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Items: 1 to 50 of 128

1.

The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome.

Newkirk DA, Chen YY, Chien R, Zeng W, Biesinger J, Flowers E, Kawauchi S, Santos R, Calof AL, Lander AD, Xie X, Yokomori K.

Clin Epigenetics. 2017 Aug 25;9:89. doi: 10.1186/s13148-017-0391-x. eCollection 2017.

2.

Expanding signaling-molecule wavefront model of cell polarization in the Drosophila wing primordium.

Wortman JC, Nahmad M, Zhang PC, Lander AD, Yu CC.

PLoS Comput Biol. 2017 Jul 3;13(7):e1005610. doi: 10.1371/journal.pcbi.1005610. eCollection 2017 Jul.

3.

Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro.

Hsia K, Yang MJ, Chen WM, Yao CL, Lin CH, Loong CC, Huang YL, Lin YT, Lander AD, Lee H, Lu JH.

Acta Biomater. 2017 Mar 15;51:341-350. doi: 10.1016/j.actbio.2017.01.050. Epub 2017 Jan 18.

PMID:
28110073
4.

Characterization of the upper pouch tracheo-oesophageal fistula in oesophageal atresia.

Summerour V, Stevens PS, Lander AD, Singh M, Soccorso G, Arul GS.

J Pediatr Surg. 2017 Feb;52(2):231-234. doi: 10.1016/j.jpedsurg.2016.11.009. Epub 2016 Nov 13.

PMID:
27939205
5.

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.

Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL.

PLoS Biol. 2016 Sep 8;14(9):e2000197. doi: 10.1371/journal.pbio.2000197. eCollection 2016 Sep.

6.

Survival of the Curviest: Noise-Driven Selection for Synergistic Epistasis.

Wilkins JF, McHale PT, Gervin J, Lander AD.

PLoS Genet. 2016 Apr 28;12(4):e1006003. doi: 10.1371/journal.pgen.1006003. eCollection 2016 Apr.

7.

Genetic enhancement of limb defects in a mouse model of Cornelia de Lange syndrome.

Lopez-Burks ME, Santos R, Kawauchi S, Calof AL, Lander AD.

Am J Med Genet C Semin Med Genet. 2016 Jun;172(2):146-54. doi: 10.1002/ajmg.c.31491. Epub 2016 Apr 27.

8.

Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange Syndrome.

Kawauchi S, Santos R, Muto A, Lopez-Burks ME, Schilling TF, Lander AD, Calof AL.

Am J Med Genet C Semin Med Genet. 2016 Jun;172(2):138-45. doi: 10.1002/ajmg.c.31484. Epub 2016 Apr 27. Review.

9.

Feedback, Lineages and Self-Organizing Morphogenesis.

Kunche S, Yan H, Calof AL, Lowengrub JS, Lander AD.

PLoS Comput Biol. 2016 Mar 18;12(3):e1004814. doi: 10.1371/journal.pcbi.1004814. eCollection 2016 Mar.

10.

Clinical, developmental and molecular update on Cornelia de Lange syndrome and the cohesin complex: abstracts from the 2014 Scientific and Educational Symposium.

Kline AD, Calof AL, Lander AD, Gerton JL, Krantz ID, Dorsett D, Deardorff MA, Blagowidow N, Yokomori K, Shirahige K, Santos R, Woodman J, Megee PC, O'Connor JT, Egense A, Noon S, Belote M, Goodban MT, Hansen BD, Timmons JG, Musio A, Ishman SL, Bryan Y, Wu Y, Bettini LR, Mehta D, Zakari M, Mills JA, Srivastava S, Haaland RE.

Am J Med Genet A. 2015 Jun;167(6):1179-92. doi: 10.1002/ajmg.a.37056. Epub 2015 Apr 21.

PMID:
25899772
11.

Organ-level quorum sensing directs regeneration in hair stem cell populations.

Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S, Widelitz RB, Lander AD, Chuong CM.

Cell. 2015 Apr 9;161(2):277-90. doi: 10.1016/j.cell.2015.02.016.

12.

Cell lineage branching as a strategy for proliferative control.

Buzi G, Lander AD, Khammash M.

BMC Biol. 2015 Feb 19;13:13. doi: 10.1186/s12915-015-0122-8.

13.

Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms.

Lo WC, Zhou S, Wan FY, Lander AD, Nie Q.

J R Soc Interface. 2015 Jan 6;12(102):20141041.

14.

Nipbl and mediator cooperatively regulate gene expression to control limb development.

Muto A, Ikeda S, Lopez-Burks ME, Kikuchi Y, Calof AL, Lander AD, Schilling TF.

PLoS Genet. 2014 Sep 25;10(9):e1004671. doi: 10.1371/journal.pgen.1004671. eCollection 2014 Sep.

15.

Making sense in biology: an appreciation of Julian Lewis.

Lander AD.

BMC Biol. 2014 Aug 2;12:57. doi: 10.1186/s12915-014-0057-5. No abstract available.

16.

The protective role of symmetric stem cell division on the accumulation of heritable damage.

McHale PT, Lander AD.

PLoS Comput Biol. 2014 Aug 14;10(8):e1003802. doi: 10.1371/journal.pcbi.1003802. eCollection 2014 Aug.

17.

Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control.

Konstorum A, Sprowl SA, Waterman ML, Lander AD, Lowengrub JS.

J Coupled Syst Multiscale Dyn. 2013 Dec 1;1(4):459-467.

18.

A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain.

Srinivasan S, Hu JS, Currle DS, Fung ES, Hayes WB, Lander AD, Monuki ES.

PLoS Comput Biol. 2014 Feb 13;10(2):e1003463. doi: 10.1371/journal.pcbi.1003463. eCollection 2014 Feb.

19.

Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I.

Visnes T, Giordano F, Kuznetsova A, Suja JA, Lander AD, Calof AL, Ström L.

Chromosoma. 2014 Jun;123(3):239-52. doi: 10.1007/s00412-013-0444-7. Epub 2013 Nov 28.

20.

Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.

Remeseiro S, Cuadrado A, Kawauchi S, Calof AL, Lander AD, Losada A.

Biochim Biophys Acta. 2013 Dec;1832(12):2097-102. doi: 10.1016/j.bbadis.2013.07.020. Epub 2013 Aug 3.

21.

How cells know where they are.

Lander AD.

Science. 2013 Feb 22;339(6122):923-7. doi: 10.1126/science.1224186. Review.

22.

Dynamics and precision in retinoic acid morphogen gradients.

Schilling TF, Nie Q, Lander AD.

Curr Opin Genet Dev. 2012 Dec;22(6):562-9. doi: 10.1016/j.gde.2012.11.012. Epub 2012 Dec 19. Review.

23.

The genetics of alcohol dependence: advancing towards systems-based approaches.

Palmer RH, McGeary JE, Francazio S, Raphael BJ, Lander AD, Heath AC, Knopik VS.

Drug Alcohol Depend. 2012 Oct 1;125(3):179-91. doi: 10.1016/j.drugalcdep.2012.07.005. Epub 2012 Jul 31. Review.

24.
25.

Cellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish.

Cai AQ, Radtke K, Linville A, Lander AD, Nie Q, Schilling TF.

Development. 2012 Jun;139(12):2150-5. doi: 10.1242/dev.077065.

26.

Multispecies model of cell lineages and feedback control in solid tumors.

Youssefpour H, Li X, Lander AD, Lowengrub JS.

J Theor Biol. 2012 Jul 7;304:39-59. doi: 10.1016/j.jtbi.2012.02.030. Epub 2012 Mar 31.

27.

Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster.

Kim MS, Kim JR, Kim D, Lander AD, Cho KH.

BMC Syst Biol. 2012 May 1;6:31. doi: 10.1186/1752-0509-6-31.

28.

Free extracellular diffusion creates the Dpp morphogen gradient of the Drosophila wing disc.

Zhou S, Lo WC, Suhalim JL, Digman MA, Gratton E, Nie Q, Lander AD.

Curr Biol. 2012 Apr 24;22(8):668-75. doi: 10.1016/j.cub.2012.02.065. Epub 2012 Mar 22.

29.

What does the concept of the stem cell niche really mean today?

Lander AD, Kimble J, Clevers H, Fuchs E, Montarras D, Buckingham M, Calof AL, Trumpp A, Oskarsson T.

BMC Biol. 2012 Mar 9;10:19. doi: 10.1186/1741-7007-10-19. No abstract available.

30.

Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome.

Muto A, Calof AL, Lander AD, Schilling TF.

PLoS Biol. 2011 Oct;9(10):e1001181. doi: 10.1371/journal.pbio.1001181. Epub 2011 Oct 25.

31.

Spatiotemporal mechanisms of morphogen gradient interpretation.

Nahmad M, Lander AD.

Curr Opin Genet Dev. 2011 Dec;21(6):726-31. doi: 10.1016/j.gde.2011.10.002. Epub 2011 Oct 25. Review.

32.

Feedback Regulation of Neurogenesis in the Mammalian Olfactory Epithelium: New Insights from Genetics and Systems Biology.

Gokoffski KK, Kawauchi S, Wu HH, Santos R, Hollenbeck PLW, Lander AD, Calof AL.

In: Menini A, editor. The Neurobiology of Olfaction. Boca Raton (FL): CRC Press/Taylor & Francis; 2010. Chapter 10.

33.

Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate.

Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL.

Development. 2011 Oct;138(19):4131-42. doi: 10.1242/dev.065870. Epub 2011 Aug 18.

34.

Size-normalized Robustness of Dpp Gradient in Drosophila Wing Imaginal Disc.

Lander AD, Nie Q, Vargas B, Wan FY.

J Mech Mater Struct. 2011 Jan 1;6(1-4):321-350.

35.

The individuality of stem cells.

Lander AD.

BMC Biol. 2011 Jun 7;9:40. doi: 10.1186/1741-7007-9-40. No abstract available.

36.

ROBUSTNESS OF SIGNALING GRADIENT IN DROSOPHILA WING IMAGINAL DISC.

Lei J, Wan FY, Lander AD, Nie Q.

Discrete Continuous Dyn Syst Ser B. 2011 Jun;16(3):835-866.

37.

Cohesin mediates chromatin interactions that regulate mammalian β-globin expression.

Chien R, Zeng W, Kawauchi S, Bender MA, Santos R, Gregson HC, Schmiesing JA, Newkirk DA, Kong X, Ball AR Jr, Calof AL, Lander AD, Groudine MT, Yokomori K.

J Biol Chem. 2011 May 20;286(20):17870-8. doi: 10.1074/jbc.M110.207365. Epub 2011 Mar 29.

38.

Pattern, growth, and control.

Lander AD.

Cell. 2011 Mar 18;144(6):955-69. doi: 10.1016/j.cell.2011.03.009. Review.

39.

Management of gastroesophageal reflux associated with malrotation in children.

Tiboni SG, Patel Y, Lander AD, Parikh DH, Jawaheer G, Arul GS.

J Pediatr Surg. 2011 Feb;46(2):289-91. doi: 10.1016/j.jpedsurg.2010.11.005.

PMID:
21292075
40.

Multispectral fluorescence imaging to assess pH in biological specimens.

Hight MR, Nolting DD, McKinley ET, Lander AD, Wyatt SK, Gonyea M, Zhao P, Manning HC.

J Biomed Opt. 2011 Jan-Feb;16(1):016007. doi: 10.1117/1.3533264.

41.

Spatial dynamics of multistage cell lineages in tissue stratification.

Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q.

Biophys J. 2010 Nov 17;99(10):3145-54. doi: 10.1016/j.bpj.2010.09.034.

42.

Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization.

Kuo WJ, Digman MA, Lander AD.

Mol Biol Cell. 2010 Nov 15;21(22):4028-41. doi: 10.1091/mbc.E10-04-0348. Epub 2010 Sep 22.

43.

The edges of understanding.

Lander AD.

BMC Biol. 2010 Apr 12;8:40. doi: 10.1186/1741-7007-8-40.

44.

Localized Ectopic Expression of Dpp Receptors in a Drosophila Embryo.

Lander AD, Nie Q, Wan FY, Zhang YT.

Stud Appl Math. 2009 Aug 1;123(2):175-214.

45.

The measure of success: constraints, objectives, and tradeoffs in morphogen-mediated patterning.

Lander AD, Lo WC, Nie Q, Wan FY.

Cold Spring Harb Perspect Biol. 2009 Jul;1(1):a002022. doi: 10.1101/cshperspect.a002022. Review.

46.

The 'stem cell' concept: is it holding us back?

Lander AD.

J Biol. 2009 Sep 21;8(8):70. doi: 10.1186/jbiol177.

47.

Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome.

Kawauchi S, Calof AL, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD.

PLoS Genet. 2009 Sep;5(9):e1000650. doi: 10.1371/journal.pgen.1000650. Epub 2009 Sep 18.

48.

Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis.

Jen YH, Musacchio M, Lander AD.

Neural Dev. 2009 Sep 4;4:33. doi: 10.1186/1749-8104-4-33.

49.

Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue.

Beites CL, Hollenbeck PL, Kim J, Lovell-Badge R, Lander AD, Calof AL.

Development. 2009 Jul;136(13):2187-97. doi: 10.1242/dev.030544. Epub 2009 May 27.

50.

Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11.

Kawauchi S, Kim J, Santos R, Wu HH, Lander AD, Calof AL.

Development. 2009 May;136(9):1453-64. doi: 10.1242/dev.034967. Epub 2009 Mar 18.

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