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Targeting growth hormone function: strategies and therapeutic applications.

Lu M, Flanagan JU, Langley RJ, Hay MP, Perry JK.

Signal Transduct Target Ther. 2019 Feb 8;4:3. doi: 10.1038/s41392-019-0036-y. eCollection 2019. Review.


Macrolides and mycobacterium abscessus abscessus: A good idea?

Langley RJ, Urquhart DS.

Int J Mycobacteriol. 2018 Oct-Dec;7(4):394. doi: 10.4103/ijmy.ijmy_127_18. No abstract available.


Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis.

Duplessis C, Gregory M, Frey K, Bell M, Truong L, Schully K, Lawler J, Langley RJ, Kingsmore SF, Woods CW, Rivers EP, Jaehne AK, Quackenbush EB, Fowler VG, Tsalik EL, Clark D.

J Intensive Care. 2018 Nov 13;6:72. doi: 10.1186/s40560-018-0341-5. eCollection 2018.


Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

Sweeney TE, Azad TD, Donato M, Haynes WA, Perumal TM, Henao R, Bermejo-Martin JF, Almansa R, Tamayo E, Howrylak JA, Choi A, Parnell GP, Tang B, Nichols M, Woods CW, Ginsburg GS, Kingsmore SF, Omberg L, Mangravite LM, Wong HR, Tsalik EL, Langley RJ, Khatri P.

Crit Care Med. 2018 Jun;46(6):915-925. doi: 10.1097/CCM.0000000000003084.


A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.


Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors.

Langley RJ, Ting YT, Clow F, Young PG, Radcliff FJ, Choi JM, Sequeira RP, Holtfreter S, Baker H, Fraser JD.

PLoS Pathog. 2017 Sep 7;13(9):e1006549. doi: 10.1371/journal.ppat.1006549. eCollection 2017 Sep.


Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?

Langley RJ, Wong HR.

Mol Diagn Ther. 2017 Oct;21(5):525-537. doi: 10.1007/s40291-017-0282-z. Review.


The curious incident of groaning in the night-time.

Langley RJ, Hill L, Hill EA, Urquhart DS.

Breathe (Sheff). 2017 Jun;13(2):123-126. doi: 10.1183/20734735.017816.


Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia.

Singh SP, Chand HS, Langley RJ, Mishra N, Barrett T, Rudolph K, Tellez C, Filipczak PT, Belinsky S, Saeed AI, Sheybani A, Exil V, Agarwal H, Sidhaye VK, Sussan T, Biswal S, Sopori M.

J Immunol. 2017 May 15;198(10):3815-3822. doi: 10.4049/jimmunol.1700014. Epub 2017 Apr 5.


Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.

Wang L, Ko ER, Gilchrist JJ, Pittman KJ, Rautanen A, Pirinen M, Thompson JW, Dubois LG, Langley RJ, Jaslow SL, Salinas RE, Rouse DC, Moseley MA, Mwarumba S, Njuguna P, Mturi N; Wellcome Trust Case Control Consortium 2; Kenyan Bacteraemia Study Group, Williams TN, Scott JA, Hill AV, Woods CW, Ginsburg GS, Tsalik EL, Ko DC.

Sci Adv. 2017 Mar 8;3(3):e1602096. doi: 10.1126/sciadv.1602096. eCollection 2017 Mar.


The 'pitfalls' of intubation: airway complications following tracheo-oesophageal fistula repair.

Langley RJ, Hufton D, Freeman J, Jackson M, Urquhart DS.

Arch Dis Child Fetal Neonatal Ed. 2016 Nov;101(6):F500-F501. doi: 10.1136/archdischild-2016-311519. Epub 2016 Aug 18. No abstract available.


Host gene expression classifiers diagnose acute respiratory illness etiology.

Tsalik EL, Henao R, Nichols M, Burke T, Ko ER, McClain MT, Hudson LL, Mazur A, Freeman DH, Veldman T, Langley RJ, Quackenbush EB, Glickman SW, Cairns CB, Jaehne AK, Rivers EP, Otero RM, Zaas AK, Kingsmore SF, Lucas J, Fowler VG Jr, Carin L, Ginsburg GS, Woods CW.

Sci Transl Med. 2016 Jan 20;8(322):322ra11. doi: 10.1126/scitranslmed.aad6873.


Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility.

Bruse S, Moreau M, Bromberg Y, Jang JH, Wang N, Ha H, Picchi M, Lin Y, Langley RJ, Qualls C, Klensney-Tait J, Zabner J, Leng S, Mao J, Belinsky SA, Xing J, Nyunoya T.

Hum Genomics. 2016 Jan 7;10:1. doi: 10.1186/s40246-015-0058-7.


Streptococcal 5'-Nucleotidase A (S5nA), a Novel Streptococcus pyogenes Virulence Factor That Facilitates Immune Evasion.

Zheng L, Khemlani A, Lorenz N, Loh JM, Langley RJ, Proft T.

J Biol Chem. 2015 Dec 25;290(52):31126-37. doi: 10.1074/jbc.M115.677443. Epub 2015 Nov 2.


The presumed central nervous system effects of rocuronium in a neonate and its reversal with sugammadex.

Langley RJ, McFadzean J, McCormack J.

Paediatr Anaesth. 2016 Jan;26(1):109-11. doi: 10.1111/pan.12789. Epub 2015 Oct 12.


HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.

Singh SP, Chand HS, Gundavarapu S, Saeed AI, Langley RJ, Tesfaigzi Y, Mishra NC, Sopori ML.

PLoS One. 2015 Sep 11;10(9):e0137757. doi: 10.1371/journal.pone.0137757. eCollection 2015.


Renal systems biology of patients with systemic inflammatory response syndrome.

Tsalik EL, Willig LK, Rice BJ, van Velkinburgh JC, Mohney RP, McDunn JE, Dinwiddie DL, Miller NA, Mayer ES, Glickman SW, Jaehne AK, Glew RH, Sopori ML, Otero RM, Harrod KS, Cairns CB, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Langley RJ.

Kidney Int. 2015 Oct;88(4):804-14. doi: 10.1038/ki.2015.150. Epub 2015 May 20.


Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS.

Kamisoglu K, Haimovich B, Calvano SE, Coyle SM, Corbett SA, Langley RJ, Kingsmore SF, Androulakis IP.

Crit Care. 2015 Mar 3;19:71. doi: 10.1186/s13054-015-0783-2.


An integrated transcriptome and expressed variant analysis of sepsis survival and death.

Tsalik EL, Langley RJ, Dinwiddie DL, Miller NA, Yoo B, van Velkinburgh JC, Smith LD, Thiffault I, Jaehne AK, Valente AM, Henao R, Yuan X, Glickman SW, Rice BJ, McClain MT, Carin L, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF.

Genome Med. 2014 Nov 26;6(11):111. doi: 10.1186/s13073-014-0111-5. eCollection 2014.


Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.

Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS.

Am J Respir Crit Care Med. 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC.


Metabolomic derangements are associated with mortality in critically ill adult patients.

Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM.

PLoS One. 2014 Jan 30;9(1):e87538. doi: 10.1371/journal.pone.0087538. eCollection 2014.


HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/α7-nicotinic acetylcholine receptors.

Gundavarapu S, Mishra NC, Singh SP, Langley RJ, Saeed AI, Feghali-Bostwick CA, McIntosh JM, Hutt J, Hegde R, Buch S, Sopori ML.

PLoS One. 2013 Oct 14;8(10):e77160. doi: 10.1371/journal.pone.0077160. eCollection 2013.


An integrated clinico-metabolomic model improves prediction of death in sepsis.

Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF.

Sci Transl Med. 2013 Jul 24;5(195):195ra95. doi: 10.1126/scitranslmed.3005893.


Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamine.

Singh SP, Gundavarapu S, Smith KR, Chand HS, Saeed AI, Mishra NC, Hutt J, Barrett EG, Husain M, Harrod KS, Langley RJ, Sopori ML.

Environ Health Perspect. 2013 Aug;121(8):957-64. doi: 10.1289/ehp.1306611. Epub 2013 Jun 11.


Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.

Ahn SH, Tsalik EL, Cyr DD, Zhang Y, van Velkinburgh JC, Langley RJ, Glickman SW, Cairns CB, Zaas AK, Rivers EP, Otero RM, Veldman T, Kingsmore SF, Lucas J, Woods CW, Ginsburg GS, Fowler VG Jr.

PLoS One. 2013;8(1):e48979. doi: 10.1371/journal.pone.0048979. Epub 2013 Jan 9.


Structural and functional properties of staphylococcal superantigen-like protein 4.

Hermans SJ, Baker HM, Sequeira RP, Langley RJ, Baker EN, Fraser JD.

Infect Immun. 2012 Nov;80(11):4004-13. doi: 10.1128/IAI.00764-12. Epub 2012 Sep 4.


Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3.

Deng L, Langley RJ, Wang Q, Topalian SL, Mariuzza RA.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14960-5. doi: 10.1073/pnas.1207186109. Epub 2012 Aug 28.


Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo.

Gundavarapu S, Wilder JA, Mishra NC, Rir-Sima-Ah J, Langley RJ, Singh SP, Saeed AI, Jaramillo RJ, Gott KM, Peña-Philippides JC, Harrod KS, McIntosh JM, Buch S, Sopori ML.

J Allergy Clin Immunol. 2012 Sep;130(3):770-780.e11. doi: 10.1016/j.jaci.2012.04.002. Epub 2012 May 9.


Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: possible role of Th17 cells in chronic lung pathology.

Mishra NC, Rir-sima-ah J, Grotendorst GR, Langley RJ, Singh SP, Gundavarapu S, Weber WM, Pena-Philippides JC, Duncan MR, Sopori ML.

Int Immunopharmacol. 2012 May;13(1):101-8. doi: 10.1016/j.intimp.2012.03.010. Epub 2012 Mar 28.


Discriminative value of inflammatory biomarkers for suspected sepsis.

Tsalik EL, Jaggers LB, Glickman SW, Langley RJ, van Velkinburgh JC, Park LP, Fowler VG, Cairns CB, Kingsmore SF, Woods CW.

J Emerg Med. 2012 Jul;43(1):97-106. doi: 10.1016/j.jemermed.2011.05.072. Epub 2011 Nov 6.


Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation.

Singh SP, Gundavarapu S, Peña-Philippides JC, Rir-Sima-ah J, Mishra NC, Wilder JA, Langley RJ, Smith KR, Sopori ML.

J Immunol. 2011 Nov 1;187(9):4542-52. doi: 10.4049/jimmunol.1101567. Epub 2011 Sep 19.


Fibrogenic and redox-related but not proinflammatory genes are upregulated in Lewis rat model of chronic silicosis.

Langley RJ, Mishra NC, Peña-Philippides JC, Rice BJ, Seagrave JC, Singh SP, Sopori ML.

J Toxicol Environ Health A. 2011;74(19):1261-79. doi: 10.1080/15287394.2011.595669.


The role of IL-1β in nicotine-induced immunosuppression and neuroimmune communication.

Razani-Boroujerdi S, Langley RJ, Singh SP, Pena-Philippides JC, Rir-sima-ah J, Gundavarapu S, Mishra NC, Sopori ML.

J Neuroimmune Pharmacol. 2011 Dec;6(4):585-96. doi: 10.1007/s11481-011-9284-5. Epub 2011 Jun 14.


Carrier testing for severe childhood recessive diseases by next-generation sequencing.

Bell CJ, Dinwiddie DL, Miller NA, Hateley SL, Ganusova EE, Mudge J, Langley RJ, Zhang L, Lee CC, Schilkey FD, Sheth V, Woodward JE, Peckham HE, Schroth GP, Kim RW, Kingsmore SF.

Sci Transl Med. 2011 Jan 12;3(65):65ra4. doi: 10.1126/scitranslmed.3001756.


Meiosis-specific gene discovery in plants: RNA-Seq applied to isolated Arabidopsis male meiocytes.

Chen C, Farmer AD, Langley RJ, Mudge J, Crow JA, May GD, Huntley J, Smith AG, Retzel EF.

BMC Plant Biol. 2010 Dec 17;10:280. doi: 10.1186/1471-2229-10-280.


Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptors.

Mishra NC, Rir-sima-ah J, Boyd RT, Singh SP, Gundavarapu S, Langley RJ, Razani-Boroujerdi S, Sopori ML.

J Immunol. 2010 Jul 1;185(1):588-96. doi: 10.4049/jimmunol.0902227. Epub 2010 May 26.


Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain.

Patel D, Wines BD, Langley RJ, Fraser JD.

J Immunol. 2010 Jun 1;184(11):6283-92. doi: 10.4049/jimmunol.0903311. Epub 2010 Apr 28.


An integrated transcriptome atlas of the crop model Glycine max, and its use in comparative analyses in plants.

Libault M, Farmer A, Joshi T, Takahashi K, Langley RJ, Franklin LD, He J, Xu D, May G, Stacey G.

Plant J. 2010 Jul 1;63(1):86-99. doi: 10.1111/j.1365-313X.2010.04222.x. Epub 2010 Apr 7.


Granuloma formation induced by low-dose chronic silica inhalation is associated with an anti-apoptotic response in Lewis rats.

Langley RJ, Mishra NC, Peña-Philippides JC, Hutt JA, Sopori ML.

J Toxicol Environ Health A. 2010;73(10):669-83. doi: 10.1080/15287390903578521.


Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis.

Glickman SW, Cairns CB, Otero RM, Woods CW, Tsalik EL, Langley RJ, van Velkinburgh JC, Park LP, Glickman LT, Fowler VG Jr, Kingsmore SF, Rivers EP.

Acad Emerg Med. 2010 Apr;17(4):383-90. doi: 10.1111/j.1553-2712.2010.00664.x.


Complete transcriptome of the soybean root hair cell, a single-cell model, and its alteration in response to Bradyrhizobium japonicum infection.

Libault M, Farmer A, Brechenmacher L, Drnevich J, Langley RJ, Bilgin DD, Radwan O, Neece DJ, Clough SJ, May GD, Stacey G.

Plant Physiol. 2010 Feb;152(2):541-52. doi: 10.1104/pp.109.148379. Epub 2009 Nov 20.


Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis.

Tsalik EL, Jones D, Nicholson B, Waring L, Liesenfeld O, Park LP, Glickman SW, Caram LB, Langley RJ, van Velkinburgh JC, Cairns CB, Rivers EP, Otero RM, Kingsmore SF, Lalani T, Fowler VG, Woods CW.

J Clin Microbiol. 2010 Jan;48(1):26-33. doi: 10.1128/JCM.01447-09. Epub 2009 Oct 21.


Management of High-Throughput DNA Sequencing Projects: Alpheus.

Miller NA, Kingsmore SF, Farmer A, Langley RJ, Mudge J, Crow JA, Gonzalez AJ, Schilkey FD, Kim RJ, van Velkinburgh J, May GD, Black CF, Myers MK, Utsey JP, Frost NS, Sugarbaker DJ, Bueno R, Gullans SR, Baxter SM, Day SW, Retzel EF.

J Comput Sci Syst Biol. 2008 Dec 26;1:132.


Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum.

Mudge J, Miller NA, Khrebtukova I, Lindquist IE, May GD, Huntley JJ, Luo S, Zhang L, van Velkinburgh JC, Farmer AD, Lewis S, Beavis WD, Schilkey FD, Virk SM, Black CF, Myers MK, Mader LC, Langley RJ, Utsey JP, Kim RW, Roberts RC, Khalsa SK, Garcia M, Ambriz-Griffith V, Harlan R, Czika W, Martin S, Wolfinger RD, Perrone-Bizzozero NI, Schroth GP, Kingsmore SF.

PLoS One. 2008;3(11):e3625. doi: 10.1371/journal.pone.0003625. Epub 2008 Nov 5.


Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens.

Mishra NC, Rir-Sima-Ah J, Langley RJ, Singh SP, Peña-Philippides JC, Koga T, Razani-Boroujerdi S, Hutt J, Campen M, Kim KC, Tesfaigzi Y, Sopori ML.

J Immunol. 2008 Jun 1;180(11):7655-63.


The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.

Chung MC, Wines BD, Baker H, Langley RJ, Baker EN, Fraser JD.

Mol Microbiol. 2007 Dec;66(6):1342-55. Erratum in: Mol Microbiol. 2008 Jan;67(2):473.


Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens.

Taylor K, McCullough B, Clarke DJ, Langley RJ, Pechenick T, Hill A, Campopiano DJ, Barran PE, Dorin JR, Govan JR.

Antimicrob Agents Chemother. 2007 May;51(5):1719-24. Epub 2007 Mar 12.


Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor.

Deng L, Langley RJ, Brown PH, Xu G, Teng L, Wang Q, Gonzales MI, Callender GG, Nishimura MI, Topalian SL, Mariuzza RA.

Nat Immunol. 2007 Apr;8(4):398-408. Epub 2007 Mar 4.


Long- and short-term changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin.

Peña-Philippides JC, Razani-Boroujerdi S, Singh SP, Langley RJ, Mishra NC, Henderson RF, Sopori ML.

Toxicol Sci. 2007 May;97(1):181-8. Epub 2007 Feb 14.


Early postnatal exposure to cigarette smoke impairs the antigen-specific T-cell responses in the spleen.

Singh SP, Razani-Boroujerdi S, Pena-Philippides JC, Langley RJ, Mishra NC, Sopori ML.

Toxicol Lett. 2006 Dec 15;167(3):231-7. Epub 2006 Oct 10.


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