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An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma.

Turnham RE, Smith FD, Kenerson HL, Omar MH, Golkowski M, Garcia I, Bauer R, Lau HT, Sullivan KM, Langeberg LK, Ong SE, Riehle KJ, Yeung RS, Scott JD.

Elife. 2019 May 7;8. pii: e44187. doi: 10.7554/eLife.44187.


Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.

Aggarwal S, Gabrovsek L, Langeberg LK, Golkowski M, Ong SE, Smith FD, Scott JD.

J Biol Chem. 2019 Mar 1;294(9):3152-3168. doi: 10.1074/jbc.RA118.006741. Epub 2018 Dec 31.


Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.

Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11465-E11474. doi: 10.1073/pnas.1816614115. Epub 2018 Nov 19.


Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity.

Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD.

Elife. 2017 Oct 2;6. pii: e30872. doi: 10.7554/eLife.30872.


Local protein kinase A action proceeds through intact holoenzymes.

Smith FD, Esseltine JL, Nygren PJ, Veesler D, Byrne DP, Vonderach M, Strashnov I, Eyers CE, Eyers PA, Langeberg LK, Scott JD.

Science. 2017 Jun 23;356(6344):1288-1293. doi: 10.1126/science.aaj1669.


AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption.

Whiting JL, Ogier L, Forbush KA, Bucko P, Gopalan J, Seternes OM, Langeberg LK, Scott JD.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4328-37. doi: 10.1073/pnas.1607745113. Epub 2016 Jul 11.


AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.

Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD.

Cell Signal. 2016 Jul;28(7):733-40. doi: 10.1016/j.cellsig.2015.12.015. Epub 2015 Dec 24.


A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.

Hehnly H, Canton D, Bucko P, Langeberg LK, Ogier L, Gelman I, Santana LF, Wordeman L, Scott JD.

Elife. 2015 Sep 25;4:e09384. doi: 10.7554/eLife.09384.


Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220.

Whiting JL, Nygren PJ, Tunquist BJ, Langeberg LK, Seternes OM, Scott JD.

J Biol Chem. 2015 Aug 7;290(32):19445-57. doi: 10.1074/jbc.M115.654822. Epub 2015 Jun 18.


A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.

Samelson BK, Gore BB, Whiting JL, Nygren PJ, Purkey AM, Colledge M, Langeberg LK, Dell'Acqua ML, Zweifel LS, Scott JD.

J Biol Chem. 2015 May 29;290(22):14107-19. doi: 10.1074/jbc.M115.637470. Epub 2015 Apr 16.


Signalling scaffolds and local organization of cellular behaviour.

Langeberg LK, Scott JD.

Nat Rev Mol Cell Biol. 2015 Apr;16(4):232-44. doi: 10.1038/nrm3966. Epub 2015 Mar 18. Review.


Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation.

Smith FD, Reichow SL, Esseltine JL, Shi D, Langeberg LK, Scott JD, Gonen T.

Elife. 2013 Nov 5;2:e01319. doi: 10.7554/eLife.01319.


Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection.

Gold MG, Fowler DM, Means CK, Pawson CT, Stephany JJ, Langeberg LK, Fields S, Scott JD.

J Biol Chem. 2013 Jun 14;288(24):17111-21. doi: 10.1074/jbc.M112.447326. Epub 2013 Apr 26.


Gravin is a transitory effector of polo-like kinase 1 during cell division.

Canton DA, Keene CD, Swinney K, Langeberg LK, Nguyen V, Pelletier L, Pawson T, Wordeman L, Stella N, Scott JD.

Mol Cell. 2012 Nov 30;48(4):547-59. doi: 10.1016/j.molcel.2012.09.002. Epub 2012 Oct 11.


Anchored phosphatases modulate glucose homeostasis.

Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD.

EMBO J. 2012 Oct 17;31(20):3991-4004. doi: 10.1038/emboj.2012.244. Epub 2012 Aug 31. Erratum in: EMBO J. 2012 Nov 28;31(23):4481.


Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation.

Kosenko A, Kang S, Smith IM, Greene DL, Langeberg LK, Scott JD, Hoshi N.

EMBO J. 2012 May 29;31(14):3147-56. doi: 10.1038/emboj.2012.156.


AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency.

Gold MG, Reichow SL, O'Neill SE, Weisbrod CR, Langeberg LK, Bruce JE, Gonen T, Scott JD.

EMBO Mol Med. 2012 Jan;4(1):15-26. doi: 10.1002/emmm.201100184. Epub 2011 Nov 16.


An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria.

Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):E1227-35. doi: 10.1073/pnas.1107182108. Epub 2011 Nov 14.


AKAP220 protein organizes signaling elements that impact cell migration.

Logue JS, Whiting JL, Tunquist B, Sacks DB, Langeberg LK, Wordeman L, Scott JD.

J Biol Chem. 2011 Nov 11;286(45):39269-81. doi: 10.1074/jbc.M111.277756. Epub 2011 Sep 2.


Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E.

Mol Cell. 2011 Apr 8;42(1):84-95. doi: 10.1016/j.molcel.2011.01.030.


Anchored protein kinase A recruitment of active Rac GTPase.

Logue JS, Whiting JL, Tunquist B, Langeberg LK, Scott JD.

J Biol Chem. 2011 Jun 24;286(25):22113-21. doi: 10.1074/jbc.M111.232660. Epub 2011 Apr 1.


Plugging PKA into ERK scaffolds.

Smith FD, Langeberg LK, Scott JD.

Cell Cycle. 2011 Mar 1;10(5):731-2. Epub 2011 Mar 1.


Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.

Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21854-9. doi: 10.1073/pnas.1010819107. Epub 2010 Nov 29.


AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.

Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ, Scott JD.

Nat Cell Biol. 2010 Dec;12(12):1242-9. doi: 10.1038/ncb2130. Epub 2010 Nov 21.


Interaction with AKAP79 modifies the cellular pharmacology of PKC.

Hoshi N, Langeberg LK, Gould CM, Newton AC, Scott JD.

Mol Cell. 2010 Feb 26;37(4):541-50. doi: 10.1016/j.molcel.2010.01.014.


mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.

Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD.

Sci Signal. 2008 Dec 23;1(51):ra18. doi: 10.1126/scisignal.2000026.


AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.

Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD.

Mol Cell. 2008 Oct 24;32(2):169-79. doi: 10.1016/j.molcel.2008.08.030.


Loss of AKAP150 perturbs distinct neuronal processes in mice.

Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, Raber J, Scott JD.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12557-62. doi: 10.1073/pnas.0805922105. Epub 2008 Aug 18.


MyRIP anchors protein kinase A to the exocyst complex.

Goehring AS, Pedroja BS, Hinke SA, Langeberg LK, Scott JD.

J Biol Chem. 2007 Nov 9;282(45):33155-67. Epub 2007 Sep 7.


A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.

Soderling SH, Guire ES, Kaech S, White J, Zhang F, Schutz K, Langeberg LK, Banker G, Raber J, Scott JD.

J Neurosci. 2007 Jan 10;27(2):355-65.


Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.

Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD.

Mol Cell. 2006 Sep 15;23(6):925-31.


AKAP signaling complexes: getting to the heart of the matter.

McConnachie G, Langeberg LK, Scott JD.

Trends Mol Med. 2006 Jul;12(7):317-23. Epub 2006 Jun 30. Review.


The where's and when's of kinase anchoring.

Smith FD, Langeberg LK, Scott JD.

Trends Biochem Sci. 2006 Jun;31(6):316-23. Epub 2006 May 11. Review.


Distinct enzyme combinations in AKAP signalling complexes permit functional diversity.

Hoshi N, Langeberg LK, Scott JD.

Nat Cell Biol. 2005 Nov;7(11):1066-73.


The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, Scott JD.

Nature. 2005 Sep 22;437(7058):574-8.


A-kinase-anchoring proteins.

Langeberg LK, Scott JD.

J Cell Sci. 2005 Aug 1;118(Pt 15):3217-20. Review. No abstract available.


AKAP-Lbc nucleates a protein kinase D activation scaffold.

Carnegie GK, Smith FD, McConnachie G, Langeberg LK, Scott JD.

Mol Cell. 2004 Sep 24;15(6):889-99.


Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T.

Curr Biol. 2004 Aug 24;14(16):1436-50.


PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex.

Carlisle Michel JJ, Dodge KL, Wong W, Mayer NC, Langeberg LK, Scott JD.

Biochem J. 2004 Aug 1;381(Pt 3):587-92.


Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

Colledge M, Snyder EM, Crozier RA, Soderling JA, Jin Y, Langeberg LK, Lu H, Bear MF, Scott JD.

Neuron. 2003 Oct 30;40(3):595-607.


AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.

Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, Langeberg LK, Yoneda Y, Scott JD, Brown DA, Higashida H.

Nat Neurosci. 2003 Jun;6(6):564-71.


Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.

Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4445-50. Epub 2003 Apr 2.


Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.

Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, Scott JD.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723-8. Epub 2003 Feb 10.


Intracellular targeting of protein kinases and phosphatases.

Alto N, Carlisle Michel JJ, Dodge KL, Langeberg LK, Scott JD.

Diabetes. 2002 Dec;51 Suppl 3:S385-8. Review.


Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression.

Tavalin SJ, Colledge M, Hell JW, Langeberg LK, Huganir RL, Scott JD.

J Neurosci. 2002 Apr 15;22(8):3044-51.


mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.

Dodge KL, Khouangsathiene S, Kapiloff MS, Mouton R, Hill EV, Houslay MD, Langeberg LK, Scott JD.

EMBO J. 2001 Apr 17;20(8):1921-30.


Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain.

Diviani D, Langeberg LK, Doxsey SJ, Scott JD.

Curr Biol. 2000 Apr 6;10(7):417-20.


Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.

Westphal RS, Soderling SH, Alto NM, Langeberg LK, Scott JD.

EMBO J. 2000 Sep 1;19(17):4589-600.


Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex.

Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL, Scott JD.

Neuron. 2000 Jul;27(1):107-19.


The molecular architecture of neuronal kinase/phosphatase signalling complexes.

Tavalin SJ, Westphal RS, Colledge M, Langeberg LK, Scott JD.

Biochem Soc Trans. 1999 Aug;27(4):539-42. Review. No abstract available.


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