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Items: 20


Sensitive determination of proteolytic proteoforms in limited microscale proteome samples.

Weng SS, Demir F, Ergin EK, Dirnberger S, Uzozie A, Tuscher D, Nierves L, Tsui J, Huesgen PF, Lange PF.

Mol Cell Proteomics. 2019 Aug 30. pii: mcp.TIR119.001560. doi: 10.1074/mcp.TIR119.001560. [Epub ahead of print]


Tumor Variant Identification That Accounts for the Unique Molecular Landscape of Pediatric Malignancies.

Lorentzian A, Biegel JA, Ostrow DG, Rolf N, Liu CC, Rassekh SR, Deyell RJ, Triche T, Schultz KR, Rozmus J, Reid GSD, Lim CJ, Lange PF, Maxwell CA.

JNCI Cancer Spectr. 2018 Oct;2(4):pky079. doi: 10.1093/jncics/pky079. Epub 2019 Jan 25.


Origins and clinical relevance of proteoforms in pediatric malignancies.

Lorentzian A, Uzozie A, Lange PF.

Expert Rev Proteomics. 2019 Mar;16(3):185-200. doi: 10.1080/14789450.2019.1575206. Epub 2019 Feb 18.


HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.

Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA.

Elife. 2017 Oct 10;6. pii: e28672. doi: 10.7554/eLife.28672.


TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM.

Cell Rep. 2016 Aug 9;16(6):1762-1773. doi: 10.1016/j.celrep.2016.06.086. Epub 2016 Jul 28.


Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.


Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UAD, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25.


LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.

Huesgen PF, Lange PF, Rogers LD, Solis N, Eckhard U, Kleifeld O, Goulas T, Gomis-Rüth FX, Overall CM.

Nat Methods. 2015 Jan;12(1):55-8. doi: 10.1038/nmeth.3177. Epub 2014 Nov 24.


Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre- and post-translational events.

Fortelny N, Yang S, Pavlidis P, Lange PF, Overall CM.

Nucleic Acids Res. 2015 Jan;43(Database issue):D290-7. doi: 10.1093/nar/gku1012. Epub 2014 Oct 20.


Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis.

Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM.

Cell Rep. 2014 Oct 23;9(2):618-32. doi: 10.1016/j.celrep.2014.09.006. Epub 2014 Oct 9.


Network analyses reveal pervasive functional regulation between proteases in the human protease web.

Fortelny N, Cox JH, Kappelhoff R, Starr AE, Lange PF, Pavlidis P, Overall CM.

PLoS Biol. 2014 May 27;12(5):e1001869. doi: 10.1371/journal.pbio.1001869. eCollection 2014 May.


Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease.

Huesgen PF, Lange PF, Overall CM.

Proteomics Clin Appl. 2014 Jun;8(5-6):338-50. doi: 10.1002/prca.201300104. Epub 2014 Mar 27. Review.


Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids.

Huesgen PF, Alami M, Lange PF, Foster LJ, Schröder WP, Overall CM, Green BR.

PLoS One. 2013 Sep 16;8(9):e74483. doi: 10.1371/journal.pone.0074483. eCollection 2013.


Protein TAILS: when termini tell tales of proteolysis and function.

Lange PF, Overall CM.

Curr Opin Chem Biol. 2013 Feb;17(1):73-82. doi: 10.1016/j.cbpa.2012.11.025. Epub 2013 Jan 6. Review.


TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function.

Lange PF, Huesgen PF, Overall CM.

Nucleic Acids Res. 2012 Jan;40(Database issue):D351-61. doi: 10.1093/nar/gkr1025. Epub 2011 Nov 18.


TopFIND, a knowledgebase linking protein termini with function.

Lange PF, Overall CM.

Nat Methods. 2011 Aug 7;8(9):703-4. doi: 10.1038/nmeth.1669. No abstract available. Erratum in: Nat Methods. 2011;8(9). doi:10.1038/nmeth.1669.


Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

auf dem Keller U, Bellac CL, Li Y, Lou Y, Lange PF, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam MJ, Ruth TJ, Bénard F, Perrin DM, Overall CM.

Cancer Res. 2010 Oct 1;70(19):7562-9. doi: 10.1158/0008-5472.CAN-10-1584. Epub 2010 Aug 20.


ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.

Lange PF, Wartosch L, Jentsch TJ, Fuhrmann JC.

Nature. 2006 Mar 9;440(7081):220-3.


Warfarin poisoning; report of fourteen cases.


U S Armed Forces Med J. 1954 Jun;5(6):872-7. No abstract available.


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