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Items: 41


Crystal structure of duck egg lysozyme isoform II (DEL-II).

Langley DB, Christ D.

BMC Struct Biol. 2018 Aug 22;18(1):10. doi: 10.1186/s12900-018-0090-7.


I-motif DNA structures are formed in the nuclei of human cells.

Zeraati M, Langley DB, Schofield P, Moye AL, Rouet R, Hughes WE, Bryan TM, Dinger ME, Christ D.

Nat Chem. 2018 Jun;10(6):631-637. doi: 10.1038/s41557-018-0046-3. Epub 2018 Apr 23.


Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

Burnett DL, Langley DB, Schofield P, Hermes JR, Chan TD, Jackson J, Bourne K, Reed JH, Patterson K, Porebski BT, Brink R, Christ D, Goodnow CC.

Science. 2018 Apr 13;360(6385):223-226. doi: 10.1126/science.aao3859.


Next-Generation Sequencing of Antibody Display Repertoires.

Rouet R, Jackson KJL, Langley DB, Christ D.

Front Immunol. 2018 Feb 2;9:118. doi: 10.3389/fimmu.2018.00118. eCollection 2018. Review.


Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes.

Loetsch C, Warren J, Laskowski A, Vazquez-Lombardi R, Jandl C, Langley DB, Christ D, Thorburn DR, Ryugo DK, Sprent J, Batten M, King C.

Cell Rep. 2017 Nov 7;21(6):1624-1638. doi: 10.1016/j.celrep.2017.10.044.


Structural basis of antigen recognition: crystal structure of duck egg lysozyme.

Langley DB, Crossett B, Schofield P, Jackson J, Zeraati M, Maltby D, Christie M, Burnett D, Brink R, Goodnow C, Christ D.

Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):910-920. doi: 10.1107/S2059798317013730. Epub 2017 Oct 25.


Structural reconstruction of protein ancestry.

Rouet R, Langley DB, Schofield P, Christie M, Roome B, Porebski BT, Buckle AM, Clifton BE, Jackson CJ, Stock D, Christ D.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3897-3902. doi: 10.1073/pnas.1613477114. Epub 2017 Mar 29.


Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments.

Jeffries CM, Graewert MA, Blanchet CE, Langley DB, Whitten AE, Svergun DI.

Nat Protoc. 2016 Nov;11(11):2122-2153. doi: 10.1038/nprot.2016.113. Epub 2016 Oct 6.


Structure of GUN4 from Chlamydomonas reinhardtii.

Tarahi Tabrizi S, Langley DB, Harrop SJ, Duff AP, Willows RD.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1094-9. doi: 10.1107/S2053230X15012248. Epub 2015 Jul 29.


Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM.

J Biol Chem. 2011 Dec 16;286(50):42971-80. doi: 10.1074/jbc.M111.248559. Epub 2011 Oct 24.


Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH.

Krishna Kumar K, Jacques DA, Pishchany G, Caradoc-Davies T, Spirig T, Malmirchegini GR, Langley DB, Dickson CF, Mackay JP, Clubb RT, Skaar EP, Guss JM, Gell DA.

J Biol Chem. 2011 Nov 4;286(44):38439-47. doi: 10.1074/jbc.M111.287300. Epub 2011 Sep 14.


The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase.

Jacques DA, Langley DB, Kuramitsu S, Yokoyama S, Trewhella J, Guss JM.

Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):105-11. doi: 10.1107/S0907444910051127. Epub 2011 Jan 8.


A novel structure of an antikinase and its inhibitor.

Jacques DA, Langley DB, Hynson RM, Whitten AE, Kwan A, Guss JM, Trewhella J.

J Mol Biol. 2011 Jan 7;405(1):214-26. doi: 10.1016/j.jmb.2010.10.047. Epub 2010 Nov 2.


Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state.

Jacques DA, Streamer M, Rowland SL, King GF, Guss JM, Trewhella J, Langley DB.

Acta Crystallogr D Biol Crystallogr. 2009 Jun;65(Pt 6):574-81. doi: 10.1107/S090744490901169X. Epub 2009 May 15.


Crystallization and diffraction of an Lhx4-Isl2 complex.

Gadd MS, Langley DB, Guss JM, Matthews JM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):151-3. doi: 10.1107/S1744309108043431. Epub 2009 Jan 31.


Histidine kinase regulation by a cyclophilin-like inhibitor.

Jacques DA, Langley DB, Jeffries CM, Cunningham KA, Burkholder WF, Guss JM, Trewhella J.

J Mol Biol. 2008 Dec 12;384(2):422-35. doi: 10.1016/j.jmb.2008.09.017. Epub 2008 Sep 16.


Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.

Langley DB, Trambaiolo DM, Duff AP, Dooley DM, Freeman HC, Guss JM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):577-83. doi: 10.1107/S174430910801556X. Epub 2008 Jun 11.


Enantiomer-specific binding of ruthenium(II) molecular wires by the amine oxidase of Arthrobacter globiformis.

Langley DB, Brown DE, Cheruzel LE, Contakes SM, Duff AP, Hilmer KM, Dooley DM, Gray HB, Guss JM, Freeman HC.

J Am Chem Soc. 2008 Jun 25;130(25):8069-78. doi: 10.1021/ja801289f. Epub 2008 May 29.


Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum.

Langley DB, Shojaei M, Chan C, Lok HC, Mackay JP, Traut TW, Guss JM, Christopherson RI.

Biochemistry. 2008 Mar 25;47(12):3842-54. doi: 10.1021/bi702390k. Epub 2008 Feb 28. Erratum in: Biochemistry. 2010 Mar 24;48(11):2570.


Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline.

Langley DB, Harty DW, Jacques NA, Hunter N, Guss JM, Collyer CA.

J Mol Biol. 2008 Mar 14;377(1):104-16. doi: 10.1016/j.jmb.2007.09.028. Epub 2007 Sep 16.


Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein.

Taraban M, Zhan H, Whitten AE, Langley DB, Matthews KS, Swint-Kruse L, Trewhella J.

J Mol Biol. 2008 Feb 15;376(2):466-81. doi: 10.1016/j.jmb.2007.11.067. Epub 2007 Nov 28.


The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition.

Whitten AE, Jacques DA, Hammouda B, Hanley T, King GF, Guss JM, Trewhella J, Langley DB.

J Mol Biol. 2007 Apr 27;368(2):407-20. Epub 2007 Feb 3.


A C-terminal disulfide bond in the copper-containing amine oxidase from pea seedlings violates the twofold symmetry of the molecular dimer.

Duff AP, Shepard EM, Langley DB, Dooley DM, Freeman HC, Guss JM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt 12):1168-73. Epub 2006 Nov 4.


The copper-containing amine oxidase from Arthrobacter globiformis: refinement at 1.55 and 2.20 A resolution in two crystal forms.

Langley DB, Duff AP, Freeman HC, Guss JM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt 11):1052-7. Epub 2006 Oct 25.


The 1.23 Angstrom structure of Pichia pastoris lysyl oxidase reveals a lysine-lysine cross-link.

Duff AP, Cohen AE, Ellis PJ, Hilmer K, Langley DB, Dooley DM, Freeman HC, Guss JM.

Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):1073-84. Epub 2006 Aug 19.


Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires.

Contakes SM, Juda GA, Langley DB, Halpern-Manners NW, Duff AP, Dunn AR, Gray HB, Dooley DM, Guss JM, Freeman HC.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13451-6. Epub 2005 Sep 12.


Crystal structures of recombinant human purple Acid phosphatase with and without an inhibitory conformation of the repression loop.

Sträter N, Jasper B, Scholte M, Krebs B, Duff AP, Langley DB, Han R, Averill BA, Freeman HC, Guss JM.

J Mol Biol. 2005 Aug 5;351(1):233-46. Epub 2005 Apr 26.


Using xenon as a probe for dioxygen-binding sites in copper amine oxidases.

Duff AP, Trambaiolo DM, Cohen AE, Ellis PJ, Juda GA, Shepard EM, Langley DB, Dooley DM, Freeman HC, Guss JM.

J Mol Biol. 2004 Nov 26;344(3):599-607.


Crystallization of GcnA, an N-acetyl-beta-D-glucosaminidase, from Streptococcus gordonii.

Langley DB, Harty DW, Graham SC, Guss JM, Hunter N, Collyer C.

Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1910-1. Epub 2004 Sep 23.


Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.

O'Connell KM, Langley DB, Shepard EM, Duff AP, Jeon HB, Sun G, Freeman HC, Guss JM, Sayre LM, Dooley DM.

Biochemistry. 2004 Aug 31;43(34):10965-78.


Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis.

Nguyen KA, DeCarlo AA, Paramaesvaran M, Collyer CA, Langley DB, Hunter N.

Infect Immun. 2004 Mar;72(3):1374-82.


The crystal structure of Pichia pastoris lysyl oxidase.

Duff AP, Cohen AE, Ellis PJ, Kuchar JA, Langley DB, Shepard EM, Dooley DM, Freeman HC, Guss JM.

Biochemistry. 2003 Dec 30;42(51):15148-57.


Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex.

Deane JE, Maher MJ, Langley DB, Graham SC, Visvader JE, Guss JM, Matthews JM.

Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1484-6. Epub 2003 Jul 23.


Porphyrin-mediated cell surface heme capture from hemoglobin by Porphyromonas gingivalis.

Paramaesvaran M, Nguyen KA, Caldon E, McDonald JA, Najdi S, Gonzaga G, Langley DB, DeCarlo A, Crossley MJ, Hunter N, Collyer CA.

J Bacteriol. 2003 Apr;185(8):2528-37.


Feasibility of an HA2 domain-based periodontitis vaccine.

DeCarlo AA, Huang Y, Collyer CA, Langley DB, Katz J.

Infect Immun. 2003 Jan;71(1):562-6.


Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism.

Langley DB, Templeton MD, Fields BA, Mitchell RE, Collyer CA.

J Biol Chem. 2000 Jun 30;275(26):20012-9. Erratum in: J Biol Chem 2000 Sep 29;275(39):30746.


Characterization of ryanodine receptors in oligodendrocytes, type 2 astrocytes, and O-2A progenitors.

Simpson PB, Holtzclaw LA, Langley DB, Russell JT.

J Neurosci Res. 1998 May 15;52(4):468-82.


The Bacillus subtilis DNA replication terminator.

Smith MT, de Vries CJ, Langley DB, King GF, Wake RG.

J Mol Biol. 1996 Jul 5;260(1):54-69.


The minimal sequence needed to define a functional DNA terminator in Bacillus subtilis.

Smith MT, Langley DB, Young PA, Wake RG.

J Mol Biol. 1994 Aug 19;241(3):335-40. Erratum in: J Mol Biol 1995 Mar 24;247(2):373.


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