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Items: 1 to 50 of 184

1.

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Singhania A, Graham CM, Gabryšová L, Moreira-Teixeira L, Stavropoulos E, Pitt JM, Chakravarty P, Warnatsch A, Branchett WJ, Conejero L, Lin JW, Davidson S, Wilson MS, Bancroft G, Langhorne J, Frickel E, Sesay AK, Priestnall SL, Herbert E, Ioannou M, Wang Q, Humphreys IR, Dodd J, Openshaw PJM, Mayer-Barber KD, Jankovic D, Sher A, Lloyd CM, Baldwin N, Chaussabel D, Papayannopoulos V, Wack A, Banchereau JF, Pascual VM, O'Garra A.

Nat Commun. 2019 Jun 28;10(1):2887. doi: 10.1038/s41467-019-10601-6.

2.

Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region.

Doritchamou J, Teo A, Morrison R, Arora G, Kwan J, Manzella-Lapeira J, Medina-Maldonado S, Langhorne J, Hviid L, Narum DL, Dicko A, Fried M, Duffy PE.

Infect Immun. 2019 Jun 20;87(7). pii: e00865-18. doi: 10.1128/IAI.00865-18. Print 2019 Jul.

PMID:
30988054
3.

Repeated clinical malaria episodes are associated with modification of the immune system in children.

Bediako Y, Adams R, Reid AJ, Valletta JJ, Ndungu FM, Sodenkamp J, Mwacharo J, Ngoi JM, Kimani D, Kai O, Wambua J, Nyangweso G, de Villiers EP, Sanders M, Lotkowska ME, Lin JW, Manni S, Addy JWG, Recker M, Newbold C, Berriman M, Bejon P, Marsh K, Langhorne J.

BMC Med. 2019 Mar 13;17(1):60. doi: 10.1186/s12916-019-1292-y.

4.

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.

Gabryšová L, Alvarez-Martinez M, Luisier R, Cox LS, Sodenkamp J, Hosking C, Pérez-Mazliah D, Whicher C, Kannan Y, Potempa K, Wu X, Bhaw L, Wende H, Sieweke MH, Elgar G, Wilson M, Briscoe J, Metzis V, Langhorne J, Luscombe NM, O'Garra A.

Nat Immunol. 2019 Mar;20(3):374. doi: 10.1038/s41590-019-0331-3.

PMID:
30733606
5.

Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel® in mice.

Coelho CH, Gazzinelli-Guimaraes PH, Howard J, Barnafo E, Alani NAH, Muratova O, McCormack A, Kelnhofer E, Urban JF Jr, Narum DL, Anderson C, Langhorne J, Nutman TB, Duffy PE.

Vaccine. 2019 Feb 14;37(8):1038-1045. doi: 10.1016/j.vaccine.2019.01.027. Epub 2019 Jan 23.

6.

Correction to: Transcriptomes of microglia in experimental cerebral malaria in mice in the presence and absence of Type I Interferon signaling.

Talavera-López C, Capuccini B, Mitter R, Lin JW, Langhorne J.

BMC Res Notes. 2019 Jan 22;12(1):48. doi: 10.1186/s13104-019-4069-7.

7.

Gamma/Delta T Cells and Their Role in Protection Against Malaria.

Deroost K, Langhorne J.

Front Immunol. 2018 Dec 20;9:2973. doi: 10.3389/fimmu.2018.02973. eCollection 2018. Review.

8.

Transcriptomes of microglia in experimental cerebral malaria in mice in the presence and absence of Type I Interferon signaling.

Talavera-López C, Capuccini B, Mitter R, Lin JW, Langhorne J.

BMC Res Notes. 2018 Dec 20;11(1):913. doi: 10.1186/s13104-018-4020-3. Erratum in: BMC Res Notes. 2019 Jan 22;12(1):48.

9.

Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern.

Lin JW, Reid AJ, Cunningham D, Böhme U, Tumwine I, Keller-Mclaughlin S, Sanders M, Berriman M, Langhorne J.

Version 2. Wellcome Open Res. 2018 Dec 6 [revised 2018 Jan 1];3:142. doi: 10.12688/wellcomeopenres.14797.2. eCollection 2018.

10.

Plasmodium-specific atypical memory B cells are short-lived activated B cells.

Pérez-Mazliah D, Gardner PJ, Schweighoffer E, McLaughlin S, Hosking C, Tumwine I, Davis RS, Potocnik AJ, Tybulewicz VL, Langhorne J.

Elife. 2018 Nov 2;7. pii: e39800. doi: 10.7554/eLife.39800.

11.

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.

Gabryšová L, Alvarez-Martinez M, Luisier R, Cox LS, Sodenkamp J, Hosking C, Pérez-Mazliah D, Whicher C, Kannan Y, Potempa K, Wu X, Bhaw L, Wende H, Sieweke MH, Elgar G, Wilson M, Briscoe J, Metzis V, Langhorne J, Luscombe NM, O'Garra A.

Nat Immunol. 2018 May;19(5):497-507. doi: 10.1038/s41590-018-0083-5. Epub 2018 Apr 16. Erratum in: Nat Immunol. 2019 Mar;20(3):374.

12.

A New Link between γδ T Cells and Myeloid Cells in Malaria?

Lewis MD, Langhorne J.

Immunity. 2018 Feb 20;48(2):193-195. doi: 10.1016/j.immuni.2018.02.003.

13.

Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection.

Pérez-Mazliah D, Nguyen MP, Hosking C, McLaughlin S, Lewis MD, Tumwine I, Levy P, Langhorne J.

EBioMedicine. 2017 Oct;24:216-230. doi: 10.1016/j.ebiom.2017.08.030. Epub 2017 Sep 4.

14.

T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.

Moreira-Teixeira L, Redford PS, Stavropoulos E, Ghilardi N, Maynard CL, Weaver CT, Freitas do Rosário AP, Wu X, Langhorne J, O'Garra A.

J Immunol. 2017 Jul 15;199(2):613-623. doi: 10.4049/jimmunol.1601340. Epub 2017 Jun 5.

15.

ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model.

Cunningham DA, Lin JW, Brugat T, Jarra W, Tumwine I, Kushinga G, Ramesar J, Franke-Fayard B, Langhorne J.

Malar J. 2017 May 3;16(1):185. doi: 10.1186/s12936-017-1834-8.

16.

Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection.

Brugat T, Reid AJ, Lin J, Cunningham D, Tumwine I, Kushinga G, McLaughlin S, Spence P, Böhme U, Sanders M, Conteh S, Bushell E, Metcalf T, Billker O, Duffy PE, Newbold C, Berriman M, Langhorne J.

Nat Microbiol. 2017 Feb 6;2:16276. doi: 10.1038/nmicrobiol.2016.276.

17.

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.

Lin JW, Sodenkamp J, Cunningham D, Deroost K, Tshitenge TC, McLaughlin S, Lamb TJ, Spencer-Dene B, Hosking C, Ramesar J, Janse CJ, Graham C, O'Garra A, Langhorne J.

Sci Rep. 2017 Feb 3;7:41722. doi: 10.1038/srep41722.

18.

Trimethoprim-Sulfamethoxazole Prophylaxis During Live Malaria Sporozoite Immunization Induces Long-Lived, Homologous, and Heterologous Protective Immunity Against Sporozoite Challenge.

Hobbs CV, Anderson C, Neal J, Sahu T, Conteh S, Voza T, Langhorne J, Borkowsky W, Duffy PE.

J Infect Dis. 2017 Jan 1;215(1):122-130. doi: 10.1093/infdis/jiw482. Epub 2016 Oct 17.

19.

Transcriptomic profiling of microglia reveals signatures of cell activation and immune response, during experimental cerebral malaria.

Capuccini B, Lin J, Talavera-López C, Khan SM, Sodenkamp J, Spaccapelo R, Langhorne J.

Sci Rep. 2016 Dec 19;6:39258. doi: 10.1038/srep39258.

20.

Heterologous Infection of Pregnant Mice Induces Low Birth Weight and Modifies Offspring Susceptibility to Malaria.

Sharma A, Conteh S, Langhorne J, Duffy PE.

PLoS One. 2016 Jul 28;11(7):e0160120. doi: 10.1371/journal.pone.0160120. eCollection 2016.

21.

Characterization of the Plasmodium Interspersed Repeats (PIR) proteins of Plasmodium chabaudi indicates functional diversity.

Yam XY, Brugat T, Siau A, Lawton J, Wong DS, Farah A, Twang JS, Gao X, Langhorne J, Preiser PR.

Sci Rep. 2016 Mar 21;6:23449. doi: 10.1038/srep23449.

22.

Expanding the antimalarial toolkit: Targeting host-parasite interactions.

Langhorne J, Duffy PE.

J Exp Med. 2016 Feb 8;213(2):143-53. doi: 10.1084/jem.20151677. Epub 2016 Feb 1. Review.

23.

Cross-stage immunity for malaria vaccine development.

Nahrendorf W, Scholzen A, Sauerwein RW, Langhorne J.

Vaccine. 2015 Dec 22;33(52):7513-7. doi: 10.1016/j.vaccine.2015.09.098. Epub 2015 Oct 19.

24.

IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.

Coomes SM, Pelly VS, Kannan Y, Okoye IS, Czieso S, Entwistle LJ, Perez-Lloret J, Nikolov N, Potocnik AJ, Biró J, Langhorne J, Wilson MS.

PLoS Pathog. 2015 Jul 6;11(7):e1004994. doi: 10.1371/journal.ppat.1004994. eCollection 2015 Jul.

25.

Mosquitoes Reset Malaria Parasites.

Spence PJ, Brugat T, Langhorne J.

PLoS Pathog. 2015 Jul 2;11(7):e1004987. doi: 10.1371/journal.ppat.1004987. eCollection 2015 Jul. No abstract available.

26.

Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance.

Lin JW, Spaccapelo R, Schwarzer E, Sajid M, Annoura T, Deroost K, Ravelli RB, Aime E, Capuccini B, Mommaas-Kienhuis AM, O'Toole T, Prins F, Franke-Fayard BM, Ramesar J, Chevalley-Maurel S, Kroeze H, Koster AJ, Tanke HJ, Crisanti A, Langhorne J, Arese P, Van den Steen PE, Janse CJ, Khan SM.

J Exp Med. 2015 Jun 1;212(6):893-903. doi: 10.1084/jem.20141731. Epub 2015 May 4.

27.

Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria.

Pérez-Mazliah D, Ng DH, Freitas do Rosário AP, McLaughlin S, Mastelic-Gavillet B, Sodenkamp J, Kushinga G, Langhorne J.

PLoS Pathog. 2015 Mar 12;11(3):e1004715. doi: 10.1371/journal.ppat.1004715. eCollection 2015 Mar.

28.

Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization.

Nahrendorf W, Spence PJ, Tumwine I, Lévy P, Jarra W, Sauerwein RW, Langhorne J.

Elife. 2015 Feb 25;4. doi: 10.7554/eLife.05165.

29.

In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.

Borges da Silva H, Fonseca R, Cassado Ados A, Machado de Salles É, de Menezes MN, Langhorne J, Perez KR, Cuccovia IM, Ryffel B, Barreto VM, Marinho CR, Boscardin SB, Álvarez JM, D'Império-Lima MR, Tadokoro CE.

PLoS Pathog. 2015 Feb 6;11(2):e1004598. doi: 10.1371/journal.ppat.1004598. eCollection 2015 Feb.

30.

CD4 T-cell subsets in malaria: TH1/TH2 revisited.

Perez-Mazliah D, Langhorne J.

Front Immunol. 2015 Jan 12;5:671. doi: 10.3389/fimmu.2014.00671. eCollection 2014. Review.

31.

A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Otto TD, Böhme U, Jackson AP, Hunt M, Franke-Fayard B, Hoeijmakers WA, Religa AA, Robertson L, Sanders M, Ogun SA, Cunningham D, Erhart A, Billker O, Khan SM, Stunnenberg HG, Langhorne J, Holder AA, Waters AP, Newbold CI, Pain A, Berriman M, Janse CJ.

BMC Biol. 2014 Oct 30;12:86. doi: 10.1186/s12915-014-0086-0.

32.

Expansion of IgG+ B-cells during mitogen stimulation for memory B-cell ELISpot analysis is influenced by size and composition of the B-cell pool.

Scholzen A, Nahrendorf W, Langhorne J, Sauerwein RW.

PLoS One. 2014 Jul 22;9(7):e102885. doi: 10.1371/journal.pone.0102885. eCollection 2014.

33.

Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.

Okoye IS, Czieso S, Ktistaki E, Roderick K, Coomes SM, Pelly VS, Kannan Y, Perez-Lloret J, Zhao JL, Baltimore D, Langhorne J, Wilson MS.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3081-90. doi: 10.1073/pnas.1406322111. Epub 2014 Jul 14.

34.

Memory B-cell and antibody responses induced by Plasmodium falciparum sporozoite immunization.

Nahrendorf W, Scholzen A, Bijker EM, Teirlinck AC, Bastiaens GJ, Schats R, Hermsen CC, Visser LG, Langhorne J, Sauerwein RW.

J Infect Dis. 2014 Dec 15;210(12):1981-90. doi: 10.1093/infdis/jiu354. Epub 2014 Jun 25.

35.

Recovery of an antiviral antibody response following attrition caused by unrelated infection.

Ng DH, Skehel JJ, Kassiotis G, Langhorne J.

PLoS Pathog. 2014 Jan;10(1):e1003843. doi: 10.1371/journal.ppat.1003843. Epub 2014 Jan 2.

36.

Sequestration and histopathology in Plasmodium chabaudi malaria are influenced by the immune response in an organ-specific manner.

Brugat T, Cunningham D, Sodenkamp J, Coomes S, Wilson M, Spence PJ, Jarra W, Thompson J, Scudamore C, Langhorne J.

Cell Microbiol. 2014 May;16(5):687-700. doi: 10.1111/cmi.12212. Epub 2013 Sep 30.

37.

Extramedullary myelopoiesis in malaria depends on mobilization of myeloid-restricted progenitors by IFN-γ induced chemokines.

Belyaev NN, Biró J, Langhorne J, Potocnik AJ.

PLoS Pathog. 2013;9(6):e1003406. doi: 10.1371/journal.ppat.1003406. Epub 2013 Jun 6.

38.

Vector transmission regulates immune control of Plasmodium virulence.

Spence PJ, Jarra W, Lévy P, Reid AJ, Chappell L, Brugat T, Sanders M, Berriman M, Langhorne J.

Nature. 2013 Jun 13;498(7453):228-31. doi: 10.1038/nature12231. Epub 2013 May 29.

39.

Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure.

Roetynck S, Olotu A, Simam J, Marsh K, Stockinger B, Urban B, Langhorne J.

PLoS One. 2013;8(1):e55195. doi: 10.1371/journal.pone.0055195. Epub 2013 Jan 28.

40.

Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi.

Spence PJ, Jarra W, Lévy P, Nahrendorf W, Langhorne J.

Malar J. 2012 Dec 6;11:407. doi: 10.1186/1475-2875-11-407.

41.

Transient deficiency of dendritic cells results in lack of a merozoite surface protein 1-specific CD4 T cell response during peak Plasmodium chabaudi blood-stage infection.

Sponaas AM, Belyaev N, Falck-Hansen M, Potocnik A, Langhorne J.

Infect Immun. 2012 Dec;80(12):4248-56. doi: 10.1128/IAI.00820-12. Epub 2012 Sep 24.

42.

T cell control of malaria pathogenesis.

Spence PJ, Langhorne J.

Curr Opin Immunol. 2012 Aug;24(4):444-8. doi: 10.1016/j.coi.2012.05.003. Epub 2012 May 30. Review.

PMID:
22658628
43.

IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection.

Mastelic B, do Rosario AP, Veldhoen M, Renauld JC, Jarra W, Sponaas AM, Roetynck S, Stockinger B, Langhorne J.

Front Immunol. 2012 Apr 25;3:85. doi: 10.3389/fimmu.2012.00085. eCollection 2012.

44.

T cell-derived IL-10 and its impact on the regulation of host responses during malaria.

Freitas do Rosario AP, Langhorne J.

Int J Parasitol. 2012 May 15;42(6):549-55. doi: 10.1016/j.ijpara.2012.03.010. Epub 2012 Apr 24. Review.

PMID:
22549022
45.

Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).

Lawton J, Brugat T, Yan YX, Reid AJ, Böhme U, Otto TD, Pain A, Jackson A, Berriman M, Cunningham D, Preiser P, Langhorne J.

BMC Genomics. 2012 Mar 29;13:125. doi: 10.1186/1471-2164-13-125.

46.

The role of animal models for research on severe malaria.

Craig AG, Grau GE, Janse C, Kazura JW, Milner D, Barnwell JW, Turner G, Langhorne J; participants of the Hinxton Retreat meeting on Animal Models for Research on Severe Malaria.

PLoS Pathog. 2012 Feb;8(2):e1002401. doi: 10.1371/journal.ppat.1002401. Epub 2012 Feb 2. No abstract available.

47.

IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.

Freitas do Rosário AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, O'Garra A, Langhorne J.

J Immunol. 2012 Feb 1;188(3):1178-90. doi: 10.4049/jimmunol.1102755. Epub 2011 Dec 28.

48.

The role of the spleen in malaria.

Del Portillo HA, Ferrer M, Brugat T, Martin-Jaular L, Langhorne J, Lacerda MV.

Cell Microbiol. 2012 Mar;14(3):343-55. doi: 10.1111/j.1462-5822.2011.01741.x. Epub 2012 Feb 2. Review.

PMID:
22188297
49.

Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.

Tulone C, Sponaas AM, Raiber EA, Tabor AB, Langhorne J, Chain BM.

PLoS One. 2011;6(10):e24886. doi: 10.1371/journal.pone.0024886. Epub 2011 Oct 28.

50.

Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malaria.

Stephens R, Seddon B, Langhorne J.

PLoS One. 2011;6(10):e26686. doi: 10.1371/journal.pone.0026686. Epub 2011 Oct 21.

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