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Items: 1 to 50 of 187

1.

Active involvement of family members in postoperative care after esophageal or pancreatic resection: A feasibility study.

Schreuder AM, Eskes AM, van Langen RGM, van Dieren S, Nieveen van Dijkum EJM.

Surgery. 2019 Jul 5. pii: S0039-6060(19)30297-1. doi: 10.1016/j.surg.2019.05.032. [Epub ahead of print]

PMID:
31285045
2.

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

Rovere M, Powers AE, Jiang H, Pitino JC, Fonseca-Ornelas L, Patel DS, Achille A, Langen R, Varkey J, Bartels T.

J Biol Chem. 2019 Jun 21;294(25):9799-9812. doi: 10.1074/jbc.RA118.006551. Epub 2019 May 2.

3.

Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL.

Vasquez-Montes V, Vargas-Uribe M, Pandey NK, Rodnin MV, Langen R, Ladokhin AS.

Biochim Biophys Acta Proteins Proteom. 2019 Jul - Aug;1867(7-8):691-700. doi: 10.1016/j.bbapap.2019.04.006. Epub 2019 Apr 18.

PMID:
31004798
4.

Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis.

Kneppers AEM, Haast RAM, Langen RCJ, Verdijk LB, Leermakers PA, Gosker HR, van Loon LJC, Lainscak M, Schols AMWJ.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):311-322. doi: 10.1002/jcsm.12370. Epub 2019 Jan 18.

5.

Directed Supramolecular Organization of N-BAR Proteins through Regulation of H0 Membrane Immersion Depth.

Kahraman O, Langen R, Haselwandter CA.

Sci Rep. 2018 Nov 6;8(1):16383. doi: 10.1038/s41598-018-34273-2.

6.

The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract.

Bravo-Arredondo JM, Kegulian NC, Schmidt T, Pandey NK, Situ AJ, Ulmer TS, Langen R.

J Biol Chem. 2018 Dec 21;293(51):19613-19623. doi: 10.1074/jbc.RA118.004808. Epub 2018 Oct 12.

PMID:
30315108
7.

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy.

de Theije CC, Schols AMWJ, Lamers WH, Neumann D, Köhler SE, Langen RCJ.

PLoS One. 2018 Sep 13;13(9):e0203630. doi: 10.1371/journal.pone.0203630. eCollection 2018.

8.

Regulation of muscle atrophy by microRNAs: 'AtromiRs' as potential target in cachexia.

van de Worp WRPH, Theys J, van Helvoort A, Langen RCJ.

Curr Opin Clin Nutr Metab Care. 2018 Nov;21(6):423-429. doi: 10.1097/MCO.0000000000000503.

PMID:
30198917
9.

Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse.

Kneppers A, Leermakers P, Pansters N, Backx E, Gosker H, van Loon L, Schols A, Langen R, Verdijk L.

FASEB J. 2019 Jan;33(1):1288-1298. doi: 10.1096/fj.201701403RRR. Epub 2018 Aug 22.

PMID:
30133324
10.

Heterotetrameric annexin A2/S100A10 (A2t) is essential for oncogenic human papillomavirus trafficking and capsid disassembly, and protects virions from lysosomal degradation.

Taylor JR, Fernandez DJ, Thornton SM, Skeate JG, Lühen KP, Da Silva DM, Langen R, Kast WM.

Sci Rep. 2018 Aug 3;8(1):11642. doi: 10.1038/s41598-018-30051-2.

11.

Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice.

Ceelen JJM, Schols AMWJ, Kneppers AEM, Rosenbrand RPHA, Drożdż MM, van Hoof SJ, de Theije CC, Kelders MCJM, Verhaegen F, Langen RCJ.

Sci Rep. 2018 Jul 17;8(1):10761. doi: 10.1038/s41598-018-28579-4.

12.

Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin.

Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, Ladinsky M, Wu WL, Rohweder H, Weiss A, Macdonald D, Munoz-Sanjuan I, Langen R, Patterson PH, Khoshnan A.

Hum Mol Genet. 2018 Jul 1;27(13):2330-2343. doi: 10.1093/hmg/ddy141.

13.

Inactivation of glycogen synthase kinase 3β (GSK-3β) enhances mitochondrial biogenesis during myogenesis.

Theeuwes WF, Gosker HR, Langen RCJ, Pansters NAM, Schols AMWJ, Remels AHV.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2913-2926. doi: 10.1016/j.bbadis.2018.06.002. Epub 2018 Jun 6.

14.

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation.

Ceelen JJM, Schols AMWJ, Thielen NGM, Haegens A, Gray DA, Kelders MCJM, de Theije CC, Langen RCJ.

Respir Res. 2018 May 2;19(1):80. doi: 10.1186/s12931-018-0753-8.

15.

Membranes as modulators of amyloid protein misfolding and target of toxicity.

Rawat A, Langen R, Varkey J.

Biochim Biophys Acta Biomembr. 2018 Apr 25. pii: S0005-2736(18)30129-9. doi: 10.1016/j.bbamem.2018.04.011. [Epub ahead of print] Review.

PMID:
29702073
16.

A novel in vitro model for the assessment of postnatal myonuclear accretion.

Kneppers A, Verdijk L, de Theije C, Corten M, Gielen E, van Loon L, Schols A, Langen R.

Skelet Muscle. 2018 Feb 14;8(1):4. doi: 10.1186/s13395-018-0151-4.

17.

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.

Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV.

Nat Med. 2018 Mar;24(3):326-337. doi: 10.1038/nm.4482. Epub 2018 Feb 5.

18.

The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms.

Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R.

J Biol Chem. 2018 Feb 16;293(7):2597-2605. doi: 10.1074/jbc.M117.813667. Epub 2017 Dec 27.

19.

Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia.

Brzeszczyńska J, Meyer A, McGregor R, Schilb A, Degen S, Tadini V, Johns N, Langen R, Schols A, Glass DJ, Roubenoff R, Ross JA, Fearon KCH, Greig CA, Jacobi C.

J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):93-105. doi: 10.1002/jcsm.12252. Epub 2017 Dec 6.

20.

Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice.

de Theije CC, Schols AMWJ, Lamers WH, Ceelen JJM, van Gorp RH, Hermans JJR, Köhler SE, Langen RCJ.

Endocrinology. 2018 Jan 1;159(1):519-534. doi: 10.1210/en.2017-00603.

PMID:
29069356
21.

Inactivation of glycogen synthase kinase-3β (GSK-3β) enhances skeletal muscle oxidative metabolism.

Theeuwes WF, Gosker HR, Langen RCJ, Verhees KJP, Pansters NAM, Schols AMWJ, Remels AHV.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3075-3086. doi: 10.1016/j.bbadis.2017.09.018. Epub 2017 Sep 22.

22.

The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity.

Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R.

Sci Rep. 2017 Aug 10;7(1):7802. doi: 10.1038/s41598-017-08372-5.

23.

Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR.

Varkey J, Langen R.

J Magn Reson. 2017 Jul;280:127-139. doi: 10.1016/j.jmr.2017.02.014. Review.

24.

Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia.

Kneppers AEM, Langen RCJ, Gosker HR, Verdijk LB, Cebron Lipovec N, Leermakers PA, Kelders MCJM, de Theije CC, Omersa D, Lainscak M, Schols AMWJ.

J Am Med Dir Assoc. 2017 Jul 1;18(7):637.e1-637.e11. doi: 10.1016/j.jamda.2017.04.016. Epub 2017 May 31.

PMID:
28578881
25.

Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation.

Ceelen JJM, Schols AMWJ, van Hoof SJ, de Theije CC, Verhaegen F, Langen RCJ.

Respir Res. 2017 May 2;18(1):75. doi: 10.1186/s12931-017-0531-z.

26.

Structural insights into the activation mechanism of dynamin-like EHD ATPases.

Melo AA, Hegde BG, Shah C, Larsson E, Isas JM, Kunz S, Lundmark R, Langen R, Daumke O.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5629-5634. doi: 10.1073/pnas.1614075114. Epub 2017 Feb 22.

27.

Identification and Structural Characterization of the N-terminal Amyloid Core of Orb2 isoform A.

Cervantes SA, Bajakian TH, Soria MA, Falk AS, Service RJ, Langen R, Siemer AB.

Sci Rep. 2016 Dec 6;6:38265. doi: 10.1038/srep38265.

28.

Hydration Dynamics of a Peripheral Membrane Protein.

Fisette O, Päslack C, Barnes R, Isas JM, Langen R, Heyden M, Han S, Schäfer LV.

J Am Chem Soc. 2016 Sep 14;138(36):11526-35. doi: 10.1021/jacs.6b07005. Epub 2016 Sep 2.

29.

Diabetic Risk Factors Promote Islet Amyloid Polypeptide Misfolding by a Common, Membrane-mediated Mechanism.

Okada AK, Teranishi K, Isas JM, Bedrood S, Chow RH, Langen R.

Sci Rep. 2016 Aug 17;6:31094. doi: 10.1038/srep31094.

30.

Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly.

Brzeszczyńska J, Johns N, Schilb A, Degen S, Degen M, Langen R, Schols A, Glass DJ, Roubenoff R, Greig CA, Jacobi C, Fearon KCh, Ross JA.

Aging (Albany NY). 2016 Aug;8(8):1690-702. doi: 10.18632/aging.101006.

31.

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective.

Sanders KJ, Kneppers AE, van de Bool C, Langen RC, Schols AM.

J Cachexia Sarcopenia Muscle. 2016 Mar;7(1):5-22. doi: 10.1002/jcsm.12062. Epub 2015 Sep 7. Review.

32.

Does the Use of Diagnostic Imaging Reduce the Rate of Negative Appendectomy?

Hendriks IG, Langen RM, Janssen L, Verrijth-Wilms IM, Wouda S, Janzing HM.

Acta Chir Belg. 2015 Nov-Dec;115(6):393-6.

PMID:
26763836
33.

α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils.

Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC.

J Biol Chem. 2016 Jan 29;291(5):2310-8. doi: 10.1074/jbc.M115.698787. Epub 2015 Dec 7.

34.

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease.

Marotta NP, Lin YH, Lewis YE, Ambroso MR, Zaro BW, Roth MT, Arnold DB, Langen R, Pratt MR.

Nat Chem. 2015 Nov;7(11):913-20. doi: 10.1038/nchem.2361. Epub 2015 Oct 12.

35.

Computer Modeling of Spin Labels: NASNOX, PRONOX, and ALLNOX.

Beasley KN, Sutch BT, Hatmal MM, Langen R, Qin PZ, Haworth IS.

Methods Enzymol. 2015;563:569-93. doi: 10.1016/bs.mie.2015.07.021. Epub 2015 Aug 31.

PMID:
26478499
36.

Structural Characterization of Membrane-Curving Proteins: Site-Directed Spin Labeling, EPR, and Computational Refinement.

Ambroso MR, Haworth IS, Langen R.

Methods Enzymol. 2015;564:259-88. doi: 10.1016/bs.mie.2015.07.002. Epub 2015 Aug 31.

PMID:
26477254
37.

Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption.

Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R.

J Biol Chem. 2015 Oct 23;290(43):25782-93. doi: 10.1074/jbc.M115.659797. Epub 2015 Aug 17.

38.

Preserved muscle oxidative metabolic phenotype in newly diagnosed non-small cell lung cancer cachexia.

Op den Kamp CM, Gosker HR, Lagarde S, Tan DY, Snepvangers FJ, Dingemans AM, Langen RC, Schols AM.

J Cachexia Sarcopenia Muscle. 2015 Jun;6(2):164-73. doi: 10.1002/jcsm.12007. Epub 2015 Apr 15.

39.

Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils.

Isas JM, Langen R, Siemer AB.

Biochemistry. 2015 Jun 30;54(25):3942-9. doi: 10.1021/acs.biochem.5b00281. Epub 2015 Jun 16.

40.

Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.

Darrow MC, Sergeeva OA, Isas JM, Galaz-Montoya JG, King JA, Langen R, Schmid MF, Chiu W.

J Biol Chem. 2015 Jul 10;290(28):17451-61. doi: 10.1074/jbc.M115.655373. Epub 2015 May 20.

41.

Tubulation by amphiphysin requires concentration-dependent switching from wedging to scaffolding.

Isas JM, Ambroso MR, Hegde PB, Langen J, Langen R.

Structure. 2015 May 5;23(5):873-881. doi: 10.1016/j.str.2015.02.014. Epub 2015 Apr 9.

42.

TNF-α-induced NF-κB activation stimulates skeletal muscle glycolytic metabolism through activation of HIF-1α.

Remels AH, Gosker HR, Verhees KJ, Langen RC, Schols AM.

Endocrinology. 2015 May;156(5):1770-81. doi: 10.1210/en.2014-1591. Epub 2015 Feb 24.

PMID:
25710281
43.

Muscle-specific GSK-3β ablation accelerates regeneration of disuse-atrophied skeletal muscle.

Pansters NA, Schols AM, Verhees KJ, de Theije CC, Snepvangers FJ, Kelders MC, Ubags ND, Haegens A, Langen RC.

Biochim Biophys Acta. 2015 Mar;1852(3):490-506. doi: 10.1016/j.bbadis.2014.12.006. Epub 2014 Dec 8.

44.

Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.

Fodale V, Kegulian NC, Verani M, Cariulo C, Azzollini L, Petricca L, Daldin M, Boggio R, Padova A, Kuhn R, Pacifici R, Macdonald D, Schoenfeld RC, Park H, Isas JM, Langen R, Weiss A, Caricasole A.

PLoS One. 2014 Dec 2;9(12):e112262. doi: 10.1371/journal.pone.0112262. eCollection 2014. Erratum in: PLoS One. 2015;10(6):e0129986.

45.

Differential sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy.

de Theije CC, Langen RC, Lamers WH, Gosker HR, Schols AM, Köhler SE.

J Appl Physiol (1985). 2015 Jan 15;118(2):200-11. doi: 10.1152/japplphysiol.00624.2014. Epub 2014 Nov 26.

46.

Systemic inflammation in chronic obstructive pulmonary disease and lung cancer: common driver of pulmonary cachexia?

Ceelen JJ, Langen RC, Schols AM.

Curr Opin Support Palliat Care. 2014 Dec;8(4):339-45. doi: 10.1097/SPC.0000000000000088. Review.

PMID:
25158627
47.

Phase II drugs that are currently in development for the treatment of cachexia.

Dingemans AM, de Vos-Geelen J, Langen R, Schols AM.

Expert Opin Investig Drugs. 2014 Dec;23(12):1655-69. doi: 10.1517/13543784.2014.942729. Epub 2014 Jul 24. Review.

PMID:
25056249
48.

Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.

Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK.

Biochemistry. 2014 Jun 24;53(24):3889-96. doi: 10.1021/bi5002536. Epub 2014 Jun 13.

49.

Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation.

Ambroso MR, Hegde BG, Langen R.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):6982-7. doi: 10.1073/pnas.1402233111. Epub 2014 Apr 28.

50.

Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2.

Shah C, Hegde BG, Morén B, Behrmann E, Mielke T, Moenke G, Spahn CMT, Lundmark R, Daumke O, Langen R.

Structure. 2014 Mar 4;22(3):409-420. doi: 10.1016/j.str.2013.12.015. Epub 2014 Feb 6.

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