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BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation.

Sartori M, Mendes T, Desai S, Lasorsa A, Herledan A, Malmanche N, Mäkinen P, Marttinen M, Malki I, Chapuis J, Flaig A, Vreulx AC, Ciancia M, Amouyel P, Leroux F, Déprez B, Cantrelle FX, Maréchal D, Pradier L, Hiltunen M, Landrieu I, Kilinc D, Herault Y, Laporte J, Lambert JC.

Acta Neuropathol. 2019 May 7. doi: 10.1007/s00401-019-02017-9. [Epub ahead of print]


Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors.

Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C.

ACS Chem Biol. 2019 Jun 21;14(6):1363-1379. doi: 10.1021/acschembio.9b00325. Epub 2019 May 15.


Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.

Albert M, Mairet-Coello G, Danis C, Lieger S, Caillierez R, Carrier S, Skrobala E, Landrieu I, Michel A, Schmitt M, Citron M, Downey P, Courade JP, Buée L, Colin M.

Brain. 2019 Jun 1;142(6):1736-1750. doi: 10.1093/brain/awz100.


The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Fichou Y, Al-Hilaly YK, Devred F, Smet-Nocca C, Tsvetkov PO, Verelst J, Winderickx J, Geukens N, Vanmechelen E, Perrotin A, Serpell L, Hanseeuw BJ, Medina M, Buée L, Landrieu I.

Acta Neuropathol Commun. 2019 Mar 1;7(1):31. doi: 10.1186/s40478-019-0682-x. Review.


Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation.

Lasorsa A, Malki I, Cantrelle FX, Merzougui H, Boll E, Lambert JC, Landrieu I.

Front Mol Neurosci. 2018 Nov 14;11:421. doi: 10.3389/fnmol.2018.00421. eCollection 2018.


Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy.

Bourré G, Cantrelle FX, Kamah A, Chambraud B, Landrieu I, Smet-Nocca C.

Front Endocrinol (Lausanne). 2018 Oct 16;9:595. doi: 10.3389/fendo.2018.00595. eCollection 2018.


Backbone chemical shift assignments of human 14-3-3σ.

Neves JF, Landrieu I, Merzougui H, Boll E, Hanoulle X, Cantrelle FX.

Biomol NMR Assign. 2019 Apr;13(1):103-107. doi: 10.1007/s12104-018-9860-1. Epub 2018 Oct 30.


Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges.

Martinho M, Allegro D, Huvent I, Chabaud C, Etienne E, Kovacic H, Guigliarelli B, Peyrot V, Landrieu I, Belle V, Barbier P.

Sci Rep. 2018 Sep 14;8(1):13846. doi: 10.1038/s41598-018-32096-9.


Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.

Andrei SA, Meijer FA, Neves JF, Brunsveld L, Landrieu I, Ottmann C, Milroy LG.

ACS Chem Neurosci. 2018 Nov 21;9(11):2639-2654. doi: 10.1021/acschemneuro.8b00118. Epub 2018 May 17.


The O-β-linked N-acetylglucosaminylation of the Lamin B receptor and its impact on DNA binding and phosphorylation.

Smet-Nocca C, Page A, Cantrelle FX, Nikolakaki E, Landrieu I, Giannakouros T.

Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):825-835. doi: 10.1016/j.bbagen.2018.01.007. Epub 2018 Jan 11.


Modulators of 14-3-3 Protein-Protein Interactions.

Stevers LM, Sijbesma E, Botta M, MacKintosh C, Obsil T, Landrieu I, Cau Y, Wilson AJ, Karawajczyk A, Eickhoff J, Davis J, Hann M, O'Mahony G, Doveston RG, Brunsveld L, Ottmann C.

J Med Chem. 2018 May 10;61(9):3755-3778. doi: 10.1021/acs.jmedchem.7b00574. Epub 2017 Oct 19. Review.


NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.

Bessa LM, Launay H, Dujardin M, Cantrelle FX, Lippens G, Landrieu I, Schneider R, Hanoulle X.

J Biol Chem. 2017 Nov 3;292(44):18024-18043. doi: 10.1074/jbc.M117.813766. Epub 2017 Sep 14.


Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7.

Lens Z, Cantrelle FX, Peruzzini R, Hanoulle X, Dewitte F, Ferreira E, Baert JL, Monté D, Aumercier M, Villeret V, Verger A, Landrieu I.

J Mol Biol. 2017 Oct 13;429(20):3043-3055. doi: 10.1016/j.jmb.2017.09.001. Epub 2017 Sep 9.


Identification of the Tau phosphorylation pattern that drives its aggregation.

Despres C, Byrne C, Qi H, Cantrelle FX, Huvent I, Chambraud B, Baulieu EE, Jacquot Y, Landrieu I, Lippens G, Smet-Nocca C.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9080-9085. doi: 10.1073/pnas.1708448114. Epub 2017 Aug 7.


Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain.

Malki I, Cantrelle FX, Sottejeau Y, Lippens G, Lambert JC, Landrieu I.

FEBS J. 2017 Oct;284(19):3218-3229. doi: 10.1111/febs.14185. Epub 2017 Aug 30.


Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins.

Danis C, Despres C, Bessa LM, Malki I, Merzougui H, Huvent I, Qi H, Lippens G, Cantrelle FX, Schneider R, Hanoulle X, Smet-Nocca C, Landrieu I.

J Vis Exp. 2016 Dec 27;(118). doi: 10.3791/55001.


A β-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52.

Byrne C, Henen MA, Belnou M, Cantrelle FX, Kamah A, Qi H, Giustiniani J, Chambraud B, Baulieu EE, Lippens G, Landrieu I, Jacquot Y.

Biochemistry. 2016 Sep 27;55(38):5366-76. doi: 10.1021/acs.biochem.6b00506. Epub 2016 Sep 19.


Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ.

Nat Commun. 2016 Aug 26;7:12673. doi: 10.1038/ncomms12673.


NMR Meets Tau: Insights into Its Function and Pathology.

Lippens G, Landrieu I, Smet C, Huvent I, Gandhi NS, Gigant B, Despres C, Qi H, Lopez J.

Biomolecules. 2016 Jun 7;6(2). pii: E28. doi: 10.3390/biom6020028. Review.


Isomerization and Oligomerization of Truncated and Mutated Tau Forms by FKBP52 are Independent Processes.

Kamah A, Cantrelle FX, Huvent I, Giustiniani J, Guillemeau K, Byrne C, Jacquot Y, Landrieu I, Baulieu EE, Smet C, Chambraud B, Lippens G.

J Mol Biol. 2016 Mar 27;428(6):1080-1090. doi: 10.1016/j.jmb.2016.02.015. Epub 2016 Feb 20.


1H, 15N and 13C assignments of the N-terminal domain of the Mediator complex subunit MED26.

Peruzzini R, Lens Z, Verger A, Dewitte F, Ferreira E, Baert JL, Villeret V, Landrieu I, Cantrelle FX.

Biomol NMR Assign. 2016 Apr;10(1):233-6. doi: 10.1007/s12104-016-9673-z. Epub 2016 Feb 9.


Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase.

Qi H, Prabakaran S, Cantrelle FX, Chambraud B, Gunawardena J, Lippens G, Landrieu I.

J Biol Chem. 2016 Apr 1;291(14):7742-53. doi: 10.1074/jbc.M115.700914. Epub 2016 Feb 8.


Proline Conformation in a Functional Tau Fragment.

Ahuja P, Cantrelle FX, Huvent I, Hanoulle X, Lopez J, Smet C, Wieruszeski JM, Landrieu I, Lippens G.

J Mol Biol. 2016 Jan 16;428(1):79-91. doi: 10.1016/j.jmb.2015.11.023. Epub 2015 Dec 2.


Stabilizer-Guided Inhibition of Protein-Protein Interactions.

Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C.

Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15720-4. doi: 10.1002/anie.201507976. Epub 2015 Nov 5.


Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain.

Sottejeau Y, Bretteville A, Cantrelle FX, Malmanche N, Demiaute F, Mendes T, Delay C, Alves Dos Alves H, Flaig A, Davies P, Dourlen P, Dermaut B, Laporte J, Amouyel P, Lippens G, Chapuis J, Landrieu I, Lambert JC.

Acta Neuropathol Commun. 2015 Sep 23;3:58. doi: 10.1186/s40478-015-0237-8.


Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25.

Landrieu I, Verger A, Baert JL, Rucktooa P, Cantrelle FX, Dewitte F, Ferreira E, Lens Z, Villeret V, Monté D.

Nucleic Acids Res. 2015 Aug 18;43(14):7110-21. doi: 10.1093/nar/gkv650. Epub 2015 Jun 29.


Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.

Joo Y, Schumacher B, Landrieu I, Bartel M, Smet-Nocca C, Jang A, Choi HS, Jeon NL, Chang KA, Kim HS, Ottmann C, Suh YH.

FASEB J. 2015 Oct;29(10):4133-44. doi: 10.1096/fj.14-265009. Epub 2015 Jun 23.


The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior.

Giustiniani J, Guillemeau K, Dounane O, Sardin E, Huvent I, Schmitt A, Hamdane M, Buée L, Landrieu I, Lippens G, Baulieu EE, Chambraud B.

FASEB J. 2015 Aug;29(8):3171-81. doi: 10.1096/fj.14-268243. Epub 2015 Apr 17.


A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.

Gandhi NS, Landrieu I, Byrne C, Kukic P, Amniai L, Cantrelle FX, Wieruszeski JM, Mancera RL, Jacquot Y, Lippens G.

Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6819-23. doi: 10.1002/anie.201501898. Epub 2015 Apr 16.


Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.

Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, Kosik KS, Landrieu I, Le Tilly V, Bach S.

Chem Biol. 2015 Apr 23;22(4):472-482. doi: 10.1016/j.chembiol.2015.03.009. Epub 2015 Apr 9.


Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation.

Qi H, Cantrelle FX, Benhelli-Mokrani H, Smet-Nocca C, Buée L, Lippens G, Bonnefoy E, Galas MC, Landrieu I.

Biochemistry. 2015 Feb 24;54(7):1525-33. doi: 10.1021/bi5014613. Epub 2015 Feb 9.


H/D exchange of a 15N labelled Tau fragment as measured by a simple Relax-EXSY experiment.

Lopez J, Ahuja P, Landrieu I, Cantrelle FX, Huvent I, Lippens G.

J Magn Reson. 2014 Dec;249:32-37. doi: 10.1016/j.jmr.2014.10.008. Epub 2014 Oct 19.


Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2.

McDowell GS, Hindley CJ, Lippens G, Landrieu I, Philpott A.

BMC Biochem. 2014 Nov 6;15:24. doi: 10.1186/s12858-014-0024-3.


Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy.

Gigant B, Landrieu I, Fauquant C, Barbier P, Huvent I, Wieruszeski JM, Knossow M, Lippens G.

J Am Chem Soc. 2014 Sep 10;136(36):12615-23. doi: 10.1021/ja504864m. Epub 2014 Aug 27.


Identification of a Plasmodium falciparum inhibitor-2 motif involved in the binding and regulation activity of protein phosphatase type 1.

Fréville A, Tellier G, Vandomme A, Pierrot C, Vicogne J, Cantrelle FX, Martoriati A, Cailliau-Maggio K, Khalife J, Landrieu I.

FEBS J. 2014 Oct;281(19):4519-34. doi: 10.1111/febs.12960. Epub 2014 Sep 8.


Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein.

Kamah A, Huvent I, Cantrelle FX, Qi H, Lippens G, Landrieu I, Smet-Nocca C.

Biochemistry. 2014 May 13;53(18):3020-32. doi: 10.1021/bi500006v. Epub 2014 Apr 23.


Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.

Giustiniani J, Chambraud B, Sardin E, Dounane O, Guillemeau K, Nakatani H, Paquet D, Kamah A, Landrieu I, Lippens G, Baulieu EE, Tawk M.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4584-9. doi: 10.1073/pnas.1402645111. Epub 2014 Mar 12.


A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge.

Huvent I, Kamah A, Cantrelle FX, Barois N, Slomianny C, Smet-Nocca C, Landrieu I, Lippens G.

Biochem Biophys Res Commun. 2014 Mar 7;445(2):299-303. doi: 10.1016/j.bbrc.2014.01.161. Epub 2014 Feb 3.


Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA.

Smet-Nocca C, Launay H, Wieruszeski JM, Lippens G, Landrieu I.

J Biomol NMR. 2013 Apr;55(4):323-37. doi: 10.1007/s10858-013-9716-z. Epub 2013 Mar 2.


Cell signaling, post-translational protein modifications and NMR spectroscopy.

Theillet FX, Smet-Nocca C, Liokatis S, Thongwichian R, Kosten J, Yoon MK, Kriwacki RW, Landrieu I, Lippens G, Selenko P.

J Biomol NMR. 2012 Nov;54(3):217-36. doi: 10.1007/s10858-012-9674-x. Epub 2012 Sep 26.


Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.

Ando K, Dourlen P, Sambo AV, Bretteville A, Bélarbi K, Vingtdeux V, Eddarkaoui S, Drobecq H, Ghestem A, Bégard S, Demey-Thomas E, Melnyk P, Smet C, Lippens G, Maurage CA, Caillet-Boudin ML, Verdier Y, Vinh J, Landrieu I, Galas MC, Blum D, Hamdane M, Sergeant N, Buée L.

Neurobiol Aging. 2013 Mar;34(3):757-69. doi: 10.1016/j.neurobiolaging.2012.08.004. Epub 2012 Aug 25.


Towards understanding the phosphorylation code of tau.

Lippens G, Amniai L, Wieruszeski JM, Sillen A, Leroy A, Landrieu I.

Biochem Soc Trans. 2012 Aug;40(4):698-703. doi: 10.1042/BST20120050. Review.


Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival.

Fréville A, Landrieu I, García-Gimeno MA, Vicogne J, Montbarbon M, Bertin B, Verger A, Kalamou H, Sanz P, Werkmeister E, Pierrot C, Khalife J.

J Biol Chem. 2012 Jan 6;287(2):1306-21. doi: 10.1074/jbc.M111.276865. Epub 2011 Nov 28.


Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein.

Sibille N, Huvent I, Fauquant C, Verdegem D, Amniai L, Leroy A, Wieruszeski JM, Lippens G, Landrieu I.

Proteins. 2012 Feb;80(2):454-62. doi: 10.1002/prot.23210. Epub 2011 Nov 9.


Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach.

Amniai L, Lippens G, Landrieu I.

Biochem Biophys Res Commun. 2011 Sep 9;412(4):743-6. doi: 10.1016/j.bbrc.2011.08.046. Epub 2011 Aug 17.


Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly.

Fauquant C, Redeker V, Landrieu I, Wieruszeski JM, Verdegem D, Laprévote O, Lippens G, Gigant B, Knossow M.

J Biol Chem. 2011 Sep 23;286(38):33358-68. doi: 10.1074/jbc.M111.223545. Epub 2011 Jul 12.


Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.

Landrieu I, Smet-Nocca C, Amniai L, Louis JV, Wieruszeski JM, Goris J, Janssens V, Lippens G.

PLoS One. 2011;6(6):e21521. doi: 10.1371/journal.pone.0021521. Epub 2011 Jun 23.


Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2.

Sami F, Smet-Nocca C, Khan M, Landrieu I, Lippens G, Brautigan DL.

Biochemistry. 2011 Aug 2;50(30):6567-78. doi: 10.1021/bi200553e. Epub 2011 Jul 8.


Ranking high affinity ligands of low solubility by NMR spectroscopy.

Landrieu I, Hanoulle X, Fritzinger B, Horvath D, Wieruszeski JM, Lippens G.

ACS Med Chem Lett. 2011 Apr 5;2(6):485-7. doi: 10.1021/ml200039u. eCollection 2011 Jun 9.

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