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Items: 1 to 50 of 58

1.

A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality.

Herzik MA Jr, Fraser JS, Lander GC.

Structure. 2018 Oct 25. pii: S0969-2126(18)30364-2. doi: 10.1016/j.str.2018.10.003. [Epub ahead of print]

PMID:
30449687
2.

Conformational ensemble of the human TRPV3 ion channel.

Zubcevic L, Herzik MA Jr, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY.

Nat Commun. 2018 Nov 14;9(1):4773. doi: 10.1038/s41467-018-07117-w.

3.

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.

de la Peña AH, Goodall EA, Gates SN, Lander GC, Martin A.

Science. 2018 Nov 30;362(6418). pii: eaav0725. doi: 10.1126/science.aav0725. Epub 2018 Oct 11.

PMID:
30309908
4.

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.

Chowdhury S, Otomo C, Leitner A, Ohashi K, Aebersold R, Lander GC, Otomo T.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9792-E9801. doi: 10.1073/pnas.1811874115. Epub 2018 Sep 5.

PMID:
30185561
5.

Cryo-EM structure of a mitochondrial calcium uniporter.

Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY.

Science. 2018 Aug 3;361(6401):506-511. doi: 10.1126/science.aar4056. Epub 2018 Jun 28.

PMID:
29954988
6.

Exploring applications of crowdsourcing to cryo-EM.

Bruggemann J, Lander GC, Su AI.

J Struct Biol. 2018 Jul;203(1):37-45. doi: 10.1016/j.jsb.2018.02.006. Epub 2018 Feb 24.

7.

Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.

Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC.

Nat Struct Mol Biol. 2018 Apr;25(4):355. doi: 10.1038/s41594-018-0043-7.

PMID:
29476122
8.

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.

Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC.

Nat Struct Mol Biol. 2018 Mar;25(3):203-207. doi: 10.1038/s41594-018-0027-7. Epub 2018 Feb 7. Erratum in: Nat Struct Mol Biol. 2018 Feb 23;:.

9.

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.

Gardner BM, Castanzo DT, Chowdhury S, Stjepanovic G, Stefely MS, Hurley JH, Lander GC, Martin A.

Nat Commun. 2018 Jan 10;9(1):135. doi: 10.1038/s41467-017-02474-4.

10.

Structure of the cold- and menthol-sensing ion channel TRPM8.

Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY.

Science. 2018 Jan 12;359(6372):237-241. doi: 10.1126/science.aan4325. Epub 2017 Dec 7.

11.

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC.

Science. 2017 Nov 3;358(6363). pii: eaao0464. doi: 10.1126/science.aao0464.

12.

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.

Hirschi M, Herzik MA Jr, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY.

Nature. 2017 Oct 19;550(7676):411-414. doi: 10.1038/nature24055. Epub 2017 Oct 11.

13.

Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV.

Herzik MA Jr, Wu M, Lander GC.

Nat Methods. 2017 Nov;14(11):1075-1078. doi: 10.1038/nmeth.4461. Epub 2017 Oct 9.

14.

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL.

EMBO J. 2017 Aug 1;36(15):2296-2309. doi: 10.15252/embj.201695616. Epub 2017 Jun 27.

15.

Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity.

Rollins MF, Chowdhury S, Carter J, Golden SM, Wilkinson RA, Bondy-Denomy J, Lander GC, Wiedenheft B.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5113-E5121. doi: 10.1073/pnas.1616395114. Epub 2017 Apr 24.

16.

Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.

Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B.

Cell. 2017 Mar 23;169(1):47-57.e11. doi: 10.1016/j.cell.2017.03.012.

17.

What's the Key to Unlocking the Proteasome's Gate?

de la Peña AH, Lander GC.

Structure. 2016 Dec 6;24(12):2037-2038. doi: 10.1016/j.str.2016.11.011.

18.

Isolation of yeast complex IV in native lipid nanodiscs.

Smirnova IA, Sjöstrand D, Li F, Björck M, Schäfer J, Östbye H, Högbom M, von Ballmoos C, Lander GC, Ädelroth P, Brzezinski P.

Biochim Biophys Acta. 2016 Dec;1858(12):2984-2992. doi: 10.1016/j.bbamem.2016.09.004. Epub 2016 Sep 13.

19.

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.

Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP.

Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611. Epub 2016 Jun 22.

PMID:
27338790
20.

Cryo-electron microscopy structure of the TRPV2 ion channel.

Zubcevic L, Herzik MA Jr, Chung BC, Liu Z, Lander GC, Lee SY.

Nat Struct Mol Biol. 2016 Feb;23(2):180-186. doi: 10.1038/nsmb.3159. Epub 2016 Jan 18.

21.

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.

Dambacher CM, Worden EJ, Herzik MA, Martin A, Lander GC.

Elife. 2016 Jan 8;5:e13027. doi: 10.7554/eLife.13027.

22.

Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex.

Yang TC, Ortiz D, Nosaka L, Lander GC, Catalano CE.

Biophys J. 2015 Oct 20;109(8):1663-75. doi: 10.1016/j.bpj.2015.08.037.

23.

Protein domain mapping by internal labeling and single particle electron microscopy.

Ciferri C, Lander GC, Nogales E.

J Struct Biol. 2015 Nov;192(2):159-62. doi: 10.1016/j.jsb.2015.09.016. Epub 2015 Sep 30.

24.

Site-specific labeling of proteins for electron microscopy.

Dambacher CM, Lander GC.

J Struct Biol. 2015 Nov;192(2):151-8. doi: 10.1016/j.jsb.2015.09.010. Epub 2015 Sep 25.

25.

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.

Bashore C, Dambacher CM, Goodall EA, Matyskiela ME, Lander GC, Martin A.

Nat Struct Mol Biol. 2015 Sep;22(9):712-9. doi: 10.1038/nsmb.3075. Epub 2015 Aug 24.

26.

Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

McNulty R, Lokareddy RK, Roy A, Yang Y, Lander GC, Heck AJR, Johnson JE, Cingolani G.

J Mol Biol. 2015 Oct 9;427(20):3285-3299. doi: 10.1016/j.jmb.2015.08.013. Epub 2015 Aug 21.

27.

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.

Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A.

Cell. 2015 May 21;161(5):1112-1123. doi: 10.1016/j.cell.2015.04.003. Epub 2015 May 7.

28.

Structural organization of the dynein-dynactin complex bound to microtubules.

Chowdhury S, Ketcham SA, Schroer TA, Lander GC.

Nat Struct Mol Biol. 2015 Apr;22(4):345-7. doi: 10.1038/nsmb.2996. Epub 2015 Mar 9.

29.

The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.

Gardner BM, Chowdhury S, Lander GC, Martin A.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1375-1388. doi: 10.1016/j.jmb.2015.01.019. Epub 2015 Feb 7.

30.

Solid-to-fluid-like DNA transition in viruses facilitates infection.

Liu T, Sae-Ueng U, Li D, Lander GC, Zuo X, Jönsson B, Rau D, Shefer I, Evilevitch A.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14675-80. doi: 10.1073/pnas.1321637111. Epub 2014 Sep 30. Erratum in: Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2410.

31.

High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis.

Alushin GM, Lander GC, Kellogg EH, Zhang R, Baker D, Nogales E.

Cell. 2014 May 22;157(5):1117-29. doi: 10.1016/j.cell.2014.03.053.

32.

Conformational switching of the 26S proteasome enables substrate degradation.

Matyskiela ME, Lander GC, Martin A.

Nat Struct Mol Biol. 2013 Jul;20(7):781-8. doi: 10.1038/nsmb.2616. Epub 2013 Jun 16.

33.

The proteasome under the microscope: the regulatory particle in focus.

Lander GC, Martin A, Nogales E.

Curr Opin Struct Biol. 2013 Apr;23(2):243-51. doi: 10.1016/j.sbi.2013.02.004. Epub 2013 Mar 13. Review.

34.

DNA bending-induced phase transition of encapsidated genome in phage λ.

Lander GC, Johnson JE, Rau DC, Potter CS, Carragher B, Evilevitch A.

Nucleic Acids Res. 2013 Apr;41(8):4518-24. doi: 10.1093/nar/gkt137. Epub 2013 Feb 28.

35.

Molecular architecture of human polycomb repressive complex 2.

Ciferri C, Lander GC, Maiolica A, Herzog F, Aebersold R, Nogales E.

Elife. 2012 Oct 30;1:e00005. doi: 10.7554/eLife.00005.

36.

Go hybrid: EM, crystallography, and beyond.

Lander GC, Saibil HR, Nogales E.

Curr Opin Struct Biol. 2012 Oct;22(5):627-35. doi: 10.1016/j.sbi.2012.07.006. Epub 2012 Jul 24. Review.

37.

Small terminase couples viral DNA binding to genome-packaging ATPase activity.

Roy A, Bhardwaj A, Datta P, Lander GC, Cingolani G.

Structure. 2012 Aug 8;20(8):1403-13. doi: 10.1016/j.str.2012.05.014. Epub 2012 Jul 5.

38.

Capsomer dynamics and stabilization in the T = 12 marine bacteriophage SIO-2 and its procapsid studied by CryoEM.

Lander GC, Baudoux AC, Azam F, Potter CS, Carragher B, Johnson JE.

Structure. 2012 Mar 7;20(3):498-503. doi: 10.1016/j.str.2012.01.007.

39.

Complete subunit architecture of the proteasome regulatory particle.

Lander GC, Estrin E, Matyskiela ME, Bashore C, Nogales E, Martin A.

Nature. 2012 Jan 11;482(7384):186-91. doi: 10.1038/nature10774.

40.

Genomic and functional analysis of Vibrio phage SIO-2 reveals novel insights into ecology and evolution of marine siphoviruses.

Baudoux AC, Hendrix RW, Lander GC, Bailly X, Podell S, Paillard C, Johnson JE, Potter CS, Carragher B, Azam F.

Environ Microbiol. 2012 Aug;14(8):2071-86. doi: 10.1111/j.1462-2920.2011.02685.x. Epub 2012 Jan 9.

41.

Structures of the RNA-guided surveillance complex from a bacterial immune system.

Wiedenheft B, Lander GC, Zhou K, Jore MM, Brouns SJJ, van der Oost J, Doudna JA, Nogales E.

Nature. 2011 Sep 21;477(7365):486-489. doi: 10.1038/nature10402.

42.

Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22.

Tang J, Lander GC, Olia AS, Li R, Casjens S, Prevelige P Jr, Cingolani G, Baker TS, Johnson JE.

Structure. 2011 Apr 13;19(4):496-502. doi: 10.1016/j.str.2011.02.010. Erratum in: Structure. 2011 May 11;19(5):748. Olia, Adam [corrected to Olia, Adam S].

43.

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex.

Hornung P, Maier M, Alushin GM, Lander GC, Nogales E, Westermann S.

J Mol Biol. 2011 Jan 14;405(2):548-59. doi: 10.1016/j.jmb.2010.11.012. Epub 2010 Nov 12.

44.

Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus.

Matsui T, Lander GC, Khayat R, Johnson JE.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14111-5. doi: 10.1073/pnas.1004221107. Epub 2010 Jul 26.

45.

An automated procedure for detecting protein folds from sub-nanometer resolution electron density.

Khayat R, Lander GC, Johnson JE.

J Struct Biol. 2010 Jun;170(3):513-21. doi: 10.1016/j.jsb.2009.12.014. Epub 2009 Dec 22.

46.

A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy.

Voss NR, Lyumkis D, Cheng A, Lau PW, Mulder A, Lander GC, Brignole EJ, Fellmann D, Irving C, Jacovetty EL, Leung A, Pulokas J, Quispe JD, Winkler H, Yoshioka C, Carragher B, Potter CS.

J Struct Biol. 2010 Mar;169(3):389-98. doi: 10.1016/j.jsb.2009.12.005. Epub 2009 Dec 16.

47.

The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit.

Lander GC, Khayat R, Li R, Prevelige PE, Potter CS, Carragher B, Johnson JE.

Structure. 2009 Jun 10;17(6):789-99. doi: 10.1016/j.str.2009.04.006.

48.

Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase.

Ambrose RL, Lander GC, Maaty WS, Bothner B, Johnson JE, Johnson KN.

J Gen Virol. 2009 Sep;90(Pt 9):2191-200. doi: 10.1099/vir.0.012104-0. Epub 2009 May 27.

50.

Appion: an integrated, database-driven pipeline to facilitate EM image processing.

Lander GC, Stagg SM, Voss NR, Cheng A, Fellmann D, Pulokas J, Yoshioka C, Irving C, Mulder A, Lau PW, Lyumkis D, Potter CS, Carragher B.

J Struct Biol. 2009 Apr;166(1):95-102.

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