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Items: 11

1.

Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions.

Wang CK, Lamothe SM, Wang AW, Yang RY, Kurata HT.

J Gen Physiol. 2018 Oct 29. pii: jgp.201812070. doi: 10.1085/jgp.201812070. [Epub ahead of print]

PMID:
30373787
2.

The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1-S2 linkage.

Lamothe SM, Hogan-Cann AE, Li W, Guo J, Yang T, Tschirhart JN, Zhang S.

J Biol Chem. 2018 Oct 5;293(40):15347-15358. doi: 10.1074/jbc.RA118.004065. Epub 2018 Aug 17.

PMID:
30121572
3.

Glycosylation stabilizes hERG channels on the plasma membrane by decreasing proteolytic susceptibility.

Lamothe SM, Hulbert M, Guo J, Li W, Yang T, Zhang S.

FASEB J. 2018 Jan 5:fj201700832R. doi: 10.1096/fj.201700832R. [Epub ahead of print]

PMID:
29162701
4.

Hypoxia reduces mature hERG channels through calpain up-regulation.

Lamothe SM, Song W, Guo J, Li W, Yang T, Baranchuk A, Graham CH, Zhang S.

FASEB J. 2017 Nov;31(11):5068-5077. doi: 10.1096/fj.201700255R. Epub 2017 Aug 7.

PMID:
28784631
5.

β-Arrestin-Mediated Regulation of the Human Ether-a-go-go-Related Gene Potassium Channel.

Sangoi MG, Lamothe SM, Guo J, Yang T, Li W, Avery EG, Fisher JT, Zhang S.

Mol Pharmacol. 2017 Aug;92(2):162-174. doi: 10.1124/mol.116.108035. Epub 2017 May 11.

6.

The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage.

Lamothe SM, Guo J, Li W, Yang T, Zhang S.

J Biol Chem. 2016 Sep 23;291(39):20387-401. doi: 10.1074/jbc.M116.743138. Epub 2016 Aug 8.

7.

Chapter Five - Ubiquitination of Ion Channels and Transporters.

Lamothe SM, Zhang S.

Prog Mol Biol Transl Sci. 2016;141:161-223. doi: 10.1016/bs.pmbts.2016.02.005. Epub 2016 Apr 2. Review.

PMID:
27378758
8.

Febrile temperature facilitates hERG/IKr degradation through an altered K(+) dependence.

Zhao Y, Wang T, Guo J, Yang T, Li W, Koichopolos J, Lamothe SM, Kang Y, Ma A, Zhang S.

Heart Rhythm. 2016 Oct;13(10):2004-11. doi: 10.1016/j.hrthm.2016.06.019. Epub 2016 Jun 16.

PMID:
27321242
9.

Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel.

Chen J, Guo J, Yang T, Li W, Lamothe SM, Kang Y, Szendrey JA, Zhang S.

J Biol Chem. 2015 Aug 21;290(34):21101-13. doi: 10.1074/jbc.M115.636324. Epub 2015 Jul 7.

10.

Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2.

Wang T, Hogan-Cann A, Kang Y, Cui Z, Guo J, Yang T, Lamothe SM, Li W, Ma A, Fisher JT, Zhang S.

Mol Pharmacol. 2014 Jun;85(6):877-86. doi: 10.1124/mol.113.091553. Epub 2014 Mar 31.

11.

The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.

Lamothe SM, Zhang S.

J Biol Chem. 2013 May 24;288(21):15075-84. doi: 10.1074/jbc.M113.453670. Epub 2013 Apr 15.

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