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Selexipag treatment for pulmonary arterial hypertension associated with congenital heart disease after defect correction: insights from the randomised controlled GRIPHON study.

Beghetti M, Channick RN, Chin KM, Di Scala L, Gaine S, Ghofrani HA, Hoeper MM, Lang IM, McLaughlin VV, Preiss R, Rubin LJ, Simonneau G, Sitbon O, Tapson VF, Galiè N.

Eur J Heart Fail. 2019 Jan 11. doi: 10.1002/ejhf.1375. [Epub ahead of print]


Endothelial cells from pulmonary endarterectomy specimens possess a high angiogenic potential and express high levels of hepatocyte growth factor.

Naito A, Sakao S, Lang IM, Voelkel NF, Jujo T, Ishida K, Sugiura T, Matsumiya G, Yoshino I, Tanabe N, Tatsumi K.

BMC Pulm Med. 2018 Dec 29;18(1):197. doi: 10.1186/s12890-018-0769-3.


Amnion-derived mesenchymal stem cells improve viability of endothelial cells exposed to shear stress in ePTFE grafts.

Pfeiffer D, Wankhammer K, Stefanitsch C, Hingerl K, Huppertz B, Dohr G, Desoye G, Lang I.

Int J Artif Organs. 2018 Dec 26:391398818815470. doi: 10.1177/0391398818815470. [Epub ahead of print]


Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells.

Wohlrab P, Soto-Gonzales L, Benesch T, Winter MP, Lang IM, Markstaller K, Tretter V, Klein KU.

Front Physiol. 2018 Dec 6;9:1754. doi: 10.3389/fphys.2018.01754. eCollection 2018.


Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial.

Barco S, Russo M, Vicaut E, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Danays T, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Klok FA, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G, Konstantinides SV.

Clin Res Cardiol. 2018 Dec 18. doi: 10.1007/s00392-018-1405-1. [Epub ahead of print]


Histological processing of un-/cellularized thermosensitive electrospun scaffolds.

Fuchs J, Mueller M, Daxböck C, Stückler M, Lang I, Leitinger G, Bock E, El-Heliebi A, Moser G, Glasmacher B, Brislinger D.

Histochem Cell Biol. 2018 Dec 17. doi: 10.1007/s00418-018-1757-7. [Epub ahead of print]


Pulmonary hypertension due to left heart disease.

Vachiéry JL, Tedford RJ, Rosenkranz S, Palazzini M, Lang I, Guazzi M, Coghlan G, Chazova I, De Marco T.

Eur Respir J. 2018 Dec 13. pii: 1801897. doi: 10.1183/13993003.01897-2018. [Epub ahead of print]


Pharyngo-Esophageal and Cardio-Respiratory Interactions: Potential Implications for Premature Infants at-risk of Clinically Significant Cardiorespiratory Events.

Hasenstab KA, Nawaz S, Lang IM, Shaker R, Jadcherla SR.

Am J Physiol Gastrointest Liver Physiol. 2018 Dec 13. doi: 10.1152/ajpgi.00303.2018. [Epub ahead of print]


Pulmonary hypertension associated with left heart disease: Updated Recommendations of the Cologne Consensus Conference 2018.

Rosenkranz S, Lang IM, Blindt R, Bonderman D, Bruch L, Diller GP, Felgendreher R, Gerges C, Hohenforst-Schmidt W, Holt S, Jung C, Kindermann I, Kramer T, Kübler WM, Mitrovic V, Riedel A, Rieth A, Schmeisser A, Wachter R, Weil J, Opitz CF.

Int J Cardiol. 2018 Dec 1;272S:53-62. doi: 10.1016/j.ijcard.2018.08.080. Epub 2018 Aug 27.


Testing of a novel Valsalva Assist Device with supine and modified positions in healthy volunteers.

FitzGerald I, Ewings P, Lang I, Appelboam A.

Emerg Med J. 2019 Jan;36(1):27-31. doi: 10.1136/emermed-2018-208004. Epub 2018 Dec 1.


Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase 3, randomised controlled trial.

Sadushi-Kolici R, Jansa P, Kopec G, Torbicki A, Skoro-Sajer N, Campean IA, Halank M, Simkova I, Karlocai K, Steringer-Mascherbauer R, Samarzija M, Salobir B, Klepetko W, Lindner J, Lang IM.

Lancet Respir Med. 2018 Nov 23. pii: S2213-2600(18)30367-9. doi: 10.1016/S2213-2600(18)30367-9. [Epub ahead of print]


Adjuvant Letrozole and Tamoxifen Alone or Sequentially for Postmenopausal Women With Hormone Receptor-Positive Breast Cancer: Long-Term Follow-Up of the BIG 1-98 Trial.

Ruhstaller T, Giobbie-Hurder A, Colleoni M, Jensen MB, Ejlertsen B, de Azambuja E, Neven P, Láng I, Jakobsen EH, Gladieff L, Bonnefoi H, Harvey VJ, Spazzapan S, Tondini C, Del Mastro L, Veyret C, Simoncini E, Gianni L, Rochlitz C, Kralidis E, Zaman K, Jassem J, Piccart-Gebhart M, Di Leo A, Gelber RD, Coates AS, Goldhirsch A, Thürlimann B, Regan MM; members of the BIG 1-98 Collaborative Group and the International Breast Cancer Study Group.

J Clin Oncol. 2019 Jan 10;37(2):105-114. doi: 10.1200/JCO.18.00440. Epub 2018 Nov 26.


Transcatheter aortic valve replacement (TAVR) leads to an increase in the subendocardial viability ratio assessed by pulse wave analysis.

Müller C, Goliasch G, Schachinger S, Kastl S, Neunteufl T, Delle-Karth G, Kastner J, Gyöngyösi M, Lang I, Gottsauner-Wolf M, Pavo N.

PLoS One. 2018 Nov 21;13(11):e0207537. doi: 10.1371/journal.pone.0207537. eCollection 2018.


Determinants of diagnostic delay in chronic thromboembolic pulmonary hypertension: results from the European CTEPH Registry.

Klok FA, Barco S, Konstantinides SV, Dartevelle P, Fadel E, Jenkins D, Kim NH, Madani M, Matsubara H, Mayer E, Pepke-Zaba J, Delcroix M, Lang IM.

Eur Respir J. 2018 Dec 6;52(6). pii: 1801687. doi: 10.1183/13993003.01687-2018. Print 2018 Dec. No abstract available.


Out-of-hospital initiation of hypothermia in ST-segment elevation myocardial infarction: a randomised trial.

Testori C, Beitzke D, Mangold A, Sterz F, Loewe C, Weiser C, Scherz T, Herkner H, Lang I.

Heart. 2018 Oct 25. pii: heartjnl-2018-313705. doi: 10.1136/heartjnl-2018-313705. [Epub ahead of print]


Chronic Thromboembolic Pulmonary Hypertension and Antiphospholipid Syndrome with Immune Thrombocytopenia: A Case Report.

Skride A, Sablinskis M, Sablinskis K, Lejniece S, Lejnieks A, Klepetko W, Lang IM.

Am J Case Rep. 2018 Oct 19;19:1245-1248. doi: 10.12659/AJCR.909778.


Correction to: Inter- and intra-observer reliability of contrast-enhanced magnetic resonance imaging parameters in children with suspected juvenile idiopathic arthritis of the hip.

Porter-Young FM, Offiah AC, Broadley P, Lang I, McMahon AM, Howsley P, Hawley DP.

Pediatr Radiol. 2018 Dec;48(13):1901. doi: 10.1007/s00247-018-4285-7.


Impact of an interatrial shunt device on survival and heart failure hospitalization in patients with preserved ejection fraction.

Kaye DM, Petrie MC, McKenzie S, Hasenfuβ G, Malek F, Post M, Doughty RN, Trochu JN, Gustafsson F, Lang I, Kolodziej A, Westenfeld R, Penicka M, Rosenberg M, Hausleiter J, Raake P, Jondeau G, Bergmann MW, Spelman T, Aytug H, Ponikowski P, Hayward C; REDUCE LAP-HF study investigators.

ESC Heart Fail. 2018 Oct 11. doi: 10.1002/ehf2.12350. [Epub ahead of print]


The Effects of Esophageal Acidification on Esophageal Reflexes Controlling the Upper Esophageal Sphincter.

Lang IM, Medda BK, Shaker R.

Am J Physiol Gastrointest Liver Physiol. 2018 Oct 11. doi: 10.1152/ajpgi.00292.2018. [Epub ahead of print]


Association of Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with the Risk of Thromboembolism and Mortality in Patients with Cancer.

Grilz E, Posch F, Königsbrügge O, Schwarzinger I, Lang IM, Marosi C, Pabinger I, Ay C.

Thromb Haemost. 2018 Nov;118(11):1875-1884. doi: 10.1055/s-0038-1673401. Epub 2018 Oct 8.


Hypoxia/reperfusion predisposes to atherosclerosis.

Finsterwalder R, Ganesan MK, Leb H, Habertheuer A, Basílio J, Lang I, Krunic M, Wiedemann D, Petzelbauer P.

PLoS One. 2018 Oct 5;13(10):e0205067. doi: 10.1371/journal.pone.0205067. eCollection 2018.


Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018.

Wilkens H, Konstantinides S, Lang IM, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohé C, Guth S, Held M, Hinrichs JB, Hoeper MM, Klepetko W, Kramm T, Krüger U, Lankeit M, Meyer BC, Olsson KM, Schäfers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E.

Int J Cardiol. 2018 Dec 1;272S:69-78. doi: 10.1016/j.ijcard.2018.08.079. Epub 2018 Aug 28.


Echocardiographic assessment of right ventricular function: current clinical practice.

Schneider M, Aschauer S, Mascherbauer J, Ran H, Binder C, Lang I, Goliasch G, Binder T.

Int J Cardiovasc Imaging. 2018 Sep 6. doi: 10.1007/s10554-018-1428-8. [Epub ahead of print]


2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy.

Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, Iung B, Johnson MR, Kintscher U, Kranke P, Lang IM, Morais J, Pieper PG, Presbitero P, Price S, Rosano GMC, Seeland U, Simoncini T, Swan L, Warnes CA; ESC Scientific Document Group .

Eur Heart J. 2018 Sep 7;39(34):3165-3241. doi: 10.1093/eurheartj/ehy340. No abstract available.


The impact of cardiopulmonary resuscitation (CPR) manikin chest stiffness on motivation and CPR performance measures in children undergoing CPR training-A prospective, randomized, single-blind, controlled trial.

Weidenauer D, Hamp T, Schriefl C, Holaubek C, Gattinger M, Krammel M, Winnisch M, Weidenauer A, Mundigler G, Lang I, Schreiber W, Sterz F, Herkner H, Domanovits H.

PLoS One. 2018 Aug 16;13(8):e0202430. doi: 10.1371/journal.pone.0202430. eCollection 2018.


Lapatinib with ECF/X in the first-line treatment of metastatic gastric cancer according to HER2neu and EGFR status: a randomized placebo-controlled phase II study (EORTC 40071).

Moehler M, Schad A, Maderer A, Atasoy A, Mauer ME, Caballero C, Thomaidis T, John JMM, Lang I, Van Cutsem E, Freire J, Lutz MP, Roth A; EORTC Gastrointestinal Tract Cancer Group.

Cancer Chemother Pharmacol. 2018 Oct;82(4):733-739. doi: 10.1007/s00280-018-3667-8. Epub 2018 Aug 13.


Case-finding in clinical practice: An appropriate strategy for dementia identification?

Ranson JM, Kuźma E, Hamilton W, Lang I, Llewellyn DJ.

Alzheimers Dement (N Y). 2018 Jul 10;4:288-296. doi: 10.1016/j.trci.2018.04.011. eCollection 2018. Review.


9-year clinical follow-up of patients with ST-segment elevation myocardial infarction with Genous or TAXUS Liberté stents.

Giurgea GA, Heuberger A, Babayev J, Winkler S, Schlager O, Lang IM, Gyöngyösi M.

PLoS One. 2018 Aug 6;13(8):e0201416. doi: 10.1371/journal.pone.0201416. eCollection 2018.


Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP).

Etscheid M, Subramaniam S, Lochnit G, Zabczyk M, Undas A, Lang IM, Hanschmann KM, Kanse SM.

Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3397-3406. doi: 10.1016/j.bbadis.2018.07.030. Epub 2018 Aug 1.


Inter- and intra-observer reliability of contrast-enhanced magnetic resonance imaging parameters in children with suspected juvenile idiopathic arthritis of the hip.

Porter-Young FM, Offiah AC, Broadley P, Lang I, McMahon AM, Howsley P, Hawley DP.

Pediatr Radiol. 2018 Dec;48(13):1891-1900. doi: 10.1007/s00247-018-4216-7. Epub 2018 Aug 3. Erratum in: Pediatr Radiol. 2018 Oct 17;:.


Lipid profile and long-term outcome in premature myocardial infarction.

Winter MP, Wiesbauer F, Blessberger H, Pavo N, Sulzgruber P, Huber K, Wojta J, Distelmaier K, Lang IM, Goliasch G.

Eur J Clin Invest. 2018 Oct;48(10):e13008. doi: 10.1111/eci.13008. Epub 2018 Aug 13.


Evaluation of the CT imaging findings in patients newly diagnosed with chronic thromboembolic pulmonary hypertension.

Grosse A, Grosse C, Lang I.

PLoS One. 2018 Jul 30;13(7):e0201468. doi: 10.1371/journal.pone.0201468. eCollection 2018.


Predictive Value of High-Sensitivity Troponin T for Systolic Dysfunction and Infarct Size (Six Months) After ST-Elevation Myocardial Infarction.

Mohammad MA, Koul S, Smith JG, Noc M, Lang I, Holzer M, Clemmensen P, Jensen U, Engstrøm T, Arheden H, James S, Lindahl B, Metzler B, Erlinge D.

Am J Cardiol. 2018 Sep 1;122(5):735-743. doi: 10.1016/j.amjcard.2018.05.005. Epub 2018 Jun 5.


Ni tolerance and its distinguished amelioration by chelating agents is reflected in root radius of B. napus cultivars.

Nawaz H, Manhalter S, Ali A, Ashraf MY, Lang I.

Protoplasma. 2018 Jul 25. doi: 10.1007/s00709-018-1287-0. [Epub ahead of print]


Bai Hu Tang, Si Ni Tang, and Xue Bi Tang amplify pro-inflammatory activities and reduce apoptosis in endothelial cells in a cell culture model of sepsis.

Brislinger D, Daxböck C, Roßmanith E, Stückler M, Lang I, Falkenhagen D.

J Ethnopharmacol. 2018 Oct 28;225:309-318. doi: 10.1016/j.jep.2018.07.021. Epub 2018 Jul 20.


Polyunsaturated fatty acids supplementation impairs anti-oxidant high-density lipoprotein function in heart failure.

Wurm R, Schrutka L, Hammer A, Moertl D, Berger R, Pavo N, Lang IM, Goliasch G, Huelsmann M, Distelmaier K.

Eur J Clin Invest. 2018 Sep;48(9):e12998. doi: 10.1111/eci.12998. Epub 2018 Aug 1.


Alternative splicing of (ppp1r12a/mypt1) in zebrafish produces a novel myosin phosphatase targeting subunit.

LaFlamme A, Young KE, Lang I, Weiser DC.

Gene. 2018 Oct 30;675:15-26. doi: 10.1016/j.gene.2018.06.092. Epub 2018 Jun 28.


Comparative study of regenerative effects of mesenchymal stem cells derived from placental amnion, chorion and umbilical cord on dermal wounds.

Ertl J, Pichlsberger M, Tuca AC, Wurzer P, Fuchs J, Geyer SH, Maurer-Gesek B, Weninger WJ, Pfeiffer D, Bubalo V, Parvizi D, Kamolz LP, Lang I.

Placenta. 2018 May;65:37-46. doi: 10.1016/j.placenta.2018.04.004. Epub 2018 Apr 10.


Adjuvant Anti-HER2 Therapy, Treatment-Related Amenorrhea, and Survival in Premenopausal HER2-Positive Early Breast Cancer Patients.

Lambertini M, Campbell C, Bines J, Korde LA, Izquierdo M, Fumagalli D, Del Mastro L, Ignatiadis M, Pritchard K, Wolff AC, Jackisch C, Lang I, Untch M, Smith I, Boyle F, Xu B, Barrios CH, Baselga J, Moreno-Aspitia A, Piccart M, Gelber RD, de Azambuja E.

J Natl Cancer Inst. 2018 Jun 5. doi: 10.1093/jnci/djy094. [Epub ahead of print]


Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.

Francis PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Láng I, Gómez HL, Tondini C, Ciruelos E, Burstein HJ, Bonnefoi HR, Bellet M, Martino S, Geyer CE Jr, Goetz MP, Stearns V, Pinotti G, Puglisi F, Spazzapan S, Climent MA, Pavesi L, Ruhstaller T, Davidson NE, Coleman R, Debled M, Buchholz S, Ingle JN, Winer EP, Maibach R, Rabaglio-Poretti M, Ruepp B, Di Leo A, Coates AS, Gelber RD, Goldhirsch A, Regan MM; SOFT and TEXT Investigators and the International Breast Cancer Study Group.

N Engl J Med. 2018 Jul 12;379(2):122-137. doi: 10.1056/NEJMoa1803164. Epub 2018 Jun 4.


Usefulness of thrombosis and inflammation biomarkers in chronic thromboembolic pulmonary hypertension-sampling plasma and surgical specimens.

Skoro-Sajer N, Gerges C, Gerges M, Panzenböck A, Jakowitsch J, Kurz A, Taghavi S, Sadushi-Kolici R, Campean I, Klepetko W, Celermajer DS, Lang IM.

J Heart Lung Transplant. 2018 Sep;37(9):1067-1074. doi: 10.1016/j.healun.2018.04.003. Epub 2018 Apr 25.


The Long-Term Impact of Post-Procedural Asymmetry and Eccentricity of Bioresorbable Everolimus-Eluting Scaffold and Metallic Everolimus-Eluting Stent on Clinical Outcomes in the ABSORB II Trial.

Katagiri Y, Serruys PW, Macaya C, Ormiston JA, Hill J, Lang IM, Egred M, Fajadet J, Lesiak M, Wykrzykowska JJ, Piek JJ, Sabaté M, Windecker S, Chevalier B, Onuma Y.

JACC Cardiovasc Interv. 2018 May 28;11(10):1013-1015. doi: 10.1016/j.jcin.2018.02.020. No abstract available.


What is new in the 2017 ESC clinical practice guidelines : Management of acute myocardial infarction in patients presenting with ST-segment elevation.

Lang IM.

Wien Klin Wochenschr. 2018 Jul;130(13-14):421-426. doi: 10.1007/s00508-018-1333-0. Epub 2018 May 23. Review.


Frequency, risk factors, and impact on mortality of arterial thromboembolism in patients with cancer.

Grilz E, Königsbrügge O, Posch F, Schmidinger M, Pirker R, Lang IM, Pabinger I, Ay C.

Haematologica. 2018 Sep;103(9):1549-1556. doi: 10.3324/haematol.2018.192419. Epub 2018 May 24.


Characteristics and survival data from Latvian pulmonary hypertension registry: comparison of prospective pulmonary hypertension registries in Europe.

Skride A, Sablinskis K, Lejnieks A, Rudzitis A, Lang I.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018780521. doi: 10.1177/2045894018780521. Epub 2018 May 16.


Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restriction?

Brook A, Hoaksey A, Gurung R, Yoong EEC, Sneyd R, Baynes GC, Bischof H, Jones S, Higgins LE, Jones C, Greenwood SL, Jones RL, Gram M, Lang I, Desoye G, Myers J, Schneider H, Hansson SR, Crocker IP, Brownbill P.

FASEB J. 2018 Oct;32(10):5436-5446. doi: 10.1096/fj.201800264R. Epub 2018 May 3.


Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors.

Sirtl S, Knoll G, Trinh DT, Lang I, Siegmund D, Gross S, Schuler-Thurner B, Neubert P, Jantsch J, Wajant H, Ehrenschwender M.

Oncogene. 2018 Jul;37(30):4122-4136. doi: 10.1038/s41388-018-0265-5. Epub 2018 Apr 30.


Heart failure subtypes and thromboembolic risk in patients with atrial fibrillation: The PREFER in AF - HF substudy.

Siller-Matula JM, Pecen L, Patti G, Lucerna M, Kirchhof P, Lesiak M, Huber K, Verheugt FWA, Lang IM, Renda G, Schnabel RB, Wachter R, Kotecha D, Sellal JM, Rohla M, Ricci F, De Caterina R; TEAM in AF group.

Int J Cardiol. 2018 Aug 15;265:141-147. doi: 10.1016/j.ijcard.2018.04.093. Epub 2018 Apr 22.


Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.

Zardoya-Laguardia P, Blaschitz A, Hirschmugl B, Lang I, Herzog SA, Nikitina L, Gauster M, Häusler M, Cervar-Zivkovic M, Karpf E, Maghzal GJ, Stanley CP, Stocker R, Wadsack C, Frank S, Sedlmayr P.

Sci Rep. 2018 Apr 3;8(1):5488. doi: 10.1038/s41598-018-23896-0.

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