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Relationship between ABCC4 SNPs and hepatitis B virus suppression during tenofovir-containing antiretroviral therapy in patients with HIV/HBV coinfection.

Archampong T, Ojewale O, Bears K, Chen Y, Lartey M, Sagoe KW, Obo-Akwa A, Gong Y, Langaee T, Kwara A.

J Acquir Immune Defic Syndr. 2019 Jul 3. doi: 10.1097/QAI.0000000000002136. [Epub ahead of print]


Effect of first-line antituberculosis therapy on nevirapine pharmacokinetics in children younger than 3 years old.

Enimil A, Antwi S, Yang H, Dompreh A, Alghamdi WA, Gillani FS, Orstin A, Bosomtwe D, Opoku T, Norman J, Wiesner L, Langaee T, Peloquin CA, Court MH, Greenblatt DJ, Kwara A.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.00839-19. doi: 10.1128/AAC.00839-19. [Epub ahead of print]


Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.

Alghamdi WA, Antwi S, Enimil A, Yang H, Dompreh A, Wiesner L, Langaee T, Peloquin CA, Kwara A.

J Antimicrob Chemother. 2019 Sep 1;74(9):2698-2706. doi: 10.1093/jac/dkz238.


Pharmacogenomics of osteonecrosis of the jaw.

Yang G, Singh S, Chen Y, Hamadeh IS, Langaee T, McDonough CW, Holliday LS, Lamba JK, Moreb JS, Katz J, Gong Y.

Bone. 2019 Jul;124:75-82. doi: 10.1016/j.bone.2019.04.010. Epub 2019 Apr 22. Review.


Development and Cross-Validation of High-Resolution Melting Analysis-Based Cardiovascular Pharmacogenetics Genotyping Panel.

Langaee T, El Rouby N, Stauffer L, Galloway C, Cavallari LH.

Genet Test Mol Biomarkers. 2019 Mar;23(3):209-214. doi: 10.1089/gtmb.2018.0298. Epub 2019 Feb 13.


Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies.

Solayman MH, Langaee TY, Gong Y, Shahin MH, Turner ST, Chapman AB, Gums JG, Boerwinkle E, Beitelshees AL, El-Hamamsy M, El-Wakeel L, Cooper-DeHoff RM, Badary OA, Johnson JA.

Eur J Pharm Sci. 2019 Apr 1;131:93-98. doi: 10.1016/j.ejps.2019.02.013. Epub 2019 Feb 10.


CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.

Smith DM, Weitzel KW, Elsey AR, Langaee T, Gong Y, Wake DT, Duong BQ, Hagen M, Harle CA, Mercado E, Nagoshi Y, Newsom K, Wright A, Rosenberg EI, Starostik P, Clare-Salzler MJ, Schmidt SO, Fillingim RB, Johnson JA, Cavallari LH.

Genet Med. 2019 Aug;21(8):1842-1850. doi: 10.1038/s41436-018-0431-8. Epub 2019 Jan 23.


Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.

Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ, Borobia AM, Tong HY, Dávila-Fajardo C, Rodrigues Botton M, Bourgeois S, Deloukas P, Caldwell MD, Burmester JK, Berg RL, Cavallari LH, Drozda K, Huang M, Zhao LZ, Cen HJ, Gonzalez-Conejero R, Roldan V, Nakamura Y, Mushiroda T, Gong IY, Kim RB, Hirai K, Itoh K, Isaza C, Beltrán L, Jiménez-Varo E, Cañadas-Garre M, Giontella A, Kringen MK, Haug KBF, Gwak HS, Lee KE, Minuz P, Lee MTM, Lubitz SA, Scott S, Mazzaccara C, Sacchetti L, Genç E, Özer M, Pathare A, Krishnamoorthy R, Paldi A, Siguret V, Loriot MA, Kutala VK, Suarez-Kurtz G, Perini J, Denny JC, Ramirez AH, Mittal B, Rathore SS, Sagreiya H, Altman R, Shahin MHA, Khalifa SI, Limdi NA, Rivers C, Shendre A, Dillon C, Suriapranata IM, Zhou HH, Tan SL, Tatarunas V, Lesauskaite V, Zhang Y, Maitland-van der Zee AH, Verhoef TI, de Boer A, Taljaard M, Zambon CF, Pengo V, Zhang JE, Pirmohamed M, Johnson JA, Fava C.

Clin Pharmacol Ther. 2019 Jun;105(6):1477-1491. doi: 10.1002/cpt.1323. Epub 2019 Feb 17.


Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old.

Kwara A, Yang H, Antwi S, Enimil A, Gillani FS, Dompreh A, Ortsin A, Opoku T, Bosomtwe D, Sarfo A, Wiesner L, Norman J, Alghamdi WA, Langaee T, Peloquin CA, Court MH, Greenblatt DJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01657-18. doi: 10.1128/AAC.01657-18. Print 2019 Jan.


Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide.

Singh S, Wang Z, Shahin MH, Langaee TY, Gong Y, Turner ST, Chapman AB, Gums JG, McDonough CW, Bailey KR, Beitelshees AL, Cooper-DeHoff RM, Scherer S, Boerwinkle E, Johnson JA.

Pharmacogenet Genomics. 2018 Nov;28(11):251-255. doi: 10.1097/FPC.0000000000000353.


The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women.

Aharon DA, Friedman EG, Overbey JR, McLaughlin M, Langaee T, Thurston RC.

Menopause. 2019 Mar;26(3):300-305. doi: 10.1097/GME.0000000000001218.


Pharmacogenetic and clinical predictors of response to clopidogrel plus aspirin after acute coronary syndrome in Egyptians.

Fathy S, Shahin MH, Langaee T, Khalil BM, Saleh A, Sabry NA, Schaalan MF, El Wakeel LL, Cavallari LH.

Pharmacogenet Genomics. 2018 Sep;28(9):207-213. doi: 10.1097/FPC.0000000000000349.


A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis.

Kawaguchi-Suzuki M, Cusi K, Bril F, Gong Y, Langaee T, Frye RF.

Front Pharmacol. 2018 Jul 17;9:752. doi: 10.3389/fphar.2018.00752. eCollection 2018.


Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

Sá ACC, Webb A, Gong Y, McDonough CW, Shahin MH, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA.

BMC Med Genomics. 2018 Jun 20;11(1):55. doi: 10.1186/s12920-018-0370-x.


Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.

Zhong G, James MO, Smeltz MG, Jahn SC, Langaee T, Simpson P, Stacpoole PW.

Drug Metab Dispos. 2018 Aug;46(8):1118-1128. doi: 10.1124/dmd.118.081810. Epub 2018 May 31.


Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.

Langaee T, Wagner R, Horne LP, Lawson LA, Becker C, Shahin M, Starostik P, Stacpoole PW.

Genet Test Mol Biomarkers. 2018 Apr;22(4):266-269. doi: 10.1089/gtmb.2017.0261. Epub 2018 Mar 19.


Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.

Mosley SA, Hicks JK, Portman DG, Donovan KA, Gopalan P, Schmit J, Starr J, Silver N, Gong Y, Langaee T, Clare-Salzler M, Starostik P, Chang YD, Rajasekhara S, Smith JE, Soares HP, George TJ Jr, McLeod HL, Cavallari LH.

Contemp Clin Trials. 2018 May;68:7-13. doi: 10.1016/j.cct.2018.03.001. Epub 2018 Mar 10.


Implementation of Standardized Clinical Processes for TPMT Testing in a Diverse Multidisciplinary Population: Challenges and Lessons Learned.

Weitzel KW, Smith DM, Elsey AR, Duong BQ, Burkley B, Clare-Salzler M, Gong Y, Higgins TA, Kong B, Langaee T, McDonough CW, Staley BJ, Vo TT, Wake DT, Cavallari LH, Johnson JA.

Clin Transl Sci. 2018 Mar;11(2):175-181. doi: 10.1111/cts.12533. Epub 2018 Jan 19.


Effect of Genetic Variation of NAT2 on Isoniazid and SLCO1B1 and CES2 on Rifampin Pharmacokinetics in Ghanaian Children with Tuberculosis.

Dompreh A, Tang X, Zhou J, Yang H, Topletz A, Adu Ahwireng E, Antwi S, Enimil A, Langaee T, Peloquin CA, Court MH, Kwara A.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02099-17. doi: 10.1128/AAC.02099-17. Print 2018 Mar.


Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.

Sá ACC, Webb A, Gong Y, McDonough CW, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA.

Sci Rep. 2017 Nov 22;7(1):16068. doi: 10.1038/s41598-017-16343-z.


Unanticipated Cardiotoxicity Associated with Targeted Anticancer Therapy in Patients with Hematologic Malignancies Patients: Natural History and Risk Factors.

Shah C, Gong Y, Szady A, Sun Q, Pepine CJ, Langaee T, Lucas AR, Moreb JS.

Cardiovasc Toxicol. 2018 Apr;18(2):184-191. doi: 10.1007/s12012-017-9429-8.


Epigenetic regulation of inflammation in localized aggressive periodontitis.

Shaddox LM, Mullersman AF, Huang H, Wallet SM, Langaee T, Aukhil I.

Clin Epigenetics. 2017 Sep 2;9:94. doi: 10.1186/s13148-017-0385-8. eCollection 2017.


SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.

Yang G, Hamadeh IS, Katz J, Riva A, Lakatos P, Balla B, Kosa J, Vaszilko M, Pelliccioni GA, Davis N, Langaee TY, Moreb JS, Gong Y.

J Bone Miner Res. 2018 Jan;33(1):91-98. doi: 10.1002/jbmr.3285. Epub 2017 Oct 16.


A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter β-Lactamase Resistance in Pseudomonas aeruginosa.

Collia D, Bannister TD, Tan H, Jin S, Langaee T, Shumate J, Scampavia L, Spicer TP.

SLAS Discov. 2018 Jan;23(1):55-64. doi: 10.1177/2472555217728489. Epub 2017 Aug 29.


Matrix Metalloproteinase Polymorphisms in Patients with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP) and FMV/MVP Syndrome.

Lima SM, Pitsis AA, Kelpis TG, Shahin MH, Langaee TY, Cavallari LH, Theofilogiannakos EK, Boudoulas H, Boudoulas KD.

Cardiology. 2017;138(3):179-185. doi: 10.1159/000477656. Epub 2017 Jul 28.


Cross-Validation of High-Resolution Melting Analysis-Based Genotyping Platform.

Langaee T, Stauffer L, Galloway C, Solayman MH, Cavallari L.

Genet Test Mol Biomarkers. 2017 Apr;21(4):259-264. doi: 10.1089/gtmb.2016.0317. Epub 2017 Feb 21.


Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections.

Hamadeh IS, Klinker KP, Borgert SJ, Richards AI, Li W, Mangal N, Hiemenz JW, Schmidt S, Langaee TY, Peloquin CA, Johnson JA, Cavallari LH.

Pharmacogenet Genomics. 2017 May;27(5):190-196. doi: 10.1097/FPC.0000000000000277.


Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.

Shahin MH, Sá AC, Webb A, Gong Y, Langaee T, McDonough CW, Riva A, Beitleshees AL, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Scherer SE, Sadee W, Cooper-DeHoff RM, Johnson JA.

Circ Cardiovasc Genet. 2017 Jan;10(1). pii: e001404. doi: 10.1161/CIRCGENETICS.116.001404.


Clinical Features and Treatment Outcomes of Primary Immune Thrombocytopenic Purpura in Hospitalized Children Under 2-Years Old.

Farhangi H, Ghasemi A, Banihashem A, Badiei Z, Jarahi L, Eslami G, Langaee T.

Iran J Ped Hematol Oncol. 2016;6(1):24-31. Epub 2016 Mar 15.


Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms.

Dotson VM, Hsu FC, Langaee TY, McDonough CW, King AC, Cohen RA, Newman AB, Kritchevsky SB, Myers V, Manini TM, Pahor M; LIFE STUDY GROUP.

J Frailty Aging. 2016;5(1):6-14. doi: 10.14283/jfa.2016.76.


Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation?

Chang SW, Gong Y, McDonough CW, Langaee TY, Nasiri Kenari N, Beitelshees AL, Gums JG, Chapman AB, Turner ST, Johnson JA, Cooper-DeHoff RM.

Clin Transl Sci. 2016 Apr;9(2):114-22. doi: 10.1111/cts.12389. Epub 2016 Mar 7.


CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.

Zhu HJ, Langaee TY, Gong Y, Wang X, Pepine CJ, Cooper-DeHoff RM, Johnson JA, Markowitz JS.

Eur J Clin Pharmacol. 2016 Jun;72(6):681-7. doi: 10.1007/s00228-016-2029-x. Epub 2016 Feb 26.


GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.

Jahn SC, Solayman MH, Lorenzo RJ, Langaee T, Stacpoole PW, James MO.

Biochim Biophys Acta. 2016 Jun;1860(6):1202-10. doi: 10.1016/j.bbagen.2016.01.024. Epub 2016 Feb 2.


Identification of Suitable Endogenous Normalizers for qRT-PCR Analysis of Plasma microRNA Expression in Essential Hypertension.

Solayman MH, Langaee T, Patel A, El-Wakeel L, El-Hamamsy M, Badary O, Johnson JA.

Mol Biotechnol. 2016 Mar;58(3):179-87. doi: 10.1007/s12033-015-9912-z.


Genetic and Nongenetic Factors Affecting Clopidogrel Response in the Egyptian Population.

Khalil BM, Shahin MH, Solayman MH, Langaee T, Schaalan MF, Gong Y, Hammad LN, Al-Mesallamy HO, Hamdy NM, El-Hammady WA, Johnson JA.

Clin Transl Sci. 2016 Feb;9(1):23-8. doi: 10.1111/cts.12383. Epub 2016 Jan 12.


Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.

Hamadeh IS, Shahin MH, Lima SM, Oliveira F, Wilson L, Khalifa SI, Langaee TY, Cooper-DeHoff RM, Cavallari LH, Johnson JA.

Clin Transl Sci. 2016 Feb;9(1):36-42. doi: 10.1111/cts.12385. Epub 2016 Jan 19.


Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans.

Gong Y, Wang Z, Beitelshees AL, McDonough CW, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Bailey KR, Boerwinkle E, Chapman AB, Turner ST, Cooper-DeHoff RM, Johnson JA.

Hypertension. 2016 Mar;67(3):556-63. doi: 10.1161/HYPERTENSIONAHA.115.06345. Epub 2016 Jan 4.


CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.

Hoh BL, Gong Y, McDonough CW, Waters MF, Royster AJ, Sheehan TO, Burkley B, Langaee TY, Mocco J, Zuckerman SL, Mummareddy N, Stephens ML 2nd, Ingram C, Shaffer CM, Denny JC, Brilliant MH, Kitchner TE, Linneman JG, Roden DM, Johnson JA.

J Neurosurg. 2016 Jun;124(6):1746-51. doi: 10.3171/2015.6.JNS15795. Epub 2015 Nov 20.


The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex.

Gruss LF, Langaee T, Keil A.

Neuroimage. 2016 Jan 15;125:633-642. doi: 10.1016/j.neuroimage.2015.11.003. Epub 2015 Nov 5.


PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.

Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O'Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA.

J Hypertens. 2015 Nov;33(11):2278-85. doi: 10.1097/HJH.0000000000000714.


Osteonecrosis of the Jaw in the United States Food and Drug Administration's Adverse Event Reporting System (FAERS).

Zhang X, Hamadeh IS, Song S, Katz J, Moreb JS, Langaee TY, Lesko LJ, Gong Y.

J Bone Miner Res. 2016 Feb;31(2):336-40. doi: 10.1002/jbmr.2693. Epub 2015 Sep 4.


Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran.

Rezai MS, Salehifar E, Rafiei A, Langaee T, Rafati M, Shafahi K, Eslami G.

Biomed Res Int. 2015;2015:309478. doi: 10.1155/2015/309478. Epub 2015 May 3.


The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.

Langaee TY, Zhong G, Li W, Hamadeh I, Solayman MH, McDonough CW, Stacpoole PW, James MO.

Pharmacogenet Genomics. 2015 May;25(5):239-45. doi: 10.1097/FPC.0000000000000129.


Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for tamoxifen pharmacogenetic studies.

Johnson JA, Hamadeh IS, Langaee TY.

J Natl Cancer Inst. 2015 Jan 31;107(2). pii: dju437. doi: 10.1093/jnci/dju437. Print 2015 Feb. No abstract available.


A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication.

Langaee T, Hamadeh I, Chapman AB, Gums JG, Johnson JA.

PLoS One. 2015 Jan 27;10(1):e0113808. doi: 10.1371/journal.pone.0113808. eCollection 2015.


Pyrosequencing of the CYP2C9 -1766T>C polymorphism as a means of detecting the CYP2C9*8 allele.

Patel SR, Langaee TY, Wong SS, Cavallari LH.

Pharmacogenomics. 2014 Sep;15(13):1717-22. doi: 10.2217/pgs.14.130.


Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.

Shroads AL, Coats BS, Langaee T, Shuster JJ, Stacpoole PW.

Drug Metab Pers Ther. 2015 Mar;30(1):49-55. doi: 10.1515/dmdi-2014-0015.


Floppy mitral valve/mitral valve prolapse syndrome: Beta-adrenergic receptor polymorphism may contribute to the pathogenesis of symptoms.

Theofilogiannakos EK, Boudoulas KD, Gawronski BE, Langaee TY, Dardas PS, Ninios V, Kelpis TG, Johnson JA, Pitsis AA, Boudoulas H.

J Cardiol. 2015 May;65(5):434-8. doi: 10.1016/j.jjcc.2014.07.020. Epub 2014 Sep 22.


Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.

Shroads AL, Coats BS, McDonough CW, Langaee T, Stacpoole PW.

J Clin Pharmacol. 2015 Jan;55(1):50-5. doi: 10.1002/jcph.371. Epub 2014 Aug 6.


Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans.

Daneshjou R, Gamazon ER, Burkley B, Cavallari LH, Johnson JA, Klein TE, Limdi N, Hillenmeyer S, Percha B, Karczewski KJ, Langaee T, Patel SR, Bustamante CD, Altman RB, Perera MA.

Blood. 2014 Oct 2;124(14):2298-305. doi: 10.1182/blood-2014-04-568436. Epub 2014 Jul 30.

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