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Items: 1 to 50 of 63


Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer.

Mota MSV, Jackson WP, Bailey SK, Vayalil P, Landar A, Rostas JW 3rd, Mulekar MS, Samant RS, Shevde LA.

Carcinogenesis. 2018 Sep 21;39(9):1165-1175. doi: 10.1093/carcin/bgy078.


Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils.

Chacko BK, Wall SB, Kramer PA, Ravi S, Mitchell T, Johnson MS, Wilson L, Barnes S, Landar A, Darley-Usmar VM.

Redox Biol. 2016 Oct;9:57-66. doi: 10.1016/j.redox.2016.06.003. Epub 2016 Jun 23.


Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.

Smith MR, Vayalil PK, Zhou F, Benavides GA, Beggs RR, Golzarian H, Nijampatnam B, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A.

Redox Biol. 2016 Aug;8:136-48. doi: 10.1016/j.redox.2016.01.002. Epub 2016 Jan 8.


Mitochondrial oncobioenergetic index: A potential biomarker to predict progression from indolent to aggressive prostate cancer.

Vayalil PK, Landar A.

Oncotarget. 2015 Dec 15;6(40):43065-80. doi: 10.18632/oncotarget.5487.


Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism.

Franco MC, Ricart KC, Gonzalez AS, Dennys CN, Nelson PA, Janes MS, Mehl RA, Landar A, Estévez AG.

J Biol Chem. 2015 Jul 31;290(31):19055-66. doi: 10.1074/jbc.M115.663278. Epub 2015 Jun 17.


A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.

Vayalil PK, Oh JY, Zhou F, Diers AR, Smith MR, Golzarian H, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A.

PLoS One. 2015 Mar 18;10(3):e0120460. doi: 10.1371/journal.pone.0120460. eCollection 2015.


Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog.

Wall SB, Oh JY, Mitchell L, Laube AH, Campbell SL, Renfrow MB, Landar A.

Redox Biol. 2015;4:346-54. doi: 10.1016/j.redox.2015.01.016. Epub 2015 Feb 3.


Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats.

Andringa KK, Udoh US, Landar A, Bailey SM.

Redox Biol. 2014;2:1038-47. doi: 10.1016/j.redox.2014.09.006. Epub 2014 Oct 5.


Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.

Liu W, Beck BH, Vaidya KS, Nash KT, Feeley KP, Ballinger SW, Pounds KM, Denning WL, Diers AR, Landar A, Dhar A, Iwakuma T, Welch DR.

Cancer Res. 2014 Feb 1;74(3):954-63. doi: 10.1158/0008-5472.CAN-13-1183. Epub 2013 Dec 18.


Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse.

Ulasova E, Perez J, Hill BG, Bradley WE, Garber DW, Landar A, Barnes S, Prasain J, Parks DA, Dell'Italia LJ, Darley-Usmar VM.

Redox Biol. 2013 Jul 16;1:381-6. doi: 10.1016/j.redox.2013.07.001. eCollection 2013.


Detection of electrophile-sensitive proteins.

Wall SB, Smith MR, Ricart K, Zhou F, Vayalil PK, Oh JY, Landar A.

Biochim Biophys Acta. 2014 Feb;1840(2):913-22. doi: 10.1016/j.bbagen.2013.09.003. Epub 2013 Sep 8. Review.


The janus of oxidative stress signaling in different pathophysiological conditions.

Miriyala S, Panchatcharam M, Landar A, Ramanujam M, Chatterjee S, Muthuswamy A.

Oxid Med Cell Longev. 2013;2013:708796. doi: 10.1155/2013/708796. Epub 2013 Jun 19. No abstract available.


Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.

Diers AR, Vayalil PK, Oliva CR, Griguer CE, Darley-Usmar V, Hurst DR, Welch DR, Landar A.

PLoS One. 2013 Jun 28;8(6):e68348. doi: 10.1371/journal.pone.0068348. Print 2013.


Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells.

Bolisetty S, Traylor A, Zarjou A, Johnson MS, Benavides GA, Ricart K, Boddu R, Moore RD, Landar A, Barnes S, Darley-Usmar V, Agarwal A.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F255-64. doi: 10.1152/ajprenal.00160.2013. Epub 2013 May 29.


Oxidative modification of proteins: an emerging mechanism of cell signaling.

Wall SB, Oh JY, Diers AR, Landar A.

Front Physiol. 2012 Sep 14;3:369. doi: 10.3389/fphys.2012.00369. eCollection 2012.


Cell signalling by reactive lipid species: new concepts and molecular mechanisms.

Higdon A, Diers AR, Oh JY, Landar A, Darley-Usmar VM.

Biochem J. 2012 Mar 15;442(3):453-64. doi: 10.1042/BJ20111752. Review.


The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function.

Higdon AN, Landar A, Barnes S, Darley-Usmar VM.

Antioxid Redox Signal. 2012 Dec 1;17(11):1580-9. Epub 2012 Apr 18. Review.


Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy.

Higdon AN, Benavides GA, Chacko BK, Ouyang X, Johnson MS, Landar A, Zhang J, Darley-Usmar VM.

Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1394-409. doi: 10.1152/ajpheart.00584.2011. Epub 2012 Jan 13.


Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression.

Bodenstine TM, Vaidya KS, Ismail A, Beck BH, Diers AR, Edmonds MD, Kirsammer GT, Landar A, Welch DR.

FEBS Lett. 2012 Jan 2;586(1):27-31. doi: 10.1016/j.febslet.2011.11.017. Epub 2011 Nov 24.


Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes.

Zelickson BR, Benavides GA, Johnson MS, Chacko BK, Venkatraman A, Landar A, Betancourt AM, Bailey SM, Darley-Usmar VM.

Biochim Biophys Acta. 2011 Dec;1807(12):1573-82. doi: 10.1016/j.bbabio.2011.09.011. Epub 2011 Sep 24.


Assessing bioenergetic function in response to oxidative stress by metabolic profiling.

Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham JC, Hill BG, Zhang J, Landar A, Darley-Usmar VM.

Free Radic Biol Med. 2011 Nov 1;51(9):1621-35. doi: 10.1016/j.freeradbiomed.2011.08.005. Epub 2011 Aug 16.


Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation.

Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P.

Circ Res. 2011 Feb 4;108(3):324-34. doi: 10.1161/CIRCRESAHA.110.235879. Epub 2010 Dec 16.


Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.

Bodenstine TM, Vaidya KS, Ismail A, Beck BH, Cook LM, Diers AR, Landar A, Welch DR.

Cancer Res. 2010 Dec 1;70(23):10002-11. doi: 10.1158/0008-5472.CAN-10-2606. Epub 2010 Nov 23.


Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain.

Oliva CR, Nozell SE, Diers A, McClugage SG 3rd, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A, Griguer CE.

J Biol Chem. 2010 Dec 17;285(51):39759-67. doi: 10.1074/jbc.M110.147504. Epub 2010 Sep 24.


Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury.

Bolisetty S, Traylor AM, Kim J, Joseph R, Ricart K, Landar A, Agarwal A.

J Am Soc Nephrol. 2010 Oct;21(10):1702-12. doi: 10.1681/ASN.2010030238. Epub 2010 Aug 12.


Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy.

Diers AR, Dranka BP, Ricart KC, Oh JY, Johnson MS, Zhou F, Pallero MA, Bodenstine TM, Murphy-Ullrich JE, Welch DR, Landar A.

Biochem J. 2010 Aug 15;430(1):69-78. doi: 10.1042/BJ20091193.


Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection.

Andringa KK, King AL, Eccleston HB, Mantena SK, Landar A, Jhala NC, Dickinson DA, Squadrito GL, Bailey SM.

Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G732-45. doi: 10.1152/ajpgi.00332.2009. Epub 2010 Feb 11.


Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms.

Diers AR, Higdon AN, Ricart KC, Johnson MS, Agarwal A, Kalyanaraman B, Landar A, Darley-Usmar VM.

Biochem J. 2010 Jan 27;426(1):31-41. doi: 10.1042/BJ20091293.


Methods for the determination and quantification of the reactive thiol proteome.

Hill BG, Reily C, Oh JY, Johnson MS, Landar A.

Free Radic Biol Med. 2009 Sep 15;47(6):675-83. doi: 10.1016/j.freeradbiomed.2009.06.012. Epub 2009 Jun 13.


Methods for imaging and detecting modification of proteins by reactive lipid species.

Higdon AN, Dranka BP, Hill BG, Oh JY, Johnson MS, Landar A, Darley-Usmar VM.

Free Radic Biol Med. 2009 Aug 1;47(3):201-12. doi: 10.1016/j.freeradbiomed.2009.05.009. Epub 2009 May 14.


The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells.

Ricart KC, Bolisetty S, Johnson MS, Perez J, Agarwal A, Murphy MP, Landar A.

Biochem J. 2009 Apr 15;419(2):427-36. doi: 10.1042/BJ20081350.


Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver disease.

Bailey SM, Andringa KK, Landar A, Darley-Usmar VM.

Methods Mol Biol. 2008;447:369-80. doi: 10.1007/978-1-59745-242-7_24.


Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease.

Mantena SK, King AL, Andringa KK, Landar A, Darley-Usmar V, Bailey SM.

World J Gastroenterol. 2007 Oct 7;13(37):4967-73. Review.


Is the soluble guanylate cyclase pathway the only one available for nitric oxide (NO) signaling?

Landar A, Darley-Usmar VM.

IUBMB Life. 2007 Feb;59(2):110-2. No abstract available.


Methods for determining the modification of protein thiols by reactive lipids.

Oh J, Johnson MS, Landar A.

Methods Cell Biol. 2007;80:417-34. Review. No abstract available.


Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells.

Gutierrez J, Ballinger SW, Darley-Usmar VM, Landar A.

Circ Res. 2006 Oct 27;99(9):924-32. Review.


S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver.

Bailey SM, Robinson G, Pinner A, Chamlee L, Ulasova E, Pompilius M, Page GP, Chhieng D, Jhala N, Landar A, Kharbanda KK, Ballinger S, Darley-Usmar V.

Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G857-67. Epub 2006 Jul 6.


Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.

Watanabe N, Zmijewski JW, Takabe W, Umezu-Goto M, Le Goffe C, Sekine A, Landar A, Watanabe A, Aoki J, Arai H, Kodama T, Murphy MP, Kalyanaraman R, Darley-Usmar VM, Noguchi N.

Am J Pathol. 2006 May;168(5):1737-48.


A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress.

Landar A, Oh JY, Giles NM, Isom A, Kirk M, Barnes S, Darley-Usmar VM.

Free Radic Biol Med. 2006 Feb 1;40(3):459-68. Epub 2005 Nov 18.


Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species.

Landar A, Zmijewski JW, Dickinson DA, Le Goffe C, Johnson MS, Milne GL, Zanoni G, Vidari G, Morrow JD, Darley-Usmar VM.

Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1777-87. Epub 2005 Dec 30.


Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria.

Landar A, Shiva S, Levonen AL, Oh JY, Zaragoza C, Johnson MS, Darley-Usmar VM.

Biochem J. 2006 Feb 15;394(Pt 1):185-95.


Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium.

Zmijewski JW, Landar A, Watanabe N, Dickinson DA, Noguchi N, Darley-Usmar VM.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1385-9. Review.


Nitric oxide signaling gone awry: nitration of glutamine synthetase and hyperammonemia in sepsis.

Landar A, Darley-Usmar VM.

Hepatology. 2005 May;41(5):980-2. Review. No abstract available.


Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells.

Zmijewski JW, Moellering DR, Le Goffe C, Landar A, Ramachandran A, Darley-Usmar VM.

Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H852-61. Epub 2005 Apr 1.


Redox signalling: from nitric oxide to oxidized lipids.

Shiva S, Moellering D, Ramachandran A, Levonen AL, Landar A, Venkatraman A, Ceaser E, Ulasova E, Crawford JH, Brookes PS, Patel RP, Darley-Usmar VM.

Biochem Soc Symp. 2004;(71):107-20. Review.


Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.

Shiva S, Oh JY, Landar AL, Ulasova E, Venkatraman A, Bailey SM, Darley-Usmar VM.

Free Radic Biol Med. 2005 Feb 1;38(3):297-306. Review.


Mitochondrial proteomics in free radical research.

Bailey SM, Landar A, Darley-Usmar V.

Free Radic Biol Med. 2005 Jan 15;38(2):175-88. Review.


Weight loss and race modulate nitric oxide metabolism in overweight women.

Fenster CP, Darley-Usmar VM, Landar AL, Gower BA, Weinsier RL, Hunter GR, Patel RP.

Free Radic Biol Med. 2004 Sep 1;37(5):695-702.


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