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Items: 1 to 50 of 59

1.

A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan Receptors.

Morfa CJ, Bassoni D, Szabo A, McAnally D, Sharir H, Hood BL, Vasile S, Wehrman T, Lamerdin J, Smith LH.

Assay Drug Dev Technol. 2018 Oct;16(7):384-396. doi: 10.1089/adt.2018.868. Epub 2018 Sep 22.

2.

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21.

3.

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27.

4.

Differential Binding Activity of TGF-β Family Proteins to Select TGF-β Receptors.

Khalil AM, Dotimas H, Kahn J, Lamerdin JE, Hayes DB, Gupta P, Franti M.

J Pharmacol Exp Ther. 2016 Sep;358(3):423-30. doi: 10.1124/jpet.116.232322. Epub 2016 Jun 23.

PMID:
27340210
5.

Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays.

Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, Mancini MA.

Chem Biol. 2014 Jun 19;21(6):743-53. doi: 10.1016/j.chembiol.2014.03.013. Epub 2014 May 22.

6.

Improving drug discovery with contextual assays and cellular systems analysis.

Westwick JK, Lamerdin JE.

Methods Mol Biol. 2011;756:61-73. doi: 10.1007/978-1-61779-160-4_3. Review.

PMID:
21870220
7.

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.

Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. doi: 10.1073/pnas.0911863107. Epub 2010 May 3.

8.

Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis.

Marietta C, Thompson LH, Lamerdin JE, Brooks PJ.

Mutat Res. 2009 May 12;664(1-2):77-83. doi: 10.1016/j.mrfmmm.2009.03.011. Epub 2009 Apr 5.

9.

Identifying off-target effects and hidden phenotypes of drugs in human cells.

MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW, Westwick JK.

Nat Chem Biol. 2006 Jun;2(6):329-37. Epub 2006 May 7.

PMID:
16680159
10.

An overview of the genome of Nostoc punctiforme, a multicellular, symbiotic cyanobacterium.

Meeks JC, Elhai J, Thiel T, Potts M, Larimer F, Lamerdin J, Predki P, Atlas R.

Photosynth Res. 2001;70(1):85-106.

PMID:
16228364
11.

The photosynthetic apparatus of Prochlorococcus: Insights through comparative genomics.

Hess WR, Rocap G, Ting CS, Larimer F, Stilwagen S, Lamerdin J, Chisholm SW.

Photosynth Res. 2001;70(1):53-71.

PMID:
16228362
12.

Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.

Chain PS, Carniel E, Larimer FW, Lamerdin J, Stoutland PO, Regala WM, Georgescu AM, Vergez LM, Land ML, Motin VL, Brubaker RR, Fowler J, Hinnebusch J, Marceau M, Medigue C, Simonet M, Chenal-Francisque V, Souza B, Dacheux D, Elliott JM, Derbise A, Hauser LJ, Garcia E.

Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13826-31. Epub 2004 Sep 9.

13.

Characterization of the hamster FancG/Xrcc9 gene and mutations in CHO UV40 and NM3.

Lamerdin JE, Yamada NA, George JW, Souza B, Christian AT, Jones NJ, Thompson LH.

Mutagenesis. 2004 May;19(3):237-44.

PMID:
15123790
14.

Measuring drug action in the cellular context using protein-fragment complementation assays.

Yu H, West M, Keon BH, Bilter GK, Owens S, Lamerdin J, Westwick JK.

Assay Drug Dev Technol. 2003 Dec;1(6):811-22.

PMID:
15090227
15.

The DNA sequence and biology of human chromosome 19.

Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM.

Nature. 2004 Apr 1;428(6982):529-35.

PMID:
15057824
16.

Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris.

Larimer FW, Chain P, Hauser L, Lamerdin J, Malfatti S, Do L, Land ML, Pelletier DA, Beatty JT, Lang AS, Tabita FR, Gibson JL, Hanson TE, Bobst C, Torres JL, Peres C, Harrison FH, Gibson J, Harwood CS.

Nat Biotechnol. 2004 Jan;22(1):55-61. Epub 2003 Dec 14.

PMID:
14704707
17.

Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation.

Rocap G, Larimer FW, Lamerdin J, Malfatti S, Chain P, Ahlgren NA, Arellano A, Coleman M, Hauser L, Hess WR, Johnson ZI, Land M, Lindell D, Post AF, Regala W, Shah M, Shaw SL, Steglich C, Sullivan MB, Ting CS, Tolonen A, Webb EA, Zinser ER, Chisholm SW.

Nature. 2003 Aug 28;424(6952):1042-7. Epub 2003 Aug 13.

18.

The genome of a motile marine Synechococcus.

Palenik B, Brahamsha B, Larimer FW, Land M, Hauser L, Chain P, Lamerdin J, Regala W, Allen EE, McCarren J, Paulsen I, Dufresne A, Partensky F, Webb EA, Waterbury J.

Nature. 2003 Aug 28;424(6952):1037-42. Epub 2003 Aug 13.

19.

Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells.

Yamamoto K, Ishiai M, Matsushita N, Arakawa H, Lamerdin JE, Buerstedde JM, Tanimoto M, Harada M, Thompson LH, Takata M.

Mol Cell Biol. 2003 Aug;23(15):5421-30.

20.

Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea.

Chain P, Lamerdin J, Larimer F, Regala W, Lao V, Land M, Hauser L, Hooper A, Klotz M, Norton J, Sayavedra-Soto L, Arciero D, Hommes N, Whittaker M, Arp D.

J Bacteriol. 2003 May;185(9):2759-73. Erratum in: J Bacteriol. 2003 Nov;185(21):6496.

21.

Restoration of nucleotide excision repair in a helicase-deficient XPD mutant from intragenic suppression by a trichothiodystrophy mutation.

George JW, Salazar EP, Vreeswijk MP, Lamerdin JE, Reardon JT, Zdzienicka MZ, Sancar A, Kadkhodayan S, Tebbs RS, Mullenders LH, Thompson LH.

Mol Cell Biol. 2001 Nov;21(21):7355-65.

22.

Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.

Puttagunta R, Gordon LA, Meyer GE, Kapfhamer D, Lamerdin JE, Kantheti P, Portman KM, Chung WK, Jenne DE, Olsen AS, Burmeister M.

Genome Res. 2000 Sep;10(9):1369-80.

23.

Characterization of the mouse Xpf DNA repair gene and differential expression during spermatogenesis.

Shannon M, Lamerdin JE, Richardson L, McCutchen-Maloney SL, Hwang MH, Handel MA, Stubbs L, Thelen MP.

Genomics. 1999 Dec 15;62(3):427-35.

PMID:
10644440
24.
25.

Structure of the gene for congenital nephrotic syndrome of the finnish type (NPHS1) and characterization of mutations.

Lenkkeri U, Männikkö M, McCready P, Lamerdin J, Gribouval O, Niaudet PM, Antignac C K, Kashtan CE, Homberg C, Olsen A, Kestilä M, Tryggvason K.

Am J Hum Genet. 1999 Jan;64(1):51-61.

26.

Structure-function analysis of a conserved aromatic cluster in the N-terminal domain of human epidermal growth factor.

Murray MB, Tadaki DK, Campion SR, Lamerdin JA, Serpersu EH, Bradrick TD, Niyogi SK.

Protein Eng. 1998 Nov;11(11):1041-50.

PMID:
9876925
27.

Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12.

Eichler EE, Hoffman SM, Adamson AA, Gordon LA, McCready P, Lamerdin JE, Mohrenweiser HW.

Genome Res. 1998 Aug;8(8):791-808.

28.

High-resolution cartography of recently integrated human chromosome 19-specific Alu fossils.

Arcot SS, Adamson AW, Risch GW, LaFleur J, Robichaux MB, Lamerdin JE, Carrano AV, Batzer MA.

J Mol Biol. 1998 Sep 4;281(5):843-56.

PMID:
9719639
29.

Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1.

Wilson DM 3rd, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE.

Nucleic Acids Res. 1998 Aug 15;26(16):3762-8.

30.

XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.

Liu N, Lamerdin JE, Tebbs RS, Schild D, Tucker JD, Shen MR, Brookman KW, Siciliano MJ, Walter CA, Fan W, Narayana LS, Zhou ZQ, Adamson AW, Sorensen KJ, Chen DJ, Jones NJ, Thompson LH.

Mol Cell. 1998 May;1(6):783-93.

31.

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.

Kestilä M, Lenkkeri U, Männikkö M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K.

Mol Cell. 1998 Mar;1(4):575-82.

32.

Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1.

Lenkkeri U, Kestilä M, Lamerdin J, McCready P, Adamson A, Olsen A, Tryggvason K.

Hum Genet. 1998 Feb;102(2):192-6.

PMID:
9521588
33.

Identification and characterization of two polymorphic Ya5 Alu repeats.

Arcot SS, DeAngelis MM, Sherry ST, Adamson AW, Lamerdin JE, Deininger PL, Carrano AV, Batzer MA.

Mutat Res. 1997 Sep;382(1-2):5-11.

PMID:
9360633
34.

The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

Liu N, Lamerdin JE, Tucker JD, Zhou ZQ, Walter CA, Albala JS, Busch DB, Thompson LH.

Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9232-7.

35.

Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity.

Price EA, Bourne SL, Radbourne R, Lawton PA, Lamerdin J, Thompson LH, Arrand JE.

Somat Cell Mol Genet. 1997 Jul;23(4):237-47.

PMID:
9542526
36.

The atherogenic lipoprotein phenotype is not caused by a mutation in the coding region of the low density lipoprotein receptor gene.

Naggert JK, Recinos A 3rd, Lamerdin JE, Krauss RM, Nishina PM.

Clin Genet. 1997 Apr;51(4):236-40.

PMID:
9184244
37.

Construction of a functional cDNA clone of the hamster ERCC2 DNA repair and transcription gene.

Kadkhodayan S, Salazar EP, Lamerdin JE, Weber CA.

Somat Cell Mol Genet. 1996 Nov;22(6):453-60.

PMID:
9131015
38.

Alu fossil relics--distribution and insertion polymorphism.

Arcot SS, Adamson AW, Lamerdin JE, Kanagy B, Deininger PL, Carrano AV, Batzer MA.

Genome Res. 1996 Nov;6(11):1084-92.

39.

Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4.

Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE, Mohrenweiser HW, Bulman DE, Ferrari M, Haan J, Lindhout D, van Ommen GJ, Hofker MH, Ferrari MD, Frants RR.

Cell. 1996 Nov 1;87(3):543-52.

40.

ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs.

Brookman KW, Lamerdin JE, Thelen MP, Hwang M, Reardon JT, Sancar A, Zhou ZQ, Walter CA, Parris CN, Thompson LH.

Mol Cell Biol. 1996 Nov;16(11):6553-62.

41.

The functional importance of Leu15 of human epidermal growth factor in receptor binding and activation.

Nandagopal K, Tadaki DK, Lamerdin JA, Serpersu EH, Niyogi SK.

Protein Eng. 1996 Sep;9(9):781-8.

PMID:
8888144
42.

Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes.

Lamerdin JE, Stilwagen SA, Ramirez MH, Stubbs L, Carrano AV.

Genomics. 1996 Jun 15;34(3):399-409.

PMID:
8786141
43.

Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7.

Shannon M, Ashworth LK, Mucenski ML, Lamerdin JE, Branscomb E, Stubbs L.

Genomics. 1996 Apr 1;33(1):112-20.

PMID:
8617494
44.

Report an abstracts of the third international workshop on human chromosome 19 mapping 1996.

Mohrenweiser H, Olsen A, Archibald A, Beattie C, Burmeister M, Lamerdin J, Lennon G, Stewart E, Stubbs L, Weber JL, Johnson K.

Cytogenet Cell Genet. 1996;74(3):161-86. No abstract available.

PMID:
8941368
45.

An integrated metric physical map of human chromosome 19.

Ashworth LK, Batzer MA, Brandriff B, Branscomb E, de Jong P, Garcia E, Garnes JA, Gordon LA, Lamerdin JE, Lennon G, Mohrenweiser H, Olsen AS, Slezak T, Carrano AV.

Nat Genet. 1995 Dec;11(4):422-7.

PMID:
7493023
46.

Chromosomal localization and expressed sequence tag generation of clones from a normalized human adult thymus cDNA library.

Lamerdin JE, Athwal RS, Kansara MS, Sandhu AK, Patanjali SR, Weissman SM, Carrano AV.

Genome Res. 1995 Nov;5(4):359-67.

47.
48.

Cloning and molecular characterization of the Chinese hamster ERCC2 nucleotide excision repair gene.

Kirchner JM, Salazar EP, Lamerdin JE, Montgomery MA, Carrano AV, Weber CA.

Genomics. 1995 May 20;27(2):387. No abstract available.

PMID:
7558017
49.

A continuous high-resolution physical map spanning 17 megabases of the q12, q13.1, and q13.2 cytogenetic bands of human chromosome 19.

Garcia E, Elliott J, Gorvad A, Brandriff B, Gordon L, Soliman KM, Ashworth LK, Lennon G, Burgin M, Lamerdin J, et al.

Genomics. 1995 May 1;27(1):52-66.

PMID:
7665184
50.

Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions.

Lamerdin JE, Montgomery MA, Stilwagen SA, Scheidecker LK, Tebbs RS, Brookman KW, Thompson LH, Carrano AV.

Genomics. 1995 Jan 20;25(2):547-54.

PMID:
7789989

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