins AL, Olins DE.

Nucleus. 2017 Nov 2;8(6):625-640. doi: 10.1080/19491034.2017.1380141. Epub 2017 Oct 30.


Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.

Charych D, Khalili S, Dixit V, Kirk P, Chang T, Langowski J, Rubas W, Doberstein SK, Eldon M, Hoch U, Zalevsky J.

PLoS One. 2017 Jul 5;12(7):e0179431. doi: 10.1371/journal.pone.0179431. eCollection 2017.


Single plane illumination microscopy as a tool for studying nucleome dynamics.

Langowski J.

Methods. 2017 Jul 1;123:3-10. doi: 10.1016/j.ymeth.2017.06.021. Epub 2017 Jun 23. Review.


Nucleosome repositioning during differentiation of a human myeloid leukemia cell line.

Teif VB, Mallm JP, Sharma T, Mark Welch DB, Rippe K, Eils R, Langowski J, Olins AL, Olins DE.

Nucleus. 2017 Mar 4;8(2):188-204. doi: 10.1080/19491034.2017.1295201.


Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1.

Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Mücke N, Langowski J, Ochsenbein F, Almouzni G, Panne D.

Elife. 2017 Mar 18;6. pii: e23474. doi: 10.7554/eLife.23474.


Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells.

Mark Welch DB, Jauch A, Langowski J, Olins AL, Olins DE.

Nucleus. 2017 Mar 4;8(2):222-237. doi: 10.1080/19491034.2017.1285989.


Histone Acetylation Regulates Chromatin Accessibility: Role of H4K16 in Inter-nucleosome Interaction.

Zhang R, Erler J, Langowski J.

Biophys J. 2017 Feb 7;112(3):450-459. doi: 10.1016/j.bpj.2016.11.015. Epub 2016 Dec 6.


EGFP oligomers as natural fluorescence and hydrodynamic standards.

Vámosi G, Mücke N, Müller G, Krieger JW, Curth U, Langowski J, Tóth K.

Sci Rep. 2016 Sep 13;6:33022. doi: 10.1038/srep33022.


In Vitro Assembly Kinetics of Cytoplasmic Intermediate Filaments: A Correlative Monte Carlo Simulation Study.

Mücke N, Winheim S, Merlitz H, Buchholz J, Langowski J, Herrmann H.

PLoS One. 2016 Jun 15;11(6):e0157451. doi: 10.1371/journal.pone.0157451. eCollection 2016.


NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models.

Charych DH, Hoch U, Langowski JL, Lee SR, Addepalli MK, Kirk PB, Sheng D, Liu X, Sims PW, VanderVeen LA, Ali CF, Chang TK, Konakova M, Pena RL, Kanhere RS, Kirksey YM, Ji C, Wang Y, Huang J, Sweeney TD, Kantak SS, Doberstein SK.

Clin Cancer Res. 2016 Feb 1;22(3):680-90. doi: 10.1158/1078-0432.CCR-15-1631.


Imaging fluorescence (cross-) correlation spectroscopy in live cells and organisms.

Krieger JW, Singh AP, Bag N, Garbe CS, Saunders TE, Langowski J, Wohland T.

Nat Protoc. 2015 Dec;10(12):1948-74. doi: 10.1038/nprot.2015.100. Epub 2015 Nov 5.


Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Burger MT, Nishiguchi G, Han W, Lan J, Simmons R, Atallah G, Ding Y, Tamez V, Zhang Y, Mathur M, Muller K, Bellamacina C, Lindvall MK, Zang R, Huh K, Feucht P, Zavorotinskaya T, Dai Y, Basham S, Chan J, Ginn E, Aycinena A, Holash J, Castillo J, Langowski JL, Wang Y, Chen MY, Lambert A, Fritsch C, Kauffmann A, Pfister E, Vanasse KG, Garcia PD.

J Med Chem. 2015 Nov 12;58(21):8373-86. doi: 10.1021/acs.jmedchem.5b01275. Epub 2015 Oct 27.


Nucleosome Core Particle Disassembly and Assembly Kinetics Studied Using Single-Molecule Fluorescence.

Hazan NP, Tomov TE, Tsukanov R, Liber M, Berger Y, Masoud R, Toth K, Langowski J, Nir E.

Biophys J. 2015 Oct 20;109(8):1676-85. doi: 10.1016/j.bpj.2015.07.004.


Imaging Fos-Jun transcription factor mobility and interaction in live cells by single plane illumination-fluorescence cross correlation spectroscopy.

Pernuš A, Langowski J.

PLoS One. 2015 Apr 14;10(4):e0123070. doi: 10.1371/journal.pone.0123070. eCollection 2015.


Opposing roles of H3- and H4-acetylation in the regulation of nucleosome structure––a FRET study.

Gansen A, Tóth K, Schwarz N, Langowski J.

Nucleic Acids Res. 2015 Feb 18;43(3):1433-43.


The effect of DNA supercoiling on nucleosome structure and stability.

Elbel T, Langowski J.

J Phys Condens Matter. 2015 Feb 18;27(6):064105. doi: 10.1088/0953-8984/27/6/064105. Epub 2015 Jan 7.


The role of histone tails in the nucleosome: a computational study.

Erler J, Zhang R, Petridis L, Cheng X, Smith JC, Langowski J.

Biophys J. 2014 Dec 16;107(12):2911-2922. doi: 10.1016/j.bpj.2014.10.065.


Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

Burger MT, Han W, Lan J, Nishiguchi G, Bellamacina C, Lindval M, Atallah G, Ding Y, Mathur M, McBride C, Beans EL, Muller K, Tamez V, Zhang Y, Huh K, Feucht P, Zavorotinskaya T, Dai Y, Holash J, Castillo J, Langowski J, Wang Y, Chen MY, Garcia PD.

ACS Med Chem Lett. 2013 Oct 15;4(12):1193-7. doi: 10.1021/ml400307j. eCollection 2013 Dec 12.


The conformational state of the nucleosome entry-exit site modulates TATA box-specific TBP binding.

Hieb AR, Gansen A, Böhm V, Langowski J.

Nucleic Acids Res. 2014 Jul;42(12):7561-76. doi: 10.1093/nar/gku423. Epub 2014 May 14.


Retrotransposon Alu is enriched in the epichromatin of HL-60 cells.

Olins AL, Ishaque N, Chotewutmontri S, Langowski J, Olins DE.

Nucleus. 2014 May-Jun;5(3):237-46. doi: 10.4161/nucl.29141. Epub 2014 May 13.


Watering down a theory: Comment on "Fluctuations in the DNA double helix: A critical review" by Frank-Kamenetskii & Prakash.

Langowski J.

Phys Life Rev. 2014 Jun;11(2):171-2. doi: 10.1016/j.plrev.2014.03.011. Epub 2014 Apr 12. No abstract available.


Dual-color fluorescence cross-correlation spectroscopy on a single plane illumination microscope (SPIM-FCCS).

Krieger JW, Singh AP, Garbe CS, Wohland T, Langowski J.

Opt Express. 2014 Feb 10;22(3):2358-75. doi: 10.1364/OE.22.002358.


Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.

Garcia PD, Langowski JL, Wang Y, Chen M, Castillo J, Fanton C, Ison M, Zavorotinskaya T, Dai Y, Lu J, Niu XH, Basham S, Chan J, Yu J, Doyle M, Feucht P, Warne R, Narberes J, Tsang T, Fritsch C, Kauffmann A, Pfister E, Drueckes P, Trappe J, Wilson C, Han W, Lan J, Nishiguchi G, Lindvall M, Bellamacina C, Aycinena JA, Zang R, Holash J, Burger MT.

Clin Cancer Res. 2014 Apr 1;20(7):1834-45. doi: 10.1158/1078-0432.CCR-13-2062. Epub 2014 Jan 28.


Ligand binding shifts highly mobile retinoid X receptor to the chromatin-bound state in a coactivator-dependent manner, as revealed by single-cell imaging.

Brazda P, Krieger J, Daniel B, Jonas D, Szekeres T, Langowski J, Tóth K, Nagy L, Vámosi G.

Mol Cell Biol. 2014 Apr;34(7):1234-45. doi: 10.1128/MCB.01097-13. Epub 2014 Jan 21.


The statistical-mechanics of chromosome conformation capture.

O'Sullivan JM, Hendy MD, Pichugina T, Wake GC, Langowski J.

Nucleus. 2013 Sep-Oct;4(5):390-8. doi: 10.4161/nucl.26513. Epub 2013 Sep 18. Review.


Spatial localization of genes determined by intranuclear DNA fragmentation with the fusion proteins lamin KRED and histone KRED und visible light.

Waldeck W, Mueller G, Glatting KH, Hotz-Wagenblatt A, Diessl N, Chotewutmonti S, Langowski J, Semmler W, Wiessler M, Braun K.

Int J Med Sci. 2013 Jul 7;10(9):1136-48. doi: 10.7150/ijms.6121. Print 2013.


Histone- and DNA sequence-dependent stability of nucleosomes studied by single-pair FRET.

Tóth K, Böhm V, Sellmann C, Danner M, Hanne J, Berg M, Barz I, Gansen A, Langowski J.

Cytometry A. 2013 Sep;83(9):839-46. doi: 10.1002/cyto.a.22320. Epub 2013 Jul 10.


Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.

Lu J, Zavorotinskaya T, Dai Y, Niu XH, Castillo J, Sim J, Yu J, Wang Y, Langowski JL, Holash J, Shannon K, Garcia PD.

Blood. 2013 Aug 29;122(9):1610-20. doi: 10.1182/blood-2013-01-481457. Epub 2013 Jul 1.


Closing the gap between single molecule and bulk FRET analysis of nucleosomes.

Gansen A, Hieb AR, Böhm V, Tóth K, Langowski J.

PLoS One. 2013 Apr 18;8(4):e57018. doi: 10.1371/journal.pone.0057018. Print 2013.


The performance of 2D array detectors for light sheet based fluorescence correlation spectroscopy.

Singh AP, Krieger JW, Buchholz J, Charbon E, Langowski J, Wohland T.

Opt Express. 2013 Apr 8;21(7):8652-68. doi: 10.1364/OE.21.008652.


FPGA implementation of a 32x32 autocorrelator array for analysis of fast image series.

Buchholz J, Krieger JW, Mocsár G, Kreith B, Charbon E, Vámosi G, Kebschull U, Langowski J.

Opt Express. 2012 Jul 30;20(16):17767-82. doi: 10.1364/OE.20.017767.


Kinetic lattice Monte Carlo simulation of viscoelastic subdiffusion.

Fritsch CC, Langowski J.

J Chem Phys. 2012 Aug 14;137(6):064114.


Chromosome positioning and the clustering of functionally related loci in yeast is driven by chromosomal interactions.

Gehlen LR, Gruenert G, Jones MB, Rodley CD, Langowski J, O'Sullivan JM.

Nucleus. 2012 Jul 1;3(4):370-83. Epub 2012 Jun 12.


Note: multiplexed multiple-tau auto- and cross-correlators on a single field programmable gate array.

Mocsár G, Kreith B, Buchholz J, Krieger JW, Langowski J, Vámosi G.

Rev Sci Instrum. 2012 Apr;83(4):046101. doi: 10.1063/1.3700810.


Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy.

Broderick R, Ramadurai S, Tóth K, Togashi DM, Ryder AG, Langowski J, Nasheuer HP.

PLoS One. 2012;7(4):e35537. doi: 10.1371/journal.pone.0035537. Epub 2012 Apr 19.


Unwrapping of nucleosomal DNA ends: a multiscale molecular dynamics study.

Voltz K, Trylska J, Calimet N, Smith JC, Langowski J.

Biophys J. 2012 Feb 22;102(4):849-58. doi: 10.1016/j.bpj.2011.11.4028. Epub 2012 Feb 21.


Role of histone tails in structural stability of the nucleosome.

Biswas M, Voltz K, Smith JC, Langowski J.

PLoS Comput Biol. 2011 Dec;7(12):e1002279. doi: 10.1371/journal.pcbi.1002279. Epub 2011 Dec 15.


IL-10 elicits IFNγ-dependent tumor immune surveillance.

Mumm JB, Emmerich J, Zhang X, Chan I, Wu L, Mauze S, Blaisdell S, Basham B, Dai J, Grein J, Sheppard C, Hong K, Cutler C, Turner S, LaFace D, Kleinschek M, Judo M, Ayanoglu G, Langowski J, Gu D, Paporello B, Murphy E, Sriram V, Naravula S, Desai B, Medicherla S, Seghezzi W, McClanahan T, Cannon-Carlson S, Beebe AM, Oft M.

Cancer Cell. 2011 Dec 13;20(6):781-96. doi: 10.1016/j.ccr.2011.11.003.


Protein diffusion in mammalian cell cytoplasm.

Kühn T, Ihalainen TO, Hyväluoma J, Dross N, Willman SF, Langowski J, Vihinen-Ranta M, Timonen J.

PLoS One. 2011;6(8):e22962. doi: 10.1371/journal.pone.0022962. Epub 2011 Aug 19.

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