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Items: 1 to 50 of 314

1.

Diagnostic impact of additional O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET following immunotherapy with dendritic cell vaccination in glioblastoma patients.

Kristin Schmitz A, Sorg RV, Stoffels G, Grauer OM, Galldiks N, Steiger HJ, Kamp MA, Langen KJ, Sabel M, Rapp M.

Br J Neurosurg. 2019 Aug 13:1-7. doi: 10.1080/02688697.2019.1639615. [Epub ahead of print]

PMID:
31407920
2.

Dynamic FET PET Imaging of a "Butterfly" IDH-Wildtype Anaplastic Astrocytoma.

Galldiks N, Brunn A, Fink GR, Langen KJ.

Clin Nucl Med. 2019 Jul 24. doi: 10.1097/RLU.0000000000002740. [Epub ahead of print]

PMID:
31348085
3.

Technical Note: Quality assurance of proton central axis pencil-beam spread-out Bragg peak using large-diameter multilayer ionization chambers.

Wang P, Zhu M, Langen K.

Med Phys. 2019 Jul 25. doi: 10.1002/mp.13732. [Epub ahead of print]

PMID:
31347182
4.

Differentiation of treatment-related changes from tumour progression: a direct comparison between dynamic FET PET and ADC values obtained from DWI MRI.

Werner JM, Stoffels G, Lichtenstein T, Borggrefe J, Lohmann P, Ceccon G, Shah NJ, Fink GR, Langen KJ, Kabbasch C, Galldiks N.

Eur J Nucl Med Mol Imaging. 2019 Aug;46(9):1889-1901. doi: 10.1007/s00259-019-04384-7. Epub 2019 Jun 15.

PMID:
31203420
5.

Post-stroke treatment with argon attenuated brain injury, reduced brain inflammation and enhanced M2 microglia/macrophage polarization: a randomized controlled animal study.

Liu J, Nolte K, Brook G, Liebenstund L, Weinandy A, Höllig A, Veldeman M, Willuweit A, Langen KJ, Rossaint R, Coburn M.

Crit Care. 2019 Jun 3;23(1):198. doi: 10.1186/s13054-019-2493-7.

6.

Sperm size is negatively related to relative testis size in West African riverine cichlid fishes.

Langen K, Thünken T, Klemm J, Sandmann S, Bakker TCM.

Naturwissenschaften. 2019 May 30;106(5-6):30. doi: 10.1007/s00114-019-1622-0.

PMID:
31147792
7.

Photopenic defects on O-(2-[18F]-fluoroethyl)-L-tyrosine PET - Clinical relevance in glioma patients.

Galldiks N, Unterrainer M, Judov N, Stoffels G, Rapp M, Lohmann P, Vettermann F, Dunkl V, Suchorska B, Tonn JC, Kreth FW, Fink GR, Bartenstein P, Langen KJ, Albert NL.

Neuro Oncol. 2019 May 11. pii: noz083. doi: 10.1093/neuonc/noz083. [Epub ahead of print]

PMID:
31077276
8.

Comparison of [18F]Fluoroethyltyrosine PET and Sodium MRI in Cerebral Gliomas: a Pilot Study.

Shymanskaya A, Worthoff WA, Stoffels G, Lindemeyer J, Neumaier B, Lohmann P, Galldiks N, Langen KJ, Shah NJ.

Mol Imaging Biol. 2019 Apr 15. doi: 10.1007/s11307-019-01349-y. [Epub ahead of print]

PMID:
30989437
9.

Cis-4-[18F]fluoro-D-proline detects neurodegeneration in patients with akinetic-rigid parkinsonism.

Sommerauer M, Galldiks N, Barbe MT, Stoffels G, Willuweit A, Coenen HH, Schroeter M, Timmermann L, Fink GR, Langen KJ.

Nucl Med Commun. 2019 Apr;40(4):383-387. doi: 10.1097/MNM.0000000000000982.

PMID:
30875335
10.

Treatment-related uptake of O-(2-[18F]fluoroethyl)-L-tyrosine and L-[methyl-3H]-methionine after tumor resection in rat glioma models.

Geisler S, Stegmayr C, Niemietz N, Lohmann P, Rapp M, Stoffels G, Willuweit A, Galldiks N, Filss CP, Sabel M, Coenen HH, Shah NJ, Langen KJ.

J Nucl Med. 2019 Mar 8. pii: jnumed.119.225680. doi: 10.2967/jnumed.119.225680. [Epub ahead of print]

PMID:
30850492
11.

[Dopamine Transporter SPECT with I-123 labelled FP-CIT (DaTSCANTM)].

Tatsch K, Buchert R, Bartenstein P, Barthel H, Boecker H, Brust P, Drzezga A, la Fougère C, Gründer G, Grünwald F, Krause BJ, Kuwert T, Langen KJ, Rominger A, Sabri O, Schreckenberger M, Meyer PT.

Nuklearmedizin. 2019 Feb;58(1):5-16. doi: 10.1055/a-0807-8137. Epub 2019 Feb 15. German.

PMID:
30769368
12.

Combined Amino Acid Positron Emission Tomography and Advanced Magnetic Resonance Imaging in Glioma Patients.

Lohmann P, Werner JM, Shah NJ, Fink GR, Langen KJ, Galldiks N.

Cancers (Basel). 2019 Jan 29;11(2). pii: E153. doi: 10.3390/cancers11020153. Review.

13.

An MR technique for simultaneous quantitative imaging of water content, conductivity and susceptibility, with application to brain tumours using a 3T hybrid MR-PET scanner.

Liao Y, Oros-Peusquens AM, Lindemeyer J, Lechea N, Weiß-Lucas C, Langen KJ, Shah NJ.

Sci Rep. 2019 Jan 14;9(1):88. doi: 10.1038/s41598-018-36435-8.

14.

O‑(2‑[18F]‑fluoroethyl)-L‑tyrosine (FET) in neurooncology: A review of experimental results.

Stegmayr C, Willuweit A, Lohmann P, Langen KJ.

Curr Radiopharm. 2019 Jan 10. doi: 10.2174/1874471012666190111111046. [Epub ahead of print]

PMID:
30636621
15.

PET imaging in patients with brain metastasis-report of the RANO/PET group.

Galldiks N, Langen KJ, Albert NL, Chamberlain M, Soffietti R, Kim MM, Law I, Le Rhun E, Chang S, Schwarting J, Combs SE, Preusser M, Forsyth P, Pope W, Weller M, Tonn JC.

Neuro Oncol. 2019 May 6;21(5):585-595. doi: 10.1093/neuonc/noz003.

PMID:
30615138
16.

Joint EANM/EANO/RANO practice guidelines/SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0.

Law I, Albert NL, Arbizu J, Boellaard R, Drzezga A, Galldiks N, la Fougère C, Langen KJ, Lopci E, Lowe V, McConathy J, Quick HH, Sattler B, Schuster DM, Tonn JC, Weller M.

Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):540-557. doi: 10.1007/s00259-018-4207-9. Epub 2018 Dec 5.

17.

Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke.

Ladwig A, Rogall R, Hucklenbroich J, Willuweit A, Schoeneck M, Langen KJ, Fink GR, Rueger MA, Schroeter M.

J Neuroimmune Pharmacol. 2019 Jun;14(2):295-311. doi: 10.1007/s11481-018-9826-1. Epub 2018 Nov 28.

PMID:
30488353
18.

Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2.

Schemmert S, Schartmann E, Honold D, Zafiu C, Ziehm T, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Neurobiol Dis. 2019 Apr;124:36-45. doi: 10.1016/j.nbd.2018.10.021. Epub 2018 Nov 2.

19.

Comparison of EEG microstates with resting state fMRI and FDG-PET measures in the default mode network via simultaneously recorded trimodal (PET/MR/EEG) data.

Rajkumar R, Farrher E, Mauler J, Sripad P, Régio Brambilla C, Rota Kops E, Scheins J, Dammers J, Lerche C, Langen KJ, Herzog H, Biswal B, Shah NJ, Neuner I.

Hum Brain Mapp. 2018 Oct 27. doi: 10.1002/hbm.24429. [Epub ahead of print]

PMID:
30367727
20.

FET PET reveals considerable spatial differences in tumour burden compared to conventional MRI in newly diagnosed glioblastoma.

Lohmann P, Stavrinou P, Lipke K, Bauer EK, Ceccon G, Werner JM, Neumaier B, Fink GR, Shah NJ, Langen KJ, Galldiks N.

Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):591-602. doi: 10.1007/s00259-018-4188-8. Epub 2018 Oct 16.

PMID:
30327856
21.

On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease.

Bachmann C, Jacobs HIL, Porta Mana P, Dillen K, Richter N, von Reutern B, Dronse J, Onur OA, Langen KJ, Fink GR, Kukolja J, Morrison A.

Front Neurosci. 2018 Sep 28;12:528. doi: 10.3389/fnins.2018.00528. eCollection 2018.

22.

Predicting IDH genotype in gliomas using FET PET radiomics.

Lohmann P, Lerche C, Bauer EK, Steger J, Stoffels G, Blau T, Dunkl V, Kocher M, Viswanathan S, Filss CP, Stegmayr C, Ruge MI, Neumaier B, Shah NJ, Fink GR, Langen KJ, Galldiks N.

Sci Rep. 2018 Sep 6;8(1):13328. doi: 10.1038/s41598-018-31806-7.

23.

Combined FET PET/MRI radiomics differentiates radiation injury from recurrent brain metastasis.

Lohmann P, Kocher M, Ceccon G, Bauer EK, Stoffels G, Viswanathan S, Ruge MI, Neumaier B, Shah NJ, Fink GR, Langen KJ, Galldiks N.

Neuroimage Clin. 2018 Aug 19;20:537-542. doi: 10.1016/j.nicl.2018.08.024. eCollection 2018.

24.

Pencil beam scanning versus passively scattered proton therapy for unresectable pancreatic cancer.

Chuong M, Badiyan SN, Yam M, Li Z, Langen K, Regine W, Morris C, Snider J 3rd, Mehta M, Huh S, Rutenberg M, Nichols RC.

J Gastrointest Oncol. 2018 Aug;9(4):687-693. doi: 10.21037/jgo.2018.03.14.

25.

FET PET in Primary Central Nervous System Vasculitis.

Burghaus L, Kabbasch C, Deckert M, Ruge MI, Fink GR, Langen KJ, Galldiks N.

Clin Nucl Med. 2018 Sep;43(9):e322-e323. doi: 10.1097/RLU.0000000000002197.

PMID:
30080188
26.

Correlation of Dynamic O-(2-[18F]Fluoroethyl)-L-Tyrosine Positron Emission Tomography, Conventional Magnetic Resonance Imaging, and Whole-Brain Histopathology in a Pretreated Glioblastoma: A Postmortem Study.

Lohmann P, Piroth MD, Sellhaus B, Weis J, Geisler S, Oros-Peusquens AM, Mohlberg H, Amunts K, Shah NJ, Galldiks N, Langen KJ.

World Neurosurg. 2018 Nov;119:e653-e660. doi: 10.1016/j.wneu.2018.07.232. Epub 2018 Aug 2.

PMID:
30077752
27.

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology.

Schemmert S, Schartmann E, Zafiu C, Kass B, Hartwig S, Lehr S, Bannach O, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Mol Neurobiol. 2019 Mar;56(3):2211-2223. doi: 10.1007/s12035-018-1209-3. Epub 2018 Jul 12.

28.

Early treatment response evaluation using FET PET compared to MRI in glioblastoma patients at first progression treated with bevacizumab plus lomustine.

Galldiks N, Dunkl V, Ceccon G, Tscherpel C, Stoffels G, Law I, Henriksen OM, Muhic A, Poulsen HS, Steger J, Bauer EK, Lohmann P, Schmidt M, Shah NJ, Fink GR, Langen KJ.

Eur J Nucl Med Mol Imaging. 2018 Dec;45(13):2377-2386. doi: 10.1007/s00259-018-4082-4. Epub 2018 Jul 7.

PMID:
29982845
29.

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease.

Schartmann E, Schemmert S, Niemietz N, Honold D, Ziehm T, Tusche M, Elfgen A, Gering I, Brener O, Shah NJ, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

J Alzheimers Dis. 2018;64(3):859-873. doi: 10.3233/JAD-180165.

30.

Voxel-based 18F-FET PET segmentation and automatic clustering of tumor voxels: A significant association with IDH1 mutation status and survival in patients with gliomas.

Blanc-Durand P, Van Der Gucht A, Verger A, Langen KJ, Dunet V, Bloch J, Brouland JP, Nicod-Lalonde M, Schaefer N, Prior JO.

PLoS One. 2018 Jun 28;13(6):e0199379. doi: 10.1371/journal.pone.0199379. eCollection 2018.

31.

Update on amino acid PET of brain tumours.

Langen KJ, Galldiks N.

Curr Opin Neurol. 2018 Aug;31(4):354-361. doi: 10.1097/WCO.0000000000000574. Review.

PMID:
29952832
32.

Concepts of PTV and Robustness in Passively Scattered and Pencil Beam Scanning Proton Therapy.

Langen K, Zhu M.

Semin Radiat Oncol. 2018 Jun;28(3):248-255. doi: 10.1016/j.semradonc.2018.02.009. Review.

PMID:
29933884
33.

Investigational PET tracers for high-grade gliomas.

Choudhary G, Langen KJ, Galldiks N, McConathy J.

Q J Nucl Med Mol Imaging. 2018 Sep;62(3):281-294. doi: 10.23736/S1824-4785.18.03105-9. Epub 2018 Jun 4. Review.

PMID:
29869489
34.

Influence of Dexamethasone on O-(2-[18F]-Fluoroethyl)-L-Tyrosine Uptake in the Human Brain and Quantification of Tumor Uptake.

Stegmayr C, Stoffels G, Kops ER, Lohmann P, Galldiks N, Shah NJ, Neumaier B, Langen KJ.

Mol Imaging Biol. 2019 Feb;21(1):168-174. doi: 10.1007/s11307-018-1221-z.

PMID:
29845426
35.

Investigation of cis-4-[18F]Fluoro-D-Proline Uptake in Human Brain Tumors After Multimodal Treatment.

Verger A, Stoffels G, Galldiks N, Lohmann P, Willuweit A, Neumaier B, Geisler S, Langen KJ.

Mol Imaging Biol. 2018 Dec;20(6):1035-1043. doi: 10.1007/s11307-018-1197-8.

PMID:
29687323
36.

Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice.

Dunkelmann T, Schemmert S, Honold D, Teichmann K, Butzküven E, Demuth HU, Shah NJ, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

J Alzheimers Dis. 2018;63(1):115-130. doi: 10.3233/JAD-170775.

37.

Use of FET PET in glioblastoma patients undergoing neurooncological treatment including tumour-treating fields: initial experience.

Ceccon G, Lazaridis L, Stoffels G, Rapp M, Weber M, Blau T, Lohmann P, Kebir S, Herrmann K, Fink GR, Langen KJ, Glas M, Galldiks N.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(9):1626-1635. doi: 10.1007/s00259-018-3992-5. Epub 2018 Mar 21.

PMID:
29564490
38.

Relevant tumor sink effect in prostate cancer patients receiving 177Lu-PSMA-617 radioligand therapy.

Filss C, Heinzel A, Miiller B, Vogg ATJ, Langen KJ, Mottaghy FM.

Nuklearmedizin. 2018 Feb;57(1):19-25. doi: 10.3413/Nukmed-0937-17-10. Epub 2018 Feb 21.

PMID:
29536496
39.

Comparison of O-(2-18F-Fluoroethyl)-L-Tyrosine Positron Emission Tomography and Perfusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Patients with Progressive and Recurrent Glioma: A Hybrid Positron Emission Tomography/Magnetic Resonance Study.

Verger A, Filss CP, Lohmann P, Stoffels G, Sabel M, Wittsack HJ, Kops ER, Galldiks N, Fink GR, Shah NJ, Langen KJ.

World Neurosurg. 2018 May;113:e727-e737. doi: 10.1016/j.wneu.2018.02.139. Epub 2018 Mar 3.

PMID:
29510293
40.

Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI.

da Silva NA, Lohmann P, Fairney J, Magill AW, Oros Peusquens AM, Choi CH, Stirnberg R, Stoffels G, Galldiks N, Golay X, Langen KJ, Jon Shah N.

Eur J Nucl Med Mol Imaging. 2018 Jun;45(6):1031-1040. doi: 10.1007/s00259-018-3940-4. Epub 2018 Feb 24.

PMID:
29478081
41.

No detectable effects of acute tryptophan depletion on short-term immune system cytokine levels in healthy adults.

Hildebrandt CS, Helmbold K, Linden M, Langen KJ, Filss CP, Runions KC, Stewart RM, Rao P, Moore JK, Mahfouda S, Morandini HAE, Wong JWY, Rink L, Zepf FD.

World J Biol Psychiatry. 2019 Jun;20(5):416-423. doi: 10.1080/15622975.2018.1428357. Epub 2018 Apr 26.

PMID:
29353534
42.

Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.

Dunkelmann T, Teichmann K, Ziehm T, Schemmert S, Frenzel D, Tusche M, Dammers C, Jürgens D, Langen KJ, Demuth HU, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Neuropeptides. 2018 Feb;67:27-35. doi: 10.1016/j.npep.2017.11.011. Epub 2017 Nov 27.

PMID:
29273382
43.

Efficient Interplay Effect Mitigation for Proton Pencil Beam Scanning by Spot-Adapted Layered Repainting Evenly Spread out Over the Full Breathing Cycle.

Poulsen PR, Eley J, Langner U, Simone CB 2nd, Langen K.

Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):226-234. doi: 10.1016/j.ijrobp.2017.09.043. Epub 2017 Oct 4.

PMID:
29254775
44.

On the Fuzziness of Machine Learning, Neural Networks, and Artificial Intelligence in Radiation Oncology.

El Naqa I, Brock K, Yu Y, Langen K, Klein EE.

Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):1-4. doi: 10.1016/j.ijrobp.2017.06.011. No abstract available.

PMID:
29254765
45.

PET Imaging in Glioblastoma: Use in Clinical Practice.

Verger A, Langen KJ.

In: De Vleeschouwer S, editor. Glioblastoma [Internet]. Brisbane (AU): Codon Publications; 2017 Sep 27. Chapter 9.

46.

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease.

Schartmann E, Schemmert S, Ziehm T, Leithold LHE, Jiang N, Tusche M, Joni Shah N, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

Eur J Pharm Sci. 2018 Mar 1;114:93-102. doi: 10.1016/j.ejps.2017.12.005. Epub 2017 Dec 7.

PMID:
29225107
47.

Evaluation of factors influencing 18F-FET uptake in the brain.

Verger A, Stegmayr C, Galldiks N, Van Der Gucht A, Lohmann P, Stoffels G, Shah NJ, Fink GR, Eickhoff SB, Guedj E, Langen KJ.

Neuroimage Clin. 2017 Nov 8;17:491-497. doi: 10.1016/j.nicl.2017.11.005. eCollection 2018.

48.

Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia.

Ladwig A, Walter HL, Hucklenbroich J, Willuweit A, Langen KJ, Fink GR, Rueger MA, Schroeter M.

Mediators Inflamm. 2017;2017:7189421. doi: 10.1155/2017/7189421. Epub 2017 Sep 20.

49.

AIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-L-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells.

Hutterer M, Bumes E, Riemenschneider MJ, Grosse J, Hellwig D, Galldiks N, Langen KJ, Hau P.

Clin Nucl Med. 2017 Dec;42(12):e506-e508. doi: 10.1097/RLU.0000000000001873.

PMID:
29076908
50.

Static and dynamic 18F-FET PET for the characterization of gliomas defined by IDH and 1p/19q status.

Verger A, Stoffels G, Bauer EK, Lohmann P, Blau T, Fink GR, Neumaier B, Shah NJ, Langen KJ, Galldiks N.

Eur J Nucl Med Mol Imaging. 2018 Mar;45(3):443-451. doi: 10.1007/s00259-017-3846-6. Epub 2017 Oct 17.

PMID:
29043400

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