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Items: 1 to 50 of 66

1.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence.

Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM.

Mol Cell. 2020 Mar 13. pii: S1097-2765(20)30152-0. doi: 10.1016/j.molcel.2020.03.004. [Epub ahead of print]

PMID:
32208170
2.

Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism.

Li Z, Votava JA, Zajac GJM, Nguyen JN, Leyva Jaimes FB, Ly SM, Brinkman JA, De Giorgi M, Kaul S, Green CL, St Clair SL, Belisle SL, Rios JM, Nelson DW, Sorci-Thomas MG, Lagor WR, Lamming DW, Eric Yen CL, Parks BW.

Cell Metab. 2020 Mar 17. pii: S1550-4131(20)30074-7. doi: 10.1016/j.cmet.2020.02.015. [Epub ahead of print]

PMID:
32197071
3.

Effects of inhaled fluticasone propionate on extrinsic tongue muscles in rats.

Setzke C, Broytman O, Russell JA, Morel N, Sonsalla M, Lamming DW, Connor NP, Teodorescu M.

J Appl Physiol (1985). 2020 Mar 1;128(3):576-585. doi: 10.1152/japplphysiol.00359.2019. Epub 2020 Jan 16.

PMID:
31944881
4.

A toolbox for the longitudinal assessment of healthspan in aging mice.

Bellantuono I, de Cabo R, Ehninger D, Di Germanio C, Lawrie A, Miller J, Mitchell SJ, Navas-Enamorado I, Potter PK, Tchkonia T, Trejo JL, Lamming DW.

Nat Protoc. 2020 Feb;15(2):540-574. doi: 10.1038/s41596-019-0256-1. Epub 2020 Jan 8.

PMID:
31915391
5.

Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension.

Yu D, Tomasiewicz JL, Yang SE, Miller BR, Wakai MH, Sherman DS, Cummings NE, Baar EL, Brinkman JA, Syed FA, Lamming DW.

Cell Rep. 2019 Oct 1;29(1):236-248.e3. doi: 10.1016/j.celrep.2019.08.084.

6.

Corrigendum to: Next Generation Strategies for Geroprotection via mTORC1 Inhibition.

Dumas SN, Lamming DW.

J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):73. doi: 10.1093/gerona/glz199. No abstract available.

7.

TORwards a Victory Over Aging.

Lamming DW, Salmon AB.

J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):1-3. doi: 10.1093/gerona/glz212. No abstract available.

PMID:
31544928
8.

Hypothalamic mTORC2 is essential for metabolic health and longevity.

Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW.

Aging Cell. 2019 Oct;18(5):e13014. doi: 10.1111/acel.13014. Epub 2019 Aug 1.

9.

A novel rapamycin analog is highly selective for mTORC1 in vivo.

Schreiber KH, Arriola Apelo SI, Yu D, Brinkman JA, Velarde MC, Syed FA, Liao CY, Baar EL, Carbajal KA, Sherman DS, Ortiz D, Brunauer R, Yang SE, Tzannis ST, Kennedy BK, Lamming DW.

Nat Commun. 2019 Jul 19;10(1):3194. doi: 10.1038/s41467-019-11174-0.

10.

Next Generation Strategies for Geroprotection via mTORC1 Inhibition.

Dumas SN, Lamming DW.

J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):14-23. doi: 10.1093/gerona/glz056. Erratum in: J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):73.

11.

The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome.

Pak HH, Cummings NE, Green CL, Brinkman JA, Yu D, Tomasiewicz JL, Yang SE, Boyle C, Konon EN, Ong IM, Lamming DW.

Sci Rep. 2019 Jan 11;9(1):67. doi: 10.1038/s41598-018-37177-3.

12.

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.

De Leon ER, Brinkman JA, Fenske RJ, Gregg T, Schmidt BA, Sherman DS, Cummings NE, Peter DC, Kimple ME, Lamming DW, Merrins MJ.

Sci Rep. 2018 Dec 13;8(1):17814. doi: 10.1038/s41598-018-36289-0.

13.

Aging and drug discovery.

Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M.

Aging (Albany NY). 2018 Nov 13;10(11):3079-3088. doi: 10.18632/aging.101646.

14.

Lysosome: The metabolic signaling hub.

Lamming DW, Bar-Peled L.

Traffic. 2019 Jan;20(1):27-38. doi: 10.1111/tra.12617. Epub 2018 Nov 14. Review.

15.

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype.

Peng Y, Shapiro SL, Banduseela VC, Dieterich IA, Hewitt KJ, Bresnick EH, Kong G, Zhang J, Schueler KL, Keller MP, Attie AD, Hacker TA, Sullivan R, Kielar-Grevstad E, Arriola Apelo SI, Lamming DW, Anderson RM, Puglielli L.

Aging Cell. 2018 Oct;17(5):e12820. doi: 10.1111/acel.12820. Epub 2018 Jul 27.

16.

Regulation of metabolic health by essential dietary amino acids.

Green CL, Lamming DW.

Mech Ageing Dev. 2019 Jan;177:186-200. doi: 10.1016/j.mad.2018.07.004. Epub 2018 Jul 22. Review.

17.

Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.

Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH.

Nature. 2018 Aug;560(7717):E26. doi: 10.1038/s41586-018-0187-y.

PMID:
29849139
18.

Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.

Yu D, Yang SE, Miller BR, Wisinski JA, Sherman DS, Brinkman JA, Tomasiewicz JL, Cummings NE, Kimple ME, Cryns VL, Lamming DW.

FASEB J. 2018 Jun;32(6):3471-3482. doi: 10.1096/fj.201701211R. Epub 2018 Jan 30.

19.

Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice.

Lamming DW, Baar EL, Arriola Apelo SI, Tosti V, Fontana L.

Nutr Healthy Aging. 2017 Dec 7;4(3):239-245. doi: 10.3233/NHA-170025.

20.

Restoration of metabolic health by decreased consumption of branched-chain amino acids.

Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, Matkowskyj KA, Kimple ME, Alexander CM, Merrins MJ, Lamming DW.

J Physiol. 2018 Feb 15;596(4):623-645. doi: 10.1113/JP275075. Epub 2017 Dec 27.

21.

SYK kinase mediates brown fat differentiation and activation.

Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF.

Nat Commun. 2017 Dec 13;8(1):2115. doi: 10.1038/s41467-017-02162-3.

22.

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

Moretti J, Roy S, Bozec D, Martinez J, Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green DR, Blander JM.

Cell. 2017 Nov 2;171(4):809-823.e13. doi: 10.1016/j.cell.2017.09.034. Epub 2017 Oct 19.

23.

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.

Waqas SFH, Hoang AC, Lin YT, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen JC, Gerling IC, Nam S, Lim JS, Martinez-Ibañez J, Real JT, Paschke S, Quillet R, Ayachi S, Simonin F, Schneider EM, Brinkman JA, Lamming DW, Seroogy CM, Röszer T.

J Clin Invest. 2017 Sep 1;127(9):3559. doi: 10.1172/JCI95841. Epub 2017 Jul 31. No abstract available.

24.

Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy.

Linnemann AK, Blumer J, Marasco MR, Battiola TJ, Umhoefer HM, Han JY, Lamming DW, Davis DB.

FASEB J. 2017 Sep;31(9):4140-4152. doi: 10.1096/fj.201700061RR. Epub 2017 Jun 7.

25.

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.

Waqas SFH, Hoang AC, Lin YT, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen JC, Gerling IC, Nam S, Lim JS, Martinez-Ibañez J, Real JT, Paschke S, Quillet R, Ayachi S, Simonin F, Schneider EM, Brinkman JA, Lamming DW, Seroogy CM, Röszer T.

J Clin Invest. 2017 Jun 30;127(7):2842-2854. doi: 10.1172/JCI90152. Epub 2017 Jun 5. Erratum in: J Clin Invest. 2017 Sep 1;127(9):3559.

26.

Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.

Cummings NE, Lamming DW.

Mol Cell Endocrinol. 2017 Nov 5;455:13-22. doi: 10.1016/j.mce.2016.11.014. Epub 2016 Nov 22. Review.

27.

mTORC2 Puts Its Shoulder to Krebs' Wheel.

Arriola Apelo SI, Lamming DW.

Mol Cell. 2016 Sep 1;63(5):723-5. doi: 10.1016/j.molcel.2016.08.016.

28.

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.

Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME, Lamming DW.

Cell Rep. 2016 Jul 12;16(2):520-530. doi: 10.1016/j.celrep.2016.05.092. Epub 2016 Jun 23.

29.

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE.

Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16.

30.

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.

Kennedy BK, Lamming DW.

Cell Metab. 2016 Jun 14;23(6):990-1003. doi: 10.1016/j.cmet.2016.05.009. Review.

31.

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.

Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ.

Diabetes. 2016 Sep;65(9):2700-10. doi: 10.2337/db16-0432. Epub 2016 Jun 9.

32.

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.

Arriola Apelo SI, Lamming DW.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):841-9. doi: 10.1093/gerona/glw090. Epub 2016 May 21. Review.

33.

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice.

Arriola Apelo SI, Pumper CP, Baar EL, Cummings NE, Lamming DW.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):876-81. doi: 10.1093/gerona/glw064. Epub 2016 Apr 18.

34.

Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond.

Lamming DW.

Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a025924. doi: 10.1101/cshperspect.a025924. Review.

35.

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.

Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH.

Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173. Erratum in: Nature. 2018 Aug;560(7717):E26.

36.

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue.

Tran CM, Mukherjee S, Ye L, Frederick DW, Kissig M, Davis JG, Lamming DW, Seale P, Baur JA.

Diabetes. 2016 Apr;65(4):927-41. doi: 10.2337/db15-0502. Epub 2016 Feb 8.

37.

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice.

Baar EL, Carbajal KA, Ong IM, Lamming DW.

Aging Cell. 2016 Feb;15(1):155-66. doi: 10.1111/acel.12425. Epub 2015 Nov 24.

38.

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.

Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW.

Aging Cell. 2016 Feb;15(1):28-38. doi: 10.1111/acel.12405. Epub 2015 Oct 13.

39.

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model.

Lamming DW, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana L.

Oncotarget. 2015 Oct 13;6(31):31233-40. doi: 10.18632/oncotarget.5180.

40.

Diminished mTOR signaling: a common mode of action for endocrine longevity factors.

Lamming DW.

Springerplus. 2014 Dec 15;3:735. doi: 10.1186/2193-1801-3-735. eCollection 2014. Review.

41.

Hot topics at the intersection of aging and energetics: Diabetes/insulin resistance, Sirtuins, and the Microbiome.

Lamming DW.

F1000Res. 2014 Oct 28;3:257. doi: 10.12688/f1000research.5625.1. eCollection 2014.

42.

Rapamycin-induced metabolic defects are reversible in both lean and obese mice.

Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DW, Richardson A, Salmon AB.

Aging (Albany NY). 2014 Sep;6(9):742-54.

43.

mTORC2 takes the longevity stAGE.

Lamming DW.

Oncotarget. 2014 Sep 15;5(17):7214-5. No abstract available.

44.

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.

Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM.

Aging Cell. 2014 Oct;13(5):911-7. doi: 10.1111/acel.12256. Epub 2014 Jul 25.

45.

RagA, but not RagB, is essential for embryonic development and adult mice.

Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM.

Dev Cell. 2014 May 12;29(3):321-9. doi: 10.1016/j.devcel.2014.03.017. Epub 2014 Apr 24.

46.

The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.

Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].

47.

The TSC-mTOR pathway regulates macrophage polarization.

Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T.

Nat Commun. 2013;4:2834. doi: 10.1038/ncomms3834.

48.

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2).

Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA.

FASEB J. 2014 Jan;28(1):300-15. doi: 10.1096/fj.13-237743. Epub 2013 Sep 26.

49.

A Central role for mTOR in lipid homeostasis.

Lamming DW, Sabatini DM.

Cell Metab. 2013 Oct 1;18(4):465-9. doi: 10.1016/j.cmet.2013.08.002. Epub 2013 Aug 22. Review.

50.

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.

Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA.

Aging (Albany NY). 2013 Jul;5(7):539-50.

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