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Identification of Breast Cancer Stem Cell Related Genes Using Functional Cellular Assays Combined With Single-Cell RNA Sequencing in MDA-MB-231 Cells.

Jonasson E, Ghannoum S, Persson E, Karlsson J, Kroneis T, Larsson E, Landberg G, Ståhlberg A.

Front Genet. 2019 May 22;10:500. doi: 10.3389/fgene.2019.00500. eCollection 2019.


Hypoxia-induced secretion stimulates breast cancer stem cell regulatory signalling pathways.

Jacobsson H, Harrison H, Hughes É, Persson E, Rhost S, Fitzpatrick P, Gustafsson A, Andersson D, Gregersson P, Magnusson Y, Ståhlberg A, Landberg G.

Mol Oncol. 2019 Aug;13(8):1693-1705. doi: 10.1002/1878-0261.12500. Epub 2019 Jun 26.


JAK-STAT signalling controls cancer stem cell properties including chemotherapy resistance in myxoid liposarcoma.

Dolatabadi S, Jonasson E, Lindén M, Fereydouni B, Bäcksten K, Nilsson M, Martner A, Forootan A, Fagman H, Landberg G, Åman P, Ståhlberg A.

Int J Cancer. 2019 Jul 15;145(2):435-449. doi: 10.1002/ijc.32123. Epub 2019 Jan 29.


Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion.

Rhost S, Hughes É, Harrison H, Rafnsdottir S, Jacobsson H, Gregersson P, Magnusson Y, Fitzpatrick P, Andersson D, Berger K, Ståhlberg A, Landberg G.

Breast Cancer Res. 2018 Nov 20;20(1):137. doi: 10.1186/s13058-018-1060-5.


Identification of inhibitors regulating cell proliferation and FUS-DDIT3 expression in myxoid liposarcoma using combined DNA, mRNA, and protein analyses.

Svec D, Dolatabadi S, Thomsen C, Cordes N, Shannon M, Fitzpatrick P, Landberg G, Åman P, Ståhlberg A.

Lab Invest. 2018 Jul;98(7):957-967. doi: 10.1038/s41374-018-0046-3. Epub 2018 Mar 27.


Cellular organization and molecular differentiation model of breast cancer-associated fibroblasts.

Busch S, Andersson D, Bom E, Walsh C, Ståhlberg A, Landberg G.

Mol Cancer. 2017 Apr 3;16(1):73. doi: 10.1186/s12943-017-0642-7.


Robotic Mammosphere Assay for High-Throughput Screening in Triple-Negative Breast Cancer.

Fitzpatrick PA, Akrap N, Söderberg EMV, Harrison H, Thomson GJ, Landberg G.

SLAS Discov. 2017 Aug;22(7):827-836. doi: 10.1177/2472555217692321. Epub 2017 Feb 21.


Cell Cycle and Cell Size Dependent Gene Expression Reveals Distinct Subpopulations at Single-Cell Level.

Dolatabadi S, Candia J, Akrap N, Vannas C, Tesan Tomic T, Losert W, Landberg G, Åman P, Ståhlberg A.

Front Genet. 2017 Jan 25;8:1. doi: 10.3389/fgene.2017.00001. eCollection 2017.


High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer.

Paulsson J, Rydén L, Strell C, Frings O, Tobin NP, Fornander T, Bergh J, Landberg G, Stål O, Östman A.

J Pathol Clin Res. 2016 Sep 14;3(1):38-43. doi: 10.1002/cjp2.56. eCollection 2017 Jan.


Tissue Factor promotes breast cancer stem cell activity in vitro.

Shaker H, Harrison H, Clarke R, Landberg G, Bundred NJ, Versteeg HH, Kirwan CC.

Oncotarget. 2017 Apr 18;8(16):25915-25927. doi: 10.18632/oncotarget.13928.


Lipid Heterogeneity Resulting from Fatty Acid Processing in the Human Breast Cancer Microenvironment Identified by GCIB-ToF-SIMS Imaging.

Angerer TB, Magnusson Y, Landberg G, Fletcher JS.

Anal Chem. 2016 Dec 6;88(23):11946-11954. Epub 2016 Nov 9.


Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei.

Abdissa N, Pan F, Gruhonjic A, Gräfenstein J, Fitzpatrick PA, Landberg G, Rissanen K, Yenesew A, Erdélyi M.

J Nat Prod. 2016 Sep 23;79(9):2181-7. doi: 10.1021/acs.jnatprod.6b00178. Epub 2016 Aug 12.


The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression and associates with good prognosis in breast cancer.

Mendoza-Villanueva D, Balamurugan K, Ali HR, Kim SR, Sharan S, Johnson RC, Merchant AS, Caldas C, Landberg G, Sterneck E.

Oncogene. 2016 Dec 1;35(48):6166-6176. doi: 10.1038/onc.2016.156. Epub 2016 May 16.


PO-21 - Stromal fibroblasts in preinvasive breast cancer (ductal carcinoma in situ, DCIS) demonstrate a cancer-like procoagulant phenotypic switch that may facilitate invasion.

Shaker H, Bundred NJ, Albadry H, Nicholson S, Castle J, Lumsden LJ, Pritchard S, Landberg G, Kirwan CC.

Thromb Res. 2016 Apr;140 Suppl 1:S184. doi: 10.1016/S0049-3848(16)30154-2. Epub 2016 Apr 8.


Identification of Distinct Breast Cancer Stem Cell Populations Based on Single-Cell Analyses of Functionally Enriched Stem and Progenitor Pools.

Akrap N, Andersson D, Bom E, Gregersson P, Ståhlberg A, Landberg G.

Stem Cell Reports. 2016 Jan 12;6(1):121-36. doi: 10.1016/j.stemcr.2015.12.006.


An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors.

Tobin NP, Wennmalm K, Lindström LS, Foukakis T, He L, Genové G, Östman A, Landberg G, Betsholtz C, Bergh J.

Clin Cancer Res. 2016 May 15;22(10):2417-26. doi: 10.1158/1078-0432.CCR-15-1691. Epub 2016 Jan 14.


Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.

Aronsson P, Munissi JJE, Gruhonjic A, Fitzpatrick PA, Landberg G, Nyandoro SS, Erdelyi M.

Diseases. 2016 Jan 15;4(1). pii: E3. doi: 10.3390/diseases4010003.


CAF-specific markers: role of the TGFβ pathway.

Busch S, Landberg G.

Oncoscience. 2015 Aug 21;2(10):835-6. eCollection 2015. No abstract available.


Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis.

Deyou T, Gumula I, Pang F, Gruhonjic A, Mumo M, Holleran J, Duffy S, Fitzpatrick PA, Heydenreich M, Landberg G, Derese S, Avery V, Rissanen K, Erdélyi M, Yenesew A.

J Nat Prod. 2015 Dec 24;78(12):2932-9. doi: 10.1021/acs.jnatprod.5b00581. Epub 2015 Dec 14.


Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

Simões BM, O'Brien CS, Eyre R, Silva A, Yu L, Sarmiento-Castro A, Alférez DG, Spence K, Santiago-Gómez A, Chemi F, Acar A, Gandhi A, Howell A, Brennan K, Rydén L, Catalano S, Andó S, Gee J, Ucar A, Sims AH, Marangoni E, Farnie G, Landberg G, Howell SJ, Clarke RB.

Cell Rep. 2015 Sep 29;12(12):1968-77. doi: 10.1016/j.celrep.2015.08.050. Epub 2015 Sep 17.


N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis.

Nyandoro SS, Ndanu J, Munissi JJ, Gruhonjic A, Fitzpatrick PA, Landberg G, Lu Y, Wang B, Pan F, Rissanen K, Erdélyi M.

J Nat Prod. 2015 Aug 28;78(8):2045-50. doi: 10.1021/acs.jnatprod.5b00356. Epub 2015 Jul 27.


Properties of targeted preamplification in DNA and cDNA quantification.

Andersson D, Akrap N, Svec D, Godfrey TE, Kubista M, Landberg G, Ståhlberg A.

Expert Rev Mol Diagn. 2015;15(8):1085-100. doi: 10.1586/14737159.2015.1057124. Epub 2015 Jul 1.


Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment.

Ward R, Sims AH, Lee A, Lo C, Wynne L, Yusuf H, Gregson H, Lisanti MP, Sotgia F, Landberg G, Lamb R.

Oncotarget. 2015 Jun 10;6(16):14687-99.


Early diagnostic value of Bcl-3 localization in colorectal cancer.

Saamarthy K, Björner S, Johansson M, Landberg G, Massoumi R, Jirström K, Masoumi KC.

BMC Cancer. 2015 May 1;15:341. doi: 10.1186/s12885-015-1342-6.


Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance.

Busch S, Sims AH, Stål O, Fernö M, Landberg G.

Cancer Res. 2015 Apr 1;75(7):1457-69. doi: 10.1158/0008-5472.CAN-14-1583.


Selenium Accumulating Leafy Vegetables Are a Potential Source of Functional Foods.

Mabeyo PE, Manoko ML, Gruhonjic A, Fitzpatrick PA, Landberg G, Erdélyi M, Nyandoro SS.

Int J Food Sci. 2015;2015:549676. doi: 10.1155/2015/549676. Epub 2015 Dec 10.


Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer.

Lamb R, Lisanti MP, Clarke RB, Landberg G.

Oncotarget. 2014 Sep 15;5(17):7833-42.


The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk.

Han L, Diehl A, Nguyen NK, Korangath P, Teo W, Cho S, Kominsky S, Huso DL, Feigenbaum L, Rein A, Argani P, Landberg G, Gessler M, Sukumar S.

Cancer Res. 2014 Nov 15;74(22):6509-18. doi: 10.1158/0008-5472.CAN-14-0816. Epub 2014 Sep 12.


Constituents of the roots and leaves of Ekebergia capensis and their potential antiplasmodial and cytotoxic activities.

Irungu BN, Orwa JA, Gruhonjic A, Fitzpatrick PA, Landberg G, Kimani F, Midiwo J, Erdélyi M, Yenesew A.

Molecules. 2014 Sep 10;19(9):14235-46. doi: 10.3390/molecules190914235.


Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.

Williams KE, Bundred NJ, Landberg G, Clarke RB, Farnie G.

Stem Cells. 2015 Feb;33(2):327-41. doi: 10.1002/stem.1843.


Epithelial and stromal microRNA signatures of columnar cell hyperplasia linking Let-7c to precancerous and cancerous breast cancer cell proliferation.

Björner S, Fitzpatrick PA, Li Y, Allred C, Howell A, Ringberg A, Olsson H, Miller CJ, Axelson H, Landberg G.

PLoS One. 2014 Aug 14;9(8):e105099. doi: 10.1371/journal.pone.0105099. eCollection 2014.


17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells.

Wright PK, Jones SB, Ardern N, Ward R, Clarke RB, Sotgia F, Lisanti MP, Landberg G, Lamb R.

Oncotarget. 2014 May 30;5(10):3055-65.


Breastfeeding in relation to risk of different breast cancer characteristics.

Butt S, Borgquist S, Anagnostaki L, Landberg G, Manjer J.

BMC Res Notes. 2014 Apr 7;7:216. doi: 10.1186/1756-0500-7-216.


Cytotoxic quinones from the roots of Aloe dawei.

Abdissa N, Induli M, Fitzpatrick P, Alao JP, Sunnerhagen P, Landberg G, Yenesew A, Erdélyi M.

Molecules. 2014 Mar 17;19(3):3264-73. doi: 10.3390/molecules19033264.


Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

Lehn S, Tobin NP, Sims AH, Stål O, Jirström K, Axelson H, Landberg G.

BMC Cancer. 2014 Feb 22;14:119. doi: 10.1186/1471-2407-14-119.


TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer.

Busch S, Acar A, Magnusson Y, Gregersson P, Rydén L, Landberg G.

Oncogene. 2015 Jan 2;34(1):27-38. doi: 10.1038/onc.2013.527. Epub 2013 Dec 16.


Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.

Keune WJ, Sims AH, Jones DR, Bultsma Y, Lynch JT, Jirström K, Landberg G, Divecha N.

Cancer Res. 2013 Dec 1;73(23):6913-25. doi: 10.1158/0008-5472.CAN-13-0424. Epub 2013 Oct 14.


Wnt pathway activity in breast cancer sub-types and stem-like cells.

Lamb R, Ablett MP, Spence K, Landberg G, Sims AH, Clarke RB.

PLoS One. 2013 Jul 4;8(7):e67811. doi: 10.1371/journal.pone.0067811. Print 2013.


Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity.

Lamb R, Lehn S, Rogerson L, Clarke RB, Landberg G.

Cell Cycle. 2013 Aug 1;12(15):2384-94. doi: 10.4161/cc.25403. Epub 2013 Jun 26.


Guidelines and considerations for conducting experiments using tissue microarrays.

Ilyas M, Grabsch H, Ellis IO, Womack C, Brown R, Berney D, Fennell D, Salto-Tellez M, Jenkins M, Landberg G, Byers R, Treanor D, Harrison D, Green AR, Ball G, Hamilton P; National Cancer Research Institute (UK) Biomarker and Imaging Clinical Studies Group.

Histopathology. 2013 May;62(6):827-39. doi: 10.1111/his.12118. Epub 2013 Apr 12. Review.


Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling.

Harrison H, Simões BM, Rogerson L, Howell SJ, Landberg G, Clarke RB.

Breast Cancer Res. 2013 Mar 8;15(2):R21. doi: 10.1186/bcr3396.


Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status.

Harrison H, Rogerson L, Gregson HJ, Brennan KR, Clarke RB, Landberg G.

Cancer Res. 2013 Feb 15;73(4):1420-33. doi: 10.1158/0008-5472.CAN-12-2505. Epub 2012 Dec 17.


Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.

Singh JK, Farnie G, Bundred NJ, Simões BM, Shergill A, Landberg G, Howell SJ, Clarke RB.

Clin Cancer Res. 2013 Feb 1;19(3):643-56. doi: 10.1158/1078-0432.CCR-12-1063. Epub 2012 Nov 13.


Low ERK phosphorylation in cancer-associated fibroblasts is associated with tamoxifen resistance in pre-menopausal breast cancer.

Busch S, Rydén L, Stål O, Jirström K, Landberg G.

PLoS One. 2012;7(9):e45669. doi: 10.1371/journal.pone.0045669. Epub 2012 Sep 24.


Genetic predisposition, parity, age at first childbirth and risk for breast cancer.

Butt S, Harlid S, Borgquist S, Ivarsson M, Landberg G, Dillner J, Carlson J, Manjer J.

BMC Res Notes. 2012 Aug 7;5:414. doi: 10.1186/1756-0500-5-414.


Automated image analysis of cyclin D1 protein expression in invasive lobular breast carcinoma provides independent prognostic information.

Tobin NP, Lundgren KL, Conway C, Anagnostaki L, Costello S, Landberg G.

Hum Pathol. 2012 Nov;43(11):2053-61. doi: 10.1016/j.humpath.2012.02.015. Epub 2012 May 29.


Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration.

Nilsson S, Möller C, Jirström K, Lee A, Busch S, Lamb R, Landberg G.

PLoS One. 2012;7(4):e36051. doi: 10.1371/journal.pone.0036051. Epub 2012 Apr 26.


Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: a TransATAC study.

Lundgren K, Brown M, Pineda S, Cuzick J, Salter J, Zabaglo L, Howell A, Dowsett M, Landberg G; TransATAC investigators.

Breast Cancer Res. 2012 Apr 4;14(2):R57.


Med1 plays a critical role in the development of tamoxifen resistance.

Nagalingam A, Tighiouart M, Ryden L, Joseph L, Landberg G, Saxena NK, Sharma D.

Carcinogenesis. 2012 Apr;33(4):918-30. doi: 10.1093/carcin/bgs105. Epub 2012 Feb 16.


The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer.

Brennan DJ, O'Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirström K, Gallagher WM.

Oncogene. 2012 Jul 26;31(30):3483-94. doi: 10.1038/onc.2011.519. Epub 2011 Dec 5.

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