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Items: 1 to 50 of 192

1.

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

Li G, Meanwell NA, Krystal MR, Langley DR, Naidu BN, Sivaprakasam P, Lewis H, Kish K, Khan JA, Ng A, Trainor GL, Cianci C, Dicker IB, Walker MA, Lin Z, Protack T, Discotto L, Jenkins S, Gerritz SW, Pendri A.

J Med Chem. 2020 Feb 21. doi: 10.1021/acs.jmedchem.9b01681. [Epub ahead of print]

PMID:
32081010
2.

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.

Singh M, Jackson KJL, Wang JJ, Schofield P, Field MA, Koppstein D, Peters TJ, Burnett DL, Rizzetto S, Nevoltris D, Masle-Farquhar E, Faulks ML, Russell A, Gokal D, Hanioka A, Horikawa K, Colella AD, Chataway TK, Blackburn J, Mercer TR, Langley DB, Goodall DM, Jefferis R, Gangadharan Komala M, Kelleher AD, Suan D, Rischmueller M, Christ D, Brink R, Luciani F, Gordon TP, Goodnow CC, Reed JH.

Cell. 2020 Feb 5. pii: S0092-8674(20)30110-0. doi: 10.1016/j.cell.2020.01.029. [Epub ahead of print]

PMID:
32059783
3.

Systematic functional identification of cancer multi-drug resistance genes.

Lau MT, Ghazanfar S, Parkin A, Chou A, Rouaen JR, Littleboy JB, Nessem D, Khuong TM, Nevoltris D, Schofield P, Langley D, Christ D, Yang J, Pajic M, Neely GG.

Genome Biol. 2020 Feb 7;21(1):27. doi: 10.1186/s13059-020-1940-8.

4.

Optimizing Time to Antibiotic Administration in Children with Possible Febrile Neutropenia through Quality Improvement Methodologies.

Burns B, Hartenstein M, Lin A, Langley D, Burns E, Heilman J, Tanski M, Stork L, Ma OJ.

Pediatr Qual Saf. 2019 Nov 21;4(6):e236. doi: 10.1097/pq9.0000000000000236. eCollection 2019 Nov-Dec.

5.

Visualization and measurement of the local absorption coefficients of single bilayer phospholipid membranes using scanning near-field optical microscopy.

Siddiquee AM, Hasan IY, Wei S, Langley D, Balaur E, Liu C, Lin J, Abbey B, Mechler A, Kou S.

Biomed Opt Express. 2019 Nov 27;10(12):6569-6579. doi: 10.1364/BOE.10.006569. eCollection 2019 Dec 1.

6.

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.

Peese KM, Naidu BN, Patel M, Li C, Langley DR, Terry B, Protack T, Gali V, Lin Z, Samanta HK, Zheng M, Jenkins S, Dicker IB, Krystal MR, Meanwell NA, Walker MA.

Bioorg Med Chem Lett. 2020 Feb 1;30(3):126784. doi: 10.1016/j.bmcl.2019.126784. Epub 2019 Nov 9.

PMID:
31761656
7.

Protein A superantigen: structure, engineering and molecular basis of antibody recognition.

Mazigi O, Schofield P, Langley DB, Christ D.

Protein Eng Des Sel. 2019 Oct 22. pii: gzz026. doi: 10.1093/protein/gzz026. [Epub ahead of print]

PMID:
31641749
8.

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.

Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST.

Nat Immunol. 2019 Oct;20(10):1299-1310. doi: 10.1038/s41590-019-0492-0. Epub 2019 Sep 18.

PMID:
31534238
9.

GSK3732394: a Multi-specific Inhibitor of HIV Entry.

Wensel D, Sun Y, Davis J, Li Z, Zhang S, McDonagh T, Langley D, Mitchell T, Tabruyn S, Nef P, Cockett M, Krystal M.

J Virol. 2019 Sep 30;93(20). pii: e00907-19. doi: 10.1128/JVI.00907-19. Print 2019 Oct 15.

PMID:
31375580
10.

Human Antibody Bispecifics through Phage Display Selection.

Luthra A, Langley DB, Schofield P, Jackson J, Abdelatti M, Rouet R, Nevoltris D, Mazigi O, Crossett B, Christie M, Christ D.

Biochemistry. 2019 Apr 2;58(13):1701-1704. doi: 10.1021/acs.biochem.9b00037. Epub 2019 Mar 22.

PMID:
30900875
11.

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.

Lai YT, Wang T, O'Dell S, Louder MK, Schön A, Cheung CSF, Chuang GY, Druz A, Lin B, McKee K, Peng D, Yang Y, Zhang B, Herschhorn A, Sodroski J, Bailer RT, Doria-Rose NA, Mascola JR, Langley DR, Kwong PD.

Nat Commun. 2019 Jan 3;10(1):47. doi: 10.1038/s41467-018-07851-1.

12.

Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.

Chowdari NS, Pan C, Rao C, Langley DR, Sivaprakasam P, Sufi B, Derwin D, Wang Y, Kwok E, Passmore D, Rangan VS, Deshpande S, Cardarelli P, Vite G, Gangwar S.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):466-470. doi: 10.1016/j.bmcl.2018.12.021. Epub 2018 Dec 11.

PMID:
30579797
13.

Discovery relies on strong support staff.

Langley D, Theron T.

Nature. 2018 Sep;561(7723):S24. doi: 10.1038/d41586-018-06624-6. No abstract available.

PMID:
30232445
14.

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.

Ni S, Garrido-Castro AF, Merchant RR, de Gruyter JN, Schmitt DC, Mousseau JJ, Gallego GM, Yang S, Collins MR, Qiao JX, Yeung KS, Langley DR, Poss MA, Scola PM, Qin T, Baran PS.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14560-14565. doi: 10.1002/anie.201809310. Epub 2018 Oct 15.

15.

Crystal structure of duck egg lysozyme isoform II (DEL-II).

Langley DB, Christ D.

BMC Struct Biol. 2018 Aug 22;18(1):10. doi: 10.1186/s12900-018-0090-7.

16.

Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir.

Wang T, Ueda Y, Zhang Z, Yin Z, Matiskella J, Pearce BC, Yang Z, Zheng M, Parker DD, Yamanaka GA, Gong YF, Ho HT, Colonno RJ, Langley DR, Lin PF, Meanwell NA, Kadow JF.

J Med Chem. 2018 Jul 26;61(14):6308-6327. doi: 10.1021/acs.jmedchem.8b00759. Epub 2018 Jul 13.

PMID:
29920093
17.

Comparing SVM and ANN based Machine Learning Methods for Species Identification of Food Contaminating Beetles.

Bisgin H, Bera T, Ding H, Semey HG, Wu L, Liu Z, Barnes AE, Langley DA, Pava-Ripoll M, Vyas HJ, Tong W, Xu J.

Sci Rep. 2018 Apr 25;8(1):6532. doi: 10.1038/s41598-018-24926-7.

18.

I-motif DNA structures are formed in the nuclei of human cells.

Zeraati M, Langley DB, Schofield P, Moye AL, Rouet R, Hughes WE, Bryan TM, Dinger ME, Christ D.

Nat Chem. 2018 Jun;10(6):631-637. doi: 10.1038/s41557-018-0046-3. Epub 2018 Apr 23.

PMID:
29686376
19.

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

Burnett DL, Langley DB, Schofield P, Hermes JR, Chan TD, Jackson J, Bourne K, Reed JH, Patterson K, Porebski BT, Brink R, Christ D, Goodnow CC.

Science. 2018 Apr 13;360(6385):223-226. doi: 10.1126/science.aao3859.

20.

Prediction of influenza-like illness based on the improved artificial tree algorithm and artificial neural network.

Hu H, Wang H, Wang F, Langley D, Avram A, Liu M.

Sci Rep. 2018 Mar 20;8(1):4895. doi: 10.1038/s41598-018-23075-1.

21.

Next-Generation Sequencing of Antibody Display Repertoires.

Rouet R, Jackson KJL, Langley DB, Christ D.

Front Immunol. 2018 Feb 2;9:118. doi: 10.3389/fimmu.2018.00118. eCollection 2018. Review.

22.

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.

Meanwell NA, Krystal MR, Nowicka-Sans B, Langley DR, Conlon DA, Eastgate MD, Grasela DM, Timmins P, Wang T, Kadow JF.

J Med Chem. 2018 Jan 11;61(1):62-80. doi: 10.1021/acs.jmedchem.7b01337. Epub 2017 Dec 22.

PMID:
29271653
23.

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes.

Loetsch C, Warren J, Laskowski A, Vazquez-Lombardi R, Jandl C, Langley DB, Christ D, Thorburn DR, Ryugo DK, Sprent J, Batten M, King C.

Cell Rep. 2017 Nov 7;21(6):1624-1638. doi: 10.1016/j.celrep.2017.10.044.

24.

Structural basis of antigen recognition: crystal structure of duck egg lysozyme.

Langley DB, Crossett B, Schofield P, Jackson J, Zeraati M, Maltby D, Christie M, Burnett D, Brink R, Goodnow C, Christ D.

Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):910-920. doi: 10.1107/S2059798317013730. Epub 2017 Oct 25.

25.

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, Madani N, Sodroski J, Freire E, Langley DR, Mascola JR, McDermott AB, Kwong PD.

Nat Chem Biol. 2017 Oct;13(10):1115-1122. doi: 10.1038/nchembio.2460. Epub 2017 Aug 21.

26.

Transparent Electrodes Based on Silver Nanowire Networks: From Physical Considerations towards Device Integration.

Bellet D, Lagrange M, Sannicolo T, Aghazadehchors S, Nguyen VH, Langley DP, Muñoz-Rojas D, Jiménez C, Bréchet Y, Nguyen ND.

Materials (Basel). 2017 May 24;10(6). pii: E570. doi: 10.3390/ma10060570.

27.

A Functional NaV1.7-NaVAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site.

Rajamani R, Wu S, Rodrigo I, Gao M, Low S, Megson L, Wensel D, Pieschl RL, Post-Munson DJ, Watson J, Langley DR, Ahlijanian MK, Bristow LJ, Herrington J.

Mol Pharmacol. 2017 Sep;92(3):310-317. doi: 10.1124/mol.117.108712. Epub 2017 Jun 23.

PMID:
28645932
28.

Structural reconstruction of protein ancestry.

Rouet R, Langley DB, Schofield P, Christie M, Roome B, Porebski BT, Buckle AM, Clifton BE, Jackson CJ, Stock D, Christ D.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3897-3902. doi: 10.1073/pnas.1613477114. Epub 2017 Mar 29.

29.

Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments.

Jeffries CM, Graewert MA, Blanchet CE, Langley DB, Whitten AE, Svergun DI.

Nat Protoc. 2016 Nov;11(11):2122-2153. doi: 10.1038/nprot.2016.113. Epub 2016 Oct 6.

30.

Correction: Species Identification of Food Contaminating Beetles by Recognizing Patterns in Microscopic Images of Elytra Fragments.

Park SI, Bisgin H, Ding H, Semey HG, Langley DA, Tong W, Xu J.

PLoS One. 2016 Sep 7;11(9):e0162757. doi: 10.1371/journal.pone.0162757. eCollection 2016.

31.

Social media use in healthcare: A systematic review of effects on patients and on their relationship with healthcare professionals.

Smailhodzic E, Hooijsma W, Boonstra A, Langley DJ.

BMC Health Serv Res. 2016 Aug 26;16:442. doi: 10.1186/s12913-016-1691-0. Review.

32.

Species Identification of Food Contaminating Beetles by Recognizing Patterns in Microscopic Images of Elytra Fragments.

Park SI, Bisgin H, Ding H, Semey HG, Langley DA, Tong W, Xu J.

PLoS One. 2016 Jun 24;11(6):e0157940. doi: 10.1371/journal.pone.0157940. eCollection 2016. Erratum in: PLoS One. 2016 Sep 7;11(9):e0162757.

33.

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.

Luo G, Chen L, Burton CR, Xiao H, Sivaprakasam P, Krause CM, Cao Y, Liu N, Lippy J, Clarke WJ, Snow K, Raybon J, Arora V, Pokross M, Kish K, Lewis HA, Langley DR, Macor JE, Dubowchik GM.

J Med Chem. 2016 Feb 11;59(3):1041-51. doi: 10.1021/acs.jmedchem.5b01550. Epub 2016 Jan 22.

PMID:
26751161
34.

Dental Management of a Patient with Multiple Idiopathic Cervical Root Resorption.

Ali R, Fayle S, Langley D, Altaie A, Nattress B.

Dent Update. 2015 Sep;42(7):667-8, 670-2.

35.

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

Sun JH, O'Boyle DR 2nd, Fridell RA, Langley DR, Wang C, Roberts SB, Nower P, Johnson BM, Moulin F, Nophsker MJ, Wang YK, Liu M, Rigat K, Tu Y, Hewawasam P, Kadow J, Meanwell NA, Cockett M, Lemm JA, Kramer M, Belema M, Gao M.

Nature. 2015 Nov 12;527(7577):245-8. doi: 10.1038/nature15711. Epub 2015 Nov 4.

PMID:
26536115
36.

Optimization of silver nanowire-based transparent electrodes: effects of density, size and thermal annealing.

Lagrange M, Langley DP, Giusti G, Jiménez C, Bréchet Y, Bellet D.

Nanoscale. 2015 Nov 7;7(41):17410-23. doi: 10.1039/c5nr04084a.

PMID:
26437607
37.

Structure of GUN4 from Chlamydomonas reinhardtii.

Tarahi Tabrizi S, Langley DB, Harrop SJ, Duff AP, Willows RD.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1094-9. doi: 10.1107/S2053230X15012248. Epub 2015 Jul 29.

38.

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.

Sivaprakasam P, Han X, Civiello RL, Jacutin-Porte S, Kish K, Pokross M, Lewis HA, Ahmed N, Szapiel N, Newitt JA, Baldwin ET, Xiao H, Krause CM, Park H, Nophsker M, Lippy JS, Burton CR, Langley DR, Macor JE, Dubowchik GM.

Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63. doi: 10.1016/j.bmcl.2015.03.046. Epub 2015 Mar 24.

PMID:
25845281
39.

Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies.

Rouet R, Dudgeon K, Christie M, Langley D, Christ D.

J Biol Chem. 2015 May 8;290(19):11905-17. doi: 10.1074/jbc.M114.614842. Epub 2015 Mar 3.

40.

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action.

Langley DR, Kimura SR, Sivaprakasam P, Zhou N, Dicker I, McAuliffe B, Wang T, Kadow JF, Meanwell NA, Krystal M.

Proteins. 2015 Feb;83(2):331-50. doi: 10.1002/prot.24726. Epub 2014 Dec 23.

41.

Metallic nanowire networks: effects of thermal annealing on electrical resistance.

Langley DP, Lagrange M, Giusti G, Jiménez C, Bréchet Y, Nguyen ND, Bellet D.

Nanoscale. 2014 Nov 21;6(22):13535-43. doi: 10.1039/c4nr04151h.

42.

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.

Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2524-9. doi: 10.1073/pnas.1403182111. Epub 2014 Jun 9.

43.

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.

44.

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors.

Lambert SM, Langley DR, Garnett JA, Angell R, Hedgethorne K, Meanwell NA, Matthews SJ.

Protein Sci. 2014 Jun;23(6):723-34. doi: 10.1002/pro.2456. Epub 2014 Apr 5.

45.

Discovery and development of hepatitis C virus NS5A replication complex inhibitors.

Belema M, Lopez OD, Bender JA, Romine JL, St Laurent DR, Langley DR, Lemm JA, O'Boyle DR 2nd, Sun JH, Wang C, Fridell RA, Meanwell NA.

J Med Chem. 2014 Mar 13;57(5):1643-72. doi: 10.1021/jm401793m. Epub 2014 Feb 3.

PMID:
24621191
46.

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

Belema M, Nguyen VN, Bachand C, Deon DH, Goodrich JT, James CA, Lavoie R, Lopez OD, Martel A, Romine JL, Ruediger EH, Snyder LB, St Laurent DR, Yang F, Zhu J, Wong HS, Langley DR, Adams SP, Cantor GH, Chimalakonda A, Fura A, Johnson BM, Knipe JO, Parker DD, Santone KS, Fridell RA, Lemm JA, O'Boyle DR 2nd, Colonno RJ, Gao M, Meanwell NA, Hamann LG.

J Med Chem. 2014 Mar 13;57(5):2013-32. doi: 10.1021/jm401836p. Epub 2014 Feb 12.

PMID:
24521299
47.

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.

Hu S, Huang Y, Wu YJ, He H, Grant-Young KA, Bertekap RL, Whiterock V, Brassil P, Lentz K, Sivaprakasam P, Langley DR, Westphal RS, Scola PM.

Bioorg Med Chem. 2014 Mar 1;22(5):1782-90. doi: 10.1016/j.bmc.2014.01.003. Epub 2014 Jan 9.

PMID:
24495863
48.

Genotypic correlates of susceptibility to HIV-1 attachment inhibitor BMS-626529, the active agent of the prodrug BMS-663068.

Zhou N, Nowicka-Sans B, McAuliffe B, Ray N, Eggers B, Fang H, Fan L, Healy M, Langley DR, Hwang C, Lataillade M, Hanna GJ, Krystal M.

J Antimicrob Chemother. 2014 Mar;69(3):573-81. doi: 10.1093/jac/dkt412. Epub 2013 Oct 14.

PMID:
24128669
49.

Flexible transparent conductive materials based on silver nanowire networks: a review.

Langley D, Giusti G, Mayousse C, Celle C, Bellet D, Simonato JP.

Nanotechnology. 2013 Nov 15;24(45):452001. doi: 10.1088/0957-4484/24/45/452001. Epub 2013 Oct 11.

50.

Characterizations of HCV NS5A replication complex inhibitors.

O'Boyle Ii DR, Sun JH, Nower PT, Lemm JA, Fridell RA, Wang C, Romine JL, Belema M, Nguyen VN, Laurent DR, Serrano-Wu M, Snyder LB, Meanwell NA, Langley DR, Gao M.

Virology. 2013 Sep;444(1-2):343-54. doi: 10.1016/j.virol.2013.06.032. Epub 2013 Jul 27.

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