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Items: 1 to 50 of 93


Vaccinia Virus Vectors Targeting Peptides for MHC Class II Presentation to CD4+ T Cells.

Hobbs SJ, Harbour JC, Yates PA, Ortiz D, Landfear SM, Nolz JC.

Immunohorizons. 2020 Jan 2;4(1):1-13. doi: 10.4049/immunohorizons.1900070.


Sensing What's Out There - Kinetoplastid Parasites.

Landfear SM, Zilberstein D.

Trends Parasitol. 2019 Apr;35(4):274-277. doi: 10.1016/ Epub 2019 Jan 14. Review.


Protean permeases: Diverse roles for membrane transport proteins in kinetoplastid protozoa.

Landfear SM.

Mol Biochem Parasitol. 2019 Jan;227:39-46. doi: 10.1016/j.molbiopara.2018.12.006. Epub 2018 Dec 24. Review.


Glucose Transporters and Virulence in Leishmania mexicana.

Feng X, Tran KD, Sanchez MA, Al Mezewghi H, Landfear SM.

mSphere. 2018 Aug 1;3(4). pii: e00349-18. doi: 10.1128/mSphere.00349-18.


Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models.

Saunders EC, Naderer T, Chambers J, Landfear SM, McConville MJ.

Mol Microbiol. 2018 Apr;108(2):143-158. doi: 10.1111/mmi.13923. Epub 2018 Mar 2.


Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.

Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, Landfear SM.

PLoS Negl Trop Dis. 2017 Dec 29;11(12):e0006157. doi: 10.1371/journal.pntd.0006157. eCollection 2017 Dec.


KHARON Is an Essential Cytoskeletal Protein Involved in the Trafficking of Flagellar Membrane Proteins and Cell Division in African Trypanosomes.

Sanchez MA, Tran KD, Valli J, Hobbs S, Johnson E, Gluenz E, Landfear SM.

J Biol Chem. 2016 Sep 16;291(38):19760-73. doi: 10.1074/jbc.M116.739235. Epub 2016 Aug 3.


Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs.

Ortiz D, Forquer I, Boitz J, Soysa R, Elya C, Fulwiler A, Nilsen A, Polley T, Riscoe MK, Ullman B, Landfear SM.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4972-82. doi: 10.1128/AAC.00850-16. Print 2016 Aug.


Flagellar membrane proteins in kinetoplastid parasites.

Landfear SM, Tran KD, Sanchez MA.

IUBMB Life. 2015 Sep;67(9):668-76. doi: 10.1002/iub.1411. Epub 2015 Aug 25. Review.


Coxiella burnetii and Leishmania mexicana residing within similar parasitophorous vacuoles elicit disparate host responses.

Millar JA, Valdés R, Kacharia FR, Landfear SM, Cambronne ED, Raghavan R.

Front Microbiol. 2015 Aug 7;6:794. doi: 10.3389/fmicb.2015.00794. eCollection 2015.


Kharon1 null mutants of Leishmania mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages.

Tran KD, Vieira DP, Sanchez MA, Valli J, Gluenz E, Landfear SM.

PLoS One. 2015 Aug 12;10(8):e0134432. doi: 10.1371/journal.pone.0134432. eCollection 2015.


Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds.

Ortiz D, Guiguemde WA, Johnson A, Elya C, Anderson J, Clark J, Connelly M, Yang L, Min J, Sato Y, Guy RK, Landfear SM.

PLoS One. 2015 Apr 20;10(4):e0123598. doi: 10.1371/journal.pone.0123598. eCollection 2015.


Transporters, channels and receptors in flagella.

Rodriguez-Contreras D, Landfear SM.

Channels (Austin). 2014;8(6):477-8. doi: 10.4161/19336950.2014.985481. No abstract available.


Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: a potential glucose sensor.

Rodriguez-Contreras D, Aslan H, Feng X, Tran K, Yates PA, Kamhawi S, Landfear SM.

FASEB J. 2015 Jan;29(1):11-24. doi: 10.1096/fj.14-251991. Epub 2014 Oct 9.


Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family.

Valdés R, Elferich J, Shinde U, Landfear SM.

J Biol Chem. 2014 Mar 28;289(13):8799-809. doi: 10.1074/jbc.M113.546960. Epub 2014 Feb 4.


KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes.

Tran KD, Rodriguez-Contreras D, Vieira DP, Yates PA, David L, Beatty W, Elferich J, Landfear SM.

J Biol Chem. 2013 Aug 2;288(31):22721-33. doi: 10.1074/jbc.M113.483461. Epub 2013 Jun 13.


'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana.

Feng X, Rodriguez-Contreras D, Polley T, Lye LF, Scott D, Burchmore RJ, Beverley SM, Landfear SM.

Mol Microbiol. 2013 Jan;87(2):412-29. doi: 10.1111/mmi.12106. Epub 2012 Dec 10.


Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1).

Valdés R, Shinde U, Landfear SM.

J Biol Chem. 2012 Dec 28;287(53):44036-45. doi: 10.1074/jbc.M112.414433. Epub 2012 Nov 13.


Both sequence and context are important for flagellar targeting of a glucose transporter.

Tran KD, Rodriguez-Contreras D, Shinde U, Landfear SM.

J Cell Sci. 2012 Jul 15;125(Pt 14):3293-8. doi: 10.1242/jcs.103028. Epub 2012 Mar 30.


Nutrient transport and pathogenesis in selected parasitic protozoa.

Landfear SM.

Eukaryot Cell. 2011 Apr;10(4):483-93. doi: 10.1128/EC.00287-10. Epub 2011 Jan 7. Review.


Adaptive responses to purine starvation in Leishmania donovani.

Carter NS, Yates PA, Gessford SK, Galagan SR, Landfear SM, Ullman B.

Mol Microbiol. 2010 Oct;78(1):92-107. doi: 10.1111/j.1365-2958.2010.07327.x.


Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes.

Feng X, Feistel T, Buffalo C, McCormack A, Kruvand E, Rodriguez-Contreras D, Akopyants NS, Umasankar PK, David L, Jardim A, Beverley SM, Landfear SM.

Mol Biochem Parasitol. 2011 Jan;175(1):39-48. doi: 10.1016/j.molbiopara.2010.08.008. Epub 2010 Sep 24.


Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major.

Ortiz D, Valdés R, Sanchez MA, Hayenga J, Elya C, Detke S, Landfear SM.

Mol Microbiol. 2010 Oct;78(1):108-18. doi: 10.1111/j.1365-2958.2010.07328.x. Epub 2010 Aug 2.


Glucose transporters in parasitic protozoa.

Landfear SM.

Methods Mol Biol. 2010;637:245-62. doi: 10.1007/978-1-60761-700-6_13.


Arsenic transport by zebrafish aquaglyceroporins.

Hamdi M, Sanchez MA, Beene LC, Liu Q, Landfear SM, Rosen BP, Liu Z.

BMC Mol Biol. 2009 Nov 25;10:104. doi: 10.1186/1471-2199-10-104.


Transporters for drug delivery and as drug targets in parasitic protozoa.

Landfear SM.

Clin Pharmacol Ther. 2010 Jan;87(1):122-5. doi: 10.1038/clpt.2009.116. Epub 2009 Jul 1. Review.


An ab Initio structural model of a nucleoside permease predicts functionally important residues.

Valdés R, Arastu-Kapur S, Landfear SM, Shinde U.

J Biol Chem. 2009 Jul 10;284(28):19067-76. doi: 10.1074/jbc.M109.017947. Epub 2009 May 8.


An acid-activated nucleobase transporter from Leishmania major.

Ortiz D, Sanchez MA, Koch HP, Larsson HP, Landfear SM.

J Biol Chem. 2009 Jun 12;284(24):16164-9. doi: 10.1074/jbc.M109.006718. Epub 2009 Apr 14.


Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana.

Feng X, Rodriguez-Contreras D, Buffalo C, Bouwer HG, Kruvand E, Beverley SM, Landfear SM.

Mol Microbiol. 2009 Jan;71(2):369-81. doi: 10.1111/j.1365-2958.2008.06531.x. Epub 2008 Nov 10.


Two novel nucleobase/pentamidine transporters from Trypanosoma brucei.

Ortiz D, Sanchez MA, Quecke P, Landfear SM.

Mol Biochem Parasitol. 2009 Feb;163(2):67-76. doi: 10.1016/j.molbiopara.2008.09.011. Epub 2008 Oct 17.


An expression system to screen for inhibitors of parasite glucose transporters.

Feistel T, Hodson CA, Peyton DH, Landfear SM.

Mol Biochem Parasitol. 2008 Nov;162(1):71-6. doi: 10.1016/j.molbiopara.2008.07.005. Epub 2008 Jul 30.


Drugs and transporters in kinetoplastid protozoa.

Landfear SM.

Adv Exp Med Biol. 2008;625:22-32. Review.


Down-regulation of the trypanosomatid signal recognition particle affects the biogenesis of polytopic membrane proteins but not of signal peptide-containing proteins.

Lustig Y, Vagima Y, Goldshmidt H, Erlanger A, Ozeri V, Vince J, McConville MJ, Dwyer DM, Landfear SM, Michaeli S.

Eukaryot Cell. 2007 Oct;6(10):1865-75. Epub 2007 Aug 22.


Molecular genetic analysis of purine nucleobase transport in Leishmania major.

Ortiz D, Sanchez MA, Pierce S, Herrmann T, Kimblin N, Archie Bouwer HG, Landfear SM.

Mol Microbiol. 2007 Jun;64(5):1228-43.


Phenotypic characterization of a glucose transporter null mutant in Leishmania mexicana.

Rodriguez-Contreras D, Feng X, Keeney KM, Bouwer HG, Landfear SM.

Mol Biochem Parasitol. 2007 May;153(1):9-18. Epub 2007 Jan 18.


Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid.

Liu Z, Sanchez MA, Jiang X, Boles E, Landfear SM, Rosen BP.

Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30. Epub 2006 Oct 17.


Comprehensive examination of charged intramembrane residues in a nucleoside transporter.

Valdés R, Liu W, Ullman B, Landfear SM.

J Biol Chem. 2006 Aug 11;281(32):22647-55. Epub 2006 Jun 12.


Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence.

Rodríguez-Contreras D, Landfear SM.

J Biol Chem. 2006 Jul 21;281(29):20068-76. Epub 2006 May 17.


Cell biology: when the tail wags the dog.

Landfear SM.

Nature. 2006 Mar 9;440(7081):153-4. No abstract available.


A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle.

Sanchez MA, Drutman S, van Ampting M, Matthews K, Landfear SM.

Mol Biochem Parasitol. 2004 Aug;136(2):265-72.


Sequences required for the flagellar targeting of an integral membrane protein.

Nasser MI, Landfear SM.

Mol Biochem Parasitol. 2004 May;135(1):89-100.


Nucleoside and nucleobase transporters in parasitic protozoa.

Landfear SM, Ullman B, Carter NS, Sanchez MA.

Eukaryot Cell. 2004 Apr;3(2):245-54. Review. No abstract available.


Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major.

Sanchez MA, Tryon R, Pierce S, Vasudevan G, Landfear SM.

Mol Membr Biol. 2004 Jan-Feb;21(1):11-8.


The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library.

Drew ME, Morris JC, Wang Z, Wells L, Sanchez M, Landfear SM, Englund PT.

J Biol Chem. 2003 Nov 21;278(47):46596-600. Epub 2003 Sep 12.


Molecular and functional characterization of the first nucleobase transporter gene from African trypanosomes.

Henriques C, Sanchez MA, Tryon R, Landfear SM.

Mol Biochem Parasitol. 2003 Aug 31;130(2):101-10.


Equilibrative nucleoside transporter family members from Leishmania donovani are electrogenic proton symporters.

Stein A, Vaseduvan G, Carter NS, Ullman B, Landfear SM, Kavanaugh MP.

J Biol Chem. 2003 Sep 12;278(37):35127-34. Epub 2003 Jun 30.


Genetic characterization of glucose transporter function in Leishmania mexicana.

Burchmore RJ, Rodriguez-Contreras D, McBride K, Merkel P, Barrett MP, Modi G, Sacks D, Landfear SM.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3901-6. Epub 2003 Mar 21. Erratum in: Proc Natl Acad Sci U S A. 2003 May 13;100(10):6287.


Trypanosomatid transcription factors: waiting for Godot.

Landfear SM.

Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):7-9. Epub 2002 Dec 30. No abstract available.


Six related nucleoside/nucleobase transporters from Trypanosoma brucei exhibit distinct biochemical functions.

Sanchez MA, Tryon R, Green J, Boor I, Landfear SM.

J Biol Chem. 2002 Jun 14;277(24):21499-504. Epub 2002 Apr 5.

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