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Items: 1 to 50 of 64

1.

Recombinant class I aldehyde dehydrogenases specific for all-trans- or 9-cis-retinal.

Montplaisir V, Lan NC, Guimond J, Savineau C, Bhat PV, Mader S.

J Biol Chem. 2002 May 17;277(20):17486-92. Epub 2002 Mar 6.

2.
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Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids.

Vanover KE, Edgar DM, Seidel WF, Hogenkamp DJ, Fick DB, Lan NC, Gee KW, Carter RB.

J Pharmacol Exp Ther. 1999 Dec;291(3):1317-23.

PMID:
10565857
5.

Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol.

Vanover KE, Suruki M, Robledo S, Huber M, Wieland S, Lan NC, Gee KW, Wood PL, Carter RB.

Psychopharmacology (Berl). 1999 Jan;141(1):77-82.

PMID:
9952068
6.

Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors.

Hawkinson JE, Acosta-Burruel M, Yang KC, Hogenkamp DJ, Chen JS, Lan NC, Drewe JA, Whittemore ER, Woodward RM, Carter RB, Upasani RB.

J Pharmacol Exp Ther. 1998 Oct;287(1):198-207.

PMID:
9765338
7.

Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593.

Wieland S, Belluzzi J, Hawkinson JE, Hogenkamp D, Upasani R, Stein L, Wood PL, Gee KW, Lan NC.

Psychopharmacology (Berl). 1997 Nov;134(1):46-54.

PMID:
9399366
8.

CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.

Edgar DM, Seidel WF, Gee KW, Lan NC, Field G, Xia H, Hawkinson JE, Wieland S, Carter RB, Wood PL.

J Pharmacol Exp Ther. 1997 Jul;282(1):420-9.

PMID:
9223583
9.

Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site.

Xue BG, Whittemore ER, Park CH, Woodward RM, Lan NC, Gee KW.

J Pharmacol Exp Ther. 1997 Jun;281(3):1095-101.

PMID:
9190841
10.

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW.

J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95.

PMID:
9067315
11.

3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors.

Upasani RB, Yang KC, Acosta-Burruel M, Konkoy CS, McLellan JA, Woodward RM, Lan NC, Carter RB, Hawkinson JE.

J Med Chem. 1997 Jan 3;40(1):73-84.

PMID:
9016330
12.

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.

Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB.

J Med Chem. 1997 Jan 3;40(1):61-72.

PMID:
9016329
13.

In vitro and in vivo activity of 16,17-dehydro-epipregnanolones: 17,20-bond torsional energy analysis and D-ring conformation.

Bolger MB, Wieland S, Hawkinson JE, Xia H, Upasani R, Lan NC.

Pharm Res. 1996 Oct;13(10):1488-94.

PMID:
8899839
14.

Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety.

Carboni E, Wieland S, Lan NC, Gee KW.

Psychopharmacology (Berl). 1996 Jul;126(2):173-8.

PMID:
8856837
15.

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor.

Hawkinson JE, Drewe JA, Kimbrough CL, Chen JS, Hogenkamp DJ, Lan NC, Gee KW, Shen KZ, Whittemore ER, Woodward RM.

Mol Pharmacol. 1996 May;49(5):897-906.

PMID:
8622640
16.

Modulation of human recombinant GABAA receptors by pregnanediols.

Belelli D, Lambert JJ, Peters JA, Gee KW, Lan NC.

Neuropharmacology. 1996;35(9-10):1223-31.

PMID:
9014137
17.
18.

Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria.

McCauley LD, Park CH, Lan NC, Tomich JM, Shively JE, Gee KW.

Eur J Pharmacol. 1995 Mar 24;276(1-2):145-53.

PMID:
7781684
19.
20.

Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain.

McCauley LD, Liu V, Chen JS, Hawkinson JE, Lan NC, Gee KW.

Mol Pharmacol. 1995 Feb;47(2):354-62.

PMID:
7870044
21.

Differential effects of 4'-chlorodiazepam on expressed human GABAA receptors.

Lan NC, Chen JS, Johnson D, Gee KW.

J Neurochem. 1995 Feb;64(2):684-8.

PMID:
7830061
22.
23.

Stable high expression of human gamma-aminobutyric acidA receptors composed of alpha and beta subunits.

Drewe JA, Chen JS, Reyes AA, Lan NC.

Life Sci. 1995;57(12):1175-82.

PMID:
7674806
24.

Neuroactive steroid actions at the GABAA receptor.

Lan NC, Gee KW.

Horm Behav. 1994 Dec;28(4):537-44. Review.

PMID:
7729823
25.

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function.

Hawkinson JE, Kimbrough CL, Belelli D, Lambert JJ, Purdy RH, Lan NC.

Mol Pharmacol. 1994 Nov;46(5):977-85.

PMID:
7969089
26.

The neuroactive steroid 3 alpha-hydroxy-5 beta-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor.

Hawkinson JE, Kimbrough CL, McCauley LD, Bolger MB, Lan NC, Gee KW.

Eur J Pharmacol. 1994 Oct 14;269(2):157-63.

PMID:
7851492
27.

Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.

Chen R, Belelli D, Lambert JJ, Peters JA, Reyes A, Lan NC.

Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6069-73. Erratum in: Proc Natl Acad Sci U S A 1994 Oct 11;91(21):10242.

28.

Identification of the GABAA receptor subtype mRNA in human pancreatic tissue.

Yang W, Reyes AA, Lan NC.

FEBS Lett. 1994 Jun 13;346(2-3):257-62.

29.

Gene structure and expression of the mouse 5-HT2 receptor.

Yang W, Chen K, Lan NC, Gallaher TK, Shih JC.

J Neurosci Res. 1992 Oct;33(2):196-204.

PMID:
1333538
30.

Pharmacology of a GABAA receptor coupled steroid recognition site.

Gee KW, Lan NC, Bolger MB, Wieland S, Belelli D, Chen JS.

Adv Biochem Psychopharmacol. 1992;47:111-7. Review. No abstract available.

PMID:
1354914
31.

Peripheral-type benzodiazepine receptors and the regulation of steroidogenesis in rat brain mitochondria.

McCauley LD, Lan NC, Tomich JM, Shively JE, Gee KW.

Adv Biochem Psychopharmacol. 1992;47:143-7. No abstract available.

PMID:
1324568
33.

Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one.

Wieland S, Lan NC, Mirasedeghi S, Gee KW.

Brain Res. 1991 Nov 29;565(2):263-8.

PMID:
1688192
34.

Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids.

Lan NC, Gee KW, Bolger MB, Chen JS.

J Neurochem. 1991 Nov;57(5):1818-21.

PMID:
1655982
35.

Human monoamine oxidase A and B genes exhibit identical exon-intron organization.

Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC.

Proc Natl Acad Sci U S A. 1991 May 1;88(9):3637-41.

36.

Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor.

Lan NC, Bolger MB, Gee KW.

Neurochem Res. 1991 Mar;16(3):347-56. Review. No abstract available.

PMID:
1664061
37.

Tissue distribution of human monoamine oxidase A and B mRNA.

Grimsby J, Lan NC, Neve R, Chen K, Shih JC.

J Neurochem. 1990 Oct;55(4):1166-9.

PMID:
2398352
38.

A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor.

Lan NC, Chen JS, Belelli D, Pritchett DB, Seeburg PH, Gee KW.

Eur J Pharmacol. 1990 Jun 12;188(6):403-6.

PMID:
2164942
39.

Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex.

Belelli D, Lan NC, Gee KW.

Neurosci Biobehav Rev. 1990 Fall;14(3):315-22. Review.

PMID:
2172879
40.

Localization of monoamine oxidase A and B genes on the mouse X chromosome.

Derry JM, Lan NC, Shih JC, Barnard EA, Barnard PJ.

Nucleic Acids Res. 1989 Oct 25;17(20):8403. No abstract available.

41.

Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.

Lan NC, Heinzmann C, Gal A, Klisak I, Orth U, Lai E, Grimsby J, Sparkes RS, Mohandas T, Shih JC.

Genomics. 1989 May;4(4):552-9.

PMID:
2744764
42.

Expression of functional human monoamine oxidase A and B cDNAs in mammalian cells.

Lan NC, Chen CH, Shih JC.

J Neurochem. 1989 May;52(5):1652-4.

PMID:
2496202
43.

cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH, Shih JC.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4934-8.

44.

Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.

Behlke MA, Henkel TJ, Anderson SJ, Lan NC, Hood L, Braciale VL, Braciale TJ, Loh DY.

J Exp Med. 1987 Jan 1;165(1):257-62.

45.

Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c.

Winoto A, Urban JL, Lan NC, Goverman J, Hood L, Hansburg D.

Nature. 1986 Dec 18-31;324(6098):679-82.

PMID:
3025740
46.

The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments.

Barth RK, Kim BS, Lan NC, Hunkapiller T, Sobieck N, Winoto A, Gershenfeld H, Okada C, Hansburg D, Weissman IL, et al.

Nature. 1985 Aug 8-14;316(6028):517-23.

PMID:
2412120
48.

Interaction of sodium molybdate with highly purified glucocorticoid receptor.

Weisz A, Baxter JD, Lan NC.

J Steroid Biochem. 1984 Jan;20(1):289-93.

PMID:
6708515
49.

Mechanisms of glucocorticoid hormone action.

Lan NC, Karin M, Nguyen T, Weisz A, Birnbaum MJ, Eberhardt NL, Baxter JD.

J Steroid Biochem. 1984 Jan;20(1):77-88. Review.

PMID:
6368989
50.

Monoclonal antibodies against human DNA polymerase-alpha do not cross-react with glucocorticoid receptors.

Lan NC, Wang TS, Johnson LK, Korn D.

J Steroid Biochem. 1984 Jan;20(1):251-4.

PMID:
6200697

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