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Items: 1 to 50 of 110

1.

BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives.

Crispo F, Notarangelo T, Pietrafesa M, Lettini G, Storto G, Sgambato A, Maddalena F, Landriscina M.

Cancers (Basel). 2019 Sep 18;11(9). pii: E1388. doi: 10.3390/cancers11091388. Review.

2.

Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression.

Crispo F, Condelli V, Lepore S, Notarangelo T, Sgambato A, Esposito F, Maddalena F, Landriscina M.

Cells. 2019 Jul 30;8(8). pii: E798. doi: 10.3390/cells8080798. Review.

3.

Heat shock proteins in cancer stem cell maintenance: A potential therapeutic target?

Lettini G, Lepore S, Crispo F, Sisinni L, Esposito F, Landriscina M.

Histol Histopathol. 2019 Jul 19:18153. doi: 10.14670/HH-18-153. [Epub ahead of print]

PMID:
31322279
4.

HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy.

Condelli V, Crispo F, Pietrafesa M, Lettini G, Matassa DS, Esposito F, Landriscina M, Maddalena F.

Cells. 2019 Jun 3;8(6). pii: E532. doi: 10.3390/cells8060532. Review.

5.

Radium-223 for the treatment of bone metastases in castration-resistant prostate cancer: when and why.

Gallicchio R, Mastrangelo PA, Nardelli A, Mainenti PP, Colasurdo AP, Landriscina M, Guglielmi G, Storto G.

Tumori. 2019 Oct;105(5):367-377. doi: 10.1177/0300891619851376. Epub 2019 May 16. Review.

PMID:
31096849
6.

Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance.

Sisinni L, Pietrafesa M, Lepore S, Maddalena F, Condelli V, Esposito F, Landriscina M.

Int J Mol Sci. 2019 Feb 16;20(4). pii: E857. doi: 10.3390/ijms20040857. Review.

7.

Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.

Avolio R, Järvelin AI, Mohammed S, Agliarulo I, Condelli V, Zoppoli P, Calice G, Sarnataro D, Bechara E, Tartaglia GG, Landriscina M, Castello A, Esposito F, Matassa DS.

Nucleic Acids Res. 2018 Dec 14;46(22):12067-12086. doi: 10.1093/nar/gky873.

8.

Adjuvant treatment for EGFR-mutated non-small cell lung cancer: do we have a major breakthrough?

Roviello G, Imperatori M, Aieta M, Sollitto F, Landriscina M.

J Thorac Dis. 2018 Jul;10(Suppl 18):S2114-S2118. doi: 10.21037/jtd.2018.06.114. No abstract available.

9.

IL6/STAT3 axis mediates resistance to BRAF inhibitors in thyroid carcinoma cells.

Notarangelo T, Sisinni L, Trino S, Calice G, Simeon V, Landriscina M.

Cancer Lett. 2018 Oct 1;433:147-155. doi: 10.1016/j.canlet.2018.06.038. Epub 2018 Jul 2.

PMID:
29969659
10.

New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting.

Rondanin R, Lettini G, Oliva P, Baruchello R, Costantini C, Trapella C, Simoni D, Bernardi T, Sisinni L, Pietrafesa M, Ponterini G, Costi MP, Vignudelli T, Luciani R, Matassa DS, Esposito F, Landriscina M.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2289-2293. doi: 10.1016/j.bmcl.2018.05.031. Epub 2018 May 15.

PMID:
29807796
11.

Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells.

Spagnoletti G, Li Bergolis V, Piscazzi A, Giannelli F, Condelli V, Sisinni L, Bove G, Storto G, Landriscina M.

Tumour Biol. 2018 Apr;40(4):1010428318770957. doi: 10.1177/1010428318770957.

PMID:
29663854
12.

TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor.

Matassa DS, Agliarulo I, Avolio R, Landriscina M, Esposito F.

Genes (Basel). 2018 Apr 5;9(4). pii: E195. doi: 10.3390/genes9040195. Review.

13.

Uncommon frame-shift exon 19 EGFR mutations are sensitive to EGFR tyrosine kinase inhibitors in non-small cell lung carcinoma.

Improta G, Zupa A, Natalicchio MI, Sisinni L, Marinaccio A, Bozza G, Vita G, Aieta M, Landriscina M.

Med Oncol. 2018 Jan 31;35(3):28. doi: 10.1007/s12032-018-1078-7.

PMID:
29387949
14.

Bladder Metastases from Breast Cancer: Managing the Unexpected. A Systematic Review.

Sanguedolce F, Landriscina M, Ambrosi A, Tartaglia N, Cianci P, Di Millo M, Carrieri G, Bufo P, Cormio L.

Urol Int. 2018;101(2):125-131. doi: 10.1159/000481576. Epub 2017 Oct 20. Review.

15.

Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated thyroid carcinoma cells.

Notarangelo T, Sisinni L, Condelli V, Landriscina M.

Cancer Cell Int. 2017 Oct 4;17:86. doi: 10.1186/s12935-017-0457-z. eCollection 2017.

16.

Human monocyte-derived dendritic cells exposed to hyperthermia show a distinct gene expression profile and selective upregulation of IGFBP6.

Liso A, Castellani S, Massenzio F, Trotta R, Pucciarini A, Bigerna B, De Luca P, Zoppoli P, Castiglione F, Palumbo MC, Stracci F, Landriscina M, Specchia G, Bach LA, Conese M, Falini B.

Oncotarget. 2017 Jun 1;8(37):60826-60840. doi: 10.18632/oncotarget.18338. eCollection 2017 Sep 22.

17.

TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination.

Sisinni L, Maddalena F, Condelli V, Pannone G, Simeon V, Li Bergolis V, Lopes E, Piscazzi A, Matassa DS, Mazzoccoli C, Nozza F, Lettini G, Amoroso MR, Bufo P, Esposito F, Landriscina M.

J Pathol. 2017 Sep;243(1):123-134. doi: 10.1002/path.4936. Epub 2017 Aug 9.

PMID:
28678347
18.

TRAP1: a viable therapeutic target for future cancer treatments?

Lettini G, Maddalena F, Sisinni L, Condelli V, Matassa DS, Costi MP, Simoni D, Esposito F, Landriscina M.

Expert Opin Ther Targets. 2017 Aug;21(8):805-815. doi: 10.1080/14728222.2017.1349755. Epub 2017 Jul 18. Review.

PMID:
28664757
19.

Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation.

Amoroso MR, Matassa DS, Agliarulo I, Avolio R, Maddalena F, Condelli V, Landriscina M, Esposito F.

Adv Protein Chem Struct Biol. 2017;108:163-198. doi: 10.1016/bs.apcsb.2017.01.004. Epub 2017 Feb 12. Review.

PMID:
28427560
20.

ALK rearrangement in specific subtypes of lung adenocarcinoma: immunophenotypic and morphological features.

Possidente L, Landriscina M, Patitucci G, Borgia L, Lalinga V, Vita G.

Med Oncol. 2017 May;34(5):76. doi: 10.1007/s12032-017-0936-z. Epub 2017 Mar 31.

PMID:
28364271
21.

TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma.

Maddalena F, Simeon V, Vita G, Bochicchio A, Possidente L, Sisinni L, Lettini G, Condelli V, Matassa DS, Li Bergolis V, Fersini A, Romito S, Aieta M, Ambrosi A, Esposito F, Landriscina M.

Oncotarget. 2017 Mar 28;8(13):21229-21240. doi: 10.18632/oncotarget.15070.

22.

DAAs Rapidly Reduce Inflammation but Increase Serum VEGF Level: A Rationale for Tumor Risk during Anti-HCV Treatment.

Villani R, Facciorusso A, Bellanti F, Tamborra R, Piscazzi A, Landriscina M, Vendemiale G, Serviddio G.

PLoS One. 2016 Dec 20;11(12):e0167934. doi: 10.1371/journal.pone.0167934. eCollection 2016.

23.

TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.

Amoroso MR, Matassa DS, Agliarulo I, Avolio R, Lu H, Sisinni L, Lettini G, Gabra H, Landriscina M, Esposito F.

Cell Death Dis. 2016 Dec 15;7(12):e2522. doi: 10.1038/cddis.2016.400.

24.

TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma.

Lettini G, Sisinni L, Condelli V, Matassa DS, Simeon V, Maddalena F, Gemei M, Lopes E, Vita G, Del Vecchio L, Esposito F, Landriscina M.

Cell Death Differ. 2016 Nov 1;23(11):1792-1803. doi: 10.1038/cdd.2016.67. Epub 2016 Sep 23.

25.

Therapeutic Strategies in HCC: Radiation Modalities.

Gallicchio R, Nardelli A, Mainenti P, Nappi A, Capacchione D, Simeon V, Sirignano C, Abbruzzi F, Barbato F, Landriscina M, Storto G.

Biomed Res Int. 2016;2016:1295329. doi: 10.1155/2016/1295329. Epub 2016 Aug 3. Review.

26.

TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells.

Palladino G, Notarangelo T, Pannone G, Piscazzi A, Lamacchia O, Sisinni L, Spagnoletti G, Toti P, Santoro A, Storto G, Bufo P, Cignarelli M, Esposito F, Landriscina M.

Endocr Relat Cancer. 2016 Sep;23(9):699-709. doi: 10.1530/ERC-16-0063. Epub 2016 Jul 15.

PMID:
27422900
27.

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

Matassa DS, Amoroso MR, Lu H, Avolio R, Arzeni D, Procaccini C, Faicchia D, Maddalena F, Simeon V, Agliarulo I, Zanini E, Mazzoccoli C, Recchi C, Stronach E, Marone G, Gabra H, Matarese G, Landriscina M, Esposito F.

Cell Death Differ. 2016 Sep 1;23(9):1542-54. doi: 10.1038/cdd.2016.39. Epub 2016 May 20.

28.

RAS/BRAF mutational status in familial non-medullary thyroid carcinomas: A retrospective study.

Landriscina M, Natalicchio MI, Lamacchia O, Conserva A, Piscazzi A, Ciampolillo A, Zingrillo M, Pennella A, Bufo P, Vita G, Antonetti R, Maiorano E, Giorgino F, Cignarelli M.

Oncol Lett. 2015 Sep;10(3):1875-1881. Epub 2015 Jun 17.

29.

The Role of Human Chorionic Gonadotropin as Tumor Marker: Biochemical and Clinical Aspects.

Sisinni L, Landriscina M.

Adv Exp Med Biol. 2015;867:159-76. doi: 10.1007/978-94-017-7215-0_11. Review.

PMID:
26530366
30.

5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits.

Denise C, Paoli P, Calvani M, Taddei ML, Giannoni E, Kopetz S, Kazmi SM, Pia MM, Pettazzoni P, Sacco E, Caselli A, Vanoni M, Landriscina M, Cirri P, Chiarugi P.

Oncotarget. 2015 Dec 8;6(39):41706-21. doi: 10.18632/oncotarget.5991.

31.

Evaluation of Glucose Uptake in Normal and Cancer Cell Lines by Positron Emission Tomography.

Maddalena F, Lettini G, Gallicchio R, Sisinni L, Simeon V, Nardelli A, Venetucci AA, Storto G, Landriscina M.

Mol Imaging. 2015;14:490-8.

PMID:
26461458
32.

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma.

Condelli V, Maddalena F, Sisinni L, Lettini G, Matassa DS, Piscazzi A, Palladino G, Amoroso MR, Esposito F, Landriscina M.

Oncotarget. 2015 Sep 8;6(26):22298-309.

33.

TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways.

Agliarulo I, Matassa DS, Amoroso MR, Maddalena F, Sisinni L, Sepe L, Ferrari MC, Arzeni D, Avolio R, Paolella G, Landriscina M, Esposito F.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2570-9. doi: 10.1016/j.bbamcr.2015.05.034. Epub 2015 Jun 10.

34.

Out-of-Hospital Perimortem Cesarean Section as Resuscitative Hysterotomy in Maternal Posttraumatic Cardiac Arrest.

Gatti F, Spagnoli M, Zerbi SM, Colombo D, Landriscina M, Kette F.

Case Rep Emerg Med. 2014;2014:121562. doi: 10.1155/2014/121562. Epub 2014 Oct 30.

35.

TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.

Condelli V, Piscazzi A, Sisinni L, Matassa DS, Maddalena F, Lettini G, Simeon V, Palladino G, Amoroso MR, Trino S, Esposito F, Landriscina M.

Cancer Res. 2014 Nov 15;74(22):6693-704. doi: 10.1158/0008-5472.CAN-14-1331. Epub 2014 Sep 19.

36.

TRAP1 revisited: novel localizations and functions of a 'next-generation' biomarker (review).

Amoroso MR, Matassa DS, Sisinni L, Lettini G, Landriscina M, Esposito F.

Int J Oncol. 2014 Sep;45(3):969-77. doi: 10.3892/ijo.2014.2530. Epub 2014 Jun 27. Review.

PMID:
24990602
37.

TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: relevance in human colorectal tumors.

Matassa DS, Agliarulo I, Amoroso MR, Maddalena F, Sepe L, Ferrari MC, Sagar V, D'Amico S, Loreni F, Paolella G, Landriscina M, Esposito F.

Mol Oncol. 2014 Dec;8(8):1482-94. doi: 10.1016/j.molonc.2014.06.003. Epub 2014 Jun 13.

38.

Pyrosequencing evaluation of low-frequency KRAS mutant alleles for EGF receptor therapy selection in metastatic colorectal carcinoma.

Natalicchio MI, Improta G, Zupa A, Cursio OE, Stampone E, Possidente L, Teresa Gerardi AM, Vita G, Martini M, Cassano A, Piccoli C, Romito S, Aieta M, Antonetti R, Barone C, Landriscina M.

Future Oncol. 2014 Apr;10(5):713-23. doi: 10.2217/fon.13.233.

PMID:
24799053
39.

Validation of vacuum-based refrigerated system for biobanking tissue preservation: analysis of cellular morphology, protein stability, and RNA quality.

Condelli V, Lettini G, Patitucci G, D'Auria F, D'Amico M, Vita G, Musto P, Cuomo C, Landriscina M.

Biopreserv Biobank. 2014 Feb;12(1):35-45. doi: 10.1089/bio.2013.0065. Epub 2014 Jan 15.

PMID:
24620768
40.

TRAP1 role in endoplasmic reticulum stress protection favors resistance to anthracyclins in breast carcinoma cells.

Sisinni L, Maddalena F, Lettini G, Condelli V, Matassa DS, Esposito F, Landriscina M.

Int J Oncol. 2014 Feb;44(2):573-82. doi: 10.3892/ijo.2013.2199. Epub 2013 Nov 29.

PMID:
24297638
41.

The role of survivin in thyroid tumors: differences of expression in well-differentiated, non-well-differentiated, and anaplastic thyroid cancers.

Pannone G, Santoro A, Pasquali D, Zamparese R, Mattoni M, Russo G, Landriscina M, Piscazzi A, Toti P, Cignarelli M, Lo Muzio L, Bufo P.

Thyroid. 2014 Mar;24(3):511-9. doi: 10.1089/thy.2013.0196. Epub 2013 Dec 13.

PMID:
24117205
42.

Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.

Matassa DS, Amoroso MR, Agliarulo I, Maddalena F, Sisinni L, Paladino S, Romano S, Romano MF, Sagar V, Loreni F, Landriscina M, Esposito F.

Cell Death Dis. 2013 Oct 10;4:e851. doi: 10.1038/cddis.2013.379.

43.

Multiple skeletal muscle metastases from colon carcinoma preceded by paraneoplastic dermatomyositis.

Landriscina M, Gerardi AM, Fersini A, Modoni S, Stoppino LP, Macarini L, Sanguedolce F, Bufo P, Neri V.

Case Rep Med. 2013;2013:392609. doi: 10.1155/2013/392609. Epub 2013 Jul 24.

44.

Small cell carcinoma of the uterine cervix metastasising to the cerebellum.

Scutiero G, Loizzi V, Macarini L, Landriscina M, Greco P.

J Obstet Gynaecol. 2013 Aug;33(6):639-41. doi: 10.3109/01443615.2013.798631. No abstract available.

PMID:
23919876
45.

Letter to the editors. The Airtraq optical.

Piacentini AG, Cattano D, Volonté M, Landriscina M.

Air Med J. 2013 Jul-Aug;32(4):176-7. doi: 10.1016/j.amj.2013.05.005. No abstract available.

PMID:
23816206
46.

The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase.

Sciacovelli M, Guzzo G, Morello V, Frezza C, Zheng L, Nannini N, Calabrese F, Laudiero G, Esposito F, Landriscina M, Defilippi P, Bernardi P, Rasola A.

Cell Metab. 2013 Jun 4;17(6):988-99. doi: 10.1016/j.cmet.2013.04.019.

47.

Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1.

Maddalena F, Sisinni L, Lettini G, Condelli V, Matassa DS, Piscazzi A, Amoroso MR, La Torre G, Esposito F, Landriscina M.

Mol Oncol. 2013 Oct;7(5):895-906. doi: 10.1016/j.molonc.2013.04.009. Epub 2013 May 2.

48.

Rapid long-lasting biochemical and radiological response to sorafenib in a case of advanced hepatocellular carcinoma.

Gerardi AM, Stoppino LP, Liso A, Macarini L, Landriscina M.

Oncol Lett. 2013 Mar;5(3):975-977. Epub 2013 Jan 11.

49.

Successful Prolonged Mechanical CPR in a Severely Poisoned Hypothermic Patient: A Case Report.

Piacentini A, Volonte' M, Rigamonti M, Guastella E, Landriscina M.

Case Rep Emerg Med. 2012;2012:381798. doi: 10.1155/2012/381798. Epub 2012 Aug 23.

50.

Identification of a new insertion in exon 20 of EGFR in a woman with NSCLC.

Zupa A, Vita G, Landriscina M, Possidente L, Aieta M, Tartarone A, Improta G.

Med Oncol. 2012 Dec;29(5):3198-201. doi: 10.1007/s12032-012-0304-y. Epub 2012 Jul 8.

PMID:
22773041

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