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Items: 1 to 50 of 121

1.

Clonality of circulating tumor cells in breast cancer brain metastasis patients.

Riebensahm C, Joosse SA, Mohme M, Hanssen A, Matschke J, Goy Y, Witzel I, Lamszus K, Kropidlowski J, Petersen C, Kolb-Kokocinski A, Sauer S, Borgmann K, Glatzel M, Müller V, Westphal M, Riethdorf S, Pantel K, Wikman H.

Breast Cancer Res. 2019 Sep 3;21(1):101. doi: 10.1186/s13058-019-1184-2.

2.

Immunologic Profiling of Mutational and Transcriptional Subgroups in Pediatric and Adult High-Grade Gliomas.

Bockmayr M, Klauschen F, Maire CL, Rutkowski S, Westphal M, Lamszus K, Schüller U, Mohme M.

Cancer Immunol Res. 2019 Sep;7(9):1401-1411. doi: 10.1158/2326-6066.CIR-18-0939. Epub 2019 Jul 2.

PMID:
31266783
3.

Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas.

Rapp C, Dettling S, Liu F, Ull AT, Warta R, Jungk C, Roesch S, Mock A, Sahm F, Schmidt M, Jungwirth G, Zweckberger K, Lamszus K, Gousias K, Kessler AF, Grabe N, Loehr M, Ketter R, Urbschat S, Senft C, Westphal M, Abdollahi A, Debus J, von Deimling A, Unterberg A, Simon M, Herold-Mende CC.

Clin Cancer Res. 2019 Sep 1;25(17):5260-5270. doi: 10.1158/1078-0432.CCR-19-0389. Epub 2019 Jun 21.

PMID:
31227506
4.

EGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients.

Scharpenseel H, Hanssen A, Loges S, Mohme M, Bernreuther C, Peine S, Lamszus K, Goy Y, Petersen C, Westphal M, Glatzel M, Riethdorf S, Pantel K, Wikman H.

Sci Rep. 2019 May 15;9(1):7406. doi: 10.1038/s41598-019-43678-6.

5.

Mass Spectrometric Lipid Profiles of Picosecond Infrared Laser-Generated Tissue Aerosols Discriminate Different Brain Tissues.

Wurlitzer M, Hessling E, Rinas K, Fuh M, Petersen H, Ricklefs F, Lamszus K, Regelsberger J, Maier S, Kruber S, Hansen NO, Miller R, Schlüter H.

Lasers Surg Med. 2019 May 8. doi: 10.1002/lsm.23096. [Epub ahead of print]

PMID:
31067361
6.

Identification of KIF11 As a Novel Target in Meningioma.

Jungwirth G, Yu T, Moustafa M, Rapp C, Warta R, Jungk C, Sahm F, Dettling S, Zweckberger K, Lamszus K, Senft C, Loehr M, Keßler AF, Ketter R, Westphal M, Debus J, von Deimling A, Simon M, Unterberg A, Abdollahi A, Herold-Mende C.

Cancers (Basel). 2019 Apr 15;11(4). pii: E545. doi: 10.3390/cancers11040545.

7.

Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours.

Ricklefs FL, Maire CL, Reimer R, Dührsen L, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel M, Heiland DH, Flitsch J, Martens T, Schmidt NO, Peine S, Breakefield XO, Lawler S, Chiocca EA, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K.

J Extracell Vesicles. 2019 Mar 21;8(1):1588555. doi: 10.1080/20013078.2019.1588555. eCollection 2019.

8.

Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis.

Körber V, Yang J, Barah P, Wu Y, Stichel D, Gu Z, Fletcher MNC, Jones D, Hentschel B, Lamszus K, Tonn JC, Schackert G, Sabel M, Felsberg J, Zacher A, Kaulich K, Hübschmann D, Herold-Mende C, von Deimling A, Weller M, Radlwimmer B, Schlesner M, Reifenberger G, Höfer T, Lichter P.

Cancer Cell. 2019 Apr 15;35(4):692-704.e12. doi: 10.1016/j.ccell.2019.02.007. Epub 2019 Mar 21.

PMID:
30905762
9.

Frequency of Circulating Tumor Cells (CTC) in Patients with Brain Metastases: Implications as a Risk Assessment Marker in Oligo-Metastatic Disease.

Hanssen A, Riebensahm C, Mohme M, Joosse SA, Velthaus JL, Berger LA, Bernreuther C, Glatzel M, Loges S, Lamszus K, Westphal M, Riethdorf S, Pantel K, Wikman H.

Cancers (Basel). 2018 Dec 19;10(12). pii: E527. doi: 10.3390/cancers10120527.

10.

Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p.

Sievers P, Stichel D, Hielscher T, Schrimpf D, Reinhardt A, Wefers AK, Reuss D, Jones DTW, Bewerunge-Hudler M, Hartmann C, Baumgarten P, Wirsching HG, Winther-Kristensen B, Brokinkel B, Ketter R, Idoate Gastearena MA, Lamszus K, Seiz-Rosenhagen M, Mawrin C, Harter PN, Felsberg J, Hänggi D, Herold-Mende C, Berghoff AS, Weller M, Pfister SM, Wick W, Reifenberger G, Preusser M, von Deimling A, Sahm F.

Acta Neuropathol. 2018 Dec;136(6):975-978. doi: 10.1007/s00401-018-1924-x. Epub 2018 Oct 31. No abstract available.

PMID:
30382370
11.

The secreted glycolytic enzyme GPI/AMF stimulates glioblastoma cell migration and invasion in an autocrine fashion but can have anti-proliferative effects.

Kathagen-Buhmann A, Maire CL, Weller J, Schulte A, Matschke J, Holz M, Ligon KL, Glatzel M, Westphal M, Lamszus K.

Neuro Oncol. 2018 Nov 12;20(12):1594-1605. doi: 10.1093/neuonc/noy117.

PMID:
30053149
12.

The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy.

Neidert MC, Kowalewski DJ, Silginer M, Kapolou K, Backert L, Freudenmann LK, Peper JK, Marcu A, Wang SS, Walz JS, Wolpert F, Rammensee HG, Henschler R, Lamszus K, Westphal M, Roth P, Regli L, Stevanović S, Weller M, Eisele G.

Acta Neuropathol. 2018 Jun;135(6):923-938. doi: 10.1007/s00401-018-1836-9. Epub 2018 Mar 20.

PMID:
29557506
13.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA.

Sci Adv. 2018 Mar 7;4(3):eaar2766. doi: 10.1126/sciadv.aar2766. eCollection 2018 Mar.

14.

Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes.

Mohme M, Schliffke S, Maire CL, Rünger A, Glau L, Mende KC, Matschke J, Gehbauer C, Akyüz N, Zapf S, Holz M, Schaper M, Martens T, Schmidt NO, Peine S, Westphal M, Binder M, Tolosa E, Lamszus K.

Clin Cancer Res. 2018 Sep 1;24(17):4187-4200. doi: 10.1158/1078-0432.CCR-17-2617. Epub 2018 Feb 14.

15.

EGFR as a Target for Glioblastoma Treatment: An Unfulfilled Promise.

Westphal M, Maire CL, Lamszus K.

CNS Drugs. 2017 Sep;31(9):723-735. doi: 10.1007/s40263-017-0456-6. Review.

16.

Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases.

Mohme M, Riethdorf S, Dreimann M, Werner S, Maire CL, Joosse SA, Bludau F, Mueller V, Neves RPL, Stoecklein NH, Lamszus K, Westphal M, Pantel K, Wikman H, Eicker SO.

Sci Rep. 2017 Aug 3;7(1):7196. doi: 10.1038/s41598-017-07649-z.

17.

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis.

Sahm F, Schrimpf D, Stichel D, Jones DTW, Hielscher T, Schefzyk S, Okonechnikov K, Koelsche C, Reuss DE, Capper D, Sturm D, Wirsching HG, Berghoff AS, Baumgarten P, Kratz A, Huang K, Wefers AK, Hovestadt V, Sill M, Ellis HP, Kurian KM, Okuducu AF, Jungk C, Drueschler K, Schick M, Bewerunge-Hudler M, Mawrin C, Seiz-Rosenhagen M, Ketter R, Simon M, Westphal M, Lamszus K, Becker A, Koch A, Schittenhelm J, Rushing EJ, Collins VP, Brehmer S, Chavez L, Platten M, Hänggi D, Unterberg A, Paulus W, Wick W, Pfister SM, Mittelbronn M, Preusser M, Herold-Mende C, Weller M, von Deimling A.

Lancet Oncol. 2017 May;18(5):682-694. doi: 10.1016/S1470-2045(17)30155-9. Epub 2017 Mar 15.

18.

Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity.

Mohme M, Maire CL, Riecken K, Zapf S, Aranyossy T, Westphal M, Lamszus K, Fehse B.

Mol Ther. 2017 Mar 1;25(3):621-633. doi: 10.1016/j.ymthe.2016.12.014. Epub 2017 Jan 18.

19.

PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression.

Hohensee I, Chuang HN, Grottke A, Werner S, Schulte A, Horn S, Lamszus K, Bartkowiak K, Witzel I, Westphal M, Matschke J, Glatzel M, Jücker M, Pukrop T, Pantel K, Wikman H.

Oncotarget. 2017 Jan 24;8(4):6155-6168. doi: 10.18632/oncotarget.14047.

20.

Human glioblastoma stem-like cells accumulate protoporphyrin IX when subjected to exogenous 5-aminolaevulinic acid, rendering them sensitive to photodynamic treatment.

Schimanski A, Ebbert L, Sabel MC, Finocchiaro G, Lamszus K, Ewelt C, Etminan N, Fischer JC, Sorg RV.

J Photochem Photobiol B. 2016 Oct;163:203-10. doi: 10.1016/j.jphotobiol.2016.08.043. Epub 2016 Aug 27.

PMID:
27588717
21.

Secretory Meningiomas: Increased Prevalence of Seizures Secondary to Edema Formation in a Rare Histologic Subtype.

Mohme M, Emami P, Regelsberger J, Matschke J, Lamszus K, Westphal M, Eicker SO.

World Neurosurg. 2016 Aug;92:418-425. doi: 10.1016/j.wneu.2016.05.046. Epub 2016 May 27.

PMID:
27241088
22.

Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation.

Kathagen-Buhmann A, Schulte A, Weller J, Holz M, Herold-Mende C, Glass R, Lamszus K.

Neuro Oncol. 2016 Sep;18(9):1219-29. doi: 10.1093/neuonc/now024. Epub 2016 Feb 24.

23.

Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.

Schmidt M, Mock A, Jungk C, Sahm F, Ull AT, Warta R, Lamszus K, Gousias K, Ketter R, Roesch S, Rapp C, Schefzyk S, Urbschat S, Lahrmann B, Kessler AF, Löhr M, Senft C, Grabe N, Reuss D, Beckhove P, Westphal M, von Deimling A, Unterberg A, Simon M, Herold-Mende C.

Oncotarget. 2016 Mar 22;7(12):14551-68. doi: 10.18632/oncotarget.7396.

24.

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

Sahm F, Schrimpf D, Olar A, Koelsche C, Reuss D, Bissel J, Kratz A, Capper D, Schefzyk S, Hielscher T, Wang Q, Sulman EP, Adeberg S, Koch A, Okuducu AF, Brehmer S, Schittenhelm J, Becker A, Brokinkel B, Schmidt M, Ull T, Gousias K, Kessler AF, Lamszus K, Debus J, Mawrin C, Kim YJ, Simon M, Ketter R, Paulus W, Aldape KD, Herold-Mende C, von Deimling A.

J Natl Cancer Inst. 2015 Dec 13;108(5). doi: 10.1093/jnci/djv377. Print 2016 May.

25.

Interferon-β Modulates the Innate Immune Response against Glioblastoma Initiating Cells.

Wolpert F, Happold C, Reifenberger G, Florea AM, Deenen R, Roth P, Neidert MC, Lamszus K, Westphal M, Weller M, Eisele G.

PLoS One. 2015 Oct 6;10(10):e0139603. doi: 10.1371/journal.pone.0139603. eCollection 2015.

26.

EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells.

Struve N, Riedel M, Schulte A, Rieckmann T, Grob TJ, Gal A, Rothkamm K, Lamszus K, Petersen C, Dikomey E, Kriegs M.

Oncotarget. 2015 Oct 20;6(32):33867-77. doi: 10.18632/oncotarget.5293.

27.

Circulating biomarkers for gliomas.

Westphal M, Lamszus K.

Nat Rev Neurol. 2015 Oct;11(10):556-66. doi: 10.1038/nrneurol.2015.171. Epub 2015 Sep 15. Review.

PMID:
26369507
28.

EGFR Amplification and Glioblastoma Stem-Like Cells.

Liffers K, Lamszus K, Schulte A.

Stem Cells Int. 2015;2015:427518. doi: 10.1155/2015/427518. Epub 2015 Jun 2. Review.

29.

Histone Deacetylase Inhibitors Resensitize EGFR/EGFRvIII-Overexpressing, Erlotinib-Resistant Glioblastoma Cells to Tyrosine Kinase Inhibition.

Liffers K, Kolbe K, Westphal M, Lamszus K, Schulte A.

Target Oncol. 2016 Feb;11(1):29-40. doi: 10.1007/s11523-015-0372-y.

PMID:
26032687
30.

Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma.

Müller N, Michen S, Tietze S, Töpfer K, Schulte A, Lamszus K, Schmitz M, Schackert G, Pastan I, Temme A.

J Immunother. 2015 Jun;38(5):197-210. doi: 10.1097/CJI.0000000000000082.

31.

Printed peptide arrays identify prognostic TNC serumantibodies in glioblastoma patients.

Mock A, Warta R, Geisenberger C, Bischoff R, Schulte A, Lamszus K, Stadler V, Felgenhauer T, Schichor C, Schwartz C, Matschke J, Jungk C, Ahmadi R, Sahm F, Capper D, Glass R, Tonn JC, Westphal M, von Deimling A, Unterberg A, Bermejo JL, Herold-Mende C.

Oncotarget. 2015 May 30;6(15):13579-90.

32.

Inhibition of intracerebral glioblastoma growth by targeting the insulin-like growth factor 1 receptor involves different context-dependent mechanisms.

Zamykal M, Martens T, Matschke J, Günther HS, Kathagen A, Schulte A, Peters R, Westphal M, Lamszus K.

Neuro Oncol. 2015 Aug;17(8):1076-85. doi: 10.1093/neuonc/nou344. Epub 2014 Dec 27.

33.

Identification of HERC5 and its potential role in NSCLC progression.

Wrage M, Hagmann W, Kemming D, Uzunoglu FG, Riethdorf S, Effenberger K, Westphal M, Lamszus K, Kim SZ, Becker N, Izbicki JR, Sandoval J, Esteller M, Pantel K, Risch A, Wikman H.

Int J Cancer. 2015 May 15;136(10):2264-72. doi: 10.1002/ijc.29298. Epub 2014 Nov 9.

34.

Hematogenous dissemination of glioblastoma multiforme.

Müller C, Holtschmidt J, Auer M, Heitzer E, Lamszus K, Schulte A, Matschke J, Langer-Freitag S, Gasch C, Stoupiec M, Mauermann O, Peine S, Glatzel M, Speicher MR, Geigl JB, Westphal M, Pantel K, Riethdorf S.

Sci Transl Med. 2014 Jul 30;6(247):247ra101. doi: 10.1126/scitranslmed.3009095.

35.

Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells.

Guichet PO, Guelfi S, Teigell M, Hoppe L, Bakalara N, Bauchet L, Duffau H, Lamszus K, Rothhut B, Hugnot JP.

Stem Cells. 2015 Jan;33(1):21-34. doi: 10.1002/stem.1767.

36.

Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients.

Wikman H, Westphal L, Schmid F, Pollari S, Kropidlowski J, Sielaff-Frimpong B, Glatzel M, Matschke J, Westphal M, Iljin K, Huhtala H, Terracciano L, Kallioniemi A, Sauter G, Müller V, Witzel I, Lamszus K, Kemming D, Pantel K.

Oncotarget. 2014 May 30;5(10):3076-87.

37.

High-frequency stimulation of the subthalamic nucleus counteracts cortical expression of major histocompatibility complex genes in a rat model of Parkinson's disease.

Grieb B, Engler G, Sharott A, von Nicolai C, Streichert T, Papageorgiou I, Schulte A, Westphal M, Lamszus K, Engel AK, Moll CK, Hamel W.

PLoS One. 2014 Mar 12;9(3):e91663. doi: 10.1371/journal.pone.0091663. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e116365.

38.

Interferon-β induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells.

Happold C, Roth P, Silginer M, Florea AM, Lamszus K, Frei K, Deenen R, Reifenberger G, Weller M.

Mol Cancer Ther. 2014 Apr;13(4):948-61. doi: 10.1158/1535-7163.MCT-13-0772. Epub 2014 Feb 13.

39.

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells.

Kathagen A, Schulte A, Balcke G, Phillips HS, Martens T, Matschke J, Günther HS, Soriano R, Modrusan Z, Sandmann T, Kuhl C, Tissier A, Holz M, Krawinkel LA, Glatzel M, Westphal M, Lamszus K.

Acta Neuropathol. 2013 Nov;126(5):763-80. doi: 10.1007/s00401-013-1173-y. Epub 2013 Sep 5.

PMID:
24005892
40.

Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110δ.

Schulte A, Liffers K, Kathagen A, Riethdorf S, Zapf S, Merlo A, Kolbe K, Westphal M, Lamszus K.

Neuro Oncol. 2013 Oct;15(10):1289-301. doi: 10.1093/neuonc/not093. Epub 2013 Jul 21.

41.

Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.

Hohensee I, Lamszus K, Riethdorf S, Meyer-Staeckling S, Glatzel M, Matschke J, Witzel I, Westphal M, Brandt B, Müller V, Pantel K, Wikman H.

Am J Pathol. 2013 Jul;183(1):83-95. doi: 10.1016/j.ajpath.2013.03.023. Epub 2013 May 9.

PMID:
23665199
42.

Functional dissection of the epidermal growth factor receptor epitopes targeted by panitumumab and cetuximab.

Voigt M, Braig F, Göthel M, Schulte A, Lamszus K, Bokemeyer C, Binder M.

Neoplasia. 2012 Nov;14(11):1023-31.

43.

Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastases.

Wikman H, Sielaff-Frimpong B, Kropidlowski J, Witzel I, Milde-Langosch K, Sauter G, Westphal M, Lamszus K, Pantel K.

PLoS One. 2012;7(10):e47537. doi: 10.1371/journal.pone.0047537. Epub 2012 Oct 31.

44.

Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.

Preukschas M, Hagel C, Schulte A, Weber K, Lamszus K, Sievert H, Pällmann N, Bokemeyer C, Hauber J, Braig M, Balabanov S.

PLoS One. 2012;7(8):e43468. doi: 10.1371/journal.pone.0043468. Epub 2012 Aug 21.

45.

HLA-E contributes to an immune-inhibitory phenotype of glioblastoma stem-like cells.

Wolpert F, Roth P, Lamszus K, Tabatabai G, Weller M, Eisele G.

J Neuroimmunol. 2012 Sep 15;250(1-2):27-34. doi: 10.1016/j.jneuroim.2012.05.010. Epub 2012 Jun 9.

PMID:
22688424
46.

The cancer stem cell subtype determines immune infiltration of glioblastoma.

Beier CP, Kumar P, Meyer K, Leukel P, Bruttel V, Aschenbrenner I, Riemenschneider MJ, Fragoulis A, Rümmele P, Lamszus K, Schulz JB, Weis J, Bogdahn U, Wischhusen J, Hau P, Spang R, Beier D.

Stem Cells Dev. 2012 Oct 10;21(15):2753-61. doi: 10.1089/scd.2011.0660. Epub 2012 Jul 16.

47.

Relevance of PTEN loss in brain metastasis formation in breast cancer patients.

Wikman H, Lamszus K, Detels N, Uslar L, Wrage M, Benner C, Hohensee I, Ylstra B, Eylmann K, Zapatka M, Sauter G, Kemming D, Glatzel M, Müller V, Westphal M, Pantel K.

Breast Cancer Res. 2012 Mar 19;14(2):R49.

48.

Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration.

Schulte A, Günther HS, Martens T, Zapf S, Riethdorf S, Wülfing C, Stoupiec M, Westphal M, Lamszus K.

Clin Cancer Res. 2012 Apr 1;18(7):1901-13. doi: 10.1158/1078-0432.CCR-11-3084. Epub 2012 Feb 7.

49.

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

Lai A, Kharbanda S, Pope WB, Tran A, Solis OE, Peale F, Forrest WF, Pujara K, Carrillo JA, Pandita A, Ellingson BM, Bowers CW, Soriano RH, Schmidt NO, Mohan S, Yong WH, Seshagiri S, Modrusan Z, Jiang Z, Aldape KD, Mischel PS, Liau LM, Escovedo CJ, Chen W, Nghiemphu PL, James CD, Prados MD, Westphal M, Lamszus K, Cloughesy T, Phillips HS.

J Clin Oncol. 2011 Dec 1;29(34):4482-90. doi: 10.1200/JCO.2010.33.8715. Epub 2011 Oct 24.

50.

The neurobiology of gliomas: from cell biology to the development of therapeutic approaches.

Westphal M, Lamszus K.

Nat Rev Neurosci. 2011 Aug 3;12(9):495-508. doi: 10.1038/nrn3060. Review.

PMID:
21811295

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