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Items: 1 to 50 of 224

1.

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cephalexin Monohydrate.

Plöger GF, Quizon PM, Abrahamsson B, Cristofoletti R, Groot DW, Parr A, Langguth P, Polli JE, Shah VP, Tajiri T, Mehta MU, Dressman J.

J Pharm Sci. 2020 Mar 30. pii: S0022-3549(20)30184-2. doi: 10.1016/j.xphs.2020.03.025. [Epub ahead of print]

PMID:
32240696
2.

Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery.

Pielenhofer J, Sohl J, Windbergs M, Langguth P, Radsak MP.

Front Immunol. 2020 Feb 26;11:266. doi: 10.3389/fimmu.2020.00266. eCollection 2020. Review.

3.

In vitro prediction of in vivo absorption of ibuprofen from suspensions through rational choice of dissolution conditions.

Hofmann M, García MA, Al-Gousous J, Ruiz-Picazo A, Thieringer F, Nguyen MA, Månsson W, Galle PR, Langguth P.

Eur J Pharm Biopharm. 2020 Apr;149:229-237. doi: 10.1016/j.ejpb.2020.02.009. Epub 2020 Feb 26.

PMID:
32112894
4.

Enteric Hard Capsules for Targeting the Small Intestine: Positive Correlation between In Vitro Disintegration and Dissolution Times.

Fu M, Al-Gousous J, Blechar JA, Langguth P.

Pharmaceutics. 2020 Feb 3;12(2). pii: E123. doi: 10.3390/pharmaceutics12020123.

5.

MRI in patients with implanted active devices: how to combine safety and image quality using a limited transmission field?

Lunden L, Wolff S, Peters S, Drews C, Gierloff C, Jensen-Kondering U, Langguth P, Madjidyar J, Piesch TC, Jansen O.

Eur Radiol. 2020 Jan 23. doi: 10.1007/s00330-019-06599-6. [Epub ahead of print]

PMID:
31974690
6.

Non-contrast enhanced diagnosis of acute myocarditis based on the 17-segment heart model using 2D-feature tracking magnetic resonance imaging.

Salehi Ravesh M, Eden M, Langguth P, Piesch TC, Lehmann JK, Lebenatus A, Hauttemann D, Graessner J, Frey N, Jansen O, Both M.

Magn Reson Imaging. 2020 Jan;65:155-165. doi: 10.1016/j.mri.2019.11.008. Epub 2019 Nov 9.

PMID:
31715249
7.

In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats.

Hemelryck SV, Dewulf J, Niekus H, van Heerden M, Ingelse B, Holm R, Mannaert E, Langguth P.

Int J Pharm X. 2019 May 24;1:100016. doi: 10.1016/j.ijpx.2019.100016. eCollection 2019 Dec.

8.

Transcutaneous immunization with CD40 ligation boosts cytotoxic T lymphocyte mediated antitumor immunity independent of CD4 helper cells in mice.

Bialojan A, Sohl J, Rausch J, Aranda Lopez P, Denny M, Langguth P, Hartmann AK, Yagita H, Probst HC, Schild H, Radsak MP.

Eur J Immunol. 2019 Nov;49(11):2083-2094. doi: 10.1002/eji.201848039. Epub 2019 Aug 19.

PMID:
31393597
9.

[Intravenous Iron Substitution in Chronic Disease - in Whom, When and How?]

Biggar P, Langguth P, Krayenbühl PA, Brandenburg V.

Dtsch Med Wochenschr. 2019 Jul;144(14):969-977. doi: 10.1055/a-0810-8596. Epub 2019 Jul 16. Review. German.

10.

In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development.

Zane P, Gieschen H, Kersten E, Mathias N, Ollier C, Johansson P, Van den Bergh A, Van Hemelryck S, Reichel A, Rotgeri A, Schäfer K, Müllertz A, Langguth P.

Eur J Pharm Biopharm. 2019 Sep;142:222-231. doi: 10.1016/j.ejpb.2019.06.010. Epub 2019 Jun 21. Review.

PMID:
31233862
11.

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Ondansetron.

Rajawat GS, Belubbi T, Nagarsenker MS, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Parr A, Polli JE, Mehta M, Shah VP, Tajiri T, Dressman J.

J Pharm Sci. 2019 Oct;108(10):3157-3168. doi: 10.1016/j.xphs.2019.05.033. Epub 2019 Jun 8.

PMID:
31181225
12.

Non-contrast-enhanced magnetic resonance imaging for visualization and quantification of endovascular aortic prosthesis, their endoleaks and aneurysm sacs at 1.5 T.

Salehi Ravesh M, Langguth P, Pfarr JA, Schupp J, Trentmann J, Koktzoglou I, Edelman RR, Graessner J, Greiser A, Hautemann D, Hennemuth A, Both M, Jansen O, Hövener JB, Schäfer JP.

Magn Reson Imaging. 2019 Jul;60:164-172. doi: 10.1016/j.mri.2019.05.012. Epub 2019 May 7.

PMID:
31075419
13.

Mass Transport Analysis of Bicarbonate Buffer: Effect of the CO2-H2CO3 Hydration-Dehydration Kinetics in the Fluid Boundary Layer and the Apparent Effective p Ka Controlling Dissolution of Acids and Bases.

Al-Gousous J, Salehi N, Amidon GE, Ziff RM, Langguth P, Amidon GL.

Mol Pharm. 2019 Jun 3;16(6):2626-2635. doi: 10.1021/acs.molpharmaceut.9b00187. Epub 2019 May 13.

PMID:
31013101
14.

Designing robust immediate release tablet formulations avoiding food effects for BCS class 3 drugs.

Zaheer K, Langguth P.

Eur J Pharm Biopharm. 2019 Jun;139:177-185. doi: 10.1016/j.ejpb.2019.03.015. Epub 2019 Mar 19.

PMID:
30902732
15.

Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications.

Al-Gousous J, Ruan H, Blechar JA, Sun KX, Salehi N, Langguth P, Job NM, Lipka E, Loebenberg R, Bermejo M, Amidon GE, Amidon GL.

Eur J Pharm Biopharm. 2019 Jun;139:47-58. doi: 10.1016/j.ejpb.2019.03.012. Epub 2019 Mar 11.

PMID:
30872012
16.

Impact of uncharged and charged stabilizers on in vitro drug performances of clarithromycin nanocrystals.

Soisuwan S, Teeranachaideekul V, Wongrakpanich A, Langguth P, Junyaprasert VB.

Eur J Pharm Biopharm. 2019 Apr;137:68-76. doi: 10.1016/j.ejpb.2019.02.004. Epub 2019 Feb 12.

PMID:
30769087
17.

Handling forces for the use of different inhaler devices.

Ciciliani AM, Langguth P, Wachtel H.

Int J Pharm. 2019 Apr 5;560:315-321. doi: 10.1016/j.ijpharm.2019.01.053. Epub 2019 Jan 31.

18.

The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir.

Kubbinga M, Augustijns P, García MA, Heinen C, Wortelboer HM, Verwei M, Langguth P.

Eur J Pharm Biopharm. 2019 Mar;136:147-155. doi: 10.1016/j.ejpb.2019.01.021. Epub 2019 Jan 22.

PMID:
30682491
19.

A novel technique for intraduodenal administration of drug suspensions/solutions with concurrent pH monitoring applied to ibuprofen formulations.

Hofmann M, Thieringer F, Nguyen MA, Månsson W, Galle PR, Langguth P.

Eur J Pharm Biopharm. 2019 Mar;136:192-202. doi: 10.1016/j.ejpb.2019.01.010. Epub 2019 Jan 16.

PMID:
30659894
20.

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration.

Butler J, Hens B, Vertzoni M, Brouwers J, Berben P, Dressman J, Andreas CJ, Schaefer KJ, Mann J, McAllister M, Jamei M, Kostewicz E, Kesisoglou F, Langguth P, Minekus M, Müllertz A, Schilderink R, Koziolek M, Jedamzik P, Weitschies W, Reppas C, Augustijns P.

Eur J Pharm Biopharm. 2019 Mar;136:70-83. doi: 10.1016/j.ejpb.2018.12.010. Epub 2018 Dec 20.

21.

Investigation of charge ratio variation in mRNA - DEAE-dextran polyplex delivery systems.

Siewert C, Haas H, Nawroth T, Ziller A, Nogueira SS, Schroer MA, Blanchet CE, Svergun DI, Radulescu A, Bates F, Huesemann Y, Radsak MP, Sahin U, Langguth P.

Biomaterials. 2019 Feb;192:612-620. doi: 10.1016/j.biomaterials.2018.10.020. Epub 2018 Nov 17.

22.

The needle in the (organ) haystack.

Langguth P, Haneya A, Both M.

Eur Heart J Cardiovasc Imaging. 2019 Jan 1;20(1):30. doi: 10.1093/ehjci/jey165. No abstract available.

PMID:
30445519
23.

Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance.

Al-Gousous J, Sun KX, McNamara DP, Hens B, Salehi N, Langguth P, Bermejo M, Amidon GE, Amidon GL.

Mol Pharm. 2018 Nov 5;15(11):5291-5301. doi: 10.1021/acs.molpharmaceut.8b00783. Epub 2018 Oct 26.

PMID:
30362350
24.

Effect of alpha-linolenic acid in combination with the flavonol quercetin on markers of cardiovascular disease risk in healthy, non-obese adults: A randomized, double-blinded placebo-controlled crossover trial.

Burak C, Wolffram S, Zur B, Langguth P, Fimmers R, Alteheld B, Stehle P, Egert S.

Nutrition. 2019 Feb;58:47-56. doi: 10.1016/j.nut.2018.06.012. Epub 2018 Jul 12.

PMID:
30278429
25.

Why Asplenic Patients Should Not Take Care of the Neighbour's Dog? A Fatal Course of Capnocytophaga canimorsus Sepsis.

Langguth P, Leissner L, Zick G, Fischer A, Stuhlmann-Laiesz C, Salehi Ravesh M, Austein F, Jansen O, Both M.

Case Rep Infect Dis. 2018 Aug 2;2018:3870640. doi: 10.1155/2018/3870640. eCollection 2018.

26.

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project.

Hens B, Sinko PD, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixão P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, Lennernäs H, Hasler WL, Marciani L, Dickens J, Shedden K, Sun D, Amidon GE, Amidon GL.

Int J Pharm. 2018 Sep 5;548(1):120-127. doi: 10.1016/j.ijpharm.2018.06.050. Epub 2018 Jun 23. Review.

PMID:
29944899
27.

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Dahlgren D, Roos C, Johansson P, Tannergren C, Lundqvist A, Langguth P, Sjöblom M, Sjögren E, Lennernäs H.

Int J Pharm. 2018 Aug 25;547(1-2):158-168. doi: 10.1016/j.ijpharm.2018.05.029. Epub 2018 May 11.

PMID:
29758344
28.

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride.

Plöger GF, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Mehta MU, Parr A, Polli JE, Shah VP, Tajiri T, Dressman JB.

J Pharm Sci. 2018 Jul;107(7):1761-1772. doi: 10.1016/j.xphs.2018.03.009. Epub 2018 Mar 20. Review.

PMID:
29571740
29.

Exploring gastric emptying rate in minipigs: Effect of food type and pre-dosing of metoclopramide.

Henze LJ, Griffin BT, Christiansen M, Bundgaard C, Langguth P, Holm R.

Eur J Pharm Sci. 2018 Jun 15;118:183-190. doi: 10.1016/j.ejps.2018.03.017. Epub 2018 Mar 17.

PMID:
29559403
30.

Bioequivalence decision for nanoparticular iron complex drugs for parenteral administration based on their disposition.

Schnorr J, Fütterer S, Spicher K, Catarinolo M, Schlösser C, Enzmann H, Langguth P.

Regul Toxicol Pharmacol. 2018 Apr;94:293-298. doi: 10.1016/j.yrtph.2018.02.009. Epub 2018 Feb 15.

PMID:
29454888
31.

A time-scaled convolution approach to construct IVIVC for enteric-coated acetylsalicylic acid tablets.

Al-Gousous J, Langguth P.

Pharmazie. 2018 Feb 1;73(2):67-69. doi: 10.1691/ph.2018.7136.

PMID:
29442006
32.

IVIVC approach based on carbamazepine bioequivalence studies combination.

González-García I, Mangas-Sanjuan V, Merino-Sanjuán M, Álvarez-Álvarez C, Díaz-Garzón Marco J, Rodríguez-Bonnín MA, Langguth T, Torrado-Durán JJ, Langguth P, García-Arieta A, Bermejo M.

Pharmazie. 2017 Aug 1;72(8):449-455. doi: 10.1691/ph.2017.7011.

PMID:
29441903
33.

Dissolution/permeation: The importance of the experimental setup for the prediction of formulation effects on fenofibrate in vivo performance.

Forner K, Hidalgo I, Lin J, Ackermann M, Langguth P.

Pharmazie. 2017 Oct 1;72(10):581-586. doi: 10.1691/ph.2017.7066.

PMID:
29441882
34.

Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration.

Ziller A, Nogueira SS, Hühn E, Funari SS, Brezesinski G, Hartmann H, Sahin U, Haas H, Langguth P.

Mol Pharm. 2018 Feb 5;15(2):642-651. doi: 10.1021/acs.molpharmaceut.7b01022. Epub 2018 Jan 18.

PMID:
29232147
35.

Extreme widening of asymmetric giant cystic Virchow-Robin spaces.

Austein F, Langguth P, Lindner T.

Neuroradiology. 2018 Jan;60(1):3-5. doi: 10.1007/s00234-017-1951-7. Epub 2017 Nov 22. No abstract available.

PMID:
29167921
36.

Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets.

Zaheer K, Langguth P.

Drug Dev Ind Pharm. 2018 Mar;44(3):444-451. doi: 10.1080/03639045.2017.1397685. Epub 2017 Nov 10.

PMID:
29098885
37.

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Folic Acid.

Hofsäss MA, Souza J, Silva-Barcellos NM, Bellavinha KR, Abrahamsson B, Cristofoletti R, Groot DW, Parr A, Langguth P, Polli JE, Shah VP, Tajiri T, Mehta MU, Dressman JB.

J Pharm Sci. 2017 Dec;106(12):3421-3430. doi: 10.1016/j.xphs.2017.08.007. Epub 2017 Aug 24.

PMID:
28842299
38.

Poly(HydroxyButyrate-co-HydroxyValerate) (PHBHV) Nanocarriers for Silymarin Release as Adjuvant Therapy in Colo-rectal Cancer.

Radu IC, Hudita A, Zaharia C, Stanescu PO, Vasile E, Iovu H, Stan M, Ginghina O, Galateanu B, Costache M, Langguth P, Tsatsakis A, Velonia K, Negrei C.

Front Pharmacol. 2017 Aug 2;8:508. doi: 10.3389/fphar.2017.00508. eCollection 2017.

39.

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA.

Dahlgren D, Roos C, Lundqvist A, Tannergren C, Langguth P, Sjöblom M, Sjögren E, Lennernäs H.

Mol Pharm. 2017 Dec 4;14(12):4243-4251. doi: 10.1021/acs.molpharmaceut.7b00353. Epub 2017 Aug 8.

PMID:
28737406
40.

Combined immunotherapy: CTLA-4 blockade potentiates anti-tumor response induced by transcutaneous immunization.

Rausch J, Lopez PA, Bialojan A, Denny M, Langguth P, Probst HC, Schild H, Radsak MP.

J Dermatol Sci. 2017 Sep;87(3):300-306. doi: 10.1016/j.jdermsci.2017.06.013. Epub 2017 Jun 16.

PMID:
28666747
41.

Transcutaneous immunization with a novel imiquimod nanoemulsion induces superior T cell responses and virus protection.

Lopez PA, Denny M, Hartmann AK, Alflen A, Probst HC, von Stebut E, Tenzer S, Schild H, Stassen M, Langguth P, Radsak MP.

J Dermatol Sci. 2017 Sep;87(3):252-259. doi: 10.1016/j.jdermsci.2017.06.012. Epub 2017 Jun 16.

PMID:
28655469
42.

In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy.

Ciciliani AM, Langguth P, Wachtel H.

Int J Chron Obstruct Pulmon Dis. 2017 May 26;12:1565-1577. doi: 10.2147/COPD.S115886. eCollection 2017.

43.

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

Thambavita D, Galappatthy P, Mannapperuma U, Jayakody L, Cristofoletti R, Abrahamsson B, Groot DW, Langguth P, Mehta M, Parr A, Polli JE, Shah VP, Dressman J.

J Pharm Sci. 2017 Oct;106(10):2930-2945. doi: 10.1016/j.xphs.2017.04.068. Epub 2017 May 5. Review.

PMID:
28483422
44.

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Enalapril.

Verbeeck RK, Kanfer I, Löbenberg R, Abrahamsson B, Cristofoletti R, Groot DW, Langguth P, Polli JE, Parr A, Shah VP, Mehta M, Dressman JB.

J Pharm Sci. 2017 Aug;106(8):1933-1943. doi: 10.1016/j.xphs.2017.04.019. Epub 2017 Apr 21. Review.

PMID:
28435140
45.

Impaired oral absorption of methylphenidate after Roux-en-Y gastric bypass.

Azran C, Langguth P, Dahan A.

Surg Obes Relat Dis. 2017 Jul;13(7):1245-1247. doi: 10.1016/j.soard.2017.03.003. Epub 2017 Mar 9. Review.

PMID:
28420586
46.

Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial.

Burak C, Wolffram S, Zur B, Langguth P, Fimmers R, Alteheld B, Stehle P, Egert S.

Br J Nutr. 2017 Mar;117(5):698-711. doi: 10.1017/S0007114517000241. Epub 2017 Apr 3.

PMID:
28366181
47.

A survey on IVIVC/IVIVR development in the pharmaceutical industry - Past experience and current perspectives.

Nguyen MA, Flanagan T, Brewster M, Kesisoglou F, Beato S, Biewenga J, Crison J, Holm R, Li R, Mannaert E, McAllister M, Mueller-Zsigmondy M, Muenster U, Ojala K, Page S, Parr A, Rossenu S, Timmins P, Van Peer A, Vermeulen A, Langguth P.

Eur J Pharm Sci. 2017 May 1;102:1-13. doi: 10.1016/j.ejps.2017.02.029. Epub 2017 Feb 21. Review.

PMID:
28235611
48.

Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive in Vitro Test Systems.

Al-Gousous J, Tsume Y, Fu M, Salem II, Langguth P.

Mol Pharm. 2017 Dec 4;14(12):4209-4219. doi: 10.1021/acs.molpharmaceut.6b00877. Epub 2017 Feb 28. Review.

PMID:
28199791
49.

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.

Margolskee A, Darwich AS, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, Mazuir F, Nicolas O, Ramusovic S, Xu C, Pathak SM, Korjamo T, Laru J, Malkki J, Pappinen S, Tuunainen J, Dressman J, Hansmann S, Kostewicz E, He H, Heimbach T, Wu F, Hoft C, Laplanche L, Pang Y, Bolger MB, Huehn E, Lukacova V, Mullin JM, Szeto KX, Costales C, Lin J, McAllister M, Modi S, Rotter C, Varma M, Wong M, Mitra A, Bevernage J, Biewenga J, Van Peer A, Lloyd R, Shardlow C, Langguth P, Mishenzon I, Nguyen MA, Brown J, Lennernäs H, Abrahamsson B.

Eur J Pharm Sci. 2017 Jan 1;96:610-625. doi: 10.1016/j.ejps.2016.10.036. Epub 2016 Nov 2.

PMID:
27816631
50.

Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs.

Forner K, Roos C, Dahlgren D, Kesisoglou F, Konerding MA, Mazur J, Lennernäs H, Langguth P.

Drug Dev Ind Pharm. 2017 Feb;43(2):338-346. doi: 10.1080/03639045.2016.1251449. Epub 2016 Nov 6.

PMID:
27762631

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