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Items: 1 to 50 of 166

1.

Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis.

Li Q, Yan Y, Liu J, Huang X, Zhang X, Kirschning C, Xu HC, Lang PA, Dittmer U, Zhang E, Lu M.

Front Immunol. 2019 Sep 12;10:2191. doi: 10.3389/fimmu.2019.02191. eCollection 2019.

2.

Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.

Huang A, Shinde PV, Huang J, Senff T, Xu HC, Margotta C, Häussinger D, Willnow TE, Zhang J, Pandyra AA, Timm J, Weggen S, Lang KS, Lang PA.

JCI Insight. 2019 Sep 5;4(17). pii: 129856. doi: 10.1172/jci.insight.129856.

3.

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.

Krajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA, Kamps JJAG, Tyrrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ.

J Med Chem. 2019 Sep 26;62(18):8544-8556. doi: 10.1021/acs.jmedchem.9b00911. Epub 2019 Sep 16.

4.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Taha MS, Herebian D, Mayatepek E, Brenner D, Ahmadian MR, Keitel V, Wieczorek D, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Gut. 2019 Aug 13. pii: gutjnl-2019-318215. doi: 10.1136/gutjnl-2019-318215. [Epub ahead of print]

5.

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.

Tooke CL, Hinchliffe P, Lang PA, Mulholland AJ, Brem J, Schofield CJ, Spencer J.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00564-19. doi: 10.1128/AAC.00564-19. Print 2019 Oct.

6.

Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen.

de Munnik M, Lohans CT, Lang PA, Langley GW, Malla TR, Tumber A, Schofield CJ, Brem J.

Chem Commun (Camb). 2019 Aug 22;55(69):10214-10217. doi: 10.1039/c9cc04145a.

PMID:
31380528
7.

NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection.

Duhan V, Hamdan TA, Xu HC, Shinde P, Bhat H, Li F, Al-Matary Y, Häussinger D, Bezgovsek J, Friedrich SK, Hardt C, Lang PA, Lang KS.

PLoS Pathog. 2019 Jun 20;15(6):e1007797. doi: 10.1371/journal.ppat.1007797. eCollection 2019 Jun.

8.

CD8+ T cells induce cachexia during chronic viral infection.

Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A.

Nat Immunol. 2019 Jun;20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20.

PMID:
31110314
9.

IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy.

Fazel Modares N, Polz R, Haghighi F, Lamertz L, Behnke K, Zhuang Y, Kordes C, Häussinger D, Sorg UR, Pfeffer K, Floss DM, Moll JM, Piekorz RP, Ahmadian MR, Lang PA, Scheller J.

Hepatology. 2019 May 17. doi: 10.1002/hep.30774. [Epub ahead of print]

PMID:
31100194
10.

Will morphing boron-based inhibitors beat the β-lactamases?

Krajnc A, Lang PA, Panduwawala TD, Brem J, Schofield CJ.

Curr Opin Chem Biol. 2019 Jun;50:101-110. doi: 10.1016/j.cbpa.2019.03.001. Epub 2019 Apr 18. Review.

11.

Reply.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2019 Sep;70(3):1074-1075. doi: 10.1002/hep.30600. No abstract available.

PMID:
30829412
12.

Stand by me(mory): Chronic infection diminishes memory pool via IL-6/STAT1.

Lang PA, Lang KS.

J Exp Med. 2019 Mar 4;216(3):474-475. doi: 10.1084/jem.20190066. Epub 2019 Feb 19.

13.

IL-23R Signaling Plays No Role in Myocardial Infarction.

Engelowski E, Modares NF, Gorressen S, Bouvain P, Semmler D, Alter C, Ding Z, Flögel U, Schrader J, Xu H, Lang PA, Fischer J, Floss DM, Scheller J.

Sci Rep. 2018 Nov 20;8(1):17078. doi: 10.1038/s41598-018-35188-8.

14.

Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease.

Friedrich SK, Lang PA, Friebus-Kardash J, Duhan V, Bezgovsek J, Lang KS.

Clin Exp Immunol. 2019 Jan;195(1):64-73. doi: 10.1111/cei.13241. Review.

PMID:
30444956
15.

Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.

Duggimpudi S, Kloetgen A, Maney SK, Münch PC, Hezaveh K, Shaykhalishahi H, Hoyer W, McHardy AC, Lang PA, Borkhardt A, Hoell JI.

J Biol Chem. 2018 Oct 5;293(40):15359-15369. doi: 10.1074/jbc.RA118.002243. Epub 2018 Aug 20.

16.

Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.

Lang E, Pozdeev VI, Shinde PV, Xu HC, Sundaram B, Zhuang Y, Poschmann G, Huang J, Stühler K, Pandyra AA, Keitel V, Häussinger D, Lang KS, Lang PA.

Sci Rep. 2018 Aug 15;8(1):12179. doi: 10.1038/s41598-018-30627-y.

17.

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.

Osei Kuffour E, Schott K, Jaguva Vasudevan AA, Holler J, Schulz WA, Lang PA, Lang KS, Kim B, Häussinger D, König R, Münk C.

J Virol. 2018 Sep 26;92(20). pii: e00592-18. doi: 10.1128/JVI.00592-18. Print 2018 Oct 15.

18.

Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function.

Probst K, Stermann J, von Bomhard I, Etich J, Pitzler L, Niehoff A, Bluhm B, Xu HC, Lang PA, Chmielewski M, Abken H, Blissenbach B, Machova A, Papadopoulou N, Brachvogel B.

Stem Cells. 2018 Nov;36(11):1752-1763. doi: 10.1002/stem.2892. Epub 2018 Sep 11.

PMID:
30063808
19.

Phospholipase D1 regulation of TNF-alpha protects against responses to LPS.

Urbahn MA, Kaup SC, Reusswig F, Krüger I, Spelleken M, Jurk K, Klier M, Lang PA, Elvers M.

Sci Rep. 2018 Jul 3;8(1):10006. doi: 10.1038/s41598-018-28331-y.

20.

CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection.

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS.

Nat Commun. 2018 Jul 2;9(1):2561. doi: 10.1038/s41467-018-04832-2.

21.

Synthetic cytokine receptors transmit biological signals using artificial ligands.

Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C, Knebel B, Al-Hasani H, Moll JM, Floß DM, Lang PA, Scheller J.

Nat Commun. 2018 May 23;9(1):2034. doi: 10.1038/s41467-018-04454-8.

22.

B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2018 Dec;68(6):2348-2361. doi: 10.1002/hep.30088. Epub 2018 Nov 5.

23.

Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection.

Xu HC, Huang J, Pandyra AA, Lang E, Zhuang Y, Thöns C, Timm J, Häussinger D, Colonna M, Cantor H, Lang KS, Lang PA.

Cell Rep. 2017 Nov 28;21(9):2528-2540. doi: 10.1016/j.celrep.2017.11.001.

24.

Corrigendum: Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues.

Delacher M, Imbusch CD, Weichenhan D, Breiling A, Hotz-Wagenblatt A, Träger U, Hofer AC, Kägebein D, Wang Q, Frauhammer F, Mallm JP, Bauer K, Herrmann C, Lang PA, Brors B, Plass C, Feuerer M.

Nat Immunol. 2017 Nov 16;18(12):1361. doi: 10.1038/ni1217-1361b.

PMID:
29144491
25.

Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.

Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA.

J Virol. 2018 Jan 17;92(3). pii: e01637-17. doi: 10.1128/JVI.01637-17. Print 2018 Feb 1.

26.

IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.

Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang PA, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ.

J Virol. 2017 Oct 27;91(22). pii: e01219-17. doi: 10.1128/JVI.01219-17. Print 2017 Nov 15.

27.

TNFα induced up-regulation of Na+,K+,2Cl- cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity.

Pozdeev VI, Lang E, Görg B, Bidmon HJ, Shinde PV, Kircheis G, Herebian D, Pfeffer K, Lang F, Häussinger D, Lang KS, Lang PA.

Sci Rep. 2017 Aug 11;7(1):7938. doi: 10.1038/s41598-017-07640-8.

28.

Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues.

Delacher M, Imbusch CD, Weichenhan D, Breiling A, Hotz-Wagenblatt A, Träger U, Hofer AC, Kägebein D, Wang Q, Frauhammer F, Mallm JP, Bauer K, Herrmann C, Lang PA, Brors B, Plass C, Feuerer M.

Nat Immunol. 2017 Oct;18(10):1160-1172. doi: 10.1038/ni.3799. Epub 2017 Aug 7. Erratum in: Nat Immunol. 2017 Nov 16;18(12 ):1361.

29.

SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice.

Sharma P, Khairnar V, Madunić IV, Singh Y, Pandyra A, Salker MS, Koepsell H, Sabolić I, Lang F, Lang PA, Lang KS.

Cell Physiol Biochem. 2017;42(4):1358-1365. doi: 10.1159/000479197. Epub 2017 Jul 14.

30.

Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D.

Immunity. 2017 Jun 20;46(6):1089-1090. doi: 10.1016/j.immuni.2017.06.009. No abstract available.

31.

Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D.

Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019. Erratum in: Immunity. 2017 Jun 20;46(6):1089-1090.

32.

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.

Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447.

33.

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells.

Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, Lang KS.

Front Immunol. 2017 Feb 10;8:113. doi: 10.3389/fimmu.2017.00113. eCollection 2017.

34.

Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection.

Honke N, Shaabani N, Hardt C, Krings C, Häussinger D, Lang PA, Lang KS, Keitel V.

Cell Physiol Biochem. 2017;41(1):323-338. doi: 10.1159/000456168. Epub 2017 Jan 25.

35.

A distinct innate lymphoid cell population regulates tumor-associated T cells.

Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS.

Nat Med. 2017 Mar;23(3):368-375. doi: 10.1038/nm.4278. Epub 2017 Feb 6.

36.

The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL.

Sci Immunol. 2016 Dec 23;1(6). pii: eaai8593. doi: 10.1126/sciimmunol.aai8593. Epub 2016 Dec 9.

37.

CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection.

Shaabani N, Duhan V, Khairnar V, Gassa A, Ferrer-Tur R, Häussinger D, Recher M, Zelinskyy G, Liu J, Dittmer U, Trilling M, Scheu S, Hardt C, Lang PA, Honke N, Lang KS.

Cell Death Dis. 2016 Nov 3;7(11):e2446. doi: 10.1038/cddis.2016.350.

38.

Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs.

Gil-Cruz C, Perez-Shibayama C, Onder L, Chai Q, Cupovic J, Cheng HW, Novkovic M, Lang PA, Geuking MB, McCoy KD, Abe S, Cui G, Ikuta K, Scandella E, Ludewig B.

Nat Immunol. 2016 Dec;17(12):1388-1396. doi: 10.1038/ni.3566. Epub 2016 Oct 31.

PMID:
27798617
39.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8.

40.

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.

Bhavsar SK, Singh Y, Sharma P, Khairnar V, Hosseinzadeh Z, Zhang S, Palmada M, Sabolic I, Koepsell H, Lang KS, Lang PA, Lang F.

Cell Physiol Biochem. 2016;39(3):1209-28. doi: 10.1159/000447827. Epub 2016 Sep 5.

41.

Storage of Erythrocytes Induces Suicidal Erythrocyte Death.

Lang E, Pozdeev VI, Xu HC, Shinde PV, Behnke K, Hamdam JM, Lehnert E, Scharf RE, Lang F, Häussinger D, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(2):668-76. doi: 10.1159/000445657. Epub 2016 Jul 21.

42.

Bile Acid-Induced Suicidal Erythrocyte Death.

Lang E, Pozdeev VI, Gatidis S, Qadri SM, Häussinger D, Kubitz R, Herebian D, Mayatepek E, Lang F, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;38(4):1500-9. doi: 10.1159/000443091. Epub 2016 Apr 7.

43.

High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model.

Gassa A, Kalkavan H, Jian F, Duhan V, Khairnar V, Shaabani N, Honke N, Carpinteiro A, Botezatu L, Crivello P, Dolff S, Ferencik S, Häussinger D, Khandanpour C, Fleischhauer K, Witzke O, Wahlers T, Hardt C, Lang PA, Lang KS.

Cell Physiol Biochem. 2016;38(4):1343-53. doi: 10.1159/000443078. Epub 2016 Mar 24.

44.

IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts.

Gassa A, Jian F, Kalkavan H, Duhan V, Honke N, Shaabani N, Friedrich SK, Dolff S, Wahlers T, Kribben A, Hardt C, Lang PA, Witzke O, Lang KS.

Cell Physiol Biochem. 2016;38(3):1171-81. doi: 10.1159/000443067. Epub 2016 Mar 11.

45.

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL.

Nat Immunol. 2016 May;17(5):593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7.

PMID:
26950238
46.

Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+) T-cell priming and viral control.

Duhan V, Khairnar V, Friedrich SK, Zhou F, Gassa A, Honke N, Shaabani N, Gailus N, Botezatu L, Khandanpour C, Dittmer U, Häussinger D, Recher M, Hardt C, Lang PA, Lang KS.

Sci Rep. 2016 Jan 25;6:19191. doi: 10.1038/srep19191.

47.

Balancing viral replication in spleen and liver determines the outcome of systemic virus infection.

Lang KS, Lang PA.

Z Gastroenterol. 2015 Dec;53(12):1432-5. doi: 10.1055/s-0041-109631. Epub 2015 Dec 14. Review.

PMID:
26666281
48.

Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.

Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A.

Immunity. 2015 Nov 17;43(5):974-86. doi: 10.1016/j.immuni.2015.10.013.

49.

Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation.

Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, Lang KS.

J Autoimmun. 2016 Feb;67:82-89. doi: 10.1016/j.jaut.2015.10.004. Epub 2015 Nov 7.

PMID:
26553386
50.

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA.

Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356.

PMID:
26535007

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