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Items: 1 to 50 of 152

1.

PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition.

Chu CH, Chen SH, Wang Q, Langenbach R, Li H, Zeldin D, Chen SL, Wang S, Gao H, Lu RB, Hong JS.

Mol Neurobiol. 2015 Aug;52(1):587-600. doi: 10.1007/s12035-014-8889-0. Epub 2014 Sep 14.

2.

Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine vasopressin.

Law AY, Hébert RL, Nasrallah R, Langenbach R, Wong CK, Wagner GF.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):210-9. doi: 10.1016/j.mce.2013.07.008. Epub 2013 Jul 20.

PMID:
23877023
3.

Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes.

Sayers BC, Taylor AJ, Glista-Baker EE, Shipley-Phillips JK, Dackor RT, Edin ML, Lih FB, Tomer KB, Zeldin DC, Langenbach R, Bonner JC.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):525-35. doi: 10.1165/rcmb.2013-0019OC.

4.

β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice.

Trivedi DB, Loftin CD, Clark J, Myers P, DeGraff LM, Cheng J, Zeldin DC, Langenbach R.

Circ Res. 2013 Apr 26;112(9):1219-29. doi: 10.1161/CIRCRESAHA.112.280399. Epub 2013 Mar 22.

5.

Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.

Lao HC, Akunda JK, Chun KS, Flake GP, Yuspa SH, Langenbach R.

Carcinogenesis. 2012 Nov;33(11):2293-300. doi: 10.1093/carcin/bgs267. Epub 2012 Aug 17.

6.

Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages.

Lee JK, Sayers BC, Chun KS, Lao HC, Shipley-Phillips JK, Bonner JC, Langenbach R.

Part Fibre Toxicol. 2012 May 9;9:14. doi: 10.1186/1743-8977-9-14.

7.

A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice.

Trempus CS, Wei SJ, Humble MM, Dang H, Bortner CD, Sifre MI, Kissling GE, Sunman JA, Akiyama SK, Roberts JD, Tucker CJ, Chun KS, Tennant RW, Langenbach R.

Mol Carcinog. 2011 Dec;50(12):981-91. doi: 10.1002/mc.20768. Epub 2011 Mar 22.

8.

The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin.

Chun KS, Langenbach R.

Mol Carcinog. 2011 Jun;50(6):439-48. doi: 10.1002/mc.20728. Epub 2011 Jan 25.

PMID:
21268125
9.

The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways.

Chun KS, Lao HC, Langenbach R.

J Biol Chem. 2010 Dec 17;285(51):39672-81. doi: 10.1074/jbc.M110.117689. Epub 2010 Oct 19.

10.

The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development.

Chun KS, Lao HC, Trempus CS, Okada M, Langenbach R.

Carcinogenesis. 2009 Sep;30(9):1620-7. doi: 10.1093/carcin/bgp168. Epub 2009 Jul 8.

11.

Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.

Zhang D, Hu X, Qian L, Wilson B, Lee C, Flood P, Langenbach R, Hong JS.

Toxicol Appl Pharmacol. 2009 Jul 1;238(1):64-70. doi: 10.1016/j.taap.2009.04.015. Epub 2009 May 3.

12.

A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2.

Iguchi G, Chrysovergis K, Lee SH, Baek SJ, Langenbach R, Eling TE.

Cancer Lett. 2009 Sep 18;282(2):152-8. doi: 10.1016/j.canlet.2009.03.006. Epub 2009 Apr 17.

13.

Fecal urge incontinence after stapled anopexia for prolapse and hemorrhoids: a prospective, observational study.

Schmidt J, Dogan N, Langenbach R, Zirngibl H.

World J Surg. 2009 Feb;33(2):355-64. doi: 10.1007/s00268-008-9818-z.

PMID:
19034570
14.

Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2.

Aid S, Langenbach R, Bosetti F.

J Neuroinflammation. 2008 May 19;5:17. doi: 10.1186/1742-2094-5-17.

15.
16.

Atherogenic diet causes lethal ileo-ceco-colitis in cyclooxygenase-2 deficient mice.

Lin JA, Watanabe J, Rozengurt N, Narasimha A, Martin MG, Wang J, Braun J, Langenbach R, Reddy ST.

Prostaglandins Other Lipid Mediat. 2007 Nov;84(3-4):98-107. Epub 2007 Apr 25.

17.

A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors.

Narasimha A, Watanabe J, Lin JA, Hama S, Langenbach R, Navab M, Fogelman AM, Reddy ST.

Prostaglandins Other Lipid Mediat. 2007 Aug;84(1-2):24-33. Epub 2007 Mar 14.

18.

A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin.

Chun KS, Langenbach R.

Mol Carcinog. 2007 Aug;46(8):699-704. Review.

PMID:
17570497
19.
20.

Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain.

Toscano CD, Prabhu VV, Langenbach R, Becker KG, Bosetti F.

Genome Biol. 2007;8(1):R14.

21.

Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure.

Akunda JK, Chun KS, Sessoms AR, Lao HC, Fischer SM, Langenbach R.

Mol Carcinog. 2007 May;46(5):354-62.

PMID:
17238138
22.

Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis.

Fischer SM, Pavone A, Mikulec C, Langenbach R, Rundhaug JE.

Mol Carcinog. 2007 May;46(5):363-71.

23.

Altered brain lipid composition in cyclooxygenase-2 knockout mouse.

Ma K, Langenbach R, Rapoport SI, Basselin M.

J Lipid Res. 2007 Apr;48(4):848-54. Epub 2007 Jan 3.

24.
25.

Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice.

Gitlin JM, Trivedi DB, Langenbach R, Loftin CD.

Cardiovasc Res. 2007 Jan 1;73(1):227-36. Epub 2006 Oct 27.

PMID:
17137566
27.

Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation.

Li GQ, Xia HH, Chen MH, Gu Q, Wang JD, Peng JZ, Chan AO, Cho CH, So HL, Lam SK, Hu PJ, Liang YJ, Lin HL, Berg DE, Feng ZH, Langenbach R, Wong BC.

J Infect Dis. 2006 Apr 1;193(7):1037-46. Epub 2006 Feb 22.

PMID:
16518767
28.

Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse.

Basselin M, Villacreses NE, Langenbach R, Ma K, Bell JM, Rapoport SI.

J Neurochem. 2006 Feb;96(3):669-79. Epub 2006 Jan 9.

29.

Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection.

Carey MA, Bradbury JA, Seubert JM, Langenbach R, Zeldin DC, Germolec DR.

J Immunol. 2005 Nov 15;175(10):6878-84.

30.

Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses.

Steiner AA, Rudaya AY, Robbins JR, Dragic AS, Langenbach R, Romanovsky AA.

Am J Physiol Regul Integr Comp Physiol. 2005 Nov;289(5):R1253-7. Epub 2005 Aug 4.

31.

Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse.

Rao JS, Langenbach R, Bosetti F.

Brain Res Mol Brain Res. 2005 Oct 3;139(2):217-24.

PMID:
16055227
32.

Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction.

Kawada N, Solis G, Ivey N, Connors S, Dennehy K, Modlinger P, Hamel R, Kawada JT, Imai E, Langenbach R, Welch WJ, Wilcox CS.

Hypertension. 2005 Jun;45(6):1131-8. Epub 2005 May 9.

PMID:
15883230
33.

MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration.

Wang T, Pei Z, Zhang W, Liu B, Langenbach R, Lee C, Wilson B, Reece JM, Miller DS, Hong JS.

FASEB J. 2005 Jul;19(9):1134-6. Epub 2005 Apr 21.

PMID:
15845609
35.

Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice.

Wormser U, Langenbach R, Peddada S, Sintov A, Brodsky B, Nyska A.

Toxicol Appl Pharmacol. 2004 Oct 1;200(1):40-7.

PMID:
15451306
36.

Generation of a conditional allele of the mouse prostaglandin EP4 receptor.

Schneider A, Guan Y, Zhang Y, Magnuson MA, Pettepher C, Loftin CD, Langenbach R, Breyer RM, Breyer MD.

Genesis. 2004 Sep;40(1):7-14.

PMID:
15354288
37.

Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling.

Gray T, Nettesheim P, Loftin C, Koo JS, Bonner J, Peddada S, Langenbach R.

Mol Pharmacol. 2004 Aug;66(2):337-46.

PMID:
15266025
38.

E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.

Goulet JL, Pace AJ, Key ML, Byrum RS, Nguyen M, Tilley SL, Morham SG, Langenbach R, Stock JL, McNeish JD, Smithies O, Coffman TM, Koller BH.

J Immunol. 2004 Jul 15;173(2):1321-6.

39.

The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice.

Darling RL, Romero JJ, Dial EJ, Akunda JK, Langenbach R, Lichtenberger LM.

Gastroenterology. 2004 Jul;127(1):94-104.

PMID:
15236176
40.

Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia.

Wang T, Qin L, Liu B, Liu Y, Wilson B, Eling TE, Langenbach R, Taniura S, Hong JS.

J Neurochem. 2004 Feb;88(4):939-47.

41.

Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo.

Akunda JK, Lao HC, Lee CA, Sessoms AR, Slade RM, Langenbach R.

FASEB J. 2004 Jan;18(1):185-7. Epub 2003 Nov 20.

PMID:
14630706
42.

Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.

Takeda H, Sonoshita M, Oshima H, Sugihara K, Chulada PC, Langenbach R, Oshima M, Taketo MM.

Cancer Res. 2003 Aug 15;63(16):4872-7.

43.

Cyclooxygenase enzymes in allergic inflammation and asthma.

Carey MA, Germolec DR, Langenbach R, Zeldin DC.

Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep;69(2-3):157-62. Review.

PMID:
12895598
44.

Mechanism of cyclooxygenase-2 upregulation in late preconditioning.

Xuan YT, Guo Y, Zhu Y, Han H, Langenbach R, Dawn B, Bolli R.

J Mol Cell Cardiol. 2003 May;35(5):525-37.

45.

Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice.

Carey MA, Germolec DR, Bradbury JA, Gooch RA, Moorman MP, Flake GP, Langenbach R, Zeldin DC.

Am J Respir Crit Care Med. 2003 Jun 1;167(11):1509-15. Epub 2003 Mar 5.

PMID:
12626351
46.

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.

Loftin CD, Tiano HF, Langenbach R.

Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:177-85. Review.

PMID:
12432917
47.
48.

Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra.

Feng ZH, Wang TG, Li DD, Fung P, Wilson BC, Liu B, Ali SF, Langenbach R, Hong JS.

Neurosci Lett. 2002 Sep 6;329(3):354-8.

PMID:
12183047
49.

Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.

Bonner JC, Rice AB, Ingram JL, Moomaw CR, Nyska A, Bradbury A, Sessoms AR, Chulada PC, Morgan DL, Zeldin DC, Langenbach R.

Am J Pathol. 2002 Aug;161(2):459-70.

50.

Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II.

Qi Z, Hao CM, Langenbach RI, Breyer RM, Redha R, Morrow JD, Breyer MD.

J Clin Invest. 2002 Jul;110(1):61-9. Erratum in: J Clin Invest 2002 Aug;110(3):419.

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