Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 98

1.

Conformationally Flexible Sites within the Transmembrane Helices of Amyloid Precursor Protein and Notch1 Receptor.

Stelzer W, Langosch D.

Biochemistry. 2019 Jul 16;58(28):3065-3068. doi: 10.1021/acs.biochem.9b00505. Epub 2019 Jul 8.

PMID:
31264841
2.

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H.

Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3.

PMID:
31130234
3.

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.

Götz A, Högel P, Silber M, Chaitoglou I, Luy B, Muhle-Goll C, Scharnagl C, Langosch D.

Sci Rep. 2019 Mar 29;9(1):5321. doi: 10.1038/s41598-019-41766-1.

4.

The Metastable XBP1u Transmembrane Domain Defines Determinants for Intramembrane Proteolysis by Signal Peptide Peptidase.

Yücel SS, Stelzer W, Lorenzoni A, Wozny M, Langosch D, Lemberg MK.

Cell Rep. 2019 Mar 12;26(11):3087-3099.e11. doi: 10.1016/j.celrep.2019.02.057.

5.

Transmembrane Helix Induces Membrane Fusion through Lipid Binding and Splay.

Scheidt HA, Kolocaj K, Veje Kristensen J, Huster D, Langosch D.

J Phys Chem Lett. 2018 Jun 21;9(12):3181-3186. doi: 10.1021/acs.jpclett.8b00859. Epub 2018 Jun 1.

PMID:
29799756
6.

Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.

Högel P, Götz A, Kuhne F, Ebert M, Stelzer W, Rand KD, Scharnagl C, Langosch D.

Biochemistry. 2018 Feb 27;57(8):1326-1337. doi: 10.1021/acs.biochem.7b01197. Epub 2018 Feb 9.

PMID:
29389107
7.

BLaTM 2.0, a Genetic Tool Revealing Preferred Antiparallel Interaction of Transmembrane Helix 4 of the Dual-Topology Protein EmrE.

Julius A, Laur L, Schanzenbach C, Langosch D.

J Mol Biol. 2017 Jun 2;429(11):1630-1637. doi: 10.1016/j.jmb.2017.04.003. Epub 2017 Apr 19.

PMID:
28432015
8.

Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions.

Schanzenbach C, Schmidt FC, Breckner P, Teese MG, Langosch D.

Sci Rep. 2017 Mar 7;7:43476. doi: 10.1038/srep43476.

9.

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Langosch D, Steiner H.

Biol Chem. 2017 Apr 1;398(4):441-453. doi: 10.1515/hsz-2016-0269. Review.

PMID:
27845877
10.

Entrapment of Water at the Transmembrane Helix-Helix Interface of Quiescin Sulfhydryl Oxidase 2.

Ried CL, Scharnagl C, Langosch D.

Biochemistry. 2016 Mar 8;55(9):1287-90. doi: 10.1021/acs.biochem.5b01239. Epub 2016 Feb 22.

PMID:
26894260
11.

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase.

Winkler E, Julius A, Steiner H, Langosch D.

Biochemistry. 2015 Oct 13;54(40):6149-52. doi: 10.1021/acs.biochem.5b00986. Epub 2015 Sep 29.

PMID:
26403946
12.

Role of GxxxG Motifs in Transmembrane Domain Interactions.

Teese MG, Langosch D.

Biochemistry. 2015 Aug 25;54(33):5125-35. doi: 10.1021/acs.biochem.5b00495. Epub 2015 Aug 13. Review.

PMID:
26244771
13.

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics.

Langosch D, Scharnagl C, Steiner H, Lemberg MK.

Trends Biochem Sci. 2015 Jun;40(6):318-27. doi: 10.1016/j.tibs.2015.04.001. Epub 2015 May 1. Review.

PMID:
25941170
14.

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.

Chen CY, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D, Lemberg MK.

EMBO J. 2014 Nov 3;33(21):2492-506. doi: 10.15252/embj.201488208. Epub 2014 Sep 19.

15.

Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix.

Scharnagl C, Pester O, Hornburg P, Hornburg D, Götz A, Langosch D.

Biophys J. 2014 Mar 18;106(6):1318-26. doi: 10.1016/j.bpj.2014.02.013.

16.

The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.

Pester O, Götz A, Multhaup G, Scharnagl C, Langosch D.

Chembiochem. 2013 Oct 11;14(15):1943-8. doi: 10.1002/cbic.201300322. Epub 2013 Sep 17.

PMID:
24115334
17.

Self-interaction of transmembrane helices representing pre-clusters from the human single-span membrane proteins.

Kirrbach J, Krugliak M, Ried CL, Pagel P, Arkin IT, Langosch D.

Bioinformatics. 2013 Jul 1;29(13):1623-30. doi: 10.1093/bioinformatics/btt247. Epub 2013 May 1.

PMID:
23640719
18.

Structural properties of model phosphatidylcholine flippases.

Langer M, Sah R, Veser A, Gütlich M, Langosch D.

Chem Biol. 2013 Jan 24;20(1):63-72. doi: 10.1016/j.chembiol.2012.11.006.

19.

The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.

Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D.

J Am Chem Soc. 2013 Jan 30;135(4):1317-29. doi: 10.1021/ja3112093. Epub 2013 Jan 16.

20.

Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix.

Stelzer W, Langosch D.

Protein Sci. 2012 Jul;21(7):1097-102. doi: 10.1002/pro.2094. Epub 2012 Jun 11.

21.

Homotypic interaction and amino acid distribution of unilaterally conserved transmembrane helices.

Ried CL, Kube S, Kirrbach J, Langosch D.

J Mol Biol. 2012 Jul 13;420(3):251-7. doi: 10.1016/j.jmb.2012.04.008. Epub 2012 May 4. Erratum in: J Mol Biol. 2012 Sep 7;422(1):161.

PMID:
22561134
22.

Conserved conformational dynamics of membrane fusion protein transmembrane domains and flanking regions indicated by sequence statistics.

Neumann S, Langosch D.

Proteins. 2011 Aug;79(8):2418-27. doi: 10.1002/prot.23063. Epub 2011 Jun 1.

PMID:
21633971
23.

Is lipid flippase activity of SNARE transmembrane domains required for membrane fusion?

Langer M, Langosch D.

FEBS Lett. 2011 Apr 6;585(7):1021-4. doi: 10.1016/j.febslet.2011.02.033. Epub 2011 Mar 5.

24.

Structure and dynamics of the lipid modifications of a transmembrane α-helical peptide determined by ²H solid-state NMR spectroscopy.

Penk A, Müller M, Scheidt HA, Langosch D, Huster D.

Biochim Biophys Acta. 2011 Mar;1808(3):784-91. doi: 10.1016/j.bbamem.2010.12.015. Epub 2010 Dec 28.

25.

Residue-specific side-chain packing determines the backbone dynamics of transmembrane model helices.

Quint S, Widmaier S, Minde D, Hornburg D, Langosch D, Scharnagl C.

Biophys J. 2010 Oct 20;99(8):2541-9. doi: 10.1016/j.bpj.2010.08.031.

26.

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.

Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2.

27.

Direct visualization of large and protein-free hemifusion diaphragms.

Nikolaus J, Stöckl M, Langosch D, Volkmer R, Herrmann A.

Biophys J. 2010 Apr 7;98(7):1192-9. doi: 10.1016/j.bpj.2009.11.042.

28.

Ionic interactions promote transmembrane helix-helix association depending on sequence context.

Herrmann JR, Fuchs A, Panitz JC, Eckert T, Unterreitmeier S, Frishman D, Langosch D.

J Mol Biol. 2010 Feb 19;396(2):452-61. doi: 10.1016/j.jmb.2009.11.054. Epub 2009 Dec 1.

PMID:
19961858
29.

Structural features of fusogenic model transmembrane domains that differentially regulate inner and outer leaflet mixing in membrane fusion.

Poschner BC, Fischer K, Herrmann JR, Hofmann MW, Langosch D.

Mol Membr Biol. 2010 Jan;27(1):1-10. doi: 10.3109/09687680903362044.

PMID:
19939203
30.

A solid-state NMR study of changes in lipid phase induced by membrane-fusogenic LV-peptides.

Agrawal P, Kiihne S, Hollander J, Hofmann M, Langosch D, de Groot H.

Biochim Biophys Acta. 2010 Feb;1798(2):202-9. doi: 10.1016/j.bbamem.2009.10.015. Epub 2009 Oct 30.

31.

Stabilization of conformationally dynamic helices by covalently attached acyl chains.

Poschner BC, Langosch D.

Protein Sci. 2009 Aug;18(8):1801-5. doi: 10.1002/pro.155.

32.

Interaction and conformational dynamics of membrane-spanning protein helices.

Langosch D, Arkin IT.

Protein Sci. 2009 Jul;18(7):1343-58. doi: 10.1002/pro.154. Review.

33.

Sequence-specific conformational dynamics of model transmembrane domains determines their membrane fusogenic function.

Poschner BC, Quint S, Hofmann MW, Langosch D.

J Mol Biol. 2009 Feb 27;386(3):733-41. doi: 10.1016/j.jmb.2008.12.077. Epub 2009 Jan 6.

PMID:
19154744
34.

Gas-phase behavior of noncovalent transmembrane segment complexes.

Weigang LM, Langosch D, Letzel T.

Rapid Commun Mass Spectrom. 2008 Dec;22(24):4089-97. doi: 10.1002/rcm.3843.

PMID:
19025888
35.

Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions.

Herrmann JR, Panitz JC, Unterreitmeier S, Fuchs A, Frishman D, Langosch D.

J Mol Biol. 2009 Jan 23;385(3):912-23. doi: 10.1016/j.jmb.2008.10.058. Epub 2008 Oct 30.

PMID:
19007788
36.

Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange.

Stelzer W, Poschner BC, Stalz H, Heck AJ, Langosch D.

Biophys J. 2008 Aug;95(3):1326-35. doi: 10.1529/biophysj.108.132928. Epub 2008 May 2.

37.

Secondary structure and distribution of fusogenic LV-peptides in lipid membranes.

Ollesch J, Poschner BC, Nikolaus J, Hofmann MW, Herrmann A, Gerwert K, Langosch D.

Eur Biophys J. 2008 Apr;37(4):435-45. Epub 2007 Nov 24.

PMID:
18038229
38.

13C and 15N NMR evidence for peripheral intercalation of uniformly labeled fusogenic peptides incorporated in a biomimetic membrane.

Agrawal P, Kiihne S, Hollander J, Langosch D, de Groot H.

Biochim Biophys Acta. 2007 Dec;1768(12):3020-8. Epub 2007 Oct 4.

39.

Phenylalanine promotes interaction of transmembrane domains via GxxxG motifs.

Unterreitmeier S, Fuchs A, Schäffler T, Heym RG, Frishman D, Langosch D.

J Mol Biol. 2007 Nov 30;374(3):705-18. Epub 2007 Sep 26.

PMID:
17949750
40.

The role of transmembrane domains in membrane fusion.

Langosch D, Hofmann M, Ungermann C.

Cell Mol Life Sci. 2007 Apr;64(7-8):850-64. Review.

PMID:
17429580
41.

An extended ToxR POSSYCCAT system for positive and negative selection of self-interacting transmembrane domains.

Lindner E, Unterreitmeier S, Ridder AN, Langosch D.

J Microbiol Methods. 2007 May;69(2):298-305. Epub 2007 Feb 6.

PMID:
17346832
42.

pH-Activated fusogenic transmembrane LV-peptides.

Hofmann MW, Poschner BC, Hauser S, Langosch D.

Biochemistry. 2007 Apr 3;46(13):4204-9. Epub 2007 Mar 9.

PMID:
17346063
43.

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

Munter LM, Voigt P, Harmeier A, Kaden D, Gottschalk KE, Weise C, Pipkorn R, Schaefer M, Langosch D, Multhaup G.

EMBO J. 2007 Mar 21;26(6):1702-12. Epub 2007 Mar 1.

44.

Solid state NMR investigation of the interaction between biomimetic lipid bilayers and de novo designed fusogenic peptides.

Agrawal P, Kiihne S, Hollander J, Hulsbergen F, Hofmann M, Langosch D, de Groot H.

Chembiochem. 2007 Mar 26;8(5):493-6. No abstract available.

PMID:
17328022
45.

An automated application for deconvolution of circular dichroism spectra of small peptides.

Poschner BC, Reed J, Langosch D, Hofmann MW.

Anal Biochem. 2007 Apr 15;363(2):306-8. Epub 2007 Jan 19. No abstract available.

PMID:
17320030
46.

Evidence that late-endosomal SNARE multimerization complex is promoted by transmembrane segments.

Mascia L, Langosch D.

Biochim Biophys Acta. 2007 Mar;1768(3):457-66. Epub 2006 Dec 20.

47.

Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides.

Agrawal PR, Hofmann MW, Meeuwenoord NJ, Filippov DV, Stalz H, Hulsbergen F, Langosch D, Overkleeft HS, De Groot H.

J Pept Sci. 2007 Feb;13(2):75-80.

PMID:
17121421
48.
49.

Self-interaction of a SNARE transmembrane domain promotes the hemifusion-to-fusion transition.

Hofmann MW, Peplowska K, Rohde J, Poschner BC, Ungermann C, Langosch D.

J Mol Biol. 2006 Dec 15;364(5):1048-60. Epub 2006 Oct 3.

PMID:
17054985
50.

Role of the Vam3p transmembrane segment in homodimerization and SNARE complex formation.

Roy R, Peplowska K, Rohde J, Ungermann C, Langosch D.

Biochemistry. 2006 Jun 20;45(24):7654-60.

PMID:
16768461

Supplemental Content

Loading ...
Support Center