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Items: 1 to 50 of 218

1.

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor.

Fyfe TJ, Kellam B, Sykes DA, Capuano B, Scammells PJ, Lane JR, Charlton SJ, Mistry SN.

J Med Chem. 2019 Nov 14;62(21):9488-9520. doi: 10.1021/acs.jmedchem.9b00864. Epub 2019 Oct 23.

PMID:
31580666
2.

Room Temperature Gibbs Energies of Hydrogen-Bonded Alcohol Dimethylselenide Complexes.

Kjaersgaard A, Lane JR, Kjaergaard HG.

J Phys Chem A. 2019 Oct 3;123(39):8427-8434. doi: 10.1021/acs.jpca.9b06855. Epub 2019 Sep 20.

PMID:
31490072
3.

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.

Klein Herenbrink C, Verma R, Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L, Lane JR.

ACS Chem Biol. 2019 Aug 16;14(8):1780-1792. doi: 10.1021/acschembio.9b00342. Epub 2019 Aug 5.

PMID:
31339684
4.

Simulated Electronic Absorption Spectra of Sulfur-Containing Molecules Present in Earth's Atmosphere.

Farahani S, Frandsen BN, Kjaergaard HG, Lane JR.

J Phys Chem A. 2019 Aug 1;123(30):6605-6617. doi: 10.1021/acs.jpca.9b04668. Epub 2019 Jul 24.

PMID:
31283236
5.

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1.

Sanchez J, Lane JR, Canals M, Stone MJ.

Int J Mol Sci. 2019 May 15;20(10). pii: E2417. doi: 10.3390/ijms20102417.

6.

Electrospray Ionization Mass Spectrometric Study of the Gas-Phase Coordination Chemistry of Be2+ Ions with 1,2- and 1,3-Diketone Ligands.

Raymond O, Brothers PJ, Buchner MR, Lane JR, Müller M, Spang N, Henderson W, Plieger PG.

Inorg Chem. 2019 May 6;58(9):6388-6398. doi: 10.1021/acs.inorgchem.9b00578. Epub 2019 Apr 9.

PMID:
30963770
7.

Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor.

Fyfe TJ, Kellam B, Mistry SN, Scammells PJ, Lane JR, Capuano B.

Eur J Med Chem. 2019 Apr 15;168:474-490. doi: 10.1016/j.ejmech.2019.01.061. Epub 2019 Feb 11.

PMID:
30849613
8.

The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface.

Schrader JM, Irving CM, Octeau JC, Christian JA, Aballo TJ, Kareemo DJ, Conti J, Camberg JL, Lane JR, Javitch JA, Kovoor A.

J Biol Chem. 2019 Apr 5;294(14):5604-5615. doi: 10.1074/jbc.RA118.004682. Epub 2019 Jan 22.

PMID:
30670597
9.

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1.

Sanchez J, E Huma Z, Lane JR, Liu X, Bridgford JL, Payne RJ, Canals M, Stone MJ.

J Biol Chem. 2019 Mar 8;294(10):3464-3475. doi: 10.1074/jbc.RA118.006535. Epub 2018 Dec 19.

PMID:
30567735
10.

Kinetics of conversion of dihydroxyacetone to methylglyoxal in New Zealand mānuka honey: Part V - The rate determining step.

Owens A, Lane JR, Manley-Harris M, Marie Jensen A, Jørgensen S.

Food Chem. 2019 Mar 15;276:636-642. doi: 10.1016/j.foodchem.2018.10.039. Epub 2018 Oct 10.

PMID:
30409643
11.

Reply to 'Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects'.

Sykes DA, Lane JR, Szabo M, Capuano B, Javitch JA, Charlton SJ.

Nat Commun. 2018 Sep 3;9(1):3568. doi: 10.1038/s41467-018-05678-4. No abstract available.

12.

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation.

Donthamsetti P, Gallo EF, Buck DC, Stahl EL, Zhu Y, Lane JR, Bohn LM, Neve KA, Kellendonk C, Javitch JA.

Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0212-4. [Epub ahead of print]

13.

Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.

Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR.

Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1.

14.
15.

A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

Fyfe TJ, Zarzycka B, Lim HD, Kellam B, Mistry SN, Katrich V, Scammells PJ, Lane JR, Capuano B.

J Med Chem. 2019 Jan 10;62(1):174-206. doi: 10.1021/acs.jmedchem.7b01565. Epub 2018 May 15.

PMID:
29683325
16.

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.

Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.

Sci Rep. 2018 Jan 19;8(1):1208. doi: 10.1038/s41598-018-19642-1.

17.

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

Verma RK, Abramyan AM, Michino M, Free RB, Sibley DR, Javitch JA, Lane JR, Shi L.

PLoS Comput Biol. 2018 Jan 16;14(1):e1005948. doi: 10.1371/journal.pcbi.1005948. eCollection 2018 Jan.

18.

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.

Draper-Joyce CJ, Michino M, Verma RK, Klein Herenbrink C, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.

Biochem Pharmacol. 2018 Feb;148:315-328. doi: 10.1016/j.bcp.2018.01.002. Epub 2018 Jan 9.

19.

Double dermal sinus tracts of the cervical and thoracic regions: a case in a 3-year-old child and review of the literature.

Mrowczynski OD, Lane JR, Shoja MM, Specht CS, Langan ST, Rizk EB.

Childs Nerv Syst. 2018 May;34(5):987-990. doi: 10.1007/s00381-017-3707-4. Epub 2017 Dec 26. Review.

PMID:
29279962
20.

Pharmacokinetic and Pharmacodynamic Analyses To Determine the Optimal Fixed Dosing Regimen of Iclaprim for Treatment of Patients with Serious Infections Caused by Gram-Positive Pathogens.

Lodise TP, Bosso J, Kelly C, Williams PJ, Lane JR, Huang DB.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01184-17. doi: 10.1128/AAC.01184-17. Print 2018 Feb.

21.

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors.

Sykes DA, Moore H, Stott L, Holliday N, Javitch JA, Lane JR, Charlton SJ.

Nat Commun. 2017 Oct 2;8(1):763. doi: 10.1038/s41467-017-00716-z.

22.

A kinetic view of GPCR allostery and biased agonism.

Lane JR, May LT, Parton RG, Sexton PM, Christopoulos A.

Nat Chem Biol. 2017 Aug 18;13(9):929-937. doi: 10.1038/nchembio.2431.

PMID:
28820879
23.

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

Huma ZE, Sanchez J, Lim HD, Bridgford JL, Huang C, Parker BJ, Pazhamalil JG, Porebski BT, Pfleger KDG, Lane JR, Canals M, Stone MJ.

Sci Signal. 2017 May 23;10(480). pii: eaai8529. doi: 10.1126/scisignal.aai8529.

PMID:
28536301
24.

Kinetics of conversion of dihydroxyacetone to methylglyoxal in New Zealand mānuka honey: Part IV - Formation of HMF.

Grainger MNC, Owens A, Manley-Harris M, Lane JR, Field RJ.

Food Chem. 2017 Oct 1;232:648-655. doi: 10.1016/j.foodchem.2017.04.066. Epub 2017 Apr 13.

PMID:
28490123
25.

Kinetic Energy Density as a Predictor of Hydrogen-Bonded OH-Stretching Frequencies.

Lane JR, Hansen AS, Mackeprang K, Kjaergaard HG.

J Phys Chem A. 2017 May 11;121(18):3452-3460. doi: 10.1021/acs.jpca.7b02523. Epub 2017 May 2.

PMID:
28436672
26.

The Effects of Beef, Chicken, or Whey Protein After Workout on Body Composition and Muscle Performance.

Sharp MH, Lowery RP, Shields KA, Lane JR, Gray JL, Partl JM, Hayes DW, Wilson GJ, Hollmer CA, Minivich JR, Wilson JM.

J Strength Cond Res. 2018 Aug;32(8):2233-2242. doi: 10.1519/JSC.0000000000001936.

PMID:
28399016
27.

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).

Kumar V, Moritz AE, Keck TM, Bonifazi A, Ellenberger MP, Sibley CD, Free RB, Shi L, Lane JR, Sibley DR, Newman AH.

J Med Chem. 2017 Feb 23;60(4):1478-1494. doi: 10.1021/acs.jmedchem.6b01688. Epub 2017 Feb 10.

28.

Procedural outcomes of fluoroless catheter ablation outside the traditional catheterization lab.

Bigelow AM, Smith PC, Timberlake DT, McNinch NL, Smith GL, Lane JR, Clark JM.

Europace. 2017 Aug 1;19(8):1378-1384. doi: 10.1093/europace/euw207.

PMID:
27915262
29.

Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior.

Choy KH, Shackleford DM, Malone DT, Mistry SN, Patil RT, Scammells PJ, Langmead CJ, Pantelis C, Sexton PM, Lane JR, Christopoulos A.

J Pharmacol Exp Ther. 2016 Nov;359(2):354-365. Epub 2016 Sep 14.

PMID:
27630144
30.

Four-Factor Prothrombin Complex Concentrate for Coagulopathy Reversal in Patients With Liver Disease.

Huang WT, Cang WC, Derry KL, Lane JR, von Drygalski A.

Clin Appl Thromb Hemost. 2017 Nov;23(8):1028-1035. doi: 10.1177/1076029616668406. Epub 2016 Sep 14.

PMID:
27628534
31.

Intramolecular Hydrogen Bonding in Substituted Aminoalcohols.

Lane JR, Schrøder SD, Saunders GC, Kjaergaard HG.

J Phys Chem A. 2016 Aug 18;120(32):6371-8. doi: 10.1021/acs.jpca.6b05898. Epub 2016 Aug 3.

PMID:
27447952
32.

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.

Kopinathan A, Scammells PJ, Lane JR, Capuano B.

Future Med Chem. 2016 Jul;8(11):1349-72. doi: 10.4155/fmc-2016-0010. Epub 2016 Jun 30. Review.

PMID:
27357619
33.

β2-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer.

Chang A, Le CP, Walker AK, Creed SJ, Pon CK, Albold S, Carroll D, Halls ML, Lane JR, Riedel B, Ferrari D, Sloan EK.

Brain Behav Immun. 2016 Oct;57:106-115. doi: 10.1016/j.bbi.2016.06.011. Epub 2016 Jun 16.

34.

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

Thompson GL, Lane JR, Coudrat T, Sexton PM, Christopoulos A, Canals M.

Biochem Pharmacol. 2016 Aug 1;113:70-87. doi: 10.1016/j.bcp.2016.05.014. Epub 2016 Jun 7.

PMID:
27286929
35.

Structure and Abundance of Nitrous Oxide Complexes in Earth's Atmosphere.

Salmon SR, de Lange KM, Lane JR.

J Phys Chem A. 2016 Apr 7;120(13):2096-105. doi: 10.1021/acs.jpca.5b11853. Epub 2016 Mar 23.

PMID:
26983553
36.

Kinetics of conversion of dihydroxyacetone to methylglyoxal in New Zealand mānuka honey: Part III--A model to simulate the conversion.

Grainger MN, Manley-Harris M, Lane JR, Field RJ.

Food Chem. 2016 Jul 1;202:500-6. doi: 10.1016/j.foodchem.2016.02.032. Epub 2016 Feb 4.

PMID:
26920324
37.

Kinetics of the conversion of dihydroxyacetone to methylglyoxal in New Zealand mānuka honey: Part II--Model systems.

Grainger MN, Manley-Harris M, Lane JR, Field RJ.

Food Chem. 2016 Jul 1;202:492-9. doi: 10.1016/j.foodchem.2016.02.030. Epub 2016 Feb 3.

PMID:
26920323
38.

Kinetics of conversion of dihydroxyacetone to methylglyoxal in New Zealand mānuka honey: Part I--Honey systems.

Grainger MN, Manley-Harris M, Lane JR, Field RJ.

Food Chem. 2016 Jul 1;202:484-91. doi: 10.1016/j.foodchem.2016.02.029. Epub 2016 Feb 4.

PMID:
26920322
39.

The role of kinetic context in apparent biased agonism at GPCRs.

Klein Herenbrink C, Sykes DA, Donthamsetti P, Canals M, Coudrat T, Shonberg J, Scammells PJ, Capuano B, Sexton PM, Charlton SJ, Javitch JA, Christopoulos A, Lane JR.

Nat Commun. 2016 Feb 24;7:10842. doi: 10.1038/ncomms10842.

40.

Plasma Levels of Advanced Glycation End Products Are Related to the Clinical Presentation and Angiographic Severity of Symptomatic Lower Extremity Peripheral Arterial Disease.

Prasad A, Lane JR, Tsimikas S, Mahmud E, Khandrika S, Bekker P, Ilapakurti M, Nguyen D, Ravandi A, Israel T.

Int J Angiol. 2016 Mar;25(1):44-53. doi: 10.1055/s-0035-1547527. Epub 2015 Mar 23.

41.

Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.

Mistry SN, Lim H, Jörg M, Capuano B, Christopoulos A, Lane JR, Scammells PJ.

ACS Chem Neurosci. 2016 May 18;7(5):647-61. doi: 10.1021/acschemneuro.6b00018. Epub 2016 Mar 3.

PMID:
26891194
42.

Journal Club: Neurosurgical Practice Liability: Relative Risk by Procedure Type.

Church EW, Anderson BL, Bogason ET, Brandmeir NJ, Daggubati LC, Davanzo JR, Hussain NS, Lane JR, McDermott D, Payne R, Rohatgi P, Savaliya S, Sieg EP, Ziu E.

Neurosurgery. 2016 Feb;78(2):306-8. doi: 10.1227/NEU.0000000000001121. Review. No abstract available.

PMID:
26779786
43.

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

Mistry SN, Jörg M, Lim H, Vinh NB, Sexton PM, Capuano B, Christopoulos A, Lane JR, Scammells PJ.

J Med Chem. 2016 Jan 14;59(1):388-409. doi: 10.1021/acs.jmedchem.5b01562. Epub 2015 Dec 31.

PMID:
26624844
44.

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

Creed SJ, Le CP, Hassan M, Pon CK, Albold S, Chan KT, Berginski ME, Huang Z, Bear JE, Lane JR, Halls ML, Ferrari D, Nowell CJ, Sloan EK.

Breast Cancer Res. 2015 Nov 25;17(1):145. doi: 10.1186/s13058-015-0655-3.

45.

The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.

Pon CK, Lane JR, Sloan EK, Halls ML.

FASEB J. 2016 Mar;30(3):1144-54. doi: 10.1096/fj.15-277798. Epub 2015 Nov 17.

46.

The structure of the O2-N2O complex.

Salmon SR, Lane JR.

J Chem Phys. 2015 Sep 28;143(12):124303. doi: 10.1063/1.4931629.

PMID:
26429007
47.

Time-to-onset and -resolution of adverse events before/after atomoxetine discontinuation in adult patients with ADHD.

Upadhyaya H, Tanaka Y, Lipsius S, Kryzhanovskaya LA, Lane JR, Escobar R, Trzepacz PT, Allen AJ.

Postgrad Med. 2015;127(7):677-85. doi: 10.1080/00325481.2015.1083394. Epub 2015 Sep 2.

PMID:
26329980
48.

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.

Mistry SN, Shonberg J, Draper-Joyce CJ, Klein Herenbrink C, Michino M, Shi L, Christopoulos A, Capuano B, Scammells PJ, Lane JR.

J Med Chem. 2015 Sep 10;58(17):6819-43. doi: 10.1021/acs.jmedchem.5b00585. Epub 2015 Aug 28.

PMID:
26258690
49.

Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.

Shonberg J, Draper-Joyce C, Mistry SN, Christopoulos A, Scammells PJ, Lane JR, Capuano B.

J Med Chem. 2015 Jul 9;58(13):5287-307. doi: 10.1021/acs.jmedchem.5b00581. Epub 2015 Jun 24.

PMID:
26052807
50.

Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor.

Thompson GL, Lane JR, Coudrat T, Sexton PM, Christopoulos A, Canals M.

Mol Pharmacol. 2015 Aug;88(2):335-46. doi: 10.1124/mol.115.098848. Epub 2015 May 26.

PMID:
26013541

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