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A Plant Pathogen Type III Effector Protein Subverts Translational Regulation to Boost Host Polyamine Levels.

Wu D, von Roepenack-Lahaye E, Buntru M, de Lange O, Schandry N, Pérez-Quintero AL, Weinberg Z, Lowe-Power TM, Szurek B, Michael AJ, Allen C, Schillberg S, Lahaye T.

Cell Host Microbe. 2019 Nov 13;26(5):638-649.e5. doi: 10.1016/j.chom.2019.09.014. Epub 2019 Oct 15.


Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution.

Kelstrup CD, Aizikov K, Batth TS, Kreutzman A, Grinfeld D, Lange O, Mourad D, Makarov AA, Olsen JV.

J Proteome Res. 2018 Nov 2;17(11):4008-4016. doi: 10.1021/acs.jproteome.8b00381. Epub 2018 Sep 28.


Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.

Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, Juen M, Hartlmüller C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M.

Nucleic Acids Res. 2017 Dec 1;45(21):12536-12550. doi: 10.1093/nar/gkx886.


Synthetic genetic circuits in crop plants.

de Lange O, Klavins E, Nemhauser J.

Curr Opin Biotechnol. 2018 Feb;49:16-22. doi: 10.1016/j.copbio.2017.07.003. Epub 2017 Jul 31. Review.


Systematic evaluation of CS-Rosetta for membrane protein structure prediction with sparse NOE restraints.

Reichel K, Fisette O, Braun T, Lange OF, Hummer G, Schäfer LV.

Proteins. 2017 May;85(5):812-826. doi: 10.1002/prot.25224. Epub 2017 Feb 28.


TALE-Like Effectors Are an Ancestral Feature of the Ralstonia solanacearum Species Complex and Converge in DNA Targeting Specificity.

Schandry N, de Lange O, Prior P, Lahaye T.

Front Plant Sci. 2016 Aug 17;7:1225. doi: 10.3389/fpls.2016.01225. eCollection 2016.


Regulatory Implications of Non-Trivial Splicing: Isoform 3 of Rab1A Shows Enhanced Basal Activity and Is Not Controlled by Accessory Proteins.

Schöppner P, Csaba G, Braun T, Daake M, Richter B, Lange OF, Zacharias M, Zimmer R, Haslbeck M.

J Mol Biol. 2016 Apr 24;428(8):1544-57. doi: 10.1016/j.jmb.2016.02.028. Epub 2016 Mar 4.


Trastuzumab in Esophagogastric Cancer: HER2-Testing and Treatment Reality outside Clinical Studies in Germany.

Merx K, Barreto Miranda M, Kellermann L, Mahlknecht U, Lange O, Gonnermann M, Hofheinz RD.

Gastroenterol Res Pract. 2016;2016:1028505. doi: 10.1155/2016/1028505. Epub 2016 Jan 28.


Combining Evolutionary Information and an Iterative Sampling Strategy for Accurate Protein Structure Prediction.

Braun T, Koehler Leman J, Lange OF.

PLoS Comput Biol. 2015 Dec 29;11(12):e1004661. doi: 10.1371/journal.pcbi.1004661. eCollection 2015 Dec.


DNA-binding proteins from marine bacteria expand the known sequence diversity of TALE-like repeats.

de Lange O, Wolf C, Thiel P, Krüger J, Kleusch C, Kohlbacher O, Lahaye T.

Nucleic Acids Res. 2015 Nov 16;43(20):10065-80. doi: 10.1093/nar/gkv1053. Epub 2015 Oct 19.


A Framework to Simplify Combined Sampling Strategies in Rosetta.

Porter JR, Weitzner BD, Lange OF.

PLoS One. 2015 Sep 18;10(9):e0138220. doi: 10.1371/journal.pone.0138220. eCollection 2015.


Application of Enhanced Sampling Monte Carlo Methods for High-Resolution Protein-Protein Docking in Rosetta.

Zhang Z, Schindler CE, Lange OF, Zacharias M.

PLoS One. 2015 Jun 8;10(6):e0125941. doi: 10.1371/journal.pone.0125941. eCollection 2015.


NMR Exchange Format: a unified and open standard for representation of NMR restraint data.

Gutmanas A, Adams PD, Bardiaux B, Berman HM, Case DA, Fogh RH, Güntert P, Hendrickx PM, Herrmann T, Kleywegt GJ, Kobayashi N, Lange OF, Markley JL, Montelione GT, Nilges M, Ragan TJ, Schwieters CD, Tejero R, Ulrich EL, Velankar S, Vranken WF, Wedell JR, Westbrook J, Wishart DS, Vuister GW.

Nat Struct Mol Biol. 2015 Jun;22(6):433-4. doi: 10.1038/nsmb.3041. No abstract available.


Side-binding proteins modulate actin filament dynamics.

Crevenna AH, Arciniega M, Dupont A, Mizuno N, Kowalska K, Lange OF, Wedlich-Söldner R, Lamb DC.

Elife. 2015 Feb 23;4. pii: e04599. doi: 10.7554/eLife.04599.


Frequency of dermatological side effects of continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes.

Binder E, Lange O, Edlinger M, Meraner D, Abt D, Moser C, Steichen E, Hofer SE.

Exp Clin Endocrinol Diabetes. 2015 Apr;123(4):260-4. doi: 10.1055/s-0034-1394381. Epub 2015 Jan 21.


Access to Cα backbone dynamics of biological solids by 13C T1 relaxation and molecular dynamics simulation.

Asami S, Porter JR, Lange OF, Reif B.

J Am Chem Soc. 2015 Jan 28;137(3):1094-100. doi: 10.1021/ja509367q. Epub 2015 Jan 15.


A hybrid NMR/SAXS-based approach for discriminating oligomeric protein interfaces using Rosetta.

Rossi P, Shi L, Liu G, Barbieri CM, Lee HW, Grant TD, Luft JR, Xiao R, Acton TB, Snell EH, Montelione GT, Baker D, Lange OF, Sgourakis NG.

Proteins. 2015 Feb;83(2):309-17. doi: 10.1002/prot.24719. Epub 2014 Dec 19.


The Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer.

Scheltema RA, Hauschild JP, Lange O, Hornburg D, Denisov E, Damoc E, Kuehn A, Makarov A, Mann M.

Mol Cell Proteomics. 2014 Dec;13(12):3698-708. doi: 10.1074/mcp.M114.043489. Epub 2014 Oct 30.


Development of a GC/Quadrupole-Orbitrap mass spectrometer, part I: design and characterization.

Peterson AC, Hauschild JP, Quarmby ST, Krumwiede D, Lange O, Lemke RA, Grosse-Coosmann F, Horning S, Donohue TJ, Westphall MS, Coon JJ, Griep-Raming J.

Anal Chem. 2014 Oct 21;86(20):10036-43. doi: 10.1021/ac5014767. Epub 2014 Sep 10.


Site-specific analysis of heteronuclear Overhauser effects in microcrystalline proteins.

del Amo JM, Agarwal V, Sarkar R, Porter J, Asami S, Rübbelke M, Fink U, Xue Y, Lange OF, Reif B.

J Biomol NMR. 2014 Aug;59(4):241-9. doi: 10.1007/s10858-014-9843-1. Epub 2014 Jul 3.


Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding.

Arciniega M, Beck P, Lange OF, Groll M, Huber R.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9479-84. doi: 10.1073/pnas.1408018111. Epub 2014 Jun 16.


A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.

Akimoto M, Zhang Z, Boulton S, Selvaratnam R, VanSchouwen B, Gloyd M, Accili EA, Lange OF, Melacini G.

J Biol Chem. 2014 Aug 8;289(32):22205-20. doi: 10.1074/jbc.M114.572164. Epub 2014 May 30.


A prospective cohort study on the impact of darbepoetin alfa on quality of life in daily practice following anemia treatment guideline revisions.

Steinmetz T, Kindler M, Lange O, Vehling-Kaiser U, Kuhn A, Hellebrand E.

Curr Med Res Opin. 2014 Sep;30(9):1813-20. doi: 10.1185/03007995.2014.924914. Epub 2014 Jun 5.


Robust and highly accurate automatic NOESY assignment and structure determination with Rosetta.

Zhang Z, Porter J, Tripsianes K, Lange OF.

J Biomol NMR. 2014 Jul;59(3):135-45. doi: 10.1007/s10858-014-9832-4. Epub 2014 May 21.


Automatic NOESY assignment in CS-RASREC-Rosetta.

Lange OF.

J Biomol NMR. 2014 Jul;59(3):147-59. doi: 10.1007/s10858-014-9833-3. Epub 2014 May 16.


Improvement of virtual screening results by docking data feature analysis.

Arciniega M, Lange OF.

J Chem Inf Model. 2014 May 27;54(5):1401-11. doi: 10.1021/ci500028u. Epub 2014 May 14.


Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain.

de Lange O, Wolf C, Dietze J, Elsaesser J, Morbitzer R, Lahaye T.

Nucleic Acids Res. 2014 Jun;42(11):7436-49. doi: 10.1093/nar/gku329. Epub 2014 May 3.


From dead leaf, to new life: TAL effectors as tools for synthetic biology.

de Lange O, Binder A, Lahaye T.

Plant J. 2014 Jun;78(5):753-71. doi: 10.1111/tpj.12431. Epub 2014 Mar 18.


Novel parallelized quadrupole/linear ion trap/Orbitrap tribrid mass spectrometer improving proteome coverage and peptide identification rates.

Senko MW, Remes PM, Canterbury JD, Mathur R, Song Q, Eliuk SM, Mullen C, Earley L, Hardman M, Blethrow JD, Bui H, Specht A, Lange O, Denisov E, Makarov A, Horning S, Zabrouskov V.

Anal Chem. 2013 Dec 17;85(24):11710-4. doi: 10.1021/ac403115c. Epub 2013 Nov 27.


Replica exchange improves sampling in low-resolution docking stage of RosettaDock.

Zhang Z, Lange OF.

PLoS One. 2013 Aug 29;8(8):e72096. doi: 10.1371/journal.pone.0072096. eCollection 2013.


Improved chemical shift based fragment selection for CS-Rosetta using Rosetta3 fragment picker.

Vernon R, Shen Y, Baker D, Lange OF.

J Biomol NMR. 2013 Oct;57(2):117-27. doi: 10.1007/s10858-013-9772-4. Epub 2013 Aug 22.


Improving 3D structure prediction from chemical shift data.

van der Schot G, Zhang Z, Vernon R, Shen Y, Vranken WF, Baker D, Bonvin AM, Lange OF.

J Biomol NMR. 2013 Sep;57(1):27-35. doi: 10.1007/s10858-013-9762-6. Epub 2013 Aug 3.


Breaking the DNA-binding code of Ralstonia solanacearum TAL effectors provides new possibilities to generate plant resistance genes against bacterial wilt disease.

de Lange O, Schreiber T, Schandry N, Radeck J, Braun KH, Koszinowski J, Heuer H, Strauß A, Lahaye T.

New Phytol. 2013 Aug;199(3):773-86. doi: 10.1111/nph.12324. Epub 2013 May 21. Erratum in: New Phytol. 2015 Feb;205(3):1368.


Evaluation and optimization of discrete state models of protein folding.

Kellogg EH, Lange OF, Baker D.

J Phys Chem B. 2012 Sep 20;116(37):11405-13. Epub 2012 Sep 7.


In support of the BMRB.

Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S.

Nat Struct Mol Biol. 2012 Sep;19(9):854-60. doi: 10.1038/nsmb.2371. No abstract available.


Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.

Lange OF, Rossi P, Sgourakis NG, Song Y, Lee HW, Aramini JM, Ertekin A, Xiao R, Acton TB, Montelione GT, Baker D.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10873-8. doi: 10.1073/pnas.1203013109. Epub 2012 Jun 25.


Blind testing of routine, fully automated determination of protein structures from NMR data.

Rosato A, Aramini JM, Arrowsmith C, Bagaria A, Baker D, Cavalli A, Doreleijers JF, Eletsky A, Giachetti A, Guerry P, Gutmanas A, Güntert P, He Y, Herrmann T, Huang YJ, Jaravine V, Jonker HR, Kennedy MA, Lange OF, Liu G, Malliavin TE, Mani R, Mao B, Montelione GT, Nilges M, Rossi P, van der Schot G, Schwalbe H, Szyperski TA, Vendruscolo M, Vernon R, Vranken WF, Vries Sd, Vuister GW, Wu B, Yang Y, Bonvin AM.

Structure. 2012 Feb 8;20(2):227-36. doi: 10.1016/j.str.2012.01.002.


Ultra high resolution linear ion trap Orbitrap mass spectrometer (Orbitrap Elite) facilitates top down LC MS/MS and versatile peptide fragmentation modes.

Michalski A, Damoc E, Lange O, Denisov E, Nolting D, Müller M, Viner R, Schwartz J, Remes P, Belford M, Dunyach JJ, Cox J, Horning S, Mann M, Makarov A.

Mol Cell Proteomics. 2012 Mar;11(3):O111.013698. doi: 10.1074/mcp.O111.013698. Epub 2011 Dec 9.


Kinetics of conformational sampling in ubiquitin.

Ban D, Funk M, Gulich R, Egger D, Sabo TM, Walter KF, Fenwick RB, Giller K, Pichierri F, de Groot BL, Lange OF, Grubmüller H, Salvatella X, Wolf M, Loidl A, Kree R, Becker S, Lakomek NA, Lee D, Lunkenheimer P, Griesinger C.

Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11437-40. doi: 10.1002/anie.201105086. Epub 2011 Oct 5. No abstract available.


Gastric neuroendocrine carcinoma after long-term use of proton pump inhibitor.

Jianu CS, Lange OJ, Viset T, Qvigstad G, Martinsen TC, Fougner R, Kleveland PM, Fossmark R, Hauso Ø, Waldum HL.

Scand J Gastroenterol. 2012 Jan;47(1):64-7. doi: 10.3109/00365521.2011.627444. Epub 2011 Nov 16.


Solution structure of a minor and transiently formed state of a T4 lysozyme mutant.

Bouvignies G, Vallurupalli P, Hansen DF, Correia BE, Lange O, Bah A, Vernon RM, Dahlquist FW, Baker D, Kay LE.

Nature. 2011 Aug 21;477(7362):111-4. doi: 10.1038/nature10349.


Gastronet survey on the use of one- or two-person technique for colonoscopy insertion.

Hoff G, Volker M, Bretthauer M, Aabakken L, Høie O, Delange T, Berset I, Kjellevold Ø, Glomsaker T, Huppertz-Hauss G, Lange O, Sandvei P.

BMC Gastroenterol. 2011 Jun 14;11:73. doi: 10.1186/1471-230X-11-73.


Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer.

Michalski A, Damoc E, Hauschild JP, Lange O, Wieghaus A, Makarov A, Nagaraj N, Cox J, Mann M, Horning S.

Mol Cell Proteomics. 2011 Sep;10(9):M111.011015. doi: 10.1074/mcp.M111.011015. Epub 2011 Jun 3.


Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set.

Warner LR, Varga K, Lange OF, Baker SL, Baker D, Sousa MC, Pardi A.

J Mol Biol. 2011 Aug 5;411(1):83-95. doi: 10.1016/j.jmb.2011.05.022. Epub 2011 May 23.


What causes treatment failure - the patient, primary care, secondary care or inadequate interaction in the health services?

Farup PG, Blix I, Førre S, Johnsen G, Lange O, Johannessen R, Petersen H.

BMC Health Serv Res. 2011 May 20;11:111. doi: 10.1186/1472-6963-11-111.


Determination of the structures of symmetric protein oligomers from NMR chemical shifts and residual dipolar couplings.

Sgourakis NG, Lange OF, DiMaio F, André I, Fitzkee NC, Rossi P, Montelione GT, Bax A, Baker D.

J Am Chem Soc. 2011 Apr 27;133(16):6288-98. doi: 10.1021/ja111318m. Epub 2011 Apr 5.


ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules.

Leaver-Fay A, Tyka M, Lewis SM, Lange OF, Thompson J, Jacak R, Kaufman K, Renfrew PD, Smith CA, Sheffler W, Davis IW, Cooper S, Treuille A, Mandell DJ, Richter F, Ban YE, Fleishman SJ, Corn JE, Kim DE, Lyskov S, Berrondo M, Mentzer S, Popović Z, Havranek JJ, Karanicolas J, Das R, Meiler J, Kortemme T, Gray JJ, Kuhlman B, Baker D, Bradley P.

Methods Enzymol. 2011;487:545-74. doi: 10.1016/B978-0-12-381270-4.00019-6.


On the application of (topographic) independent and tree-dependent component analysis for the examination of DCE-MRI data.

Saalbach A, Lange O, Nattkemper T, Meyer-Baese A.

Biomed Signal Process Control. 2009 Jul;4(3):247-253.


Scrutinizing molecular mechanics force fields on the submicrosecond timescale with NMR data.

Lange OF, van der Spoel D, de Groot BL.

Biophys J. 2010 Jul 21;99(2):647-55. doi: 10.1016/j.bpj.2010.04.062.

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