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Items: 21


TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C.

Sci Transl Med. 2014 Jul 2;6(243):243ra86. doi: 10.1126/scitranslmed.3009093.


Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.

Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.

J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013.


hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.

Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C.

Acta Neuropathol. 2013 Mar;125(3):413-23. doi: 10.1007/s00401-013-1088-7. Epub 2013 Feb 5.


Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.

Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, Herms J.

J Cell Mol Med. 2013 Feb;17(2):293-302. doi: 10.1111/jcmm.12008. Epub 2013 Feb 5.


Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.

Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C.

J Biol Chem. 2011 Dec 30;286(52):45063-72. doi: 10.1074/jbc.M111.296921. Epub 2011 Nov 7.


Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C.

J Neurosci. 2011 Feb 2;31(5):1885-94. doi: 10.1523/JNEUROSCI.5757-10.2011.


Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region.

Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Lichtenthaler SF, Prinzen C, Fahrenholz F, Haass C.

J Biol Chem. 2010 May 21;285(21):15753-60. doi: 10.1074/jbc.M110.110742. Epub 2010 Mar 26.


Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.

Pérez-Revuelta BI, Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H.

J Neurochem. 2010 Feb;112(4):940-50. doi: 10.1111/j.1471-4159.2009.06510.x. Epub 2009 Dec 15.


Function, regulation and therapeutic properties of beta-secretase (BACE1).

Willem M, Lammich S, Haass C.

Semin Cell Dev Biol. 2009 Apr;20(2):175-82. doi: 10.1016/j.semcdb.2009.01.003. Epub 2009 Jan 20. Review.


Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R.

Neuron. 2008 Dec 26;60(6):988-1009. doi: 10.1016/j.neuron.2008.10.047.


Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.

Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A.

Mol Cell Biol. 2006 May;26(10):3917-34.


Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.

Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C.

EMBO Rep. 2004 Jun;5(6):620-5. Epub 2004 May 28.


Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.

Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C.

J Biol Chem. 2003 Feb 21;278(8):5531-8. Epub 2002 Dec 5.


Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C.

J Biol Chem. 2002 Nov 22;277(47):44754-9. Epub 2002 Sep 9.


Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.

J Cell Biol. 2002 Aug 5;158(3):551-61. Epub 2002 Jul 29.


Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).

Edbauer D, Willem M, Lammich S, Steiner H, Haass C.

J Biol Chem. 2002 Apr 19;277(16):13389-93. Epub 2002 Jan 23.


Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F.

Proc Natl Acad Sci U S A. 2001 May 8;98(10):5815-20. Epub 2001 Apr 17.


Phosphorylation regulates intracellular trafficking of beta-secretase.

Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2001 May 4;276(18):14634-41. Epub 2001 Jan 29.


Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure.

Fahrenholz F, Gilbert S, Kojro E, Lammich S, Postina R.

Ann N Y Acad Sci. 2000;920:215-22. Review.


Maturation and pro-peptide cleavage of beta-secretase.

Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2000 Oct 6;275(40):30849-54.


Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.

Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3922-7.

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