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Items: 1 to 50 of 66

1.

Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C.

Lambrecht RW, Sterling RK, Naishadham D, Stoddard AM, Rogers T, Morishima C, Morgan TR, Bonkovsky HL; HALT-C Trial Group.

Gastroenterology. 2011 May;140(5):1490-500.e3. doi: 10.1053/j.gastro.2011.01.053. Epub 2011 Feb 15.

2.

Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis.

Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR.

Cancer Prev Res (Phila). 2011 Apr;4(4):530-43. doi: 10.1158/1940-6207.CAPR-10-0143. Epub 2011 Feb 14.

3.

Increased frequency of serrated aberrant crypt foci among smokers.

Anderson JC, Pleau DC, Rajan TV, Protiva P, Swede H, Brenner B, Heinen CD, Lambrecht RW, Rosenberg DW.

Am J Gastroenterol. 2010 Jul;105(7):1648-54. doi: 10.1038/ajg.2010.109. Epub 2010 Mar 16.

PMID:
20234347
4.

Genetic variations in heme oxygenase-1 and chronic hepatitis.

Bonkovsky HL, Lambrecht RW, Naishadham D.

Hepatology. 2010 Jul;52(1):400-1. doi: 10.1002/hep.23562. No abstract available.

PMID:
20232486
5.

Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells.

Hou WH, Rossi L, Shan Y, Zheng JY, Lambrecht RW, Bonkovsky HL.

World J Gastroenterol. 2009 Sep 28;15(36):4499-510.

6.

Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin.

Zheng J, Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL.

Mol Cell Biochem. 2008 Dec;319(1-2):153-61. doi: 10.1007/s11010-008-9888-0. Epub 2008 Aug 22.

PMID:
18719978
7.

Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells.

Bonifaz V, Shan Y, Lambrecht RW, Donohue SE, Moschenross D, Bonkovsky HL.

Liver Int. 2009 Mar;29(3):366-73. doi: 10.1111/j.1478-3231.2008.01833.x. Epub 2008 Aug 7.

8.

DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial.

Morgan TR, Lambrecht RW, Bonkovsky HL, Chung RT, Naishadham D, Sterling RK, Fontana RJ, Lee WM, Ghany MG, Wright EC, O'Brien TR; HALT-C Trial Group.

J Hepatol. 2008 Oct;49(4):548-56. doi: 10.1016/j.jhep.2008.05.011. Epub 2008 Jun 5.

9.

Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1.

Hou W, Shan Y, Zheng J, Lambrecht RW, Donohue SE, Bonkovsky HL.

Biochim Biophys Acta. 2008 Mar;1779(3):195-203. doi: 10.1016/j.bbagrm.2008.01.006. Epub 2008 Feb 14.

10.

Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes.

Shan Y, Zheng J, Lambrecht RW, Bonkovsky HL.

Gastroenterology. 2007 Oct;133(4):1166-74. Epub 2007 Aug 3.

11.

Serum measures of iron status and HFE gene mutations in patients with hepatitis B virus infection.

Ghaziani T, Alavian SM, Zali MR, Shahraz S, Agah M, Jensen KP, Ansari S, Sendi H, Lambrecht RW, Covault J, Bonkovsky HL.

Hepatol Res. 2007 Mar;37(3):172-8.

PMID:
17362299
12.

Genetic aspects of porphyria cutanea tarda.

Lambrecht RW, Thapar M, Bonkovsky HL.

Semin Liver Dis. 2007 Feb;27(1):99-108. Review.

PMID:
17295179
13.

Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C.

Bonkovsky HL, Naishadham D, Lambrecht RW, Chung RT, Hoefs JC, Nash SR, Rogers TE, Banner BF, Sterling RK, Donovan JA, Fontana RJ, Di Bisceglie AM, Ghany MG, Morishima C; HALT-C Trial Group.

Gastroenterology. 2006 Nov;131(5):1440-51. Epub 2006 Aug 18.

PMID:
17101320
14.

Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin.

Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL.

FASEB J. 2006 Dec;20(14):2651-3. Epub 2006 Oct 25.

PMID:
17065227
15.

HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells.

Ghaziani T, Shan Y, Lambrecht RW, Donohue SE, Pietschmann T, Bartenschlager R, Bonkovsky HL.

J Hepatol. 2006 Jul;45(1):5-12. Epub 2006 Feb 3.

PMID:
16530877
16.

Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey.

Shan Y, Lambrecht RW, Bonkovsky HL.

Clin Infect Dis. 2005 Mar 15;40(6):834-41. Epub 2005 Feb 21.

PMID:
15736017
17.

Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS.

Shan Y, Lambrecht RW, Ghaziani T, Donohue SE, Bonkovsky HL.

J Biol Chem. 2004 Dec 10;279(50):51769-74. Epub 2004 Oct 1.

18.

Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene.

Shan Y, Lambrecht RW, Bonkovsky HL.

Biochim Biophys Acta. 2004 Aug 12;1679(2):87-94.

PMID:
15297142
19.

Iron as a co-morbid factor in nonhemochromatotic liver disease.

Bonkovsky HL, Lambrecht RW, Shan Y.

Alcohol. 2003 Jun;30(2):137-44. Review.

PMID:
12957298
20.

Hemochromatosis and porphyria.

Lambrecht RW, Bonkovsky HL.

Semin Gastrointest Dis. 2002 Apr;13(2):109-19. Review.

PMID:
12064861
21.

Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins.

Shan Y, Pepe J, Lambrecht RW, Bonkovsky HL.

Arch Biochem Biophys. 2002 Mar 15;399(2):159-66.

PMID:
11888201
22.

Induction of heme oxygenase-1 by phenylarsine oxide. Studies in cultured primary liver cells.

Gildemeister OS, Pepe JA, Lambrecht RW, Bonkovsky HL.

Mol Cell Biochem. 2001 Oct;226(1-2):17-26.

PMID:
11768235
23.
24.

Iron-induced liver injury.

Bonkovsky HL, Lambrecht RW.

Clin Liver Dis. 2000 May;4(2):409-29, vi-vii.

PMID:
11232198
25.

Upstream regulatory elements in chick heme oxygenase-1 promoter: a study in primary cultures of chick embryo liver cells.

Lu TH, Shan Y, Pepe J, Lambrecht RW, Bonkovsky HL.

Mol Cell Biochem. 2000 Jun;209(1-2):17-27.

PMID:
10942197
26.

Induction of the heme oxygenase-1 gene by metalloporphyrins.

Shan Y, Pepe J, Lu TH, Elbirt KK, Lambrecht RW, Bonkovsky HL.

Arch Biochem Biophys. 2000 Aug 15;380(2):219-27.

PMID:
10933875
27.
28.

Effects of antidepressants and benzodiazepine-type anxiolytic agents on hepatic porphyrin accumulation in primary cultures of chick embryo liver cells.

Lambrecht RW, Gildemeister OS, Pepe JA, Tortorelli KD, Williams A, Bonkovsky HL.

J Pharmacol Exp Ther. 1999 Dec;291(3):1150-5.

PMID:
10565836
29.

Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis.

Bonkovsky HL, Jawaid Q, Tortorelli K, LeClair P, Cobb J, Lambrecht RW, Banner BF.

J Hepatol. 1999 Sep;31(3):421-9.

PMID:
10488699
30.

Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation: implications for clinical porphyria.

Lambrecht RW, Gildemeister OS, Williams A, Pepe JA, Tortorelli KD, Bonkovsky HL.

Biochem Pharmacol. 1999 Sep 1;58(5):887-96.

PMID:
10449201
31.

Porphyrin loading of lipofuscin granules in inflamed striated muscle.

Kiefer CR, McKenney JB, Trainor JF, Lambrecht RW, Bonkovsky HL, Lifshitz LM, Valeri CR, Snyder LM.

Am J Pathol. 1998 Sep;153(3):703-8.

32.

Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America.

Bonkovsky HL, Poh-Fitzpatrick M, Pimstone N, Obando J, Di Bisceglie A, Tattrie C, Tortorelli K, LeClair P, Mercurio MG, Lambrecht RW.

Hepatology. 1998 Jun;27(6):1661-9.

PMID:
9620340
33.
34.

Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells: potential implications for patients with acute porphyria.

Hahn M, Gildemeister OS, Krauss GL, Pepe JA, Lambrecht RW, Donohue S, Bonkovsky HL.

Neurology. 1997 Jul;49(1):97-106.

PMID:
9222176
35.

Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response.

Cable EE, Gildemeister OS, Pepe JA, Lambrecht RW, Bonkovsky HL.

Mol Cell Biochem. 1997 Apr;169(1-2):13-20.

PMID:
9089626
36.

Haemopexin and uptake of haem by liver cells.

Bonkovsky HL, Gildemeister OS, Pepe JA, Lambrecht RW, Hrkal Z.

Eur J Clin Chem Clin Biochem. 1996 Nov;34(11):931-2. No abstract available.

PMID:
8960469
37.

Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins.

Cable EE, Gildemeister OS, Pepe JA, Donohue SE, Lambrecht RW, Bonkovsky HL.

Eur J Biochem. 1996 Aug 15;240(1):112-7.

38.

Induction of heme oxygenase-1 in LMH cells. Comparison of LMH cells to primary cultures of chick embryo liver cells.

Gabis KK, Gildemeister OS, Pepe JA, Lambrecht RW, Bonkovsky HL.

Biochim Biophys Acta. 1996 May 21;1290(1):113-20.

PMID:
8645700
39.

Iron in liver diseases other than hemochromatosis.

Bonkovsky HL, Banner BF, Lambrecht RW, Rubin RB.

Semin Liver Dis. 1996 Feb;16(1):65-82. Review.

PMID:
8723325
40.
41.

Ascorbic acid inhibits chemically induced uroporphyria in ascorbate-requiring rats.

Sinclair PR, Gorman N, Sinclair JF, Walton HS, Bement WJ, Lambrecht RW.

Hepatology. 1995 Aug;22(2):565-72.

PMID:
7635426
42.

Tissue distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase.

Russo SM, Pepe JA, Donohue S, Cable EE, Lambrecht RW, Bonkovsky HL.

J Pharmacol Exp Ther. 1995 Feb;272(2):766-74.

PMID:
7853192
43.
44.
45.

Repression of ALA synthase by heme and zinc-mesoporphyrin in a chick embryo liver cell culture model of acute porphyria.

Russo SM, Pepe JA, Cable EE, Lambrecht RW, Bonkovsky HL.

Eur J Clin Invest. 1994 Jun;24(6):406-15.

PMID:
7957494
46.

3,5,5-Trimethylhexanoylferrocene induction of heme oxygenase activity in normal hepatocytes.

Lambrecht RW, Cable JW, Pepe JA, Bonkovsky HL.

Biochem Pharmacol. 1994 Apr 29;47(9):1669-76.

PMID:
8185682
47.

Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh).

Bonkovsky HL, Cable EE, Cable JW, Donohue SE, White EC, Greene YJ, Lambrecht RW, Srivastava KK, Arnold WN.

Biochem Pharmacol. 1992 Jun 9;43(11):2359-68.

PMID:
1610401
48.

Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2.

Lambrecht RW, Sinclair PR, Gorman N, Sinclair JF.

Arch Biochem Biophys. 1992 May 1;294(2):504-10.

PMID:
1567206
49.

Chlorinated biphenyls induce cytochrome P450IA2 and uroporphyrin accumulation in cultures of mouse hepatocytes.

Sinclair PR, Bement WJ, Lambrecht RW, Gorman N, Sinclair JF.

Arch Biochem Biophys. 1990 Sep;281(2):225-32.

PMID:
2118331
50.

Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation.

Lambrecht RW, Jacobs JM, Sinclair PR, Sinclair JF.

Biochem J. 1990 Jul 15;269(2):437-41.

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