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Items: 1 to 50 of 51

1.

EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC.

Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein R, Knauf JA, Rätsch G, Fagin JA.

Cancer Discov. 2018 Oct 10. pii: CD-18-0606. doi: 10.1158/2159-8290.CD-18-0606. [Epub ahead of print]

PMID:
30305285
2.

Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes.

Ganly I, Makarov V, Deraje S, Dong Y, Reznik E, Seshan V, Nanjangud G, Eng S, Bose P, Kuo F, Morris LGT, Landa I, Carrillo Albornoz PB, Riaz N, Nikiforov YE, Patel K, Umbricht C, Zeiger M, Kebebew E, Sherman E, Ghossein R, Fagin JA, Chan TA.

Cancer Cell. 2018 Aug 13;34(2):256-270.e5. doi: 10.1016/j.ccell.2018.07.002.

PMID:
30107176
3.

Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers During Active Surveillance.

Tuttle RM, Fagin JA, Minkowitz G, Wong RJ, Roman B, Patel S, Untch B, Ganly I, Shaha AR, Shah JP, Pace M, Li D, Bach A, Lin O, Whiting A, Ghossein R, Landa I, Sabra M, Boucai L, Fish S, Morris LGT.

JAMA Otolaryngol Head Neck Surg. 2017 Oct 1;143(10):1015-1020. doi: 10.1001/jamaoto.2017.1442.

PMID:
28859191
4.

Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence.

Ibrahimpasic T, Xu B, Landa I, Dogan S, Middha S, Seshan V, Deraje S, Carlson DL, Migliacci J, Knauf JA, Untch B, Berger MF, Morris L, Tuttle RM, Chan T, Fagin JA, Ghossein R, Ganly I.

Clin Cancer Res. 2017 Oct 1;23(19):5970-5980. doi: 10.1158/1078-0432.CCR-17-1183. Epub 2017 Jun 20.

5.

Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.

Montero-Conde C, Leandro-Garcia LJ, Chen X, Oler G, Ruiz-Llorente S, Ryder M, Landa I, Sanchez-Vega F, La K, Ghossein RA, Bajorin DF, Knauf JA, Riordan JD, Dupuy AJ, Fagin JA.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4951-E4960. doi: 10.1073/pnas.1702723114. Epub 2017 Jun 5.

6.

Science That Matters: The Importance of a Cultural Connection in Underrepresented Students' Science Pursuit.

Jackson MC, Galvez G, Landa I, Buonora P, Thoman DB.

CBE Life Sci Educ. 2016 fall;15(3). pii: ar42. doi: 10.1187/cbe.16-01-0067.

7.

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.

Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA.

J Clin Invest. 2016 Mar 1;126(3):1052-66. doi: 10.1172/JCI85271. Epub 2016 Feb 15.

8.

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.

Wiesner T, Lee W, Obenauf AC, Ran L, Murali R, Zhang QF, Wong EW, Hu W, Scott SN, Shah RH, Landa I, Button J, Lailler N, Sboner A, Gao D, Murphy DA, Cao Z, Shukla S, Hollmann TJ, Wang L, Borsu L, Merghoub T, Schwartz GK, Postow MA, Ariyan CE, Fagin JA, Zheng D, Ladanyi M, Busam KJ, Berger MF, Chen Y, Chi P.

Nature. 2015 Oct 15;526(7573):453-7. doi: 10.1038/nature15258. Epub 2015 Oct 7.

9.

NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.

Garcia-Rendueles ME, Ricarte-Filho JC, Untch BR, Landa I, Knauf JA, Voza F, Smith VE, Ganly I, Taylor BS, Persaud Y, Oler G, Fang Y, Jhanwar SC, Viale A, Heguy A, Huberman KH, Giancotti F, Ghossein R, Fagin JA.

Cancer Discov. 2015 Nov;5(11):1178-93. doi: 10.1158/2159-8290.CD-15-0330. Epub 2015 Sep 10.

10.

Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations.

Mancikova V, Cruz R, Inglada-Pérez L, Fernández-Rozadilla C, Landa I, Cameselle-Teijeiro J, Celeiro C, Pastor S, Velázquez A, Marcos R, Andía V, Álvarez-Escolá C, Meoro A, Schiavi F, Opocher G, Quintela I, Ansede-Bermejo J, Ruiz-Ponte C, Santisteban P, Robledo M, Carracedo A.

Int J Cancer. 2015 Oct 15;137(8):1870-8. doi: 10.1002/ijc.29557. Epub 2015 Apr 22.

11.

An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.

Landa I, Boullosa C, Inglada-Pérez L, Sastre-Perona A, Pastor S, Velázquez A, Mancikova V, Ruiz-Llorente S, Schiavi F, Marcos R, Malats N, Opocher G, Diaz-Uriarte R, Santisteban P, Valencia A, Robledo M.

PLoS One. 2013 Sep 23;8(9):e74765. doi: 10.1371/journal.pone.0074765. eCollection 2013. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/cd94c3eb-70f2-4dfa-85be-b3fc41e495c3.

12.

Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

Landa I, Ganly I, Chan TA, Mitsutake N, Matsuse M, Ibrahimpasic T, Ghossein RA, Fagin JA.

J Clin Endocrinol Metab. 2013 Sep;98(9):E1562-6. doi: 10.1210/jc.2013-2383. Epub 2013 Jul 5.

13.

Targeting mTOR in RET mutant medullary and differentiated thyroid cancer cells.

Gild ML, Landa I, Ryder M, Ghossein RA, Knauf JA, Fagin JA.

Endocr Relat Cancer. 2013 Aug 21;20(5):659-67. doi: 10.1530/ERC-13-0085. Print 2013 Oct.

14.

Differential gene expression of medullary thyroid carcinoma reveals specific markers associated with genetic conditions.

Maliszewska A, Leandro-Garcia LJ, Castelblanco E, Macià A, de Cubas A, Goméz-López G, Inglada-Pérez L, Álvarez-Escolá C, De la Vega L, Letón R, Gómez-Graña Á, Landa I, Cascón A, Rodríguez-Antona C, Borrego S, Zane M, Schiavi F, Merante-Boschin I, Pelizzo MR, Pisano DG, Opocher G, Matias-Guiu X, Encinas M, Robledo M.

Am J Pathol. 2013 Feb;182(2):350-62. doi: 10.1016/j.ajpath.2012.10.025. Epub 2012 Nov 28.

PMID:
23201134
15.

Hematologic β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicity.

Leandro-García LJ, Leskelä S, Inglada-Pérez L, Landa I, de Cubas AA, Maliszewska A, Comino-Méndez I, Letón R, Gómez-Graña Á, Torres R, Ramírez JC, Álvarez S, Rivera J, Martínez C, Lozano ML, Cascón A, Robledo M, Rodríguez-Antona C.

Cancer Res. 2012 Sep 15;72(18):4744-52. doi: 10.1158/0008-5472.CAN-11-2861. Epub 2012 Jul 17.

16.

Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family.

Cascón A, Huarte-Mendicoa CV, Javier Leandro-García L, Letón R, Suela J, Santana A, Costa MB, Comino-Méndez I, Landa I, Sánchez L, Rodríguez-Antona C, Cigudosa JC, Robledo M.

Genes Chromosomes Cancer. 2011 Nov;50(11):922-9. doi: 10.1002/gcc.20911. Epub 2011 Aug 11.

PMID:
21837707
17.

Association studies in thyroid cancer susceptibility: are we on the right track?

Landa I, Robledo M.

J Mol Endocrinol. 2011 Aug;47(1):R43-58. Review.

PMID:
21830323
18.

Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma.

Comino-Méndez I, Gracia-Aznárez FJ, Schiavi F, Landa I, Leandro-García LJ, Letón R, Honrado E, Ramos-Medina R, Caronia D, Pita G, Gómez-Graña A, de Cubas AA, Inglada-Pérez L, Maliszewska A, Taschin E, Bobisse S, Pica G, Loli P, Hernández-Lavado R, Díaz JA, Gómez-Morales M, González-Neira A, Roncador G, Rodríguez-Antona C, Benítez J, Mannelli M, Opocher G, Robledo M, Cascón A.

Nat Genet. 2011 Jun 19;43(7):663-7. doi: 10.1038/ng.861.

PMID:
21685915
19.

Association studies in thyroid cancer susceptibility: are we on the right track?

Landa I, Robledo M.

J Mol Endocrinol. 2011 Aug 3;47(1):R43-58. Print 2011.

PMID:
21610006
20.

Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas.

López-Jiménez E, Gómez-López G, Leandro-García LJ, Muñoz I, Schiavi F, Montero-Conde C, de Cubas AA, Ramires R, Landa I, Leskelä S, Maliszewska A, Inglada-Pérez L, de la Vega L, Rodríguez-Antona C, Letón R, Bernal C, de Campos JM, Diez-Tascón C, Fraga MF, Boullosa C, Pisano DG, Opocher G, Robledo M, Cascón A.

Mol Endocrinol. 2010 Dec;24(12):2382-91. doi: 10.1210/me.2010-0256. Epub 2010 Oct 27.

21.

Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.

Leskelä S, Jara C, Leandro-García LJ, Martínez A, García-Donas J, Hernando S, Hurtado A, Vicario JC, Montero-Conde C, Landa I, López-Jiménez E, Cascón A, Milne RL, Robledo M, Rodríguez-Antona C.

Pharmacogenomics J. 2011 Apr;11(2):121-9. doi: 10.1038/tpj.2010.13. Epub 2010 Mar 9.

PMID:
20212519
22.

Tumoral and tissue-specific expression of the major human beta-tubulin isotypes.

Leandro-García LJ, Leskelä S, Landa I, Montero-Conde C, López-Jiménez E, Letón R, Cascón A, Robledo M, Rodríguez-Antona C.

Cytoskeleton (Hoboken). 2010 Apr;67(4):214-23. doi: 10.1002/cm.20436.

PMID:
20191564
23.

Allelic variant at -79 (C>T) in CDKN1B (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels.

Landa I, Montero-Conde C, Malanga D, De Gisi S, Pita G, Leandro-García LJ, Inglada-Pérez L, Letón R, De Marco C, Rodríguez-Antona C, Viglietto G, Robledo M.

Endocr Relat Cancer. 2010 Jun 1;17(2):317-28. doi: 10.1677/ERC-09-0016. Print 2010 Jun.

PMID:
20075119
24.

Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis.

Rodríguez-Antona C, Pallares J, Montero-Conde C, Inglada-Pérez L, Castelblanco E, Landa I, Leskelä S, Leandro-García LJ, López-Jiménez E, Letón R, Cascón A, Lerma E, Martin MC, Carralero MC, Mauricio D, Cigudosa JC, Matias-Guiu X, Robledo M.

Endocr Relat Cancer. 2010 Jan 29;17(1):7-16. doi: 10.1677/ERC-08-0304. Print 2010 Mar.

PMID:
19776290
25.

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M.

PLoS Genet. 2009 Sep;5(9):e1000637. doi: 10.1371/journal.pgen.1000637. Epub 2009 Sep 4.

26.

Rationalization of genetic testing in patients with apparently sporadic pheochromocytoma/paraganglioma.

Cascón A, López-Jiménez E, Landa I, Leskelä S, Leandro-García LJ, Maliszewska A, Letón R, de la Vega L, García-Barcina MJ, Sanabria C, Alvarez-Escolá C, Rodríguez-Antona C, Robledo M.

Horm Metab Res. 2009 Sep;41(9):672-5. doi: 10.1055/s-0029-1202814. Epub 2009 Apr 2.

PMID:
19343621
27.

Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis.

Leandro-García LJ, Leskelä S, Montero-Conde C, Landa I, López-Jimenez E, Letón R, Seeringer A, Kirchheiner J, Cascón A, Robledo M, Rodríguez-Antona C.

Anal Biochem. 2009 Jun 1;389(1):74-6. doi: 10.1016/j.ab.2009.03.021. Epub 2009 Mar 20.

PMID:
19303860
28.

Genetics of pheochromocytoma and paraganglioma in Spanish patients.

Cascón A, Pita G, Burnichon N, Landa I, López-Jiménez E, Montero-Conde C, Leskelä S, Leandro-García LJ, Letón R, Rodríguez-Antona C, Díaz JA, López-Vidriero E, González-Neira A, Velasco A, Matias-Guiu X, Gimenez-Roqueplo AP, Robledo M.

J Clin Endocrinol Metab. 2009 May;94(5):1701-5. doi: 10.1210/jc.2008-2756. Epub 2009 Mar 3.

PMID:
19258401
29.

SDHC mutation in an elderly patient without familial antecedents.

López-Jiménez E, de Campos JM, Kusak EM, Landa I, Leskelä S, Montero-Conde C, Leandro-García LJ, Vallejo LA, Madrigal B, Rodríguez-Antona C, Robledo M, Cascón A.

Clin Endocrinol (Oxf). 2008 Dec;69(6):906-10. doi: 10.1111/j.1365-2265.2008.03368.x. Epub 2008 Aug 4.

PMID:
18681855
30.

Molecular characterisation of a common SDHB deletion in paraganglioma patients.

Cascón A, Landa I, López-Jiménez E, Díez-Hernández A, Buchta M, Montero-Conde C, Leskelä S, Leandro-García LJ, Letón R, Rodríguez-Antona C, Eng C, Neumann HP, Robledo M.

J Med Genet. 2008 Apr;45(4):233-8. Epub 2007 Dec 5.

PMID:
18057081
31.

Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer.

Leskelä S, Honrado E, Montero-Conde C, Landa I, Cascón A, Letón R, Talavera P, Cózar JM, Concha A, Robledo M, Rodríguez-Antona C.

Endocr Relat Cancer. 2007 Sep;14(3):645-54.

PMID:
17914095
32.

Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma.

Ruiz-Llorente S, Montero-Conde C, Milne RL, Moya CM, Cebrián A, Letón R, Cascón A, Mercadillo F, Landa I, Borrego S, Pérez de Nanclares G, Alvarez-Escolá C, Díaz-Pérez JA, Carracedo A, Urioste M, González-Neira A, Benítez J, Santisteban P, Dopazo J, Ponder BA, Robledo M; Medullary Thyroid Carcinoma Clinical Group.

Cancer Res. 2007 Oct 1;67(19):9561-7.

33.

Hyperthermophilic redox chemistry: a re-evaluation.

Hagedoorn PL, Driessen MC, van den Bosch M, Landa I, Hagen WR.

FEBS Lett. 1998 Dec 4;440(3):311-4.

34.

[Experience with the production of a serial cryotherapy instrument].

Landa IuI, Savchenko AIu, Nevel'skiĭ IV, Shneĭder LA.

Med Tekh. 1997 Nov-Dec;(6):36-9. Russian.

PMID:
9460665
35.

Cytoprotective effect of somatostatin in a rat model of hepatic ischemic reperfusion.

Landa I, Arias J, Gómez M, Quadros M, Moreno A, Balibrea JL.

Hepatology. 1992 Dec;16(6):1474-6.

PMID:
1359996
36.

Effect of University of Wisconsin solution pancreas preservation period on function of isolated human islets.

Gómez M, Vara E, Landa I, Arias J, Moreno A, Balibrea JL, Tamarit-Rodriguez J.

Transplant Proc. 1992 Jun;24(3):1013-5. No abstract available.

PMID:
1351323
37.

Acute experimental pancreatitis in rat induced by sodium taurocholic acid: objective quantification of pancreatic necrosis.

Rueda JC, Ortega L, Argüello JM, Torres AJ, Landa I, Balibrea JL.

Virchows Arch A Pathol Anat Histopathol. 1992;420(2):117-20.

PMID:
1372456
38.

Evaluation of a prospective protocol for liver transplantation in the treatment of acute liver failure.

Landa I, Calleja J, Gomez M, Jover J, Arias J, Sevilla P, Valenzuela C, Moreno E.

Transplant Proc. 1990 Oct;22(5):2293-4. No abstract available.

PMID:
2219374
39.
40.

Somatostatin in the treatment of severe upper gastrointestinal bleeding: a multicentre controlled trial.

Torres AJ, Landa I, Hernández F, Jover JM, Suárez A, Arias J, Cuberes R, Santoyo J, Fernández R, Calleja J, et al.

Br J Surg. 1986 Oct;73(10):786-9.

PMID:
2876741
41.
42.

[Gigantic cyst of the choledochus].

Landa IE, Samoĭlov VI, Vasil'kovskaia DIa, Kunun IA.

Khirurgiia (Mosk). 1977 Mar;(3):132-3. Russian. No abstract available.

PMID:
864924
43.

[Perforated primary pancreatic hydatidosis].

Miguel Velasco JE, Domínguez Sayans J, Suárez San Pedro F, Parada Herrero R, Soleto Saez E, Landa I.

Rev Esp Enferm Apar Dig. 1976 Jun;47(6):771-84. Spanish. No abstract available.

PMID:
948691
44.

[Errors in diagnosis of diaphragmatic hernia].

Frankenberg BE, Geshelin SA, Landa IE, Levandovskiĭ VM, Belotserkovskaia RV.

Khirurgiia (Mosk). 1975 Jun;(7):91-4. Russian. No abstract available.

PMID:
1221204
45.

[Surgical treatment of bronchial asthma].

Landa IE, Kravetskaia RM.

Klin Khir. 1974 Nov;(11):70-1. Russian. No abstract available.

PMID:
4444164
46.

[Repeat operations for diaphragmatic hernias].

Frankenberg BE, Landa IE.

Vestn Khir Im I I Grek. 1974 Jan;112(1):127-9. Russian. No abstract available.

PMID:
4458179
47.

[Strangulated obturated hernia].

Landa IE, Vasil'kovskaia DIa.

Vestn Khir Im I I Grek. 1973 Jul;111(7):130. Russian. No abstract available.

PMID:
4776752
48.

[Diagnosis of tuberculosis pericholedochal lymphadenitis].

Landa IE, Kravetskaia RM.

Probl Tuberk. 1973;51(10):90. Russian. No abstract available.

PMID:
4784050
49.

[Giant true non-parasitic cyst of the liver].

Landa IE.

Klin Khir. 1965 Oct;5:68. Russian. No abstract available.

PMID:
5872848
50.

[ON THE MOST FREQUENT CAUSES OF ADHESIVE INTESTINAL OBSTRUCTION].

LANDA Ie.

Khirurgiia (Mosk). 1964 Sep;40:136-7. Russian. No abstract available.

PMID:
14249483

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