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Items: 37

1.

Novel genetic tools that enable highly pure protein production in Trichoderma reesei.

Rantasalo A, Vitikainen M, Paasikallio T, Jäntti J, Landowski CP, Mojzita D.

Sci Rep. 2019 Mar 22;9(1):5032. doi: 10.1038/s41598-019-41573-8.

2.

Phase transitions as intermediate steps in the formation of molecularly engineered protein fibers.

Mohammadi P, Aranko AS, Lemetti L, Cenev Z, Zhou Q, Virtanen S, Landowski CP, Penttilä M, Fischer WJ, Wagermaier W, Linder MB.

Commun Biol. 2018 Jul 2;1:86. doi: 10.1038/s42003-018-0090-y. eCollection 2018.

3.

Coacervation of resilin fusion proteins containing terminal functionalities.

Fang W, Nonappa, Vitikainen M, Mohammadi P, Koskela S, Soikkeli M, Westerholm-Parvinen A, Landowski CP, Penttilä M, Linder MB, Laaksonen P.

Colloids Surf B Biointerfaces. 2018 Nov 1;171:590-596. doi: 10.1016/j.colsurfb.2018.07.048. Epub 2018 Jul 24.

PMID:
30098537
4.

A universal gene expression system for fungi.

Rantasalo A, Landowski CP, Kuivanen J, Korppoo A, Reuter L, Koivistoinen O, Valkonen M, Penttilä M, Jäntti J, Mojzita D.

Nucleic Acids Res. 2018 Oct 12;46(18):e111. doi: 10.1093/nar/gky558.

5.

Transient Silencing of DNA Repair Genes Improves Targeted Gene Integration in the Filamentous Fungus Trichoderma reesei.

Chum PY, Schmidt G, Saloheimo M, Landowski CP.

Appl Environ Microbiol. 2017 Jul 17;83(15). pii: e00535-17. doi: 10.1128/AEM.00535-17. Print 2017 Aug 1.

6.

Elastic and pH-Responsive Hybrid Interfaces Created with Engineered Resilin and Nanocellulose.

Fang W, Paananen A, Vitikainen M, Koskela S, Westerholm-Parvinen A, Joensuu JJ, Landowski CP, Penttilä M, Linder MB, Laaksonen P.

Biomacromolecules. 2017 Jun 12;18(6):1866-1873. doi: 10.1021/acs.biomac.7b00294. Epub 2017 May 3.

7.

Enabling low cost biopharmaceuticals: high level interferon alpha-2b production in Trichoderma reesei.

Landowski CP, Mustalahti E, Wahl R, Croute L, Sivasiddarthan D, Westerholm-Parvinen A, Sommer B, Ostermeier C, Helk B, Saarinen J, Saloheimo M.

Microb Cell Fact. 2016 Jun 10;15(1):104. doi: 10.1186/s12934-016-0508-5.

8.

Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei.

Landowski CP, Huuskonen A, Wahl R, Westerholm-Parvinen A, Kanerva A, Hänninen AL, Salovuori N, Penttilä M, Natunen J, Ostermeier C, Helk B, Saarinen J, Saloheimo M.

PLoS One. 2015 Aug 26;10(8):e0134723. doi: 10.1371/journal.pone.0134723. eCollection 2015.

9.

Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers.

Dahan A, Wolk O, Yang P, Mittal S, Wu Z, Landowski CP, Amidon GL.

Mol Pharm. 2014 Dec 1;11(12):4385-94. doi: 10.1021/mp500483v. Epub 2014 Nov 13.

10.

Chemical inhibitors of the calcium entry channel TRPV6.

Landowski CP, Bolanz KA, Suzuki Y, Hediger MA.

Pharm Res. 2011 Feb;28(2):322-30. doi: 10.1007/s11095-010-0249-9. Epub 2010 Nov 6.

11.

Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells.

Bolanz KA, Kovacs GG, Landowski CP, Hediger MA.

Mol Cancer Res. 2009 Dec;7(12):2000-10. doi: 10.1158/1541-7786.MCR-09-0188. Epub 2009 Dec 8.

12.

Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers.

Foster DR, Landowski CP, Zheng X, Amidon GL, Welage LS.

Pharmacol Res. 2009 Mar;59(3):215-20. doi: 10.1016/j.phrs.2008.11.001. Epub 2008 Nov 25.

PMID:
19084598
13.

Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters.

Tsume Y, Vig BS, Sun J, Landowski CP, Hilfinger JM, Ramachandran C, Amidon GL.

Molecules. 2008 Jun 28;13(7):1441-54.

14.

Characterization of a stem cell population in lung cancer A549 cells.

Sung JM, Cho HJ, Yi H, Lee CH, Kim HS, Kim DK, Abd El-Aty AM, Kim JS, Landowski CP, Hediger MA, Shin HC.

Biochem Biophys Res Commun. 2008 Jun 20;371(1):163-7. doi: 10.1016/j.bbrc.2008.04.038. Epub 2008 Apr 24.

PMID:
18423378
15.

Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport.

Suzuki Y, Kovacs CS, Takanaga H, Peng JB, Landowski CP, Hediger MA.

J Bone Miner Res. 2008 Aug;23(8):1249-56. doi: 10.1359/jbmr.080314.

16.

The role of TRPV6 in breast carcinogenesis.

Bolanz KA, Hediger MA, Landowski CP.

Mol Cancer Ther. 2008 Feb;7(2):271-9. doi: 10.1158/1535-7163.MCT-07-0478. Epub 2008 Feb 1. Erratum in: Mol Cancer Ther. 2008 Apr;7(4):1000.

17.

Mechanisms and regulation of epithelial Ca2+ absorption in health and disease.

Suzuki Y, Landowski CP, Hediger MA.

Annu Rev Physiol. 2008;70:257-71. Review.

PMID:
17850211
18.

Comparative gene expression profiles of intestinal transporters in mice, rats and humans.

Kim HR, Park SW, Cho HJ, Chae KA, Sung JM, Kim JS, Landowski CP, Sun D, Abd El-Aty AM, Amidon GL, Shin HC.

Pharmacol Res. 2007 Sep;56(3):224-36. Epub 2007 Jun 23.

PMID:
17681807
19.

Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model.

Mittal S, Tsume Y, Landowski CP, Lee KD, Hilfinger JM, Amidon GL.

Eur J Pharm Biopharm. 2007 Nov;67(3):752-8. Epub 2007 Apr 4.

PMID:
17560100
20.

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

Cao X, Gibbs ST, Fang L, Miller HA, Landowski CP, Shin HC, Lennernas H, Zhong Y, Amidon GL, Yu LX, Sun D.

Pharm Res. 2006 Aug;23(8):1675-86. Review.

PMID:
16841194
21.

N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL.

Drug Metab Dispos. 2006 Jun;34(6):1070-7. Epub 2006 Mar 24.

PMID:
16565170
22.

Nucleoside ester prodrug substrate specificity of liver carboxylesterase.

Landowski CP, Lorenzi PL, Song X, Amidon GL.

J Pharmacol Exp Ther. 2006 Feb;316(2):572-80. Epub 2005 Oct 13.

PMID:
16223870
23.

Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism.

Landowski CP, Song X, Lorenzi PL, Hilfinger JM, Amidon GL.

Pharm Res. 2005 Sep;22(9):1510-8. Epub 2005 Aug 24.

24.

Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability.

Cao X, Yu LX, Barbaciru C, Landowski CP, Shin HC, Gibbs S, Miller HA, Amidon GL, Sun D.

Mol Pharm. 2005 Jul-Aug;2(4):329-40.

PMID:
16053336
25.

Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.

Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL.

J Pharmacol Exp Ther. 2005 Aug;314(2):883-90. Epub 2005 May 18.

PMID:
15901797
26.

A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists.

Faria TN, Timoszyk JK, Stouch TR, Vig BS, Landowski CP, Amidon GL, Weaver CD, Wall DA, Smith RL.

Mol Pharm. 2004 Jan 12;1(1):67-76.

PMID:
15832502
27.
28.

Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport.

Song X, Lorenzi PL, Landowski CP, Vig BS, Hilfinger JM, Amidon GL.

Mol Pharm. 2005 Mar-Apr;2(2):157-67.

PMID:
15804190
29.

Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs.

Mittal S, Song X, Vig BS, Landowski CP, Kim I, Hilfinger JM, Amidon GL.

Mol Pharm. 2005 Jan-Feb;2(1):37-46.

PMID:
15804176
30.
31.

A fluorescent hPept1 transporter substrate for uptake screening.

Landowski CP, Han HK, Lee KD, Amidon GL.

Pharm Res. 2003 Nov;20(11):1738-45.

32.

Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.

Vig BS, Lorenzi PJ, Mittal S, Landowski CP, Shin HC, Mosberg HI, Hilfinger JM, Amidon GL.

Pharm Res. 2003 Sep;20(9):1381-8.

33.

Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum.

Shin HC, Landowski CP, Sun D, Vig BS, Kim I, Mittal S, Lane M, Rosania G, Drach JC, Amidon GL.

Biochem Biophys Res Commun. 2003 Aug 1;307(3):696-703.

PMID:
12893280
34.

Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters.

Landowski CP, Sun D, Foster DR, Menon SS, Barnett JL, Welage LS, Ramachandran C, Amidon GL.

J Pharmacol Exp Ther. 2003 Aug;306(2):778-86. Epub 2003 May 15.

PMID:
12750437
35.

Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs.

Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, Amidon GL.

Pharm Res. 2002 Oct;19(10):1400-16.

36.

Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein.

Sun D, Landowski CP, Chu X, Wallsten R, Komorowski TE, Fleisher D, Amidon GL.

AAPS PharmSci. 2001;3(1):E2.

37.

Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis.

Landowski CP, Godfrey HP, Bentley-Hibbert SI, Liu X, Huang Z, Sepulveda R, Huygen K, Gennaro ML, Moy FH, Lesley SA, Haak-Frendscho M.

J Clin Microbiol. 2001 Jul;39(7):2418-24.

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