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Items: 1 to 50 of 193

1.

Profiling surface proteins on individual exosomes using a proximity barcoding assay.

Wu D, Yan J, Shen X, Sun Y, Thulin M, Cai Y, Wik L, Shen Q, Oelrich J, Qian X, Dubois KL, Ronquist KG, Nilsson M, Landegren U, Kamali-Moghaddam M.

Nat Commun. 2019 Aug 26;10(1):3854. doi: 10.1038/s41467-019-11486-1.

2.

A compendium on single-cell analysis for the curious.

Gallant CJ, Landegren U.

FEBS J. 2019 Apr;286(8):1442-1444. doi: 10.1111/febs.14820.

PMID:
31012288
3.

Next wave advances in single-cell analyses.

Herr AE, Kitamori T, Landegren U, Kamali-Moghaddam M.

Analyst. 2019 Jan 28;144(3):735-737. doi: 10.1039/c9an90011j. No abstract available.

PMID:
30656308
4.

Protein profiling of fine-needle aspirates reveals subtype-associated immune signatures and involvement of chemokines in breast cancer.

Franzén B, Alexeyenko A, Kamali-Moghaddam M, Hatschek T, Kanter L, Ramqvist T, Kierkegaard J, Masucci G, Auer G, Landegren U, Lewensohn R.

Mol Oncol. 2019 Feb;13(2):376-391. doi: 10.1002/1878-0261.12410. Epub 2019 Jan 7.

5.

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury.

Lindblom RPF, Shen Q, Axén S, Landegren U, Kamali-Moghaddam M, Thelin S.

J Cardiovasc Transl Res. 2018 Dec;11(6):503-516. doi: 10.1007/s12265-018-9835-8. Epub 2018 Oct 26.

6.

A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions.

Franzén B, Kamali-Moghaddam M, Alexeyenko A, Hatschek T, Becker S, Wik L, Kierkegaard J, Eriksson A, Muppani NR, Auer G, Landegren U, Lewensohn R.

Mol Oncol. 2018 Sep;12(9):1415-1428. doi: 10.1002/1878-0261.12350. Epub 2018 Aug 9.

7.

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes.

Klaesson A, Grannas K, Ebai T, Heldin J, Koos B, Leino M, Raykova D, Oelrich J, Arngården L, Söderberg O, Landegren U.

Sci Rep. 2018 Mar 29;8(1):5400. doi: 10.1038/s41598-018-23582-1.

8.

A myopic perspective on the future of protein diagnostics.

Landegren U, Al-Amin RA, Björkesten J.

N Biotechnol. 2018 Oct 25;45:14-18. doi: 10.1016/j.nbt.2018.01.002. Epub 2018 Jan 5. Review.

9.

Strong impact on plasma protein profiles by precentrifugation delay but not by repeated freeze-thaw cycles, as analyzed using multiplex proximity extension assays.

Shen Q, Björkesten J, Galli J, Ekman D, Broberg J, Nordberg N, Tillander A, Kamali-Moghaddam M, Tybring G, Landegren U.

Clin Chem Lab Med. 2018 Mar 28;56(4):582-594. doi: 10.1515/cclm-2017-0648.

PMID:
29040064
10.

In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation.

Zieba A, Ponten F, Uhlén M, Landegren U.

Mod Pathol. 2018 Feb;31(2):253-263. doi: 10.1038/modpathol.2017.102. Epub 2017 Sep 22.

11.

Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays.

Larssen P, Wik L, Czarnewski P, Eldh M, Löf L, Ronquist KG, Dubois L, Freyhult E, Gallant CJ, Oelrich J, Larsson A, Ronquist G, Villablanca EJ, Landegren U, Gabrielsson S, Kamali-Moghaddam M.

Mol Cell Proteomics. 2017 Aug;16(8):1547. doi: 10.1074/mcp.A116.064725. No abstract available.

12.

Detection of Extracellular Vesicles Using Proximity Ligation Assay with Flow Cytometry Readout-ExoPLA.

Löf L, Arngården L, Ebai T, Landegren U, Söderberg O, Kamali-Moghaddam M.

Curr Protoc Cytom. 2017 Jul 5;81:4.8.1-4.8.10. doi: 10.1002/cpcy.22.

PMID:
28678418
13.

Analytically Sensitive Protein Detection in Microtiter Plates by Proximity Ligation with Rolling Circle Amplification.

Ebai T, Souza de Oliveira FM, Löf L, Wik L, Schweiger C, Larsson A, Keilholtz U, Haybaeck J, Landegren U, Kamali-Moghaddam M.

Clin Chem. 2017 Sep;63(9):1497-1505. doi: 10.1373/clinchem.2017.271833. Epub 2017 Jun 30.

14.

Close Encounters - Probing Proximal Proteins in Live or Fixed Cells.

Lönn P, Landegren U.

Trends Biochem Sci. 2017 Jul;42(7):504-515. doi: 10.1016/j.tibs.2017.05.003. Epub 2017 May 28. Review.

PMID:
28566215
15.

Stability of Proteins in Dried Blood Spot Biobanks.

Björkesten J, Enroth S, Shen Q, Wik L, Hougaard DM, Cohen AS, Sörensen L, Giedraitis V, Ingelsson M, Larsson A, Kamali-Moghaddam M, Landegren U.

Mol Cell Proteomics. 2017 Jul;16(7):1286-1296. doi: 10.1074/mcp.RA117.000015. Epub 2017 May 13.

16.

Highly sensitive and specific protein detection via combined capillary isoelectric focusing and proximity ligation.

Padhan N, Yan J, Boge A, Scrivener E, Birgisson H, Zieba A, Gullberg M, Kamali-Moghaddam M, Claesson-Welsh L, Landegren U.

Sci Rep. 2017 May 4;7(1):1490. doi: 10.1038/s41598-017-01516-7.

17.

Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia.

Löf L, Arngården L, Olsson-Strömberg U, Siart B, Jansson M, Dahlin JS, Thörn I, Christiansson L, Hermansson M, Larsson A, Ahlstrand E, Wålinder G, Söderberg O, Rosenquist R, Landegren U, Kamali-Moghaddam M.

Sci Rep. 2017 Apr 4;7(1):623. doi: 10.1038/s41598-017-00755-y.

18.

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML.

Nat Commun. 2017 Feb 10;8:14262. doi: 10.1038/ncomms14262.

19.

Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays.

Larssen P, Wik L, Czarnewski P, Eldh M, Löf L, Ronquist KG, Dubois L, Freyhult E, Gallant CJ, Oelrich J, Larsson A, Ronquist G, Villablanca EJ, Landegren U, Gabrielsson S, Kamali-Moghaddam M.

Mol Cell Proteomics. 2017 Mar;16(3):502-511. doi: 10.1074/mcp.M116.064725. Epub 2017 Jan 22. Erratum in: Mol Cell Proteomics. 2017 Aug;16(8):1547.

20.

Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout.

Löf L, Ebai T, Dubois L, Wik L, Ronquist KG, Nolander O, Lundin E, Söderberg O, Landegren U, Kamali-Moghaddam M.

Sci Rep. 2016 Sep 29;6:34358. doi: 10.1038/srep34358.

21.

Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction.

Genshaft AS, Li S, Gallant CJ, Darmanis S, Prakadan SM, Ziegler CG, Lundberg M, Fredriksson S, Hong J, Regev A, Livak KJ, Landegren U, Shalek AK.

Genome Biol. 2016 Sep 19;17(1):188. doi: 10.1186/s13059-016-1045-6.

22.

Detection of Biomarkers with Solid-Phase Proximity Ligation Assay in Patients with Colorectal Cancer.

Ghanipour L, Darmanis S, Landegren U, Glimelius B, Påhlman L, Birgisson H.

Transl Oncol. 2016 Jun;9(3):251-5. doi: 10.1016/j.tranon.2016.04.001.

23.

Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay.

Blokzijl A, Chen LE, Gustafsdottir SM, Vuu J, Ullenhag G, Kämpe O, Landegren U, Kamali-Moghaddam M, Hedstrand H.

PLoS One. 2016 Apr 25;11(4):e0154214. doi: 10.1371/journal.pone.0154214. eCollection 2016.

24.

Single Chain Antibodies as Tools to Study transforming growth factor-β-Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens.

Blokzijl A, Zieba A, Hust M, Schirrmann T, Helmsing S, Grannas K, Hertz E, Moren A, Chen L, Söderberg O, Moustakas A, Dübel S, Landegren U.

Mol Cell Proteomics. 2016 Jun;15(6):1848-56. doi: 10.1074/mcp.M115.055756. Epub 2016 Feb 29.

25.

A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients.

Lind AL, Wu D, Freyhult E, Bodolea C, Ekegren T, Larsson A, Gustafsson MG, Katila L, Bergquist J, Gordh T, Landegren U, Kamali-Moghaddam M.

PLoS One. 2016 Feb 25;11(2):e0149821. doi: 10.1371/journal.pone.0149821. eCollection 2016.

26.

Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells.

Darmanis S, Gallant CJ, Marinescu VD, Niklasson M, Segerman A, Flamourakis G, Fredriksson S, Assarsson E, Lundberg M, Nelander S, Westermark B, Landegren U.

Cell Rep. 2016 Jan 12;14(2):380-9. doi: 10.1016/j.celrep.2015.12.021. Epub 2015 Dec 31.

27.

AFFINOMICS and the prospects for large-scale protein analyses.

Landegren U.

N Biotechnol. 2016 Sep 25;33(5 Pt A):491-3. doi: 10.1016/j.nbt.2015.09.006. Epub 2015 Oct 9. No abstract available.

PMID:
26455639
28.

Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.

Gu Urban GJ, Friedman M, Ren P, Törn C, Fex M, Hampe CS, Lernmark Å, Landegren U, Kamali-Moghaddam M.

Sci Rep. 2015 Jun 16;5:11196. doi: 10.1038/srep11196.

29.

Corrigendum: solid-phase proximity ligation assays for individual or parallel protein analyses with readout via real-time PCR or sequencing.

Nong RY, Wu D, Yan J, Hammond M, Gu GJ, Kamali-Moghaddam M, Landegren U, Darmanis S.

Nat Protoc. 2015 Apr;10(4):643. doi: 10.1038/nprot0415-644b. Epub 2015 Mar 26. No abstract available.

PMID:
25811899
30.

CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation.

Kourti M, Ikonomou G, Giakoumakis NN, Rapsomaniki MA, Landegren U, Siniossoglou S, Lygerou Z, Simos G, Mylonis I.

Cell Signal. 2015 Jun;27(6):1129-40. doi: 10.1016/j.cellsig.2015.02.017. Epub 2015 Mar 3.

31.

Parallel protein detection by solid-phase proximity ligation assay with real-time PCR or sequencing.

Ebai T, Kamali-Moghaddam M, Landegren U.

Curr Protoc Mol Biol. 2015 Jan 5;109:20.10.1-25. doi: 10.1002/0471142727.mb2010s109.

PMID:
25559104
32.

Sensitive detection of aggregated prion protein via proximity ligation.

Hammond M, Wik L, Deslys JP, Comoy E, Linné T, Landegren U, Kamali-Moghaddam M.

Prion. 2014;8(3):261-5. doi: 10.4161/pri.32231.

33.

BBMRI-ERIC as a resource for pharmaceutical and life science industries: the development of biobank-based Expert Centres.

van Ommen GJ, Törnwall O, Bréchot C, Dagher G, Galli J, Hveem K, Landegren U, Luchinat C, Metspalu A, Nilsson C, Solesvik OV, Perola M, Litton JE, Zatloukal K.

Eur J Hum Genet. 2015 Jul;23(7):893-900. doi: 10.1038/ejhg.2014.235. Epub 2014 Nov 19.

34.

The Biobanking Analysis Resource Catalogue (BARCdb): a new research tool for the analysis of biobank samples.

Galli J, Oelrich J, Taussig MJ, Andreasson U, Ortega-Paino E, Landegren U.

Nucleic Acids Res. 2015 Jan;43(Database issue):D1158-62. doi: 10.1093/nar/gku1008. Epub 2014 Oct 21.

35.

A universal approach to prepare reagents for DNA-assisted protein analysis.

Yan J, Gu GJ, Jost C, Hammond M, Plückthun A, Landegren U, Kamali-Moghaddam M.

PLoS One. 2014 Sep 18;9(9):e108061. doi: 10.1371/journal.pone.0108061. eCollection 2014.

36.

Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies.

Zatloukal B, Kufferath I, Thueringer A, Landegren U, Zatloukal K, Haybaeck J.

PLoS One. 2014 May 5;9(5):e96690. doi: 10.1371/journal.pone.0096690. eCollection 2014.

37.

Protein biomarker validation via proximity ligation assays.

Blokzijl A, Nong R, Darmanis S, Hertz E, Landegren U, Kamali-Moghaddam M.

Biochim Biophys Acta. 2014 May;1844(5):933-9. doi: 10.1016/j.bbapap.2013.07.016. Epub 2013 Aug 7. Review.

PMID:
23933049
38.

Improving precision of proximity ligation assay by amplified single molecule detection.

Ke R, Nong RY, Fredriksson S, Landegren U, Nilsson M.

PLoS One. 2013 Jul 16;8(7):e69813. doi: 10.1371/journal.pone.0069813. Print 2013.

39.

Solid-phase proximity ligation assays for individual or parallel protein analyses with readout via real-time PCR or sequencing.

Nong RY, Wu D, Yan J, Hammond M, Gu GJ, Kamali-Moghaddam M, Landegren U, Darmanis S.

Nat Protoc. 2013 Jun;8(6):1234-48. doi: 10.1038/nprot.2013.070. Epub 2013 May 30. Erratum in: Nat Protoc. 2015 Apr;10(4):643.

PMID:
23722261
40.

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.

Gu GJ, Lund H, Wu D, Blokzijl A, Classon C, von Euler G, Landegren U, Sunnemark D, Kamali-Moghaddam M.

Neuromolecular Med. 2013 Sep;15(3):458-69. doi: 10.1007/s12017-013-8232-3. Epub 2013 May 12.

PMID:
23666762
41.

Improving the diagnosis and management of neuroendocrine tumors: utilizing new advances in biomarker and molecular imaging science.

Giandomenico V, Modlin IM, Pontén F, Nilsson M, Landegren U, Bergqvist J, Khan MS, Millar RP, Långström B, Borlak J, Eriksson B, Nielsen B, Baltzer L, Waterton JC, Ahlström H, Öberg K.

Neuroendocrinology. 2013;98(1):16-30. doi: 10.1159/000348832. Epub 2013 Jun 28.

42.

Parallel visualization of multiple protein complexes in individual cells in tumor tissue.

Leuchowius KJ, Clausson CM, Grannas K, Erbilgin Y, Botling J, Zieba A, Landegren U, Söderberg O.

Mol Cell Proteomics. 2013 Jun;12(6):1563-71. doi: 10.1074/mcp.O112.023374. Epub 2013 Feb 22.

43.

Offshoots of the ESF functional genomics programme.

Landegren U.

N Biotechnol. 2013 Mar 25;30(3):296-8. doi: 10.1016/j.nbt.2012.12.003. Epub 2013 Jan 4. Review.

PMID:
23295551
44.

Multiplex protein detection with DNA readout via mass spectrometry.

Flanigon J, Kamali-Moghaddam M, Burbulis I, Annink C, Steffen M, Oeth P, Brent R, van den Boom D, Landegren U, Cantor C.

N Biotechnol. 2013 Jan 25;30(2):153-8. doi: 10.1016/j.nbt.2012.11.003. Epub 2012 Nov 28.

45.

PCR-based multiparametric assays in single cells.

Darmanis S, Gallant C, Landegren U.

Clin Chem. 2012 Dec;58(12):1618-9. doi: 10.1373/clinchem.2012.195867. Epub 2012 Oct 15. No abstract available.

46.

Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.

Gu GJ, Wu D, Lund H, Sunnemark D, Kvist AJ, Milner R, Eckersley S, Nilsson LN, Agerman K, Landegren U, Kamali-Moghaddam M.

J Alzheimers Dis. 2013;33(3):699-713. doi: 10.3233/JAD-2012-121357.

PMID:
23001711
47.

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.

Sundqvist A, Zieba A, Vasilaki E, Herrera Hidalgo C, Söderberg O, Koinuma D, Miyazono K, Heldin CH, Landegren U, Ten Dijke P, van Dam H.

Oncogene. 2013 Aug 1;32(31):3606-15. doi: 10.1038/onc.2012.370. Epub 2012 Aug 27.

PMID:
22926518
48.

Profiling cellular protein complexes by proximity ligation with dual tag microarray readout.

Hammond M, Nong RY, Ericsson O, Pardali K, Landegren U.

PLoS One. 2012;7(7):e40405. doi: 10.1371/journal.pone.0040405. Epub 2012 Jul 10. Erratum in: PLoS One. 2015;10(3):e0119890.

49.

Workshop on laboratory protocol standards for the Molecular Methods Database.

Klingström T, Soldatova L, Stevens R, Roos TE, Swertz MA, Müller KM, Kalaš M, Lambrix P, Taussig MJ, Litton JE, Landegren U, Bongcam-Rudloff E.

N Biotechnol. 2013 Jan 25;30(2):109-13. doi: 10.1016/j.nbt.2012.05.019. Epub 2012 Jun 2.

PMID:
22687389
50.

Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation.

Gu GJ, Friedman M, Jost C, Johnsson K, Kamali-Moghaddam M, Plückthun A, Landegren U, Söderberg O.

N Biotechnol. 2013 Jan 25;30(2):144-52. doi: 10.1016/j.nbt.2012.05.005. Epub 2012 Jun 2.

PMID:
22664266

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