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Items: 1 to 50 of 79

1.

Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner.

Picariello HS, Kenchappa RS, Rai V, Crish JF, Dovas A, Pogoda K, McMahon M, Bell ES, Chandrasekharan U, Luu A, West R, Lammerding J, Canoll P, Odde DJ, Janmey PA, Egelhoff T, Rosenfeld SS.

Proc Natl Acad Sci U S A. 2019 Jun 24. pii: 201902847. doi: 10.1073/pnas.1902847116. [Epub ahead of print]

PMID:
31235578
2.

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease.

Maurer M, Lammerding J.

Annu Rev Biomed Eng. 2019 Jun 4;21:443-468. doi: 10.1146/annurev-bioeng-060418-052139. Epub 2019 Mar 27.

PMID:
30916994
3.

Local, transient tensile stress on the nuclear membrane causes membrane rupture.

Zhang Q, Tamashunas AC, Agrawal A, Torbati M, Katiyar A, Dickinson RB, Lammerding J, Lele TP.

Mol Biol Cell. 2019 Mar 21;30(7):899-906. doi: 10.1091/mbc.E18-09-0604. Epub 2018 Dec 19.

4.

Assembly and Use of a Microfluidic Device to Study Cell Migration in Confined Environments.

Keys J, Windsor A, Lammerding J.

Methods Mol Biol. 2018;1840:101-118. doi: 10.1007/978-1-4939-8691-0_10.

PMID:
30141042
5.

Automated analysis of cell migration and nuclear envelope rupture in confined environments.

Elacqua JJ, McGregor AL, Lammerding J.

PLoS One. 2018 Apr 12;13(4):e0195664. doi: 10.1371/journal.pone.0195664. eCollection 2018.

6.

Beyond Tissue Stiffness and Bioadhesivity: Advanced Biomaterials to Model Tumor Microenvironments and Drug Resistance.

Singh A, Brito I, Lammerding J.

Trends Cancer. 2018 Apr;4(4):281-291. doi: 10.1016/j.trecan.2018.01.008. Epub 2018 Mar 10. Review.

7.

Frontline Science: Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers.

Yadav SK, Feigelson SW, Roncato F, Antman-Passig M, Shefi O, Lammerding J, Alon R.

J Leukoc Biol. 2018 Aug;104(2):239-251. doi: 10.1002/JLB.3HI1217-488R. Epub 2018 Mar 30.

PMID:
29601096
8.

Emerging views of the nucleus as a cellular mechanosensor.

Kirby TJ, Lammerding J.

Nat Cell Biol. 2018 Apr;20(4):373-381. doi: 10.1038/s41556-018-0038-y. Epub 2018 Feb 21. Review.

9.

Chromosomal instability drives metastasis through a cytosolic DNA response.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC.

Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.

10.

Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.

Morelli FF, Verbeek DS, Bertacchini J, Vinet J, Mediani L, Marmiroli S, Cenacchi G, Nasi M, De Biasi S, Brunsting JF, Lammerding J, Pegoraro E, Angelini C, Tupler R, Alberti S, Carra S.

Cell Rep. 2017 Aug 29;20(9):2100-2115. doi: 10.1016/j.celrep.2017.08.018.

11.

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM.

Mol Biol Cell. 2017 Jun 1;28(11):1467-1488. doi: 10.1091/mbc.E16-09-0654. Epub 2017 Apr 5.

12.

Connecting the plasma membrane to the nucleus by intermediate filaments.

Etienne-Manneville S, Lammerding J.

Mol Biol Cell. 2017 Mar 15;28(6):695-696. doi: 10.1091/mbc.E16-11-0794. No abstract available.

13.

Consequences of a tight squeeze: Nuclear envelope rupture and repair.

Isermann P, Lammerding J.

Nucleus. 2017 May 4;8(3):268-274. doi: 10.1080/19491034.2017.1292191. Epub 2017 Mar 13. Review.

14.

Bursting the Bubble - Nuclear Envelope Rupture as a Path to Genomic Instability?

Shah P, Wolf K, Lammerding J.

Trends Cell Biol. 2017 Aug;27(8):546-555. doi: 10.1016/j.tcb.2017.02.008. Epub 2017 Mar 9. Review.

15.

Cell mechanotransduction: Stretch to express.

Kirby TJ, Lammerding J.

Nat Mater. 2016 Nov 23;15(12):1227-1229. doi: 10.1038/nmat4809. No abstract available.

PMID:
27876751
16.

A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration.

Cao X, Moeendarbary E, Isermann P, Davidson PM, Wang X, Chen MB, Burkart AK, Lammerding J, Kamm RD, Shenoy VB.

Biophys J. 2016 Oct 4;111(7):1541-1552. doi: 10.1016/j.bpj.2016.08.011.

17.

Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus.

Lammerding J, Wolf K.

J Cell Biol. 2016 Oct 10;215(1):5-8. Epub 2016 Oct 3.

18.

Causes and consequences of nuclear envelope alterations in tumour progression.

Bell ES, Lammerding J.

Eur J Cell Biol. 2016 Nov;95(11):449-464. doi: 10.1016/j.ejcb.2016.06.007. Epub 2016 Jun 25. Review.

19.

Cellular and molecular remodelling of a host cell for vertical transmission of bacterial symbionts.

Luan JB, Shan HW, Isermann P, Huang JH, Lammerding J, Liu SS, Douglas AE.

Proc Biol Sci. 2016 Jun 29;283(1833). pii: 20160580. doi: 10.1098/rspb.2016.0580.

20.

Cell Microharpooning to Study Nucleo-Cytoskeletal Coupling.

Fedorchak G, Lammerding J.

Methods Mol Biol. 2016;1411:241-54. doi: 10.1007/978-1-4939-3530-7_16.

21.

Nuclear envelope rupture and repair during cancer cell migration.

Denais CM, Gilbert RM, Isermann P, McGregor AL, te Lindert M, Weigelin B, Davidson PM, Friedl P, Wolf K, Lammerding J.

Science. 2016 Apr 15;352(6283):353-8. doi: 10.1126/science.aad7297. Epub 2016 Mar 24.

22.

Squish and squeeze-the nucleus as a physical barrier during migration in confined environments.

McGregor AL, Hsia CR, Lammerding J.

Curr Opin Cell Biol. 2016 Jun;40:32-40. doi: 10.1016/j.ceb.2016.01.011. Epub 2016 Feb 16. Review.

23.

Design (and) principles of nuclear dynamics in Stockholm.

Shav-Tal Y, Lammerding J.

Nucleus. 2015;6(6):425-9. doi: 10.1080/19491034.2015.1128609.

24.

Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments.

Davidson PM, Sliz J, Isermann P, Denais C, Lammerding J.

Integr Biol (Camb). 2015 Dec;7(12):1534-46. doi: 10.1039/c5ib00200a. Epub 2015 Nov 9.

25.

Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress.

Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J, King MR.

Am J Physiol Cell Physiol. 2015 Dec 1;309(11):C736-46. doi: 10.1152/ajpcell.00050.2015. Epub 2015 Oct 7.

26.

Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins.

Zwerger M, Roschitzki-Voser H, Zbinden R, Denais C, Herrmann H, Lammerding J, Grütter MG, Medalia O.

J Cell Sci. 2015 Oct 1;128(19):3607-20. doi: 10.1242/jcs.171843. Epub 2015 Aug 14.

27.

Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.

Thomas DG, Yenepalli A, Denais CM, Rape A, Beach JR, Wang YL, Schiemann WP, Baskaran H, Lammerding J, Egelhoff TT.

J Cell Biol. 2015 Aug 17;210(4):583-94. doi: 10.1083/jcb.201502039. Epub 2015 Aug 10.

28.

Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway.

Dialynas G, Shrestha OK, Ponce JM, Zwerger M, Thiemann DA, Young GH, Moore SA, Yu L, Lammerding J, Wallrath LL.

PLoS Genet. 2015 May 21;11(5):e1005231. doi: 10.1371/journal.pgen.1005231. eCollection 2015 May.

29.

Nuclear deformability constitutes a rate-limiting step during cell migration in 3-D environments.

Davidson PM, Denais C, Bakshi MC, Lammerding J.

Cell Mol Bioeng. 2014 Sep 1;7(3):293-306.

30.

The cellular mastermind(?)-mechanotransduction and the nucleus.

Kaminski A, Fedorchak GR, Lammerding J.

Prog Mol Biol Transl Sci. 2014;126:157-203. doi: 10.1016/B978-0-12-394624-9.00007-5. Review.

31.

Cellular mechanosensing: getting to the nucleus of it all.

Fedorchak GR, Kaminski A, Lammerding J.

Prog Biophys Mol Biol. 2014 Aug;115(2-3):76-92. doi: 10.1016/j.pbiomolbio.2014.06.009. Epub 2014 Jul 5. Review.

32.

Nuclear mechanics in cancer.

Denais C, Lammerding J.

Adv Exp Med Biol. 2014;773:435-70. doi: 10.1007/978-1-4899-8032-8_20. Review.

33.

Nuclear mechanics and mechanotransduction in health and disease.

Isermann P, Lammerding J.

Curr Biol. 2013 Dec 16;23(24):R1113-21. doi: 10.1016/j.cub.2013.11.009. Review.

34.

Broken nuclei--lamins, nuclear mechanics, and disease.

Davidson PM, Lammerding J.

Trends Cell Biol. 2014 Apr;24(4):247-56. doi: 10.1016/j.tcb.2013.11.004. Epub 2013 Dec 2. Review.

35.

Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics.

Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J.

Nature. 2013 May 23;497(7450):507-11. doi: 10.1038/nature12105. Epub 2013 May 5.

36.

Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling.

Zwerger M, Jaalouk DE, Lombardi ML, Isermann P, Mauermann M, Dialynas G, Herrmann H, Wallrath LL, Lammerding J.

Hum Mol Genet. 2013 Jun 15;22(12):2335-49. doi: 10.1093/hmg/ddt079. Epub 2013 Feb 19.

37.

Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions.

Rowat AC, Jaalouk DE, Zwerger M, Ung WL, Eydelnant IA, Olins DE, Olins AL, Herrmann H, Weitz DA, Lammerding J.

J Biol Chem. 2013 Mar 22;288(12):8610-8. doi: 10.1074/jbc.M112.441535. Epub 2013 Jan 25.

38.

Novel insights into the disease etiology of laminopathies.

Ho CY, Jaalouk DE, Lammerding J.

Rare Dis. 2013 Jan 1;1(1):e27002. doi: 10.4161/rdis.27002. Epub 2013 Nov 6.

39.

Assays to measure nuclear mechanics in interphase cells.

Isermann P, Davidson PM, Sliz JD, Lammerding J.

Curr Protoc Cell Biol. 2012 Sep;Chapter 22:Unit22.16. doi: 10.1002/0471143030.cb2216s56.

40.

Lamins at a glance.

Ho CY, Lammerding J.

J Cell Sci. 2012 May 1;125(Pt 9):2087-93. doi: 10.1242/jcs.087288. Review. No abstract available.

41.

Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function.

Lombardi ML, Lammerding J.

Biochem Soc Trans. 2011 Dec;39(6):1729-34. doi: 10.1042/BST20110686. Review.

42.
43.

Cell-surface sensors for real-time probing of cellular environments.

Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM.

Nat Nanotechnol. 2011 Jul 17;6(8):524-31. doi: 10.1038/nnano.2011.101.

44.

Nuclear mechanics in disease.

Zwerger M, Ho CY, Lammerding J.

Annu Rev Biomed Eng. 2011 Aug 15;13:397-428. doi: 10.1146/annurev-bioeng-071910-124736. Review.

45.

The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton.

Lombardi ML, Jaalouk DE, Shanahan CM, Burke B, Roux KJ, Lammerding J.

J Biol Chem. 2011 Jul 29;286(30):26743-53. doi: 10.1074/jbc.M111.233700. Epub 2011 Jun 7.

46.

Mechanics of the nucleus.

Lammerding J.

Compr Physiol. 2011 Apr;1(2):783-807. doi: 10.1002/cphy.c100038. Review.

47.

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect.

Verstraeten VL, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4997-5002. doi: 10.1073/pnas.1019532108. Epub 2011 Mar 7.

48.

Nuclear mechanics during cell migration.

Friedl P, Wolf K, Lammerding J.

Curr Opin Cell Biol. 2011 Feb;23(1):55-64. doi: 10.1016/j.ceb.2010.10.015. Epub 2010 Nov 23. Erratum in: Curr Opin Cell Biol. 2011 Apr;23(2):253.

49.

Altered mechanical properties of the nucleus in disease.

Lombardi ML, Lammerding J.

Methods Cell Biol. 2010;98:121-41. doi: 10.1016/S0091-679X(10)98006-0. Review.

PMID:
20816233
50.

Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.

Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG.

J Biol Chem. 2010 Jul 2;285(27):20818-26. doi: 10.1074/jbc.M110.128835. Epub 2010 May 3.

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