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Items: 1 to 50 of 111

1.

Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat.

Olson E, Pravenec M, Landa V, Koh-Tan HHC, Dominiczak AF, McBride MW, Graham D.

J Hypertens. 2019 May;37(5):985-996. doi: 10.1097/HJH.0000000000001960.

PMID:
30308595
2.

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid.

Kuda O, Brezinova M, Silhavy J, Landa V, Zidek V, Dodia C, Kreuchwig F, Vrbacky M, Balas L, Durand T, Hübner N, Fisher AB, Kopecky J, Pravenec M.

Diabetes. 2018 Jun;67(6):1190-1199. doi: 10.2337/db17-1087. Epub 2018 Mar 16.

3.

Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity.

Pravenec M, Zídek V, Landa V, Mlejnek P, Šilhavý J, Šimáková M, Trnovská J, Škop V, Marková I, Malínská H, Hüttl M, Kazdová L, Bardová K, Tauchmannová K, Vrbacký M, Nůsková H, Mráček T, Kopecký J, Houštěk J.

Physiol Res. 2017 Dec 20;66(6):917-924.

4.

Systems genetic analysis of brown adipose tissue function.

Pravenec M, Saba LM, Zídek V, Landa V, Mlejnek P, Šilhavý J, Šimáková M, Strnad H, Trnovská J, Škop V, Hüttl M, Marková I, Oliyarnyk O, Malínská H, Kazdová L, Smith H, Tabakoff B.

Physiol Genomics. 2018 Jan 1;50(1):52-66. doi: 10.1152/physiolgenomics.00091.2017. Epub 2017 Nov 10.

5.

Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls.

Trnovská J, Šilhavý J, Kuda O, Landa V, Zídek V, Mlejnek P, Šimáková M, Strnad H, Škop V, Oliyarnyk O, Kazdová L, Haluzík M, Pravenec M.

PLoS One. 2017 Jun 6;12(6):e0179063. doi: 10.1371/journal.pone.0179063. eCollection 2017.

6.

Design of a cluster-randomized minority recruitment trial: RECRUIT.

Tilley BC, Mainous AG 3rd, Smith DW, McKee MD, Amorrortu RP, Alvidrez J, Diaz V, Ford ME, Fernandez ME, Hauser RA, Singer C, Landa V, Trevino A, DeSantis SM, Zhang Y, Daniels E, Tabor D, Vernon SW.

Clin Trials. 2017 Jun;14(3):286-298. doi: 10.1177/1740774517690146. Epub 2017 Mar 19.

7.

Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Liška F, Landa V, Zídek V, Mlejnek P, Šilhavý J, Šimáková M, Strnad H, Trnovská J, Škop V, Kazdová L, Starker CG, Voytas DF, Izsvák Z, Mancini M, Šeda O, Křen V, Pravenec M.

Hypertension. 2017 Jun;69(6):1084-1091. doi: 10.1161/HYPERTENSIONAHA.116.08798. Epub 2017 Apr 10.

PMID:
28396530
8.

Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats.

Pravenec M, Landa V, Zídek V, Mlejnek P, Šilhavý J, Mir SA, Vaingankar SM, Wang J, Kurtz TW.

Physiol Res. 2016 Dec 13;65(6):1039-1044.

9.

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats.

Liška F, Peterková R, Peterka M, Landa V, Zídek V, Mlejnek P, Šilhavý J, Šimáková M, Křen V, Starker CG, Voytas DF, Izsvák Z, Pravenec M.

PLoS One. 2016 Oct 11;11(10):e0164206. doi: 10.1371/journal.pone.0164206. eCollection 2016.

10.

Hepatotoxic effects of fenofibrate in spontaneously hypertensive rats expressing human C-reactive protein.

Škop V, Trnovská J, Oliyarnyk O, Marková I, Malínská H, Kazdová L, Zídek V, Landa V, Mlejnek P, Šimáková M, Kůdela M, Pravenec M, Šilhavý J.

Physiol Res. 2016 Dec 13;65(6):891-899. Epub 2016 Aug 19.

11.

Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue.

Pravenec M, Mlejnek P, Zídek V, Landa V, Šimáková M, Šilhavý J, Strnad H, Eigner S, Eigner Henke K, Škop V, Malínská H, Trnovská J, Kazdová L, Drahota Z, Mráček T, Houštěk J.

Physiol Genomics. 2016 Jun;48(6):420-7. doi: 10.1152/physiolgenomics.00122.2015. Epub 2016 Apr 25.

PMID:
27113533
12.

Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein.

Malínská H, Oliyarnyk O, Škop V, Šilhavý J, Landa V, Zídek V, Mlejnek P, Šimáková M, Strnad H, Kazdová L, Pravenec M.

PLoS One. 2016 Mar 10;11(3):e0150924. doi: 10.1371/journal.pone.0150924. eCollection 2016.

13.

Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome.

Pravenec M, Kožich V, Krijt J, Sokolová J, Zídek V, Landa V, Mlejnek P, Šilhavý J, Šimáková M, Škop V, Trnovská J, Kazdová L, Kajiya T, Wang J, Kurtz TW.

Hypertension. 2016 Feb;67(2):335-41. doi: 10.1161/HYPERTENSIONAHA.115.06158. Epub 2015 Dec 14.

PMID:
26667416
14.

Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein.

Šilhavý J, Zídek V, Landa V, Šimáková M, Mlejnek P, Oliyarnyk O, Malínská H, Kazdová L, Mancini M, Pravenec M.

Physiol Res. 2015;64(3):295-301. Epub 2014 Dec 22.

15.

Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat.

Trnovská J, Šilhavý J, Zídek V, Šimáková M, Mlejnek P, Landa V, Eigner S, Eigner Henke K, Škop V, Oliyarnyk O, Kazdová L, Mráček T, Houštěk J, Pravenec M.

Physiol Res. 2015;64(1):51-60. Epub 2014 Sep 5.

16.

Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction.

Houštěk J, Vrbacký M, Hejzlarová K, Zídek V, Landa V, Šilhavý J, Šimáková M, Mlejnek P, Kazdová L, Mikšík I, Neckář J, Papoušek F, Kolář F, Kurtz TW, Pravenec M.

Physiol Genomics. 2014 Sep 15;46(18):671-8. doi: 10.1152/physiolgenomics.00069.2014. Epub 2014 Jul 29.

PMID:
25073601
17.

Fumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats.

Šilhavý J, Zídek V, Mlejnek P, Landa V, Šimáková M, Strnad H, Oliyarnyk O, Škop V, Kazdová L, Kurtz T, Pravenec M.

PLoS One. 2014 Jul 10;9(7):e101906. doi: 10.1371/journal.pone.0101906. eCollection 2014.

18.

Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats.

Landa V, Zídek V, Mlejnek P, Šimáková M, Šilhavý J, Trnovská J, Kazdová L, Pravenec M.

Physiol Res. 2014;63(5):587-90. Epub 2014 Jun 5.

19.

Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons.

Ivics Z, Garrels W, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Kues WA, Izsvák Z.

Nat Protoc. 2014 Apr;9(4):810-27. doi: 10.1038/nprot.2014.010. Epub 2014 Mar 13.

PMID:
24625780
20.

Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons.

Ivics Z, Hiripi L, Hoffmann OI, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Bösze Z, Izsvák Z.

Nat Protoc. 2014 Apr;9(4):794-809. doi: 10.1038/nprot.2014.009. Epub 2014 Mar 13.

PMID:
24625779
21.

Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.

Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z.

Nat Protoc. 2014 Apr;9(4):773-93. doi: 10.1038/nprot.2014.008. Epub 2014 Mar 13.

PMID:
24625778
22.

Recent progress in the genetics of spontaneously hypertensive rats.

Pravenec M, Křen V, Landa V, Mlejnek P, Musilová A, Šilhavý J, Šimáková M, Zídek V.

Physiol Res. 2014;63 Suppl 1:S1-8. Review.

23.

Effectiveness of "primary bereavement care" for widows: a cluster randomized controlled trial involving family physicians.

García JA, Landa V, Grandes G, Pombo H, Mauriz A.

Death Stud. 2013 Apr;37(4):287-310.

PMID:
24520889
24.

Rosuvastatin can block pro-inflammatory actions of transgenic human C-reactive protein without reducing its circulating levels.

Šilhavý J, Zídek V, Landa V, Šimáková M, Mlejnek P, Škop V, Oliyarnyk O, Kazdová L, Mancini M, Saar K, Schulz H, Hübner N, Kurtz TW, Pravenec M.

Cardiovasc Ther. 2014 Apr;32(2):59-65. doi: 10.1111/1755-5922.12061.

PMID:
24410968
25.

Plzf as a candidate gene predisposing the spontaneously hypertensive rat to hypertension, left ventricular hypertrophy, and interstitial fibrosis.

Liška F, Mancini M, Krupková M, Chylíková B, Křenová D, Šeda O, Šilhavý J, Mlejnek P, Landa V, Zídek V, d' Amati G, Pravenec M, Křen V.

Am J Hypertens. 2014 Jan;27(1):99-106. doi: 10.1093/ajh/hpt156. Epub 2013 Aug 23.

PMID:
23975223
26.

Tissue-specific peroxisome proliferator activated receptor gamma expression and metabolic effects of telmisartan.

Zídek V, Mlejnek P, Simáková M, Silhavy J, Landa V, Kazdová L, Pravenec M, Kurtz TW.

Am J Hypertens. 2013 Jun;26(6):829-35. doi: 10.1093/ajh/hpt019. Epub 2013 Feb 20.

PMID:
23426788
27.

Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats.

Pravenec M, Kozich V, Krijt J, Sokolová J, Zídek V, Landa V, Simáková M, Mlejnek P, Silhavy J, Oliyarnyk O, Kazdová L, Kurtz TW.

Am J Hypertens. 2013 Jan;26(1):135-40. doi: 10.1093/ajh/hps015.

28.

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.

Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z.

FASEB J. 2013 Mar;27(3):930-41. doi: 10.1096/fj.12-205526. Epub 2012 Nov 29.

29.

Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.

Houštek J, Hejzlarová K, Vrbacký M, Drahota Z, Landa V, Zídek V, Mlejnek P, Šimáková M, Šilhavy J, Mikšík I, Kazdová L, Oliyarnyk O, Kurtz T, Pravenec M.

Physiol Genomics. 2012 May 1;44(9):487-94. doi: 10.1152/physiolgenomics.00156.2011. Epub 2012 Mar 13.

30.

CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.

Neckář J, Šilhavy J, Zídek V, Landa V, Mlejnek P, Šimáková M, Seidman JG, Seidman C, Kazdová L, Klevstig M, Novák F, Vecka M, Papoušek F, Houštěk J, Drahota Z, Kurtz TW, Kolář F, Pravenec M.

Physiol Genomics. 2012 Feb 1;44(2):173-82. doi: 10.1152/physiolgenomics.00083.2011. Epub 2011 Nov 29.

31.

Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome.

Pravenec M, Kajiya T, Zídek V, Landa V, Mlejnek P, Simáková M, Silhavý J, Malínská H, Oliyarnyk O, Kazdová L, Fan J, Wang J, Kurtz TW.

Hypertension. 2011 Apr;57(4):731-7. doi: 10.1161/HYPERTENSIONAHA.110.164350. Epub 2011 Feb 28.

32.

Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis.

Pravenec M, Zídek V, Landa V, Simáková M, Mlejnek P, Silhavy J, Maxová M, Kazdová L, Seidman JG, Seidman CE, Eminaga S, Gorham J, Wang J, Kurtz TW.

Physiol Genomics. 2011 Apr 12;43(7):372-9. doi: 10.1152/physiolgenomics.00112.2010. Epub 2011 Feb 1.

33.

Generation of rat "supersonic" congenic/conplastic strains using superovulation and embryo transfer.

Landa V, Zídek V, Pravenec M.

Methods Mol Biol. 2010;597:267-75. doi: 10.1007/978-1-60327-389-3_18.

PMID:
20013239
34.

Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain.

Drahota Z, Vrbacký M, Nůsková H, Kazdová L, Zídek V, Landa V, Pravenec M, Houstek J.

Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51. doi: 10.1016/j.bbrc.2009.12.050. Epub 2009 Dec 16.

PMID:
20006584
35.

[D-2-hydroxyglutaric aciduria. Report of two cases].

Mahfoud A, Domínguez CL, Rashed M, Durán M, Rodríguez T, Rodríguez D, Landa V.

Invest Clin. 2009 Sep;50(3):369-75. Spanish.

PMID:
19961059
36.

Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis.

Malínská H, Oliyarnyk O, Hubová M, Zídek V, Landa V, Simáková M, Mlejnek P, Kazdová L, Kurtz TW, Pravenec M.

Mol Cell Biochem. 2010 Feb;335(1-2):119-25. doi: 10.1007/s11010-009-0248-5. Epub 2009 Sep 12.

PMID:
19756959
37.

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension.

Pravenec M, Churchill PC, Churchill MC, Viklicky O, Kazdova L, Aitman TJ, Petretto E, Hubner N, Wallace CA, Zimdahl H, Zidek V, Landa V, Dunbar J, Bidani A, Griffin K, Qi N, Maxova M, Kren V, Mlejnek P, Wang J, Kurtz TW.

Nat Genet. 2008 Aug;40(8):952-4. doi: 10.1038/ng.164. Epub 2008 Jun 29.

PMID:
18587397
38.

Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat.

Pravenec M, Kazdova L, Landa V, Zidek V, Mlejnek P, Simakova M, Jansa P, Forejt J, Kren V, Krenova D, Qi N, Wang JM, Chan D, Aitman TJ, Kurtz TW.

Hypertension. 2008 Jan;51(1):148-53. Epub 2007 Dec 10.

PMID:
18071061
39.

Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.

Pravenec M, Hyakukoku M, Houstek J, Zidek V, Landa V, Mlejnek P, Miksik I, Dudová-Mothejzikova K, Pecina P, Vrbacky M, Drahota Z, Vojtiskova A, Mracek T, Kazdova L, Oliyarnyk O, Wang J, Ho C, Qi N, Sugimoto K, Kurtz T.

Genome Res. 2007 Sep;17(9):1319-26. Epub 2007 Aug 10. Erratum in: Genome Res. 2008 Oct;18(10):1680.

40.

Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification.

Pravenec M, Kazdová L, Cahová M, Landa V, Zídek V, Mlejnek P, Simáková M, Wang J, Qi N, Kurtz TW.

Int J Obes (Lond). 2006 Jul;30(7):1157-9. Epub 2006 Jan 24.

PMID:
16432541
41.

A new transgenic rat model of hepatic steatosis and the metabolic syndrome.

Qi NR, Wang J, Zidek V, Landa V, Mlejnek P, Kazdová L, Pravenec M, Kurtz TW.

Hypertension. 2005 May;45(5):1004-11. Epub 2005 Apr 4.

PMID:
15809359
42.

Generation and phenotypic analysis of a transgenic line of rabbits secreting active recombinant human erythropoietin in the milk.

Mikus T, Poplstein M, Sedláková J, Landa V, Jeníkova G, Trefil P, Lidický J, Malý P.

Transgenic Res. 2004 Oct;13(5):487-98.

PMID:
15587272
43.

Ultrastructural morphometry of precompacted bovine embryos produced in vivo and in vitro after activation by electric pulse AC/DC.

Pivko J, Landa V, Kubovicová E, Supová A, Grafenau P, Makarevich AV, Zibrín M.

Gen Physiol Biophys. 2004 Mar;23(1):101-12.

44.

Genetic analysis of "metabolic syndrome" in the spontaneously hypertensive rat.

Pravenec M, Zídek V, Landa V, Simáková M, Mlejnek P, Kazdová L, Bílá V, Krenová D, Kren V.

Physiol Res. 2004;53 Suppl 1:S15-22. Review.

45.

The CD36 protein functions as an immunogenic domain of the RT8 alloantigen.

Mlejnek P, Kren V, Liska F, Zídek V, Landa V, Kurtz TW, Pravenec M.

Eur J Immunogenet. 2003 Oct;30(5):325-7.

PMID:
14641538
46.

Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension.

Pravenec M, Landa V, Zídek V, Musilová A, Kazdová L, Qi N, Wang J, St Lezin E, Kurtz TW.

Physiol Res. 2003;52(6):681-8.

47.
48.

Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat.

Pravenec M, Kazdová L, Landa V, Zidek V, Mlejnek P, Jansa P, Wang J, Qi N, Kurtz TW.

J Biol Chem. 2003 Nov 14;278(46):45209-15. Epub 2003 Aug 27.

49.

Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone.

Qi N, Kazdova L, Zidek V, Landa V, Kren V, Pershadsingh HA, Lezin ES, Abumrad NA, Pravenec M, Kurtz TW.

J Biol Chem. 2002 Dec 13;277(50):48501-7. Epub 2002 Oct 15.

50.

Chromosome assignment of Cd36 transgenes in two rat SHR lines by FISH and linkage mapping of transgenic insert in the SHR-TG19 line.

Liska F, Levan G, Helou K, Sladká M, Pravenec M, Zídek V, Landa V, Kren V.

Folia Biol (Praha). 2002;48(4):139-44.

PMID:
12194200

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