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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M.

J Hepatol. 2020 Jan 15. pii: S0168-8278(20)30010-6. doi: 10.1016/j.jhep.2019.12.019. [Epub ahead of print]


A Sub-Clone of RAW264.7-Cells Form Osteoclast-Like Cells Capable of Bone Resorption Faster than Parental RAW264.7 through Increased De Novo Expression and Nuclear Translocation of NFATc1.

Mira-Pascual L, Tran AN, Andersson G, Näreoja T, Lång P.

Int J Mol Sci. 2020 Jan 14;21(2). pii: E538. doi: 10.3390/ijms21020538.


Effect of 9 weeks continuous vs. interval aerobic training on plasma BDNF levels, aerobic fitness, cognitive capacity and quality of life among seniors with mild to moderate Alzheimer's disease: a randomized controlled trial.

Enette L, Vogel T, Merle S, Valard-Guiguet AG, Ozier-Lafontaine N, Neviere R, Leuly-Joncart C, Fanon JL, Lang PO.

Eur Rev Aging Phys Act. 2020 Jan 6;17:2. doi: 10.1186/s11556-019-0234-1. eCollection 2020.


Human Apoptotic Cells, Generated by Extracorporeal Photopheresis, Modulate Allogeneic Immune Response.

Pilon C, Stehlé T, Beldi-Ferchiou A, Matignon M, Thiolat A, Burlion A, Grondin C, Birebent B, Pirenne F, Rouard H, Lang P, Marodon G, Grimbert P, Cohen JL.

Front Immunol. 2019 Dec 18;10:2908. doi: 10.3389/fimmu.2019.02908. eCollection 2019.


Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma - a case report.

Issels RD, Lindner LH, von Bergwelt-Baildon M, Lang P, Rischpler C, Diem H, Mosetter B, Eckl J, Schendel DJ, Salat C, Stötzer O, Burdach S, von Luettichau-Teichert I, Handgretinger R, Neumann J, Kirchner T, Steiger K, Boxberg M, Mansmann U, Multhoff G, Noessner E.

Int J Hyperthermia. 2020;37(1):55-65. doi: 10.1080/02656736.2019.1709666.


Applying the soft sphere model to improve the understanding of bonding in transition metals.

Lang PF.

Heliyon. 2019 Dec 30;6(1):e03110. doi: 10.1016/j.heliyon.2019.e03110. eCollection 2020 Jan.


Sleep, Experimental Pain and Clinical Pain in Patients with Chronic Musculoskeletal Pain and Healthy Controls.

Stroemel-Scheder C, Karmann AJ, Ziegler E, Heesen M, Knippenberg-Bigge K, Lang PM, Lautenbacher S.

J Pain Res. 2019 Dec 19;12:3381-3393. doi: 10.2147/JPR.S211574. eCollection 2019.


Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice.

Lang P, Hasselwander S, Li H, Xia N.

Sci Rep. 2019 Dec 20;9(1):19556. doi: 10.1038/s41598-019-55987-x.


Children and Adults with Refractory Acute Graft-versus-Host Disease Respond to Treatment with the Mesenchymal Stromal Cell Preparation "MSC-FFM"-Outcome Report of 92 Patients.

Bonig H, Kuçi Z, Kuçi S, Bakhtiar S, Basu O, Bug G, Dennis M, Greil J, Barta A, Kállay KM, Lang P, Lucchini G, Pol R, Schulz A, Sykora KW, Teichert von Luettichau I, Herter-Sprie G, Ashab Uddin M, Jenkin P, Alsultan A, Buechner J, Stein J, Kelemen A, Jarisch A, Soerensen J, Salzmann-Manrique E, Hutter M, Schäfer R, Seifried E, Paneesha S, Novitzky-Basso I, Gefen A, Nevo N, Beutel G, Schlegel PG, Klingebiel T, Bader P.

Cells. 2019 Dec 5;8(12). pii: E1577. doi: 10.3390/cells8121577.


Dose-dependent effectiveness of acellular pertussis vaccine in infants: A population-based case-control study.

Mack I, Erlanger TE, Lang P, Sinniger P, Perisa D, Heininger U.

Vaccine. 2019 Dec 5. pii: S0264-410X(19)31623-8. doi: 10.1016/j.vaccine.2019.11.069. [Epub ahead of print]


Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial.

Attarbaschi A, Mann G, Zimmermann M, Bader P, Barisone E, Basso G, Biondi A, Cario G, Cazzaniga G, Colombini A, Flotho C, Kuhlen M, Lang P, Lauten M, Linderkamp C, Locatelli F, Lo Nigro L, Möricke A, Niggli F, Panzer-Grümayer R, Parasole R, Peters C, Caterina Putti M, Rizzari C, Suttorp M, Valsecchi MG, Conter V, Schrappe M; on behalf of the AIEOP-BFM (Associazione Italiana di Ematologia e Oncologia Pediatrica & Berlin-Frankfurt-Münster) Study Group.

Leukemia. 2019 Dec 5. doi: 10.1038/s41375-019-0670-y. [Epub ahead of print] No abstract available.


Correction to: Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.

Schober S, Schilbach K, Doering M, Cabanillas Stanchi KM, Holzer U, Kasteleiner P, Schittenhelm J, Schaefer JF, Mueller I, Lang P, Handgretinger R.

BMC Pediatr. 2019 Dec 2;19(1):470. doi: 10.1186/s12887-019-1851-6.


[Internal meniscus resections do not affect anterior knee joint stability].

Lang P, Hanel C, Friemert B, Riesner HJ, Achatz G, Palm HG.

Orthopade. 2019 Nov 29. doi: 10.1007/s00132-019-03840-4. [Epub ahead of print] German.


Correction: Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial.

Sauer MG, Lang PJ, Albert MH, Bader P, Creutzig U, Eyrich M, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mauz-Körholz C, Meisel R, Mischke K, Müller I, Niemeyer CM, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schlegel PG, Schulz AS, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Borkhardt A.

Leukemia. 2019 Nov 25. doi: 10.1038/s41375-019-0648-9. [Epub ahead of print]


Chronic neurological disorders and related comorbidities: Role of age-associated physiological changes.

Roca F, Lang PO, Chassagne P.

Handb Clin Neurol. 2019;167:105-122. doi: 10.1016/B978-0-12-804766-8.00007-8.


Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1+ monocytes.

Lin QY, Lang PP, Zhang YL, Yang XL, Xia YL, Bai J, Li HH.

Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1301-H1311. doi: 10.1152/ajpheart.00566.2019. Epub 2019 Nov 15.


Urinary Catheter Management Approaches Among Women Undergoing Benign Gynecologic Surgery: A Randomized Trial.

Lang P, Quezada Y, Whiteside J.

Female Pelvic Med Reconstr Surg. 2019 Oct 28. doi: 10.1097/SPV.0000000000000781. [Epub ahead of print]


Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies.

Cabanillas Stanchi KM, Ebinger M, Hartmann U, Queudeville M, Feucht J, Ost M, Koch MS, Malaval C, Mezger M, Schober S, Weber S, Michaelis S, Lange V, Lang P, Handgretinger R, Döring M.

Drug Des Devel Ther. 2019 Sep 30;13:3439-3451. doi: 10.2147/DDDT.S214264. eCollection 2019.


Surgical Reconstruction Options in Chronic Distal Biceps Tendon Ruptures - Case Report and Literature Review.

Riesner HJ, Hackenbroch C, Lang P, Achatz G, Palm HG, Friemert B.

Z Orthop Unfall. 2019 Nov 4. doi: 10.1055/a-1014-3703. [Epub ahead of print] English, German.


iRhom2 inhibits bile duct obstruction-induced liver fibrosis.

Sundaram B, Behnke K, Belancic A, Al-Salihi MA, Thabet Y, Polz R, Pellegrino R, Zhuang Y, Shinde PV, Xu HC, Vasilevska J, Longerich T, Herebian D, Mayatepek E, Bock HH, May P, Kordes C, Aghaeepour N, Mak TW, Keitel V, Häussinger D, Scheller J, Pandyra AA, Lang KS, Lang PA.

Sci Signal. 2019 Oct 29;12(605). pii: eaax1194. doi: 10.1126/scisignal.aax1194.


A Novel Sandwich ELISA for Tartrate-Resistant Acid Phosphatase 5a and 5b Protein Reveals that Both Isoforms are Secreted by Differentiating Osteoclasts and Correlate to the Type I Collagen Degradation Marker CTX-I In Vivo and In Vitro.

Mira-Pascual L, Patlaka C, Desai S, Paulie S, Näreoja T, Lång P, Andersson G.

Calcif Tissue Int. 2019 Oct 25. doi: 10.1007/s00223-019-00618-w. [Epub ahead of print]


Vaccination for quality of life: herpes-zoster vaccines.

Lang PO, Aspinall R.

Aging Clin Exp Res. 2019 Oct 23. doi: 10.1007/s40520-019-01374-5. [Epub ahead of print]


TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity.

Zhang E, Ma Z, Li Q, Yan H, Liu J, Wu W, Guo J, Zhang X, Kirschning CJ, Xu H, Lang PA, Yang D, Dittmer U, Yan H, Lu M.

J Immunol. 2019 Dec 1;203(11):2872-2886. doi: 10.4049/jimmunol.1900065. Epub 2019 Oct 21.


Outcome of adolescent patients with acute lymphoblastic leukaemia aged 10-14 years as compared with those aged 15-17 years: Long-term results of 1094 patients of the AIEOP-BFM ALL 2000 study.

Testi AM, Attarbaschi A, Valsecchi MG, Möricke A, Cario G, Niggli F, Silvestri D, Bader P, Kuhlen M, Parasole R, Putti MC, Lang P, Flotho C, Mann G, Rizzari C, Barisone E, Locatelli F, Linderkamp C, Lauten M, Suttorp M, Zimmermann M, Basso G, Biondi A, Conter V, Schrappe M; AIEOP-BFM (Associazione Italiana di Ematologia e Oncologia Pediatrica & Berlin-Frankfurt-Münster) Study Group.

Eur J Cancer. 2019 Nov;122:61-71. doi: 10.1016/j.ejca.2019.09.004. Epub 2019 Oct 17.


Dual-energy CT as an innovative method for diagnosing fragility fractures of the pelvic ring: a retrospective comparison with MRI as the gold standard.

Palm HG, Lang P, Hackenbroch C, Sailer L, Friemert B.

Arch Orthop Trauma Surg. 2019 Oct 14. doi: 10.1007/s00402-019-03283-8. [Epub ahead of print]


Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature.

Schober S, Schilbach K, Doering M, Cabanillas Stanchi KM, Holzer U, Kasteleiner P, Schittenhelm J, Schaefer JF, Mueller I, Lang P, Handgretinger R.

BMC Pediatr. 2019 Oct 11;19(1):346. doi: 10.1186/s12887-019-1724-z. Erratum in: BMC Pediatr. 2019 Dec 2;19(1):470.


Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial.

Sauer MG, Lang PJ, Albert MH, Bader P, Creutzig U, Eyrich M, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mauz-Körholz C, Meisel R, Mischke K, Müller I, Niemeyer CM, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schlegel PG, Schulz AS, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Borkhardt A.

Leukemia. 2019 Oct 2. doi: 10.1038/s41375-019-0584-8. [Epub ahead of print] Erratum in: Leukemia. 2019 Nov 25;:.


Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis.

Li Q, Yan Y, Liu J, Huang X, Zhang X, Kirschning C, Xu HC, Lang PA, Dittmer U, Zhang E, Lu M.

Front Immunol. 2019 Sep 12;10:2191. doi: 10.3389/fimmu.2019.02191. eCollection 2019.


Magnetic Resonance Imaging in Pelvic Fractures - Part 2: Gaining Information and Clinical Therapeutic Relevance.

Hackenbroch C, Merz C, Palm HG, Friemert B, Stuby F, Lang P; AG Becken III der DGU®.

Z Orthop Unfall. 2019 Sep 25. doi: 10.1055/a-0965-7686. [Epub ahead of print] English, German.


Reserve Flux Capacity in the Pentose Phosphate Pathway by NADPH Binding Is Conserved across Kingdoms.

Christodoulou D, Kuehne A, Estermann A, Fuhrer T, Lang P, Sauer U.

iScience. 2019 Sep 27;19:1133-1144. doi: 10.1016/j.isci.2019.08.047. Epub 2019 Aug 29.


Magnetic Resonance Imaging in Pelvic Fractures - Part 1: Which Criteria Lead Us to Supplementary MRI Diagnostics?

Lang P, Merz C, Hackenbroch C, Friemert B, Stuby F, Palm HG; AG Becken III der DGU® .

Z Orthop Unfall. 2019 Sep 18. doi: 10.1055/a-0965-7589. [Epub ahead of print] English, German.


Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels.

Patlaka C, Tubic B, Lång P, Paulie S, Swolin-Eide D, Magnusson P, Andersson G.

Eat Weight Disord. 2019 Sep 17. doi: 10.1007/s40519-019-00776-8. [Epub ahead of print]


Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction.

Lang PP, Bai J, Zhang YL, Yang XL, Xia YL, Lin QY, Li HH.

Lab Invest. 2019 Sep 16. doi: 10.1038/s41374-019-0320-z. [Epub ahead of print]


Transthoracic fine-needle aspiration diagnosis of solid, subsolid, and partially calcified lung nodules: A retrospective study from a single academic center.

Zhou Y, Gong G, Wang H, Habibabady ZA, Lang P, Hales R, Askin F, Gabrielson E, Li QK.

Cytojournal. 2019 Aug 22;16:16. doi: 10.4103/cytojournal.cytojournal_43_18. eCollection 2019.


Scientific instrument Femtosecond X-ray Experiments (FXE): instrumentation and baseline experimental capabilities.

Galler A, Gawelda W, Biednov M, Bomer C, Britz A, Brockhauser S, Choi TK, Diez M, Frankenberger P, French M, Görries D, Hart M, Hauf S, Khakhulin D, Knoll M, Korsch T, Kubicek K, Kuster M, Lang P, Alves Lima F, Otte F, Schulz S, Zalden P, Bressler C.

J Synchrotron Radiat. 2019 Sep 1;26(Pt 5):1432-1447. doi: 10.1107/S1600577519006647. Epub 2019 Aug 9.


Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.

Huang A, Shinde PV, Huang J, Senff T, Xu HC, Margotta C, Häussinger D, Willnow TE, Zhang J, Pandyra AA, Timm J, Weggen S, Lang KS, Lang PA.

JCI Insight. 2019 Sep 5;4(17). pii: 129856. doi: 10.1172/jci.insight.129856.


Comparative Study of Triboelectric Nanogenerators with Differently Woven Cotton Textiles for Wearable Electronics.

Jeong J, Kwon JH, Lim K, Biswas S, Tibaldi A, Lee S, Oh HJ, Kim JH, Ko J, Lee DW, Cho H, Lang P, Jang J, Lee S, Bae JH, Kim H.

Polymers (Basel). 2019 Sep 3;11(9). pii: E1443. doi: 10.3390/polym11091443.


RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis.

Lange H, Ndecky SYA, Gomez-Diaz C, Pflieger D, Butel N, Zumsteg J, Kuhn L, Piermaria C, Chicher J, Christie M, Karaaslan ES, Lang PLM, Weigel D, Vaucheret H, Hammann P, Gagliardi D.

Nat Commun. 2019 Aug 27;10(1):3871. doi: 10.1038/s41467-019-11807-4.


Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.

Krajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA, Kamps JJAG, Tyrrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ.

J Med Chem. 2019 Sep 26;62(18):8544-8556. doi: 10.1021/acs.jmedchem.9b00911. Epub 2019 Sep 16.


Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patients.

Cabanillas Stanchi KM, Queudeville M, Malaval C, Feucht J, Schlegel P, Dobratz M, Seitz C, Müller I, Lang P, Handgretinger R, Döring M.

J Cancer Res Clin Oncol. 2019 Nov;145(11):2779-2791. doi: 10.1007/s00432-019-03008-9. Epub 2019 Aug 24.


Ex vivo expansion of autologous, donor-derived NK-, γδT-, and cytokine induced killer (CIK) cells post haploidentical hematopoietic stem cell transplantation results in increased antitumor activity.

Schlegel P, Lang AM, Matela M, Horrer A, Schilling A, Jöchner A, Wiedenmann M, Seitz C, Döring M, Feuchtinger T, Heubach F, Rabsteyn A, Handgretinger R, Lang P.

Bone Marrow Transplant. 2019 Aug;54(Suppl 2):727-732. doi: 10.1038/s41409-019-0609-y.


ADCC can improve graft vs leukemia effect after T- and B-cell depleted haploidentical stem cell transplantation in pediatric B-lineage ALL.

Schlegel P, Jung G, Lang AM, Döring M, Schulte JH, Ebinger M, Holzer U, Heubach F, Seitz C, Lang B, Hundsdörfer P, Eggert A, Eichholz T, Kreyenberg H, Lang P, Handgretinger R.

Bone Marrow Transplant. 2019 Aug;54(Suppl 2):689-693. doi: 10.1038/s41409-019-0606-1.


HLA-haploidentical hematopoietic stem cell transplantation in pediatric patients with hemoglobinopathies: current practice and new approaches.

Oevermann L, Schulte JH, Hundsdörfer P, Hakimeh D, Kogel F, Lang P, Corbacioglu S, Eggert A, Sodani P.

Bone Marrow Transplant. 2019 Aug;54(Suppl 2):743-748. doi: 10.1038/s41409-019-0598-x. Review.


Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Taha MS, Herebian D, Mayatepek E, Brenner D, Ahmadian MR, Keitel V, Wieczorek D, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Gut. 2020 Jan;69(1):133-145. doi: 10.1136/gutjnl-2019-318215. Epub 2019 Aug 13.


Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.

Tooke CL, Hinchliffe P, Lang PA, Mulholland AJ, Brem J, Schofield CJ, Spencer J.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00564-19. doi: 10.1128/AAC.00564-19. Print 2019 Oct.


Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen.

de Munnik M, Lohans CT, Lang PA, Langley GW, Malla TR, Tumber A, Schofield CJ, Brem J.

Chem Commun (Camb). 2019 Aug 22;55(69):10214-10217. doi: 10.1039/c9cc04145a.


Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy.

Blaeschke F, Paul MC, Schuhmann MU, Rabsteyn A, Schroeder C, Casadei N, Matthes J, Mohr C, Lotfi R, Wagner B, Kaeuferle T, Feucht J, Willier S, Handgretinger R, StevanoviĆ S, Lang P, Feuchtinger T.

Cytotherapy. 2019 Sep;21(9):973-986. doi: 10.1016/j.jcyt.2019.06.009. Epub 2019 Jul 25.


Potential Statin Overuse in Older Patients: A Retrospective Cross-Sectional Study Using French Health Insurance Databases.

Borne E, Meyer N, Rybarczyck-Vigouret MC, Blanchard O, Lombard M, Lang PO, Vogel T, Michel B.

Drugs Aging. 2019 Oct;36(10):947-955. doi: 10.1007/s40266-019-00695-4.


NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection.

Duhan V, Hamdan TA, Xu HC, Shinde P, Bhat H, Li F, Al-Matary Y, Häussinger D, Bezgovsek J, Friedrich SK, Hardt C, Lang PA, Lang KS.

PLoS Pathog. 2019 Jun 20;15(6):e1007797. doi: 10.1371/journal.ppat.1007797. eCollection 2019 Jun.


Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial.

Legouté F, Bensadoun RJ, Seegers V, Pointreau Y, Caron D, Lang P, Prévost A, Martin L, Schick U, Morvant B, Capitain O, Calais G, Jadaud E.

Radiat Oncol. 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2.

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