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Items: 20


The E3 Ubiquitin Ligase Asb2α in T Helper 2 Cells Negatively Regulates Antitumor Immunity in Colorectal Cancer.

Spinner CA, Lamsoul I, Métais A, Febrissy C, Moog-Lutz C, Lutz PG.

Cancer Immunol Res. 2019 Aug;7(8):1332-1344. doi: 10.1158/2326-6066.CIR-18-0562. Epub 2019 Jun 7.


Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.

Métais A, Lamsoul I, Melet A, Uttenweiler-Joseph S, Poincloux R, Stefanovic S, Valière A, Gonzalez de Peredo A, Stella A, Burlet-Schiltz O, Zaffran S, Lutz PG, Moog-Lutz C.

Circ Res. 2018 Mar 16;122(6):e34-e48. doi: 10.1161/CIRCRESAHA.117.312015. Epub 2018 Jan 26.


Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells.

Spinner CA, Uttenweiler-Joseph S, Metais A, Stella A, Burlet-Schiltz O, Moog-Lutz C, Lamsoul I, Lutz PG.

Sci Rep. 2015 Nov 5;5:16269. doi: 10.1038/srep16269.


Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?

Lamsoul I, Uttenweiler-Joseph S, Moog-Lutz C, Lutz PG.

Biochimie. 2016 Mar;122:339-47. doi: 10.1016/j.biochi.2015.08.003. Epub 2015 Aug 4. Review.


Phosphorylation of serine 323 of ASB2α is pivotal for the targeting of filamin A to degradation.

Zakaria R, Lamsoul I, Uttenweiler-Joseph S, Erard M, Monsarrat B, Burlet-Schiltz O, Moog-Lutz C, Lutz PG.

Cell Signal. 2013 Dec;25(12):2823-30. doi: 10.1016/j.cellsig.2013.09.011. Epub 2013 Sep 15.


ASB2α regulates migration of immature dendritic cells.

Lamsoul I, Métais A, Gouot E, Heuzé ML, Lennon-Duménil AM, Moog-Lutz C, Lutz PG.

Blood. 2013 Jul 25;122(4):533-41. doi: 10.1182/blood-2012-11-466649. Epub 2013 Apr 30.


Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells.

Lamsoul I, Erard M, van der Ven PF, Lutz PG.

PLoS One. 2012;7(8):e43798. doi: 10.1371/journal.pone.0043798. Epub 2012 Aug 20.


Macrophage mesenchymal migration requires podosome stabilization by filamin A.

Guiet R, Vérollet C, Lamsoul I, Cougoule C, Poincloux R, Labrousse A, Calderwood DA, Glogauer M, Lutz PG, Maridonneau-Parini I.

J Biol Chem. 2012 Apr 13;287(16):13051-62. doi: 10.1074/jbc.M111.307124. Epub 2012 Feb 9.


Move or die: the fate of the Tax oncoprotein of HTLV-1.

Lodewick J, Lamsoul I, Bex F.

Viruses. 2011 Jun;3(6):829-57. doi: 10.3390/v3060829. Epub 2011 Jun 15. Review.


The E3 ubiquitin ligase specificity subunit ASB2α targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain.

Razinia Z, Baldassarre M, Bouaouina M, Lamsoul I, Lutz PG, Calderwood DA.

J Cell Sci. 2011 Aug 1;124(Pt 15):2631-41. doi: 10.1242/jcs.084343. Epub 2011 Jul 12.


Functional and structural insights into ASB2alpha, a novel regulator of integrin-dependent adhesion of hematopoietic cells.

Lamsoul I, Burande CF, Razinia Z, Houles TC, Menoret D, Baldassarre M, Erard M, Moog-Lutz C, Calderwood DA, Lutz PG.

J Biol Chem. 2011 Sep 2;286(35):30571-81. doi: 10.1074/jbc.M111.220921. Epub 2011 Jul 7.


Filamins regulate cell spreading and initiation of cell migration.

Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA.

PLoS One. 2009 Nov 13;4(11):e7830. doi: 10.1371/journal.pone.0007830.


A label-free quantitative proteomics strategy to identify E3 ubiquitin ligase substrates targeted to proteasome degradation.

Burande CF, Heuzé ML, Lamsoul I, Monsarrat B, Uttenweiler-Joseph S, Lutz PG.

Mol Cell Proteomics. 2009 Jul;8(7):1719-27. doi: 10.1074/mcp.M800410-MCP200. Epub 2009 Apr 17.


The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation.

Bello NF, Lamsoul I, Heuzé ML, Métais A, Moreaux G, Calderwood DA, Duprez D, Moog-Lutz C, Lutz PG.

Cell Death Differ. 2009 Jun;16(6):921-32. doi: 10.1038/cdd.2009.27. Epub 2009 Mar 20.


Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway.

Lodewick J, Lamsoul I, Polania A, Lebrun S, Burny A, Ratner L, Bex F.

Virology. 2009 Mar 30;386(1):68-78. doi: 10.1016/j.virol.2008.12.043. Epub 2009 Feb 5.


ASB2 targets filamins A and B to proteasomal degradation.

Heuzé ML, Lamsoul I, Baldassarre M, Lad Y, Lévêque S, Razinia Z, Moog-Lutz C, Calderwood DA, Lutz PG.

Blood. 2008 Dec 15;112(13):5130-40. doi: 10.1182/blood-2007-12-128744. Epub 2008 Sep 17.


Ubiquitin-mediated proteasomal degradation in normal and malignant hematopoiesis.

Heuzé ML, Lamsoul I, Moog-Lutz C, Lutz PG.

Blood Cells Mol Dis. 2008 Mar-Apr;40(2):200-10. Epub 2007 Oct 4. Review.


Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein.

Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor RB, Bex F.

Mol Cell Biol. 2005 Dec;25(23):10391-406.


Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding.

Chiari E, Lamsoul I, Lodewick J, Chopin C, Bex F, Pique C.

J Virol. 2004 Nov;78(21):11823-32.


Gene activation and gene silencing: a subtle equilibrium.

Quivy V, Calomme C, Dekoninck A, Demonte D, Bex F, Lamsoul I, Vanhulle C, Burny A, Van Lint C.

Cloning Stem Cells. 2004;6(2):140-9. Review.


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