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Items: 14


Critical Function of γH2A in S-Phase.

Mejia-Ramirez E, Limbo O, Langerak P, Russell P.

PLoS Genet. 2015 Sep 14;11(9):e1005517. doi: 10.1371/journal.pgen.1005517. eCollection 2015 Sep.


The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.

Beisner DR, Langerak P, Parker AE, Dahlberg C, Otero FJ, Sutton SE, Poirot L, Barnes W, Young MA, Niessen S, Wiltshire T, Bodendorf U, Martoglio B, Cravatt B, Cooke MP.

J Exp Med. 2013 Jan 14;210(1):23-30. doi: 10.1084/jem.20121072. Epub 2012 Dec 24.


Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.

Langerak P, Russell P.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3562-71. doi: 10.1098/rstb.2011.0070. Review.


Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Langerak P, Mejia-Ramirez E, Limbo O, Russell P.

PLoS Genet. 2011 Sep;7(9):e1002271. doi: 10.1371/journal.pgen.1002271. Epub 2011 Sep 8.


PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.

Hendel A, Krijger PH, Diamant N, Goren Z, Langerak P, Kim J, Reissner T, Lee KY, Geacintov NE, Carell T, Myung K, Tateishi S, D'Andrea A, Jacobs H, Livneh Z.

PLoS Genet. 2011 Sep;7(9):e1002262. doi: 10.1371/journal.pgen.1002262. Epub 2011 Sep 8.


PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

Krijger PH, van den Berk PC, Wit N, Langerak P, Jansen JG, Reynaud CA, de Wind N, Jacobs H.

DNA Repair (Amst). 2011 Oct 10;10(10):1051-9. doi: 10.1016/j.dnarep.2011.08.005. Epub 2011 Sep 1.


Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

Krijger PH, Langerak P, van den Berk PC, Jacobs H.

J Exp Med. 2009 Nov 23;206(12):2603-11. doi: 10.1084/jem.20091707. Epub 2009 Nov 9.


Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.

Langerak P, Krijger PH, Heideman MR, van den Berk PC, Jacobs H.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):621-9. doi: 10.1098/rstb.2008.0223.


A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.

Langerak P, Nygren AO, Krijger PH, van den Berk PC, Jacobs H.

J Exp Med. 2007 Aug 6;204(8):1989-98. Epub 2007 Jul 30.


Epidermal growth factor receptor-induced activator protein 1 activity controls density-dependent growth inhibition in normal rat kidney fibroblasts.

Hornberg JJ, Dekker H, Peters PH, Langerak P, Westerhoff HV, Lankelma J, van Zoelen EJ.

Mol Biotechnol. 2006 Oct;34(2):101-8.


Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice.

Jansen JG, Langerak P, Tsaalbi-Shtylik A, van den Berk P, Jacobs H, de Wind N.

J Exp Med. 2006 Feb 20;203(2):319-23. Epub 2006 Feb 13.


Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.

Langerak P, Nygren AO, Schouten JP, Jacobs H.

Nucleic Acids Res. 2005 Dec 9;33(22):e188.


The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis.

Jansen JG, Tsaalbi-Shtylik A, Langerak P, Calléja F, Meijers CM, Jacobs H, de Wind N.

Nucleic Acids Res. 2005 Jan 13;33(1):356-65. Print 2005.


CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation.

Xiao Y, Hendriks J, Langerak P, Jacobs H, Borst J.

J Immunol. 2004 Jun 15;172(12):7432-41.

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