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Nonhuman Primate Models of Hepatitis A Virus and Hepatitis E Virus Infections.

Lanford RE, Walker CM, Lemon SM.

Cold Spring Harb Perspect Med. 2019 Feb 1;9(2). pii: a031815. doi: 10.1101/cshperspect.a031815. Review.


Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.

Li L, Barry V, Daffis S, Niu C, Huntzicker E, French DM, Mikaelian I, Lanford RE, Delaney WE 4th, Fletcher SP.

J Hepatol. 2018 May;68(5):912-921. doi: 10.1016/j.jhep.2017.12.008. Epub 2017 Dec 14.


The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis.

Lanford RE, Walker CM, Lemon SM.

ILAR J. 2017 Dec 1;58(2):172-189. doi: 10.1093/ilar/ilx028. Review.


RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg.

Wooddell CI, Yuen MF, Chan HL, Gish RG, Locarnini SA, Chavez D, Ferrari C, Given BD, Hamilton J, Kanner SB, Lai CL, Lau JYN, Schluep T, Xu Z, Lanford RE, Lewis DL.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaan0241. doi: 10.1126/scitranslmed.aan0241.


Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review.

Kumar S, Laurence H, Owston MA, Sharp RM, Williams P, Lanford RE, Hubbard GB, Dick EJ Jr.

J Med Primatol. 2017 Oct;46(5):271-290. doi: 10.1111/jmp.12277. Epub 2017 May 23. Review.


Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R.

Mitchell JK, Midkiff BR, Israelow B, Evans MJ, Lanford RE, Walker CM, Lemon SM, McGivern DR.

MBio. 2017 Apr 25;8(2). pii: e00121-17. doi: 10.1128/mBio.00121-17.


Natural mortality and cause of death analysis of the captive chimpanzee (Pan troglodytes): A 35-year review.

Laurence H, Kumar S, Owston MA, Lanford RE, Hubbard GB, Dick EJ Jr.

J Med Primatol. 2017 Jun;46(3):106-115. doi: 10.1111/jmp.12267. Epub 2017 Apr 18. Review.


Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection.

Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB.

PLoS Genet. 2016 Sep 30;12(9):e1006338. doi: 10.1371/journal.pgen.1006338. eCollection 2016 Sep.


Determinants Involved in Hepatitis C Virus and GB Virus B Primate Host Restriction.

Marnata C, Saulnier A, Mompelat D, Krey T, Cohen L, Boukadida C, Warter L, Fresquet J, Vasiliauskaite I, Escriou N, Cosset FL, Rey FA, Lanford RE, Karayiannis P, Rose NJ, Lavillette D, Martin A.

J Virol. 2015 Dec;89(23):12131-44. doi: 10.1128/JVI.01161-15. Epub 2015 Sep 23.


Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.

Greenwood EJ, Schmidt F, Kondova I, Niphuis H, Hodara VL, Clissold L, McLay K, Guerra B, Redrobe S, Giavedoni LD, Lanford RE, Murthy KK, Rouet F, Heeney JL.

PLoS Pathog. 2015 Sep 11;11(9):e1005146. doi: 10.1371/journal.ppat.1005146. eCollection 2015 Sep.


Marmoset induced pluripotent stem cells: Robust neural differentiation following pretreatment with dimethyl sulfoxide.

Qiu Z, Mishra A, Li M, Farnsworth SL, Guerra B, Lanford RE, Hornsby PJ.

Stem Cell Res. 2015 Jul;15(1):141-50. doi: 10.1016/j.scr.2015.05.010. Epub 2015 May 27.


Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C.

Selitsky SR, Baran-Gale J, Honda M, Yamane D, Masaki T, Fannin EE, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford RE, Lemon SM, Sethupathy P.

Sci Rep. 2015 Jan 8;5:7675. doi: 10.1038/srep07675.


Nonhuman primate models in translational regenerative medicine.

Daadi MM, Barberi T, Shi Q, Lanford RE.

Stem Cells Dev. 2014 Dec;23 Suppl 1:83-7. doi: 10.1089/scd.2014.0374.


Human pDCs preferentially sense enveloped hepatitis A virions.

Feng Z, Li Y, McKnight KL, Hensley L, Lanford RE, Walker CM, Lemon SM.

J Clin Invest. 2015 Jan;125(1):169-76. doi: 10.1172/JCI77527. Epub 2014 Nov 21.


Evolution of a cell culture-derived genotype 1a hepatitis C virus (H77S.2) during persistent infection with chronic hepatitis in a chimpanzee.

Yi M, Hu F, Joyce M, Saxena V, Welsch C, Chavez D, Guerra B, Yamane D, Veselenak R, Pyles R, Walker CM, Tyrrell L, Bourne N, Lanford RE, Lemon SM.

J Virol. 2014 Apr;88(7):3678-94. doi: 10.1128/JVI.03540-13. Epub 2014 Jan 15.


microRNA-122 abundance in hepatocellular carcinoma and non-tumor liver tissue from Japanese patients with persistent HCV versus HBV infection.

Spaniel C, Honda M, Selitsky SR, Yamane D, Shimakami T, Kaneko S, Lanford RE, Lemon SM.

PLoS One. 2013 Oct 9;8(10):e76867. doi: 10.1371/journal.pone.0076867. eCollection 2013.


Experimental cross-species infection of common marmosets by titi monkey adenovirus.

Yu G, Yagi S, Carrion R Jr, Chen EC, Liu M, Brasky KM, Lanford RE, Kelly KR, Bales KL, Schnurr DP, Canfield DR, Patterson JL, Chiu CY.

PLoS One. 2013 Jul 24;8(7):e68558. doi: 10.1371/journal.pone.0068558. Print 2013.


Persistent human hepatitis B virus infection in cynomolgus monkeys: a novel animal model in the search for a cure?

Bukh J, Lanford RE, Purcell RH.

Hepatology. 2013 Nov;58(5):1533-6. doi: 10.1002/hep.26560. Epub 2013 Sep 19. No abstract available.


A pathogenic picornavirus acquires an envelope by hijacking cellular membranes.

Feng Z, Hensley L, McKnight KL, Hu F, Madden V, Ping L, Jeong SH, Walker C, Lanford RE, Lemon SM.

Nature. 2013 Apr 18;496(7445):367-71. doi: 10.1038/nature12029. Epub 2013 Mar 31.


GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.

Lanford RE, Guerra B, Chavez D, Giavedoni L, Hodara VL, Brasky KM, Fosdick A, Frey CR, Zheng J, Wolfgang G, Halcomb RL, Tumas DB.

Gastroenterology. 2013 Jun;144(7):1508-17, 1517.e1-10. doi: 10.1053/j.gastro.2013.02.003. Epub 2013 Feb 13.


Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees.

Morin TJ, Broering TJ, Leav BA, Blair BM, Rowley KJ, Boucher EN, Wang Y, Cheslock PS, Knauber M, Olsen DB, Ludmerer SW, Szabo G, Finberg RW, Purcell RH, Lanford RE, Ambrosino DM, Molrine DC, Babcock GJ.

PLoS Pathog. 2012;8(8):e1002895. doi: 10.1371/journal.ppat.1002895. Epub 2012 Aug 30.


Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection.

Zhou Y, Callendret B, Xu D, Brasky KM, Feng Z, Hensley LL, Guedj J, Perelson AS, Lemon SM, Lanford RE, Walker CM.

J Exp Med. 2012 Jul 30;209(8):1481-92. doi: 10.1084/jem.20111906. Epub 2012 Jul 2.


Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.

Qu L, Feng Z, Yamane D, Liang Y, Lanford RE, Li K, Lemon SM.

PLoS Pathog. 2011 Sep;7(9):e1002169. doi: 10.1371/journal.ppat.1002169. Epub 2011 Sep 8.


Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA.

Lanford RE, Feng Z, Chavez D, Guerra B, Brasky KM, Zhou Y, Yamane D, Perelson AS, Walker CM, Lemon SM.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11223-8. doi: 10.1073/pnas.1101939108. Epub 2011 Jun 20.


Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection.

Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, Kauppinen S, Ørum H.

Science. 2010 Jan 8;327(5962):198-201. doi: 10.1126/science.1178178. Epub 2009 Dec 3.


Hepatitis C: recent successes and continuing challenges in the development of improved treatment modalities.

Shimakami T, Lanford RE, Lemon SM.

Curr Opin Pharmacol. 2009 Oct;9(5):537-44. doi: 10.1016/j.coph.2009.08.008. Epub 2009 Sep 15. Review.


Detection of clonally expanded hepatocytes in chimpanzees with chronic hepatitis B virus infection.

Mason WS, Low HC, Xu C, Aldrich CE, Scougall CA, Grosse A, Clouston A, Chavez D, Litwin S, Peri S, Jilbert AR, Lanford RE.

J Virol. 2009 Sep;83(17):8396-408. doi: 10.1128/JVI.00700-09. Epub 2009 Jun 17.


Antiviral activity and host gene induction by tamarin and marmoset interferon-alpha and interferon-gamma in the GBV-B primary hepatocyte culture model.

Chavez D, Guerra B, Lanford RE.

Virology. 2009 Aug 1;390(2):186-96. doi: 10.1016/j.virol.2009.05.005. Epub 2009 Jun 7.


Lack of adaptation of chimeric GB virus B/hepatitis C virus in the marmoset model: possible effects of bottleneck.

Weatherford T, Chavez D, Brasky KM, Lemon SM, Martin A, Lanford RE.

J Virol. 2009 Aug;83(16):8062-75. doi: 10.1128/JVI.00032-09. Epub 2009 May 27.


The marmoset model of GB virus B infections: adaptation to host phenotypic variation.

Weatherford T, Chavez D, Brasky KM, Lanford RE.

J Virol. 2009 Jun;83(11):5806-14. doi: 10.1128/JVI.00033-09. Epub 2009 Mar 11.


A cooperative interaction between nontranslated RNA sequences and NS5A protein promotes in vivo fitness of a chimeric hepatitis C/GB virus B.

Warter L, Cohen L, Benureau Y, Chavez D, Yang Y, Bodola F, Lemon SM, Traboni C, Lanford RE, Martin A.

PLoS One. 2009;4(2):e4419. doi: 10.1371/journal.pone.0004419. Epub 2009 Feb 10.


The accelerating pace of HCV research: a summary of the 15th International Symposium on Hepatitis C Virus And Related Viruses.

Lanford RE, Evans MJ, Lohmann V, Lindenbach B, Gale M Jr, Rehermann B, Chang KM, Lemon SM.

Gastroenterology. 2009 Jan;136(1):9-16. doi: 10.1053/j.gastro.2008.11.019. Epub 2008 Nov 19. No abstract available.


Differential expression of the CXCR3 ligands in chronic hepatitis C virus (HCV) infection and their modulation by HCV in vitro.

Helbig KJ, Ruszkiewicz A, Lanford RE, Berzsenyi MD, Harley HA, McColl SR, Beard MR.

J Virol. 2009 Jan;83(2):836-46. doi: 10.1128/JVI.01388-08. Epub 2008 Nov 5.


Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.

Chen CM, He Y, Lu L, Lim HB, Tripathi RL, Middleton T, Hernandez LE, Beno DW, Long MA, Kati WM, Bosse TD, Larson DP, Wagner R, Lanford RE, Kohlbrenner WE, Kempf DJ, Pilot-Matias TJ, Molla A.

Antimicrob Agents Chemother. 2007 Dec;51(12):4290-6. Epub 2007 Oct 1.


Lack of response to exogenous interferon-alpha in the liver of chimpanzees chronically infected with hepatitis C virus.

Lanford RE, Guerra B, Bigger CB, Lee H, Chavez D, Brasky KM.

Hepatology. 2007 Oct;46(4):999-1008.


GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS.

Chen Z, Benureau Y, Rijnbrand R, Yi J, Wang T, Warter L, Lanford RE, Weinman SA, Lemon SM, Martin A, Li K.

J Virol. 2007 Jan;81(2):964-76. Epub 2006 Nov 8.


Hepatitis C virus genotype 1b chimeric replicon containing genotype 3 NS5A domain.

Lanford RE, Guerra B, Lee H.

Virology. 2006 Nov 25;355(2):192-202. Epub 2006 Aug 21.


Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo.

Targett-Adams P, Schaller T, Hope G, Lanford RE, Lemon SM, Martin A, McLauchlan J.

J Biol Chem. 2006 Sep 29;281(39):29221-7. Epub 2006 Aug 1.


Genomic response to interferon-alpha in chimpanzees: implications of rapid downregulation for hepatitis C kinetics.

Lanford RE, Guerra B, Lee H, Chavez D, Brasky KM, Bigger CB.

Hepatology. 2006 May;43(5):961-72.


Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.

Lindenbach BD, Meuleman P, Ploss A, Vanwolleghem T, Syder AJ, McKeating JA, Lanford RE, Feinstone SM, Major ME, Leroux-Roels G, Rice CM.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3805-9. Epub 2006 Feb 16.


Mapping of the hepatitis B virus pre-S1 domain involved in receptor recognition.

Barrera A, Guerra B, Notvall L, Lanford RE.

J Virol. 2005 Aug;79(15):9786-98.


A chimeric GB virus B with 5' nontranslated RNA sequence from hepatitis C virus causes hepatitis in tamarins.

Rijnbrand R, Yang Y, Beales L, Bodola F, Goettge K, Cohen L, Lanford RE, Lemon SM, Martin A.

Hepatology. 2005 May;41(5):986-94.


Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees.

Bigger CB, Guerra B, Brasky KM, Hubbard G, Beard MR, Luxon BA, Lemon SM, Lanford RE.

J Virol. 2004 Dec;78(24):13779-92.


Expression and purification of functional hepatitis B virus polymerase in the baculovirus insect cell system.

Lott L, Notvall L, Lanford RE.

Methods Mol Med. 2004;95:271-9. No abstract available.


Cross-genotype immunity to hepatitis C virus.

Lanford RE, Guerra B, Chavez D, Bigger C, Brasky KM, Wang XH, Ray SC, Thomas DL.

J Virol. 2004 Feb;78(3):1575-81.


Chronic hepatitis associated with GB virus B persistence in a tamarin after intrahepatic inoculation of synthetic viral RNA.

Martin A, Bodola F, Sangar DV, Goettge K, Popov V, Rijnbrand R, Lanford RE, Lemon SM.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9962-7. Epub 2003 Aug 7.


An infectious clone of woolly monkey hepatitis B virus.

Lanford RE, Chavez D, Barrera A, Brasky KM.

J Virol. 2003 Jul;77(14):7814-9.

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