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Items: 1 to 50 of 165

1.

iRhom2 inhibits bile duct obstruction-induced liver fibrosis.

Sundaram B, Behnke K, Belancic A, Al-Salihi MA, Thabet Y, Polz R, Pellegrino R, Zhuang Y, Shinde PV, Xu HC, Vasilevska J, Longerich T, Herebian D, Mayatepek E, Bock HH, May P, Kordes C, Aghaeepour N, Mak TW, Keitel V, Häussinger D, Scheller J, Pandyra AA, Lang KS, Lang PA.

Sci Signal. 2019 Oct 29;12(605). pii: eaax1194. doi: 10.1126/scisignal.aax1194.

PMID:
31662486
2.

Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses.

Dickow J, Francois S, Kaiserling RL, Malyshkina A, Drexler I, Westendorf AM, Lang KS, Santiago ML, Dittmer U, Sutter K.

Front Immunol. 2019 Sep 24;10:2255. doi: 10.3389/fimmu.2019.02255. eCollection 2019.

3.

Tamoxifen Protects from Vesicular Stomatitis Virus Infection.

Cham LB, Friedrich SK, Adomati T, Bhat H, Schiller M, Bergerhausen M, Hamdan T, Li F, Machlah YM, Ali M, Duhan V, Lang KS, Friebus-Kardash J, Bezgovsek J.

Pharmaceuticals (Basel). 2019 Sep 20;12(4). pii: E142. doi: 10.3390/ph12040142.

4.

Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.

Huang A, Shinde PV, Huang J, Senff T, Xu HC, Margotta C, Häussinger D, Willnow TE, Zhang J, Pandyra AA, Timm J, Weggen S, Lang KS, Lang PA.

JCI Insight. 2019 Sep 5;4(17). pii: 129856. doi: 10.1172/jci.insight.129856.

5.

The uric acid crystal receptor Clec12A potentiates type I interferon responses.

Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwalder M, Lang KS, Ruland J.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18544-18549. doi: 10.1073/pnas.1821351116. Epub 2019 Aug 26.

6.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Taha MS, Herebian D, Mayatepek E, Brenner D, Ahmadian MR, Keitel V, Wieczorek D, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Gut. 2019 Aug 13. pii: gutjnl-2019-318215. doi: 10.1136/gutjnl-2019-318215. [Epub ahead of print]

7.

NK cell-intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection.

Duhan V, Hamdan TA, Xu HC, Shinde P, Bhat H, Li F, Al-Matary Y, Häussinger D, Bezgovsek J, Friedrich SK, Hardt C, Lang PA, Lang KS.

PLoS Pathog. 2019 Jun 20;15(6):e1007797. doi: 10.1371/journal.ppat.1007797. eCollection 2019 Jun.

8.

TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion.

Solmaz G, Puttur F, Francozo M, Lindenberg M, Guderian M, Swallow M, Duhan V, Khairnar V, Kalinke U, Ludewig B, Clausen BE, Wagner H, Lang KS, Sparwasser TD.

Front Immunol. 2019 Mar 15;10:466. doi: 10.3389/fimmu.2019.00466. eCollection 2019.

9.

Reply.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2019 Sep;70(3):1074-1075. doi: 10.1002/hep.30600. No abstract available.

PMID:
30829412
10.

Stand by me(mory): Chronic infection diminishes memory pool via IL-6/STAT1.

Lang PA, Lang KS.

J Exp Med. 2019 Mar 4;216(3):474-475. doi: 10.1084/jem.20190066. Epub 2019 Feb 19.

11.

Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans.

Poetsch JH, Dahlke C, Zinser ME, Kasonta R, Lunemann S, Rechtien A, Ly ML, Stubbe HC, Krähling V, Biedenkopf N, Eickmann M, Fehling SK, Olearo F, Strecker T, Sharma P, Lang KS, Lohse AW, Schmiedel S, Becker S; VSV-Ebola Consortium (VEBCON), Addo MM.

J Infect Dis. 2019 Jan 29;219(4):556-561. doi: 10.1093/infdis/jiy565.

12.

Mechanisms of lymphatic system-specific viral replication and its potential role in autoimmune disease.

Friedrich SK, Lang PA, Friebus-Kardash J, Duhan V, Bezgovsek J, Lang KS.

Clin Exp Immunol. 2019 Jan;195(1):64-73. doi: 10.1111/cei.13241. Review.

PMID:
30444956
13.

Crystal structure of a membrane-bound O-acyltransferase.

Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W.

Nature. 2018 Oct;562(7726):286-290. doi: 10.1038/s41586-018-0568-2. Epub 2018 Oct 3.

14.

The probacterial effect of type I interferon signaling requires its own negative regulator USP18.

Shaabani N, Honke N, Nguyen N, Huang Z, Arimoto KI, Lazar D, Loe TK, Lang KS, Prinz M, Knobeloch KP, Zhang DE, Teijaro JR.

Sci Immunol. 2018 Sep 28;3(27). pii: eaau2125. doi: 10.1126/sciimmunol.aau2125.

15.

Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.

Lang E, Pozdeev VI, Shinde PV, Xu HC, Sundaram B, Zhuang Y, Poschmann G, Huang J, Stühler K, Pandyra AA, Keitel V, Häussinger D, Lang KS, Lang PA.

Sci Rep. 2018 Aug 15;8(1):12179. doi: 10.1038/s41598-018-30627-y.

16.

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.

Osei Kuffour E, Schott K, Jaguva Vasudevan AA, Holler J, Schulz WA, Lang PA, Lang KS, Kim B, Häussinger D, König R, Münk C.

J Virol. 2018 Sep 26;92(20). pii: e00592-18. doi: 10.1128/JVI.00592-18. Print 2018 Oct 15.

17.

Sphingolipids in early viral replication and innate immune activation.

Bezgovsek J, Gulbins E, Friedrich SK, Lang KS, Duhan V.

Biol Chem. 2018 Sep 25;399(10):1115-1123. doi: 10.1515/hsz-2018-0181. Review.

PMID:
29975662
18.

CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection.

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS.

Nat Commun. 2018 Jul 2;9(1):2561. doi: 10.1038/s41467-018-04832-2.

19.

The Clash of Macromolecular Titans: Replication-Transcription Conflicts in Bacteria.

Lang KS, Merrikh H.

Annu Rev Microbiol. 2018 Sep 8;72:71-88. doi: 10.1146/annurev-micro-090817-062514. Epub 2018 Jun 1. Review.

20.

B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2018 Dec;68(6):2348-2361. doi: 10.1002/hep.30088. Epub 2018 Nov 5.

21.

Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection.

Knuschke T, Rotan O, Bayer W, Kollenda S, Dickow J, Sutter K, Hansen W, Dittmer U, Lang KS, Epple M, Buer J, Westendorf AM.

Front Immunol. 2018 Apr 23;9:614. doi: 10.3389/fimmu.2018.00614. eCollection 2018.

22.

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming.

van Dinther D, Veninga H, Iborra S, Borg EGF, Hoogterp L, Olesek K, Beijer MR, Schetters STT, Kalay H, Garcia-Vallejo JJ, Franken KL, Cham LB, Lang KS, van Kooyk Y, Sancho D, Crocker PR, den Haan JMM.

Cell Rep. 2018 Feb 6;22(6):1484-1495. doi: 10.1016/j.celrep.2018.01.021.

23.

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.

Horst AK, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G.

Hepatology. 2018 Jul;68(1):200-214. doi: 10.1002/hep.29812. Epub 2018 May 14.

PMID:
29377208
24.

Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection.

Xu HC, Huang J, Pandyra AA, Lang E, Zhuang Y, Thöns C, Timm J, Häussinger D, Colonna M, Cantor H, Lang KS, Lang PA.

Cell Rep. 2017 Nov 28;21(9):2528-2540. doi: 10.1016/j.celrep.2017.11.001.

25.

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH Jr, Trottein F, Paget C, Lang KS, Futerman AH.

Front Immunol. 2017 Nov 1;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.

26.

Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.

Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA.

J Virol. 2018 Jan 17;92(3). pii: e01637-17. doi: 10.1128/JVI.01637-17. Print 2018 Feb 1.

27.

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS.

J Immunol. 2017 Dec 15;199(12):4056-4065. doi: 10.4049/jimmunol.1600396. Epub 2017 Nov 6.

28.

IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.

Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang PA, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ.

J Virol. 2017 Oct 27;91(22). pii: e01219-17. doi: 10.1128/JVI.01219-17. Print 2017 Nov 15.

29.

Virotherapy Research in Germany: From Engineering to Translation.

Ungerechts G, Engeland CE, Buchholz CJ, Eberle J, Fechner H, Geletneky K, Holm PS, Kreppel F, Kühnel F, Lang KS, Leber MF, Marchini A, Moehler M, Mühlebach MD, Rommelaere J, Springfeld C, Lauer UM, Nettelbeck DM.

Hum Gene Ther. 2017 Oct;28(10):800-819. doi: 10.1089/hum.2017.138. Review.

PMID:
28870120
30.

Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis.

Lang KS, Hall AN, Merrikh CN, Ragheb M, Tabakh H, Pollock AJ, Woodward JJ, Dreifus JE, Merrikh H.

Cell. 2017 Aug 10;170(4):787-799.e18. doi: 10.1016/j.cell.2017.07.044.

31.

TNFα induced up-regulation of Na+,K+,2Cl- cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity.

Pozdeev VI, Lang E, Görg B, Bidmon HJ, Shinde PV, Kircheis G, Herebian D, Pfeffer K, Lang F, Häussinger D, Lang KS, Lang PA.

Sci Rep. 2017 Aug 11;7(1):7938. doi: 10.1038/s41598-017-07640-8.

32.

SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice.

Sharma P, Khairnar V, Madunić IV, Singh Y, Pandyra A, Salker MS, Koepsell H, Sabolić I, Lang F, Lang PA, Lang KS.

Cell Physiol Biochem. 2017;42(4):1358-1365. doi: 10.1159/000479197. Epub 2017 Jul 14.

33.

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.

Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447.

34.

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells.

Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, Lang KS.

Front Immunol. 2017 Feb 10;8:113. doi: 10.3389/fimmu.2017.00113. eCollection 2017.

35.

Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection.

Honke N, Shaabani N, Hardt C, Krings C, Häussinger D, Lang PA, Lang KS, Keitel V.

Cell Physiol Biochem. 2017;41(1):323-338. doi: 10.1159/000456168. Epub 2017 Jan 25.

36.

CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection.

Shaabani N, Duhan V, Khairnar V, Gassa A, Ferrer-Tur R, Häussinger D, Recher M, Zelinskyy G, Liu J, Dittmer U, Trilling M, Scheu S, Hardt C, Lang PA, Honke N, Lang KS.

Cell Death Dis. 2016 Nov 3;7(11):e2446. doi: 10.1038/cddis.2016.350.

37.

Multiple functions of USP18.

Honke N, Shaabani N, Zhang DE, Hardt C, Lang KS.

Cell Death Dis. 2016 Nov 3;7(11):e2444. doi: 10.1038/cddis.2016.326. Review.

38.

Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells.

Singh Y, Zhou Y, Shi X, Zhang S, Umbach AT, Salker MS, Lang KS, Lang F.

J Biol Chem. 2016 Nov 4;291(45):23662-23671. Epub 2016 Sep 14.

39.

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.

Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8.

40.

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.

Bhavsar SK, Singh Y, Sharma P, Khairnar V, Hosseinzadeh Z, Zhang S, Palmada M, Sabolic I, Koepsell H, Lang KS, Lang PA, Lang F.

Cell Physiol Biochem. 2016;39(3):1209-28. doi: 10.1159/000447827. Epub 2016 Sep 5.

41.

Characterization of Acr2, an H-NS-like protein encoded on A/C2-type plasmids.

Lang KS, Johnson TJ.

Plasmid. 2016 Sep - Nov;87-88:17-27. doi: 10.1016/j.plasmid.2016.07.004. Epub 2016 Aug 1.

PMID:
27492737
42.

Storage of Erythrocytes Induces Suicidal Erythrocyte Death.

Lang E, Pozdeev VI, Xu HC, Shinde PV, Behnke K, Hamdam JM, Lehnert E, Scharf RE, Lang F, Häussinger D, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;39(2):668-76. doi: 10.1159/000445657. Epub 2016 Jul 21.

43.

Induction of the type I interferon response in neurological forms of Gaucher disease.

Vitner EB, Farfel-Becker T, Ferreira NS, Leshkowitz D, Sharma P, Lang KS, Futerman AH.

J Neuroinflammation. 2016 May 12;13(1):104. doi: 10.1186/s12974-016-0570-2.

44.

Bile Acid-Induced Suicidal Erythrocyte Death.

Lang E, Pozdeev VI, Gatidis S, Qadri SM, Häussinger D, Kubitz R, Herebian D, Mayatepek E, Lang F, Lang KS, Lang PA.

Cell Physiol Biochem. 2016;38(4):1500-9. doi: 10.1159/000443091. Epub 2016 Apr 7.

45.

High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model.

Gassa A, Kalkavan H, Jian F, Duhan V, Khairnar V, Shaabani N, Honke N, Carpinteiro A, Botezatu L, Crivello P, Dolff S, Ferencik S, Häussinger D, Khandanpour C, Fleischhauer K, Witzke O, Wahlers T, Hardt C, Lang PA, Lang KS.

Cell Physiol Biochem. 2016;38(4):1343-53. doi: 10.1159/000443078. Epub 2016 Mar 24.

46.

IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts.

Gassa A, Jian F, Kalkavan H, Duhan V, Honke N, Shaabani N, Friedrich SK, Dolff S, Wahlers T, Kribben A, Hardt C, Lang PA, Witzke O, Lang KS.

Cell Physiol Biochem. 2016;38(3):1171-81. doi: 10.1159/000443067. Epub 2016 Mar 11.

47.

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL.

Nat Immunol. 2016 May;17(5):593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7.

PMID:
26950238
48.

Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+) T-cell priming and viral control.

Duhan V, Khairnar V, Friedrich SK, Zhou F, Gassa A, Honke N, Shaabani N, Gailus N, Botezatu L, Khandanpour C, Dittmer U, Häussinger D, Recher M, Hardt C, Lang PA, Lang KS.

Sci Rep. 2016 Jan 25;6:19191. doi: 10.1038/srep19191.

49.

IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites.

Wadwa M, Klopfleisch R, Adamczyk A, Frede A, Pastille E, Mahnke K, Hansen W, Geffers R, Lang KS, Buer J, Büning J, Westendorf AM.

Mucosal Immunol. 2016 Sep;9(5):1263-77. doi: 10.1038/mi.2015.132. Epub 2016 Jan 6.

PMID:
26732675
50.

Correction: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing.

Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G.

PLoS Pathog. 2015 Dec 18;11(12):e1005364. doi: 10.1371/journal.ppat.1005364. eCollection 2015 Dec. No abstract available.

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