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Protecting effect of PrP codons M142 and K222 in goats orally challenged with bovine spongiform encephalopathy prions.

Fast C, Goldmann W, Berthon P, Tauscher K, Andréoletti O, Lantier I, Rossignol C, Bossers A, Jacobs JG, Hunter N, Groschup MH, Lantier F, Langeveld JPM.

Vet Res. 2017 Sep 19;48(1):52. doi: 10.1186/s13567-017-0455-0.


Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats.

Mazza M, Guglielmetti C, Ingravalle F, Brusadore S, Langeveld JPM, Ekateriniadou LV, Andréoletti O, Casalone C, Acutis PL.

J Gen Virol. 2017 Jul;98(7):1963-1967. doi: 10.1099/jgv.0.000843. Epub 2017 Jul 13.


EU-approved rapid tests might underestimate bovine spongiform encephalopathy infection in goats.

Meloni D, Bozzetta E, Langeveld JP, Groschup MH, Goldmann W, Andrèoletti O, Lantier I, Van Keulen L, Bossers A, Pitardi D, Nonno R, Sklaviadis T, Ingravalle F, Peletto S, Colussi S, Acutis PL.

J Vet Diagn Invest. 2017 Mar;29(2):232-236. doi: 10.1177/1040638716688045. Epub 2017 Jan 9.


Scrapie incidence and PRNP polymorphisms: rare small ruminant breeds of Sicily with TSE protecting genetic reservoirs.

Vitale M, Migliore S, La Giglia M, Alberti P, Di Marco Lo Presti V, Langeveld JP.

BMC Vet Res. 2016 Jul 15;12(1):141. doi: 10.1186/s12917-016-0766-9.


Variation in the prion protein sequence in Dutch goat breeds.

Windig JJ, Hoving RA, Priem J, Bossers A, van Keulen LJ, Langeveld JP.

J Anim Breed Genet. 2016 Oct;133(5):366-74. doi: 10.1111/jbg.12211. Epub 2016 Mar 14.


Prion Type-Dependent Deposition of PRNP Allelic Products in Heterozygous Sheep.

Langeveld JP, Jacobs JG, Hunter N, van Keulen LJ, Lantier F, van Zijderveld FG, Bossers A.

J Virol. 2015 Oct 28;90(2):805-12. doi: 10.1128/JVI.02316-15. Print 2016 Jan 15.


Sheep prions with molecular properties intermediate between classical scrapie, BSE and CH1641-scrapie.

Langeveld JP, Jacobs JG, Erkens JH, Baron T, Andréoletti O, Yokoyama T, van Keulen LJ, van Zijderveld FG, Davidse A, Hope J, Tang Y, Bossers A.

Prion. 2014;8(4):296-305. doi: 10.4161/19336896.2014.983396.


TSE strain differentiation in mice by immunohistochemical PrP(Sc) profiles and triplex Western blot.

van Keulen LJ, Langeveld JP, Dolstra CH, Jacobs J, Bossers A, van Zijderveld FG.

Neuropathol Appl Neurobiol. 2015 Oct;41(6):756-79. doi: 10.1111/nan.12181. Epub 2015 Apr 30.


Evaluation of two commercial, rapid, ELISA kits testing for scrapie in retro-pharyngeal lymph nodes in sheep.

Kittelberger R, McIntyre L, Watts J, MacDiarmid S, Hannah MJ, Jenner J, Bueno R, Swainsbury R, Langeveld JP, van Keulen LJ, van Zijderveld FG, Wemheuer WM, Richt JA, Sorensen SJ, Pigott CJ, O'Keefe JS.

N Z Vet J. 2014 Nov;62(6):343-50. doi: 10.1080/00480169.2014.933729. Epub 2014 Sep 2.


Prion protein-specific antibodies that detect multiple TSE agents with high sensitivity.

McCutcheon S, Langeveld JP, Tan BC, Gill AC, de Wolf C, Martin S, Gonzalez L, Alibhai J, Blanco AR, Campbell L, Hunter N, Houston EF.

PLoS One. 2014 Mar 7;9(3):e91143. doi: 10.1371/journal.pone.0091143. eCollection 2014.


Enhanced virulence of sheep-passaged bovine spongiform encephalopathy agent is revealed by decreased polymorphism barriers in prion protein conversion studies.

Priem J, Langeveld JP, van Keulen LJ, van Zijderveld FG, Andreoletti O, Bossers A.

J Virol. 2014 Mar;88(5):2903-12. doi: 10.1128/JVI.02446-13. Epub 2013 Dec 26.


Variably protease-sensitive prionopathy in the UK: a retrospective review 1991-2008.

Head MW, Yull HM, Ritchie DL, Langeveld JP, Fletcher NA, Knight RS, Ironside JW.

Brain. 2013 Apr;136(Pt 4):1102-15. doi: 10.1093/brain/aws366. Review. Erratum in: Brain. 2013 Nov;136(Pt 11):i1.


EU-approved rapid tests for bovine spongiform encephalopathy detect atypical forms: a study for their sensitivities.

Meloni D, Davidse A, Langeveld JP, Varello K, Casalone C, Corona C, Balkema-Buschmann A, Groschup MH, Ingravalle F, Bozzetta E.

PLoS One. 2012;7(9):e43133. doi: 10.1371/journal.pone.0043133. Epub 2012 Sep 11.


Detection of prion protein particles in blood plasma of scrapie infected sheep.

Bannach O, Birkmann E, Reinartz E, Jaeger KE, Langeveld JP, Rohwer RG, Gregori L, Terry LA, Willbold D, Riesner D.

PLoS One. 2012;7(5):e36620. doi: 10.1371/journal.pone.0036620. Epub 2012 May 2.


All major prion types recognised by a multiplex immunofluorometric assay for disease screening and confirmation in sheep.

Tang Y, Gielbert A, Jacobs JG, Baron T, Andreoletti O, Yokoyama T, Langeveld JP, Sauer MJ.

J Immunol Methods. 2012 Jun 29;380(1-2):30-9. doi: 10.1016/j.jim.2012.03.004. Epub 2012 Mar 29.


Studies of the transmissibility of the agent of bovine spongiform encephalopathy to the domestic chicken.

Moore J, Hawkins SA, Austin AR, Konold T, Green RB, Blamire IW, Dexter I, Stack MJ, Chaplin MJ, Langeveld JP, Simmons MM, Spencer YI, Webb PR, Dawson M, Wells GA.

BMC Res Notes. 2011 Nov 17;4:501. doi: 10.1186/1756-0500-4-501.


Prion protein self-interaction in prion disease therapy approaches.

Rigter A, Priem J, Langeveld JP, Bossers A.

Vet Q. 2011 Sep;31(3):115-28. doi: 10.1080/01652176.2011.604976. Review.


Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.

Jacobs JG, Bossers A, Rezaei H, van Keulen LJ, McCutcheon S, Sklaviadis T, Lantier I, Berthon P, Lantier F, van Zijderveld FG, Langeveld JP.

J Virol. 2011 Dec;85(23):12537-46. doi: 10.1128/JVI.00448-11. Epub 2011 Sep 14.


Four independent molecular prion protein parameters for discriminating new cases of C, L, and h bovine spongiform encephalopathy in cattle.

Langeveld JP, Erkens JH, Rammel I, Jacobs JG, Davidse A, van Zijderveld FG, Bossers A, Schildorfer H.

J Clin Microbiol. 2011 Aug;49(8):3026-8. doi: 10.1128/JCM.01102-11. Epub 2011 Jun 15.


Distinct proteinase K-resistant prion protein fragment in goats with no signs of disease in a classical scrapie outbreak.

Bouzalas IG, Lörtscher F, Dovas CI, Oevermann A, Langeveld JP, Papanastassopoulou M, Papadopoulos O, Zurbriggen A, Seuberlich T.

J Clin Microbiol. 2011 Jun;49(6):2109-15. doi: 10.1128/JCM.02033-10. Epub 2011 Mar 30.


A duplex approach for immunochemical staining and typing of proteins in Western blots.

Kuczius T, Brandstädter L, Karch H, Langeveld JP.

Anal Biochem. 2011 Feb 15;409(2):260-6. doi: 10.1016/j.ab.2010.10.018. Epub 2010 Nov 2.


Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie.

Jacobs JG, Sauer M, van Keulen LJ, Tang Y, Bossers A, Langeveld JP.

J Gen Virol. 2011 Jan;92(Pt 1):222-32. doi: 10.1099/vir.0.026153-0. Epub 2010 Oct 13.


Prion protein self-interactions: a gateway to novel therapeutic strategies?

Rigter A, Langeveld JP, van Zijderveld FG, Bossers A.

Vaccine. 2010 Nov 16;28(49):7810-23. doi: 10.1016/j.vaccine.2010.09.012. Epub 2010 Oct 20. Review.


Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein.

Zou WQ, Puoti G, Xiao X, Yuan J, Qing L, Cali I, Shimoji M, Langeveld JP, Castellani R, Notari S, Crain B, Schmidt RE, Geschwind M, Dearmond SJ, Cairns NJ, Dickson D, Honig L, Torres JM, Mastrianni J, Capellari S, Giaccone G, Belay ED, Schonberger LB, Cohen M, Perry G, Kong Q, Parchi P, Tagliavini F, Gambetti P.

Ann Neurol. 2010 Aug;68(2):162-72. doi: 10.1002/ana.22094.


Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe.

González L, Sisó S, Monleón E, Casalone C, van Keulen LJ, Balkema-Buschmann A, Ortiz-Peláez A, Iulini B, Langeveld JP, Hoffmann C, Badiola JJ, Jeffrey M, Acín C.

J Gen Virol. 2010 Oct;91(Pt 10):2630-41. doi: 10.1099/vir.0.022574-0. Epub 2010 Jun 9.


Prion protein self-peptides modulate prion interactions and conversion.

Rigter A, Priem J, Timmers-Parohi D, Langeveld JP, van Zijderveld FG, Bossers A.

BMC Biochem. 2009 Nov 30;10:29. doi: 10.1186/1471-2091-10-29.


Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics.

Cali I, Castellani R, Alshekhlee A, Cohen Y, Blevins J, Yuan J, Langeveld JP, Parchi P, Safar JG, Zou WQ, Gambetti P.

Brain. 2009 Oct;132(Pt 10):2643-58. doi: 10.1093/brain/awp196. Epub 2009 Sep 4.


Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification.

Parchi P, Strammiello R, Notari S, Giese A, Langeveld JP, Ladogana A, Zerr I, Roncaroli F, Cras P, Ghetti B, Pocchiari M, Kretzschmar H, Capellari S.

Acta Neuropathol. 2009 Nov;118(5):659-71. doi: 10.1007/s00401-009-0585-1. Epub 2009 Aug 29.


Diagnosis of the first cases of scrapie in Poland.

Polak MP, Larska M, Langeveld JP, Buschmann A, Groschup MH, Zmudzinski JF.

Vet J. 2010 Oct;186(1):47-52. doi: 10.1016/j.tvjl.2009.07.032. Epub 2009 Aug 27.


Mapping functional prion-prion protein interaction sites using prion protein based peptide-arrays.

Rigter A, Priem J, Timmers-Parohi D, Langeveld JP, Bossers A.

Methods Mol Biol. 2009;570:257-71. doi: 10.1007/978-1-60327-394-7_12. Review.


Variant Creutzfeldt-Jakob disease in France and the United Kingdom: Evidence for the same agent strain.

Brandel JP, Heath CA, Head MW, Levavasseur E, Knight R, Laplanche JL, Langeveld JP, Ironside JW, Hauw JJ, Mackenzie J, Alpérovitch A, Will RG, Haïk S.

Ann Neurol. 2009 Mar;65(3):249-56. doi: 10.1002/ana.21583.


Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease.

Notari S, Strammiello R, Capellari S, Giese A, Cescatti M, Grassi J, Ghetti B, Langeveld JP, Zou WQ, Gambetti P, Kretzschmar HA, Parchi P.

J Biol Chem. 2008 Nov 7;283(45):30557-65. doi: 10.1074/jbc.M801877200. Epub 2008 Aug 27.


Bovine spongiform encephalopathy in Sweden: an H-type variant.

Gavier-Widén D, Nöremark M, Langeveld JP, Stack M, Biacabe AG, Vulin J, Chaplin M, Richt JA, Jacobs J, Acín C, Monleón E, Renström L, Klingeborn B, Baron TG.

J Vet Diagn Invest. 2008 Jan;20(1):2-10.


Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study.

Polak MP, Zmudzinski JF, Jacobs JG, Langeveld JP.

Arch Virol. 2008;153(1):69-79. Epub 2007 Sep 26.


Molecular discrimination of atypical bovine spongiform encephalopathy strains from a geographical region spanning a wide area in Europe.

Jacobs JG, Langeveld JP, Biacabe AG, Acutis PL, Polak MP, Gavier-Widen D, Buschmann A, Caramelli M, Casalone C, Mazza M, Groschup M, Erkens JH, Davidse A, van Zijderveld FG, Baron T.

J Clin Microbiol. 2007 Jun;45(6):1821-9. Epub 2007 Apr 18.


Mapping of possible prion protein self-interaction domains using peptide arrays.

Rigter A, Langeveld JP, Timmers-Parohi D, Jacobs JG, Moonen PL, Bossers A.

BMC Biochem. 2007 Apr 12;8:6.


H-type bovine spongiform encephalopathy: complex molecular features and similarities with human prion diseases.

Biacabe AG, Jacobs JG, Bencsik A, Langeveld JP, Baron TG.

Prion. 2007 Jan-Mar;1(1):61-8. Epub 2007 Jan 11.


Intracellular accumulation of a 46 kDa species of mouse prion protein as a result of loss of glycosylation in cultured mammalian cells.

Biswas S, Langeveld JP, Tipper D, Lu S.

Biochem Biophys Res Commun. 2006 Oct 13;349(1):153-61. Epub 2006 Aug 14.


Transmission of new bovine prion to mice.

Baron TG, Biacabe AG, Bencsik A, Langeveld JP.

Emerg Infect Dis. 2006 Jul;12(7):1125-8.


Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep.

Langeveld JP, Jacobs JG, Erkens JH, Bossers A, van Zijderveld FG, van Keulen LJ.

BMC Vet Res. 2006 Jun 9;2:19.


A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure.

Antonis AF, Bruschke CJ, Rueda P, Maranga L, Casal JI, Vela C, Hilgers LA, Belt PB, Weerdmeester K, Carrondo MJ, Langeveld JP.

Vaccine. 2006 Jun 29;24(26):5481-90. Epub 2006 Apr 18.


Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies.

Jeffrey M, Martin S, González L, Foster J, Langeveld JP, van Zijderveld FG, Grassi J, Hunter N.

J Comp Pathol. 2006 Feb-Apr;134(2-3):171-81. Epub 2006 Mar 20.


Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease.

Yull HM, Ritchie DL, Langeveld JP, van Zijderveld FG, Bruce ME, Ironside JW, Head MW.

Am J Pathol. 2006 Jan;168(1):151-7.


Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease.

Raymond GJ, Olsen EA, Lee KS, Raymond LD, Bryant PK 3rd, Baron GS, Caughey WS, Kocisko DA, McHolland LE, Favara C, Langeveld JP, van Zijderveld FG, Mayer RT, Miller MW, Williams ES, Caughey B.

J Virol. 2006 Jan;80(2):596-604.


Immunohistochemical studies of scrapie archival material from Irish ARQ/ARQ sheep for evidence of bovine spongiform encephalopathy-derived disease.

Sharpe A, McElroy M, Langeveld JP, Bassett H, O'Donoghue AM, Sweeney T.

Res Vet Sci. 2005 Aug;79(1):29-35. Epub 2004 Dec 16.


Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q.

Veerhuis R, Boshuizen RS, Morbin M, Mazzoleni G, Hoozemans JJ, Langedijk JP, Tagliavini F, Langeveld JP, Eikelenboom P.

Neurobiol Dis. 2005 Jun-Jul;19(1-2):273-82.


Immunohistochemical distinction between preclinical bovine spongiform encephalopathy and scrapie infection in sheep.

Thuring CM, van Keulen LJ, Langeveld JP, Vromans ME, van Zijderveld FG, Sweeney T.

J Comp Pathol. 2005 Jan;132(1):59-69.


An in vitro screening assay based on synthetic prion protein peptides for identification of fibril-interfering compounds.

Boshuizen RS, Langeveld JP, Salmona M, Williams A, Meloen RH, Langedijk JP.

Anal Biochem. 2004 Oct 15;333(2):372-80.


Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein.

Thuring CM, Erkens JH, Jacobs JG, Bossers A, Van Keulen LJ, Garssen GJ, Van Zijderveld FG, Ryder SJ, Groschup MH, Sweeney T, Langeveld JP.

J Clin Microbiol. 2004 Mar;42(3):972-80.


Antigenic profile of human recombinant PrP: generation and characterization of a versatile polyclonal antiserum.

Sachsamanoglou M, Paspaltsis I, Petrakis S, Verghese-Nikolakaki S, Panagiotidis CH, Voigtlander T, Budka H, Langeveld JP, Sklaviadis T.

J Neuroimmunol. 2004 Jan;146(1-2):22-32.


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