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Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear.

Gant JC, Kadish I, Chen KC, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Alzheimers Dis. 2018;66(4):1371-1378. doi: 10.3233/JAD-180618.


FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.

Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2018 Jan 24;38(4):1030-1041. doi: 10.1523/JNEUROSCI.2234-17.2017. Epub 2017 Dec 18.


Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.

Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2015 Jul 29;35(30):10878-87. doi: 10.1523/JNEUROSCI.1248-15.2015.


Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats.

Latimer CS, Brewer LD, Searcy JL, Chen KC, Popović J, Kraner SD, Thibault O, Blalock EM, Landfield PW, Porter NM.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4359-66. doi: 10.1073/pnas.1404477111. Epub 2014 Sep 29.


FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

Gant JC, Blalock EM, Chen KC, Kadish I, Porter NM, Norris CM, Thibault O, Landfield PW.

Eur J Pharmacol. 2014 Sep 15;739:74-82. doi: 10.1016/j.ejphar.2013.10.070. Epub 2013 Nov 28. Review.


Hippocampal calcium dysregulation at the nexus of diabetes and brain aging.

Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM.

Eur J Pharmacol. 2013 Nov 5;719(1-3):34-43. doi: 10.1016/j.ejphar.2013.07.024. Epub 2013 Jul 17. Review.


Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging.

Chen KC, Blalock EM, Curran-Rauhut MA, Kadish I, Blalock SJ, Brewer L, Porter NM, Landfield PW.

Endocrinology. 2013 Aug;154(8):2807-20. doi: 10.1210/en.2013-1139. Epub 2013 Jun 4.


Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats.

Pancani T, Anderson KL, Brewer LD, Kadish I, DeMoll C, Landfield PW, Blalock EM, Porter NM, Thibault O.

Neurobiol Aging. 2013 Aug;34(8):1977-87. doi: 10.1016/j.neurobiolaging.2013.02.019. Epub 2013 Mar 29.


Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes.

Craft S, Foster TC, Landfield PW, Maier SF, Resnick SM, Yaffe K.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):754-9. doi: 10.1093/gerona/gls112. Epub 2012 May 8.


Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.

Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O.

J Alzheimers Dis. 2012;30(4):943-61. doi: 10.3233/JAD-2012-111661.


Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.

Thibault O, Pancani T, Landfield PW, Norris CM.

Biochim Biophys Acta. 2012 Apr;1822(4):546-9. doi: 10.1016/j.bbadis.2012.01.004. Epub 2012 Jan 10.


Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice.

Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popović J, Blalock EM, Landfield PW, Thibault O, Porter NM.

PLoS One. 2011;6(10):e26812. doi: 10.1371/journal.pone.0026812. Epub 2011 Oct 25.


Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.

Blalock EM, Buechel HM, Popovic J, Geddes JW, Landfield PW.

J Chem Neuroanat. 2011 Oct;42(2):118-26. doi: 10.1016/j.jchemneu.2011.06.007. Epub 2011 Jul 2.


Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Neurosci. 2011 Feb 2;31(5):1693-703. doi: 10.1523/JNEUROSCI.4805-10.2011.


Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys.

Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW.

J Neurosci. 2010 Apr 28;30(17):6058-71. doi: 10.1523/JNEUROSCI.3956-09.2010.


Estradiol reverses a calcium-related biomarker of brain aging in female rats.

Brewer LD, Dowling AL, Curran-Rauhut MA, Landfield PW, Porter NM, Blalock EM.

J Neurosci. 2009 May 13;29(19):6058-67. doi: 10.1523/JNEUROSCI.5253-08.2009.


Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW.

J Neurosci. 2009 Feb 11;29(6):1805-16. doi: 10.1523/JNEUROSCI.4599-08.2009.


Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging.

Norris CM, Blalock EM, Chen KC, Porter NM, Thibault O, Kraner SD, Landfield PW.

Neurobiol Aging. 2010 Feb;31(2):328-38. doi: 10.1016/j.neurobiolaging.2008.03.026.


Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store.

Thibault O, Gant JC, Landfield PW.

Aging Cell. 2007 Jun;6(3):307-17. Epub 2007 Apr 26. Review.


Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels.

Brewer LD, Thibault O, Staton J, Thibault V, Rogers JT, Garcia-Ramos G, Kraner S, Landfield PW, Porter NM.

Brain Res. 2007 Jun 2;1151:20-31. Epub 2007 Mar 12.


A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease.

Landfield PW, Blalock EM, Chen KC, Porter NM.

Curr Alzheimer Res. 2007 Apr;4(2):205-12. Review.


Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats.

Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW.

J Neurosci. 2007 Mar 21;27(12):3098-110.


Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release.

Norris CM, Blalock EM, Thibault O, Brewer LD, Clodfelter GV, Porter NM, Landfield PW.

J Neurophysiol. 2006 Nov;96(5):2488-500. Epub 2006 Aug 16.


Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging.

Brewer LD, Porter NM, Kerr DS, Landfield PW, Thibault O.

Cell Calcium. 2006 Sep;40(3):277-86. Epub 2006 Jun 14.


Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation.

Blalock EM, Chen KC, Stromberg AJ, Norris CM, Kadish I, Kraner SD, Porter NM, Landfield PW.

Ageing Res Rev. 2005 Nov;4(4):481-512. Epub 2005 Oct 27. Review.


Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.

Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD.

J Neurosci. 2005 May 4;25(18):4649-58.


Ca2+ regulation and gene expression in normal brain aging.

Toescu EC, Verkhratsky A, Landfield PW.

Trends Neurosci. 2004 Oct;27(10):614-20. Review.


Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.

Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2173-8. Epub 2004 Feb 9.


Statistical implications of pooling RNA samples for microarray experiments.

Peng X, Wood CL, Blalock EM, Chen KC, Landfield PW, Stromberg AJ.

BMC Bioinformatics. 2003 Jun 24;4:26. Epub 2003 Jun 24.


Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment.

Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW.

J Neurosci. 2003 May 1;23(9):3807-19.


Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons.

Clodfelter GV, Porter NM, Landfield PW, Thibault O.

Eur J Pharmacol. 2002 Jul 5;447(2-3):189-200.


Preface. Ca2+ and neuronal pathology.

Verkhratsky A, Landfield PW, Thibault O.

Eur J Pharmacol. 2002 Jul 5;447(2-3):115-7. No abstract available.


Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity.

Attucci S, Clodfelter GV, Thibault O, Staton J, Moroni F, Landfield PW, Porter NM.

Neuroscience. 2002;112(1):183-94.


Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture.

Norris CM, Blalock EM, Chen KC, Porter NM, Landfield PW.

Neuroscience. 2002;110(2):213-25.


Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.

Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM.

J Neurosci. 2001 Jan 1;21(1):98-108.


Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices.

Chen KC, Blalock EM, Thibault O, Kaminker P, Landfield PW.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4357-62.


Stress hormones and brain aging: adding injury to insult?

Porter NM, Landfield PW.

Nat Neurosci. 1998 May;1(1):3-4. No abstract available.


Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats.

Herman JP, Chen KC, Booze R, Landfield PW.

Neurobiol Aging. 1998 Nov-Dec;19(6):581-7.


Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions.

Thibault O, Porter NM, Chen KC, Blalock EM, Kaminker PG, Clodfelter GV, Brewer LD, Landfield PW.

Cell Calcium. 1998 Nov-Dec;24(5-6):417-33. Review. No abstract available.


Long-term treatment with calcitriol (1,25(OH)2 vit D3) retards a biomarker of hippocampal aging in rats.

Landfield PW, Cadwallader-Neal L.

Neurobiol Aging. 1998 Sep-Oct;19(5):469-77.


Brain creatine kinase with aging in F-344 rats: analysis by saturation transfer magnetic resonance spectroscopy.

Smith CD, Landrum W, Carney JM, Landfield PW, Avison MJ.

Neurobiol Aging. 1997 Nov-Dec;18(6):617-22.


Calcium channel density and hippocampal cell death with age in long-term culture.

Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW.

J Neurosci. 1997 Jul 15;17(14):5629-39.


Hippocampal neurodegeneration in aging.

Gallagher M, Landfield PW, McEwen B, Meaney MJ, Rapp PR, Sapolsky R, West MJ.

Science. 1996 Oct 25;274(5287):484-5. No abstract available.


Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons.

Campbell LW, Hao SY, Thibault O, Blalock EM, Landfield PW.

J Neurosci. 1996 Oct 1;16(19):6286-95.


Hippocampal cell death.

Landfield PW, McEwen BS, Sapolsky RM, Meaney MJ.

Science. 1996 May 31;272(5266):1249b-51b. No abstract available.


Hippocampal cell death.

Landfield PW, McEwan BS, Sapolsky RM, Meaney MJ.

Science. 1996 May 31;272(5266):1249-51. No abstract available.


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