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Items: 47


Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties.

Al-Adwani S, Wallin C, Balhuizen MD, Veldhuizen EJA, Coorens M, Landreh M, Végvári Á, Smith ME, Qvarfordt I, Lindén A, Gräslund A, Agerberth B, Bergman P.

Sci Rep. 2020 Feb 11;10(1):2376. doi: 10.1038/s41598-020-59071-7.


Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro.

Chen G, Andrade-Talavera Y, Tambaro S, Leppert A, Nilsson HE, Zhong X, Landreh M, Nilsson P, Hebert H, Biverstål H, Fisahn A, Abelein A, Johansson J.

Commun Biol. 2020 Jan 20;3(1):32. doi: 10.1038/s42003-020-0757-z.


High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Abelein A, Chen G, Kitoka K, Aleksis R, Oleskovs F, Sarr M, Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson J, Biverstål H.

Sci Rep. 2020 Jan 14;10(1):235. doi: 10.1038/s41598-019-57143-x.


A Mass-Spectrometry-Based Approach to Distinguish Annular and Specific Lipid Binding to Membrane Proteins.

Bolla JR, Corey RA, Sahin C, Gault J, Hummer A, Hopper JTS, Lane DP, Drew D, Allison TM, Stansfeld PJ, Robinson CV, Landreh M.

Angew Chem Int Ed Engl. 2020 Feb 24;59(9):3523-3528. doi: 10.1002/anie.201914411. Epub 2020 Jan 29.


High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry.

Kaldmäe M, Leppert A, Chen G, Sarr M, Sahin C, Nordling K, Kronqvist N, Gonzalvo-Ulla M, Fritz N, Abelein A, Laίn S, Biverstål H, Jörnvall H, Lane DP, Rising A, Johansson J, Landreh M.

FEBS J. 2019 Dec 9. doi: 10.1111/febs.15169. [Epub ahead of print]


Efficient delipidation of a recombinant lung surfactant lipopeptide analogue by liquid-gel chromatography.

Basabe-Burgos O, Ahlström JZ, Mikolka P, Landreh M, Johansson J, Curstedt T, Rising A.

PLoS One. 2019 Dec 4;14(12):e0226072. doi: 10.1371/journal.pone.0226072. eCollection 2019.


Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction.

Kaldmäe M, Österlund N, Lianoudaki D, Sahin C, Bergman P, Nyman T, Kronqvist N, Ilag LL, Allison TM, Marklund EG, Landreh M.

J Am Soc Mass Spectrom. 2019 Aug;30(8):1385-1388. doi: 10.1007/s13361-019-02177-8. Epub 2019 Jul 8.


A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes.

Kaldmäe M, Sahin C, Saluri M, Marklund EG, Landreh M.

Protein Sci. 2019 Jun;28(6):1024-1030. doi: 10.1002/pro.3609. Epub 2019 Apr 19.


An engineered thermal-shift screen reveals specific lipid preferences of eukaryotic and prokaryotic membrane proteins.

Nji E, Chatzikyriakidou Y, Landreh M, Drew D.

Nat Commun. 2018 Oct 12;9(1):4253. doi: 10.1038/s41467-018-06702-3.


Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone.

Gault J, Lianoudaki D, Kaldmäe M, Kronqvist N, Rising A, Johansson J, Lohkamp B, Laín S, Allison TM, Lane DP, Marklund EG, Landreh M.

J Phys Chem Lett. 2018 Jul 19;9(14):4082-4086. doi: 10.1021/acs.jpclett.8b01817. Epub 2018 Jul 9.


Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase.

Costeira-Paulo J, Gault J, Popova G, Ladds MJGW, van Leeuwen IMM, Sarr M, Olsson A, Lane DP, Laín S, Marklund EG, Landreh M.

Cell Chem Biol. 2018 Mar 15;25(3):309-317.e4. doi: 10.1016/j.chembiol.2017.12.012. Epub 2018 Jan 18.


Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state.

Chen G, Abelein A, Nilsson HE, Leppert A, Andrade-Talavera Y, Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck PJB, Presto J, Hebert H, Fisahn A, Johansson J.

Nat Commun. 2017 Dec 12;8(1):2081. doi: 10.1038/s41467-017-02056-4.


Effects of Detergent Micelles on Lipid Binding to Proteins in Electrospray Ionization Mass Spectrometry.

Landreh M, Costeira-Paulo J, Gault J, Marklund EG, Robinson CV.

Anal Chem. 2017 Jul 18;89(14):7425-7430. doi: 10.1021/acs.analchem.7b00922. Epub 2017 Jul 3.


Efficient protein production inspired by how spiders make silk.

Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J.

Nat Commun. 2017 May 23;8:15504. doi: 10.1038/ncomms15504.


Mass spectrometry captures structural intermediates in protein fiber self-assembly.

Landreh M, Andersson M, Marklund EG, Jia Q, Meng Q, Johansson J, Robinson CV, Rising A.

Chem Commun (Camb). 2017 Mar 16;53(23):3319-3322. doi: 10.1039/c7cc00307b.


The role of interfacial lipids in stabilizing membrane protein oligomers.

Gupta K, Donlan JAC, Hopper JTS, Uzdavinys P, Landreh M, Struwe WB, Drew D, Baldwin AJ, Stansfeld PJ, Robinson CV.

Nature. 2017 Jan 19;541(7637):421-424. doi: 10.1038/nature20820. Epub 2017 Jan 11.


Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters.

Landreh M, Marklund EG, Uzdavinys P, Degiacomi MT, Coincon M, Gault J, Gupta K, Liko I, Benesch JL, Drew D, Robinson CV.

Nat Commun. 2017 Jan 10;8:13993. doi: 10.1038/ncomms13993.


Biomimetic spinning of artificial spider silk from a chimeric minispidroin.

Andersson M, Jia Q, Abella A, Lee XY, Landreh M, Purhonen P, Hebert H, Tenje M, Robinson CV, Meng Q, Plaza GR, Johansson J, Rising A.

Nat Chem Biol. 2017 Mar;13(3):262-264. doi: 10.1038/nchembio.2269. Epub 2017 Jan 9.


A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.

Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lönnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E.

EMBO J. 2016 Sep 15;35(18):1963-78. doi: 10.15252/embj.201593725. Epub 2016 Jun 28.


The formation, function and regulation of amyloids: insights from structural biology.

Landreh M, Sawaya MR, Hipp MS, Eisenberg DS, Wüthrich K, Hartl FU.

J Intern Med. 2016 Aug;280(2):164-76. doi: 10.1111/joim.12500. Epub 2016 May 30. Review.


A sliding selectivity scale for lipid binding to membrane proteins.

Landreh M, Marty MT, Gault J, Robinson CV.

Curr Opin Struct Biol. 2016 Aug;39:54-60. doi: 10.1016/ Epub 2016 May 4. Review.


Low Charge and Reduced Mobility of Membrane Protein Complexes Has Implications for Calibration of Collision Cross Section Measurements.

Allison TM, Landreh M, Benesch JLP, Robinson CV.

Anal Chem. 2016 Jun 7;88(11):5879-5884. doi: 10.1021/acs.analchem.6b00691. Epub 2016 May 13.


Controlling release, unfolding and dissociation of membrane protein complexes in the gas phase through collisional cooling.

Landreh M, Liko I, Uzdavinys P, Coincon M, Hopper JT, Drew D, Robinson CV.

Chem Commun (Camb). 2015 Nov 4;51(85):15582-4. doi: 10.1039/c5cc07045g.


Specific chaperones and regulatory domains in control of amyloid formation.

Landreh M, Rising A, Presto J, Jörnvall H, Johansson J.

J Biol Chem. 2015 Oct 30;290(44):26430-6. doi: 10.1074/jbc.R115.653097. Epub 2015 Sep 9. Review.


Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains.

Otikovs M, Chen G, Nordling K, Landreh M, Meng Q, Jörnvall H, Kronqvist N, Rising A, Johansson J, Jaudzems K.

Chembiochem. 2015 Aug 17;16(12):1720-4. doi: 10.1002/cbic.201500263. Epub 2015 Jul 1.


A new window into the molecular physiology of membrane proteins.

Landreh M, Robinson CV.

J Physiol. 2015 Jan 15;593(2):355-62. doi: 10.1113/jphysiol.2014.283150. Epub 2014 Dec 1. Review.


C-peptide evolution: generation from few structural restrictions of bioactivities not necessarily functional.

Landreh M, Jörnvall H.

FEBS Lett. 2015 Feb 13;589(4):415-8. doi: 10.1016/j.febslet.2015.01.006. Epub 2015 Jan 14.


Derivation and characterization of a cytocompatible scaffold from human testis.

Baert Y, Stukenborg JB, Landreh M, De Kock J, Jörnvall H, Söder O, Goossens E.

Hum Reprod. 2015 Feb;30(2):256-67. doi: 10.1093/humrep/deu330. Epub 2014 Dec 11.


Alcohol dehydrogenase, SDR and MDR structural stages, present update and altered era.

Jörnvall H, Landreh M, Östberg LJ.

Chem Biol Interact. 2015 Jun 5;234:75-9. doi: 10.1016/j.cbi.2014.10.017. Epub 2014 Oct 29.


Transthyretin microheterogeneity and molecular interactions: implications for amyloid formation.

Landreh M, Ostberg LJ, Pettersson TM, Jörnvall H.

Biomol Concepts. 2014 Jun;5(3):257-64. doi: 10.1515/bmc-2014-0006.


The structure, molecular interactions and bioactivities of proinsulin C-peptide correlate with a tripartite molecule.

Landreh M, Johansson J, Wahren J, Jörnvall H.

Biomol Concepts. 2014 May;5(2):109-18. doi: 10.1515/bmc-2014-0005. Review.


Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains.

Andersson M, Chen G, Otikovs M, Landreh M, Nordling K, Kronqvist N, Westermark P, Jörnvall H, Knight S, Ridderstråle Y, Holm L, Meng Q, Jaudzems K, Chesler M, Johansson J, Rising A.

PLoS Biol. 2014 Aug 5;12(8):e1001921. doi: 10.1371/journal.pbio.1001921. eCollection 2014 Aug.


A subdivided molecular architecture with separate features and stepwise emergence among proinsulin C-peptides.

Landreh M, Ostberg LJ, Jörnvall H.

Biochem Biophys Res Commun. 2014 Aug 8;450(4):1433-8. doi: 10.1016/j.bbrc.2014.07.012. Epub 2014 Jul 10.


Protective effects of dimethyl sulfoxide on labile protein interactions during electrospray ionization.

Landreh M, Alvelius G, Johansson J, Jörnvall H.

Anal Chem. 2014 May 6;86(9):4135-9. doi: 10.1021/ac500879c. Epub 2014 Apr 24.


Separate molecular determinants in amyloidogenic and antimicrobial peptides.

Landreh M, Johansson J, Jörnvall H.

J Mol Biol. 2014 May 29;426(11):2159-66. doi: 10.1016/j.jmb.2014.03.005. Epub 2014 Mar 17.


Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.

Kronqvist N, Otikovs M, Chmyrov V, Chen G, Andersson M, Nordling K, Landreh M, Sarr M, Jörnvall H, Wennmalm S, Widengren J, Meng Q, Rising A, Otzen D, Knight SD, Jaudzems K, Johansson J.

Nat Commun. 2014;5:3254. doi: 10.1038/ncomms4254.


Insulin, islet amyloid polypeptide and C-peptide interactions evaluated by mass spectrometric analysis.

Landreh M, Alvelius G, Johansson J, Jörnvall H.

Rapid Commun Mass Spectrom. 2014 Jan 30;28(2):178-84. doi: 10.1002/rcm.6772.


C-peptide: a molecule balancing insulin states in secretion and diabetes-associated depository conditions.

Landreh M, Johansson J, Jörnvall H.

Horm Metab Res. 2013 Oct;45(11):769-73. doi: 10.1055/s-0033-1347208. Epub 2013 Jun 18. Review.


Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide.

Landreh M, Alvelius G, Willander H, Stukenborg JB, Söder O, Johansson J, Jörnvall H.

FEBS J. 2012 Dec;279(24):4589-97. doi: 10.1111/febs.12045. Epub 2012 Nov 21.


Control of amyloid assembly by autoregulation.

Landreh M, Johansson J, Rising A, Presto J, Jörnvall H.

Biochem J. 2012 Oct 15;447(2):185-92. Review.


pH-dependent dimerization of spider silk N-terminal domain requires relocation of a wedged tryptophan side chain.

Jaudzems K, Askarieh G, Landreh M, Nordling K, Hedhammar M, Jörnvall H, Rising A, Knight SD, Johansson J.

J Mol Biol. 2012 Sep 28;422(4):477-87. doi: 10.1016/j.jmb.2012.06.004. Epub 2012 Jun 15.


The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila.

Liu N, Landreh M, Cao K, Abe M, Hendriks GJ, Kennerdell JR, Zhu Y, Wang LS, Bonini NM.

Nature. 2012 Feb 15;482(7386):519-23. doi: 10.1038/nature10810.


High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.

Willander H, Askarieh G, Landreh M, Westermark P, Nordling K, Keränen H, Hermansson E, Hamvas A, Nogee LM, Bergman T, Saenz A, Casals C, Åqvistg J, Jörnvall H, Berglund H, Presto J, Knight SD, Johansson J.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2325-9. doi: 10.1073/pnas.1114740109. Epub 2012 Feb 2.


Proinsulin C-peptide interferes with insulin fibril formation.

Landreh M, Stukenborg JB, Willander H, Söder O, Johansson J, Jörnvall H.

Biochem Biophys Res Commun. 2012 Feb 17;418(3):489-93. doi: 10.1016/j.bbrc.2012.01.051. Epub 2012 Jan 18.


New developments in protein structure-function analysis by MS and use of hydrogen-deuterium exchange microfluidics.

Landreh M, Astorga-Wells J, Johansson J, Bergman T, Jörnvall H.

FEBS J. 2011 Oct;278(20):3815-21. doi: 10.1111/j.1742-4658.2011.08215.x. Epub 2011 Jul 5. Review.


A membrane cell for on-line hydrogen/deuterium exchange to study protein folding and protein-protein interactions by mass spectrometry.

Astorga-Wells J, Landreh M, Johansson J, Bergman T, Jörnvall H.

Mol Cell Proteomics. 2011 Sep;10(9):M110.006510. doi: 10.1074/mcp.M110.006510. Epub 2011 May 24.


A pH-dependent dimer lock in spider silk protein.

Landreh M, Askarieh G, Nordling K, Hedhammar M, Rising A, Casals C, Astorga-Wells J, Alvelius G, Knight SD, Johansson J, Jörnvall H, Bergman T.

J Mol Biol. 2010 Nov 26;404(2):328-36. doi: 10.1016/j.jmb.2010.09.054. Epub 2010 Sep 29.


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