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Items: 1 to 50 of 79


ARF GTPases and their GEFs and GAPs: concepts and challenges.

Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA.

Mol Biol Cell. 2019 May 15;30(11):1249-1271. doi: 10.1091/mbc.E18-12-0820.


TRAPPing a Rab GTPase by the Tail.

Duan J, Lambright DG.

Dev Cell. 2019 Jan 7;48(1):9-11. doi: 10.1016/j.devcel.2018.12.008.


Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.

Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG.

Structure. 2018 Jan 2;26(1):106-117.e6. doi: 10.1016/j.str.2017.11.019. Epub 2017 Dec 21.


Special Issue: GTPases in trafficking, autophagy, and disease (FASEB SRC).

Kahn RA, Lambright D, De Matteis A.

Small GTPases. 2016 Oct;7(4):187. No abstract available.


Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses.

Das S, Lambright DG.

Curr Biol. 2016 Oct 24;26(20):R927-R929. doi: 10.1016/j.cub.2016.08.056.


Invited review: Small GTPases and their GAPs.

Mishra AK, Lambright DG.

Biopolymers. 2016 Aug;105(8):431-48. doi: 10.1002/bip.22833. Review.


A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1.

Kahn RA, Lambright DG.

Structure. 2015 Nov 3;23(11):1971-3. doi: 10.1016/j.str.2015.10.002.


Methods for analysis of size-exclusion chromatography-small-angle X-ray scattering and reconstruction of protein scattering.

Malaby AW, Chakravarthy S, Irving TC, Kathuria SV, Bilsel O, Lambright DG.

J Appl Crystallogr. 2015 Jul 8;48(Pt 4):1102-1113. eCollection 2015 Aug 1.


High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins.

Mishra AK, Lambright DG.

Methods Mol Biol. 2015;1298:47-60. doi: 10.1007/978-1-4939-2569-8_4.


Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35.

Priya A, Kalaidzidis IV, Kalaidzidis Y, Lambright D, Datta S.

Traffic. 2015 Jan;16(1):68-84. doi: 10.1111/tra.12237. Epub 2014 Dec 1.


Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.

Stockler S, Corvera S, Lambright D, Fogarty K, Nosova E, Leonard D, Steinfeld R, Ackerley C, Shyr C, Au N, Selby K, van Allen M, Vallance H, Wevers R, Watkins D, Rosenblatt D, Ross CJ, Conibear E, Wasserman W, van Karnebeek C.

Orphanet J Rare Dis. 2014 Sep 20;9:141. doi: 10.1186/s13023-014-0141-5.


Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity.

Rahman M, Nirala NK, Singh A, Zhu LJ, Taguchi K, Bamba T, Fukusaki E, Shaw LM, Lambright DG, Acharya JK, Acharya UR.

J Cell Biol. 2014 Jul 21;206(2):289-305. doi: 10.1083/jcb.201404118. Epub 2014 Jul 14.


The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins.

Hubber A, Arasaki K, Nakatsu F, Hardiman C, Lambright D, De Camilli P, Nagai H, Roy CR.

PLoS Pathog. 2014 Jul 3;10(7):e1004222. doi: 10.1371/journal.ppat.1004222. eCollection 2014 Jul.


Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.

Del Campo CM, Mishra AK, Wang YH, Roy CR, Janmey PA, Lambright DG.

Structure. 2014 Mar 4;22(3):397-408. doi: 10.1016/j.str.2013.12.018. Epub 2014 Feb 13.


Older Adults without Radiographic Knee Osteoarthritis: Knee Alignment and Knee Range of Motion.

Fahlman L, Sangeorzan E, Chheda N, Lambright D.

Clin Med Insights Arthritis Musculoskelet Disord. 2014 Jan 12;7:1-11. doi: 10.4137/CMAMD.S13009. eCollection 2014 Jan 12.


Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.

Malaby AW, van den Berg B, Lambright DG.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14213-8. doi: 10.1073/pnas.1301883110. Epub 2013 Aug 12.


The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.

Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG.

J Biol Chem. 2013 Aug 16;288(33):24000-11. doi: 10.1074/jbc.M113.470625. Epub 2013 Jul 2.


Germline mutations affecting Gα11 in hypoparathyroidism.

Mannstadt M, Harris M, Bravenboer B, Chitturi S, Dreijerink KM, Lambright DG, Lim ET, Daly MJ, Gabriel S, Jüppner H.

N Engl J Med. 2013 Jun 27;368(26):2532-4. doi: 10.1056/NEJMc1300278. No abstract available.


The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.

Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, Stöckli J, James DE.

Mol Cell Biol. 2012 Dec;32(24):4946-59. doi: 10.1128/MCB.00761-12. Epub 2012 Oct 8.


TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes.

Davey JR, Humphrey SJ, Junutula JR, Mishra AK, Lambright DG, James DE, Stöckli J.

Traffic. 2012 Oct;13(10):1429-41. doi: 10.1111/j.1600-0854.2012.01397.x. Epub 2012 Jul 29.


RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.

Nottingham RM, Pusapati GV, Ganley IG, Barr FA, Lambright DG, Pfeffer SR.

J Biol Chem. 2012 Jun 29;287(27):22740-8. doi: 10.1074/jbc.M112.362558. Epub 2012 May 25.


Grp1 plays a key role in linking insulin signaling to glut4 recycling.

Li J, Malaby AW, Famulok M, Sabe H, Lambright DG, Hsu VW.

Dev Cell. 2012 Jun 12;22(6):1286-98. doi: 10.1016/j.devcel.2012.03.004. Epub 2012 May 17.


Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis.

Navaroli DM, Bellvé KD, Standley C, Lifshitz LM, Cardia J, Lambright D, Leonard D, Fogarty KE, Corvera S.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E471-80. doi: 10.1073/pnas.1115495109. Epub 2012 Jan 30.


RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.

Nottingham RM, Ganley IG, Barr FA, Lambright DG, Pfeffer SR.

J Biol Chem. 2011 Sep 23;286(38):33213-22. doi: 10.1074/jbc.M111.261115. Epub 2011 Aug 1.


A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.

Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP.

J Biol Chem. 2010 Sep 3;285(36):27581-9. doi: 10.1074/jbc.M110.146886. Epub 2010 Jun 28.


Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1).

Mishra A, Eathiraj S, Corvera S, Lambright DG.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10866-71. doi: 10.1073/pnas.1000843107. Epub 2010 Jun 1.


Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors.

DiNitto JP, Lee MT, Malaby AW, Lambright DG.

Biochemistry. 2010 Jul 27;49(29):6083-92. doi: 10.1021/bi1000454.


Rab GEFs and GAPs.

Barr F, Lambright DG.

Curr Opin Cell Biol. 2010 Aug;22(4):461-70. doi: 10.1016/ Epub 2010 May 11. Review.


TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans.

Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG, Rocheleau CE.

Mol Biol Cell. 2010 Jul 1;21(13):2285-96. doi: 10.1091/mbc.E09-11-0947. Epub 2010 May 12.


The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility.

Fang Z, Takizawa N, Wilson KA, Smith TC, Delprato A, Davidson MW, Lambright DG, Luna EJ.

Traffic. 2010 Jun;11(6):782-99. doi: 10.1111/j.1600-0854.2010.01062.x. Epub 2010 Mar 17.


Structural mechanisms for regulation of membrane traffic by rab GTPases.

Lee MT, Mishra A, Lambright DG.

Traffic. 2009 Oct;10(10):1377-89. doi: 10.1111/j.1600-0854.2009.00942.x. Epub 2009 May 19. Review.


Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes.

Leonard D, Hayakawa A, Lawe D, Lambright D, Bellve KD, Standley C, Lifshitz LM, Fogarty KE, Corvera S.

J Cell Sci. 2008 Oct 15;121(Pt 20):3445-58. doi: 10.1242/jcs.031484. Epub 2008 Sep 30.


Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.

DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG.

Mol Cell. 2007 Nov 30;28(4):569-83.


Legionella pneumophila proteins that regulate Rab1 membrane cycling.

Ingmundson A, Delprato A, Lambright DG, Roy CR.

Nature. 2007 Nov 15;450(7168):365-9. Epub 2007 Oct 21.


TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS.

J Biol Chem. 2007 Dec 14;282(50):36354-61. Epub 2007 Sep 27.


An endocytic pathway as a target of tubby for regulation of fat storage.

Mukhopadhyay A, Pan X, Lambright DG, Tissenbaum HA.

EMBO Rep. 2007 Oct;8(10):931-8. Epub 2007 Aug 31. Erratum in: EMBO Rep. 2007 Oct;8(10):974.


Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.

Mishra AK, Gangwani L, Davis RJ, Lambright DG.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13930-5. Epub 2007 Aug 17.


Structural basis for Rab GTPase activation by VPS9 domain exchange factors.

Delprato A, Lambright DG.

Nat Struct Mol Biol. 2007 May;14(5):406-12. Epub 2007 Apr 22.


Evolutionarily conserved structural and functional roles of the FYVE domain.

Hayakawa A, Hayes S, Leonard D, Lambright D, Corvera S.

Biochem Soc Symp. 2007;(74):95-105. Review.


Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes.

Eathiraj S, Mishra A, Prekeris R, Lambright DG.

J Mol Biol. 2006 Nov 24;364(2):121-35. Epub 2006 Aug 26.


ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).

Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R.

J Biol Chem. 2006 Nov 3;281(44):33363-72. Epub 2006 Aug 24.


The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.

Murata T, Delprato A, Ingmundson A, Toomre DK, Lambright DG, Roy CR.

Nat Cell Biol. 2006 Sep;8(9):971-7. Epub 2006 Aug 13.


The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.

Hayakawa A, Leonard D, Murphy S, Hayes S, Soto M, Fogarty K, Standley C, Bellve K, Lambright D, Mello C, Corvera S.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11928-33. Epub 2006 Jul 27.


TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.

Pan X, Eathiraj S, Munson M, Lambright DG.

Nature. 2006 Jul 20;442(7100):303-6.


Membrane and juxtamembrane targeting by PH and PTB domains.

DiNitto JP, Lambright DG.

Biochim Biophys Acta. 2006 Aug;1761(8):850-67. Epub 2006 May 6. Review.


ESCRT complexes assembled and GLUEd.

Eathiraj S, Lambright DG.

Structure. 2006 Apr;14(4):631-2.


Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

Eathiraj S, Pan X, Ritacco C, Lambright DG.

Nature. 2005 Jul 21;436(7049):415-9.


Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains.

Cronin TC, DiNitto JP, Czech MP, Lambright DG.

EMBO J. 2004 Oct 1;23(19):3711-20. Epub 2004 Sep 9.


Membrane recognition and targeting by lipid-binding domains.

DiNitto JP, Cronin TC, Lambright DG.

Sci STKE. 2003 Dec 16;2003(213):re16. Review.


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