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Items: 1 to 50 of 325

1.

How a farming environment protects from atopy.

Deckers J, Lambrecht BN, Hammad H.

Curr Opin Immunol. 2019 Sep 6;60:163-169. doi: 10.1016/j.coi.2019.08.001. [Epub ahead of print] Review.

PMID:
31499321
2.

Charcot-Leyden crystals promote neutrophilic inflammation in nasal polyposis.

Gevaert E, Delemarre T, De Volder J, Zhang N, Holtappels G, De Ruyck N, Persson E, Heyndrickx I, Verstraete K, Aegerter H, Nauwynck H, Savvides SN, Lambrecht BN, Bachert C.

J Allergy Clin Immunol. 2019 Sep 4. pii: S0091-6749(19)31120-0. doi: 10.1016/j.jaci.2019.08.027. [Epub ahead of print]

PMID:
31493418
3.

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells.

Uvyn A, De Coen R, De Wever O, Deswarte K, Lambrecht BN, De Geest BG.

Chem Commun (Camb). 2019 Sep 10;55(73):10952-10955. doi: 10.1039/c9cc03379c.

PMID:
31441915
4.

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists.

De Vrieze J, Louage B, Deswarte K, Zhong Z, De Coen R, Van Herck S, Nuhn L, Kaas Frich C, Zelikin AN, Lienenklaus S, Sanders NN, Lambrecht BN, David SA, De Geest BG.

Angew Chem Int Ed Engl. 2019 Aug 9. doi: 10.1002/anie.201905687. [Epub ahead of print]

PMID:
31397948
5.

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice.

Debeuf N, Zhakupova A, Steiner R, Van Gassen S, Deswarte K, Fayazpour F, Van Moorleghem J, Vergote K, Pavie B, Lemeire K, Hammad H, Hornemann T, Janssens S, Lambrecht BN.

J Allergy Clin Immunol. 2019 Jul 20. pii: S0091-6749(19)30943-1. doi: 10.1016/j.jaci.2019.06.041. [Epub ahead of print]

PMID:
31330218
6.

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.

Vetters J, van Helden MJ, Wahlen S, Tavernier SJ, Martens A, Fayazpour F, Vergote K, Vanheerswynghels M, Deswarte K, Van Moorleghem J, De Prijck S, Takahashi N, Vandenabeele P, Boon L, van Loo G, Vivier E, Lambrecht BN, Janssens S.

J Exp Med. 2019 Sep 2;216(9):2010-2023. doi: 10.1084/jem.20182164. Epub 2019 Jul 11.

PMID:
31296735
7.

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.

Tibbitt CA, Stark JM, Martens L, Ma J, Mold JE, Deswarte K, Oliynyk G, Feng X, Lambrecht BN, De Bleser P, Nylén S, Hammad H, Arsenian Henriksson M, Saeys Y, Coquet JM.

Immunity. 2019 Jul 16;51(1):169-184.e5. doi: 10.1016/j.immuni.2019.05.014. Epub 2019 Jun 20.

PMID:
31231035
8.

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.

Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Gonçalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN.

Science. 2019 May 24;364(6442). pii: eaaw4295. doi: 10.1126/science.aaw4295.

PMID:
31123109
9.

The Cytokines of Asthma.

Lambrecht BN, Hammad H, Fahy JV.

Immunity. 2019 Apr 16;50(4):975-991. doi: 10.1016/j.immuni.2019.03.018. Review.

PMID:
30995510
10.

A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window.

Zhang Z, Li H, Kasmi S, Van Herck S, Deswarte K, Lambrecht BN, Hoogenboom R, Nuhn L, De Geest BG.

Angew Chem Int Ed Engl. 2019 Jun 3;58(23):7866-7872. doi: 10.1002/anie.201900224. Epub 2019 Apr 30.

PMID:
30925024
11.

Short-Term Preoperative Protein Restriction Attenuates Vein Graft Disease via Induction of Cystathionine ϒ-Lyase.

Trocha KM, Kip P, Tao M, MacArthur MR, Treviño-Villarreal H, Longchamp A, Toussaint W, Lambrecht BN, de Vries MR, Quax PHA, Mitchell JR, Ozaki CK.

Cardiovasc Res. 2019 Mar 29. pii: cvz086. doi: 10.1093/cvr/cvz086. [Epub ahead of print]

PMID:
30924866
12.

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation.

Holgado A, Braun H, Van Nuffel E, Detry S, Schuijs MJ, Deswarte K, Vergote K, Haegman M, Baudelet G, Haustraete J, Hammad H, Lambrecht BN, Savvides SN, Afonina IS, Beyaert R.

J Allergy Clin Immunol. 2019 Jul;144(1):204-215. doi: 10.1016/j.jaci.2019.02.028. Epub 2019 Mar 13.

PMID:
30876911
13.

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF.

Haspeslagh E, Vanheerswynghels M, Deswarte K, Van Moorleghem J, Jacquet A, Lambrecht BN, Hammad H.

J Allergy Clin Immunol. 2019 Jun;143(6):2307-2311.e5. doi: 10.1016/j.jaci.2019.02.007. Epub 2019 Feb 20. No abstract available.

PMID:
30796980
14.

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.

Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB.

Nat Commun. 2018 Dec 17;9(1):5340. doi: 10.1038/s41467-018-07758-x.

15.

Regulators of A20 (TNFAIP3): new drug-able targets in inflammation.

Momtazi G, Lambrecht BN, Naranjo JR, Schock BC.

Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L456-L469. doi: 10.1152/ajplung.00335.2018. Epub 2018 Dec 13.

PMID:
30543305
16.

Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells.

Van der Borght K, Scott CL, Martens L, Sichien D, Van Isterdael G, Nindl V, Saeys Y, Boon L, Ludewig B, Gillebert TC, Lambrecht BN.

Front Immunol. 2018 Nov 21;9:2714. doi: 10.3389/fimmu.2018.02714. eCollection 2018.

17.

Professional and 'Amateur' Antigen-Presenting Cells In Type 2 Immunity.

Schuijs MJ, Hammad H, Lambrecht BN.

Trends Immunol. 2019 Jan;40(1):22-34. doi: 10.1016/j.it.2018.11.001. Epub 2018 Nov 27. Review.

PMID:
30502024
18.

A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation.

De Bruyne M, Hoste L, Bogaert DJ, Van den Bossche L, Tavernier SJ, Parthoens E, Migaud M, Konopnicki D, Yombi JC, Lambrecht BN, van Daele S, Alves de Medeiros AK, Brochez L, Beyaert R, De Baere E, Puel A, Casanova JL, Goffard JC, Savvides SN, Haerynck F, Staal J, Dullaers M.

Front Immunol. 2018 Oct 31;9:2366. doi: 10.3389/fimmu.2018.02366. eCollection 2018.

19.

Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates.

Van Herck S, Deswarte K, Nuhn L, Zhong Z, Portela Catani JP, Li Y, Sanders NN, Lienenklaus S, De Koker S, Lambrecht BN, David SA, De Geest BG.

J Am Chem Soc. 2018 Oct 31;140(43):14300-14307. doi: 10.1021/jacs.8b08595. Epub 2018 Oct 17.

PMID:
30277761
20.

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses.

Nuhn L, De Koker S, Van Lint S, Zhong Z, Catani JP, Combes F, Deswarte K, Li Y, Lambrecht BN, Lienenklaus S, Sanders NN, David SA, Tavernier J, De Geest BG.

Adv Mater. 2018 Nov;30(45):e1803397. doi: 10.1002/adma.201803397. Epub 2018 Oct 1.

PMID:
30276880
21.

The emerging role of ADAM metalloproteinases in immunity.

Lambrecht BN, Vanderkerken M, Hammad H.

Nat Rev Immunol. 2018 Dec;18(12):745-758. doi: 10.1038/s41577-018-0068-5. Review.

PMID:
30242265
22.

Eicosanoid Control Over Antigen Presenting Cells in Asthma.

Debeuf N, Lambrecht BN.

Front Immunol. 2018 Sep 4;9:2006. doi: 10.3389/fimmu.2018.02006. eCollection 2018. Review.

23.

Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology.

Post S, Heijink IH, Hesse L, Koo HK, Shaheen F, Fouadi M, Kuchibhotla VNS, Lambrecht BN, Van Oosterhout AJM, Hackett TL, Nawijn MC.

Sci Rep. 2018 Sep 5;8(1):13275. doi: 10.1038/s41598-018-31500-8.

24.

Isolated Schistosoma mansoni eggs prevent allergic airway inflammation.

Obieglo K, Schuijs MJ, Ozir-Fazalalikhan A, Otto F, van Wijck Y, Boon L, Lambrecht BN, Taube C, Smits HH.

Parasite Immunol. 2018 Oct;40(10):e12579. doi: 10.1111/pim.12579. Epub 2018 Sep 16.

25.

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.

Scott CL, T'Jonck W, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A, Saeys Y, Guilliams M.

Immunity. 2018 Aug 21;49(2):312-325.e5. doi: 10.1016/j.immuni.2018.07.004. Epub 2018 Jul 31.

26.

FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles.

Nuhn L, Van Herck S, Best A, Deswarte K, Kokkinopoulou M, Lieberwirth I, Koynov K, Lambrecht BN, De Geest BG.

Angew Chem Int Ed Engl. 2018 Aug 13;57(33):10760-10764. doi: 10.1002/anie.201803847. Epub 2018 Jul 25.

PMID:
30043442
27.

The hygiene hypothesis: immunological mechanisms of airway tolerance.

Haspeslagh E, Heyndrickx I, Hammad H, Lambrecht BN.

Curr Opin Immunol. 2018 Oct;54:102-108. doi: 10.1016/j.coi.2018.06.007. Epub 2018 Jul 7. Review.

28.

Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue.

Yoo E, Salyer ACD, Brush MJH, Li Y, Trautman KL, Shukla NM, De Beuckelaer A, Lienenklaus S, Deswarte K, Lambrecht BN, De Geest BG, David SA.

Bioconjug Chem. 2018 Aug 15;29(8):2741-2754. doi: 10.1021/acs.bioconjchem.8b00386. Epub 2018 Jul 17.

PMID:
29969553
29.

The Generation and Use of Allergen-Specific TCR Transgenic Animals.

Vanheerswynghels M, Toussaint W, Schuijs M, Vanhoutte L, Killeen N, Hammad H, Lambrecht BN.

Methods Mol Biol. 2018;1799:183-210. doi: 10.1007/978-1-4939-7896-0_15.

PMID:
29956153
30.

Author Correction: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes.

Machiels B, Dourcy M, Xiao X, Javaux J, Mesnil C, Sabatel C, Desmecht D, Lallemand F, Martinive P, Hammad H, Guilliams M, Dewals B, Vanderplasschen A, Lambrecht BN, Bureau F, Gillet L.

Nat Immunol. 2018 Sep;19(9):1035. doi: 10.1038/s41590-017-0024-8.

31.

A bispecific antibody strategy to target multiple type 2 cytokines in asthma.

Godar M, Deswarte K, Vergote K, Saunders M, de Haard H, Hammad H, Blanchetot C, Lambrecht BN.

J Allergy Clin Immunol. 2018 Oct;142(4):1185-1193.e4. doi: 10.1016/j.jaci.2018.06.002. Epub 2018 Jun 8.

PMID:
29890236
32.

KIRA1 and ORESARA1 terminate flower receptivity by promoting cell death in the stigma of Arabidopsis.

Gao Z, Daneva A, Salanenka Y, Van Durme M, Huysmans M, Lin Z, De Winter F, Vanneste S, Karimi M, Van de Velde J, Vandepoele K, Van de Walle D, Dewettinck K, Lambrecht BN, Nowack MK.

Nat Plants. 2018 Jun;4(6):365-375. doi: 10.1038/s41477-018-0160-7. Epub 2018 May 28.

PMID:
29808023
33.

Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways.

Osorio F, Lambrecht BN, Janssens S.

Curr Opin Immunol. 2018 Jun;52:100-107. doi: 10.1016/j.coi.2018.04.020. Epub 2018 May 11. Review.

PMID:
29754111
34.

FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy.

Berings M, Gevaert P, De Ruyck N, Derycke L, Holtappels G, Pilette C, Bachert C, Lambrecht BN, Dullaers M.

Clin Exp Allergy. 2018 Aug;48(8):970-980. doi: 10.1111/cea.13157. Epub 2018 May 17.

PMID:
29682789
35.

Heart macrophages and dendritic cells in sickness and in health: A tale of a complicated marriage.

Van der Borght K, Lambrecht BN.

Cell Immunol. 2018 Aug;330:105-113. doi: 10.1016/j.cellimm.2018.03.011. Epub 2018 Apr 5. Review.

PMID:
29650244
36.

Erratum: Author Correction: Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity.

Coccia M, Collignon C, Hervé C, Chalon A, Welsby I, Detienne S, van Helden MJ, Dutta S, Genito CJ, Waters NC, Van Deun K, Smilde AK, van den Berg RA, Franco D, Bourguignon P, Morel S, Garçon N, Lambrecht BN, Goriely S, van der Most R, Didierlaurent AM.

NPJ Vaccines. 2018 Mar 21;3:13. doi: 10.1038/s41541-018-0047-7. eCollection 2018.

37.

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist.

Nuhn L, Van Hoecke L, Deswarte K, Schepens B, Li Y, Lambrecht BN, De Koker S, David SA, Saelens X, De Geest BG.

Biomaterials. 2018 Sep;178:643-651. doi: 10.1016/j.biomaterials.2018.03.026. Epub 2018 Mar 16.

PMID:
29573820
38.

Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model.

D'hondt S, Guillemyn B, Syx D, Symoens S, De Rycke R, Vanhoutte L, Toussaint W, Lambrecht BN, De Paepe A, Keene DR, Ishikawa Y, Bächinger HP, Janssens S, Bertrand MJM, Malfait F.

Matrix Biol. 2018 Sep;70:72-83. doi: 10.1016/j.matbio.2018.03.008. Epub 2018 Mar 15.

PMID:
29551664
39.

Isolation of Conventional Murine Lung Dendritic Cell Subsets.

Bosteels C, Lambrecht BN, Hammad H.

Curr Protoc Immunol. 2018 Feb 21;120:3.7B.1-3.7B.16. doi: 10.1002/cpim.39.

PMID:
29512143
40.

Role of NKp46+ natural killer cells in house dust mite-driven asthma.

Haspeslagh E, van Helden MJ, Deswarte K, De Prijck S, van Moorleghem J, Boon L, Hammad H, Vivier E, Lambrecht BN.

EMBO Mol Med. 2018 Apr;10(4). pii: e8657. doi: 10.15252/emmm.201708657.

41.

A pathophysiological role of PDE3 in allergic airway inflammation.

Beute J, Lukkes M, Koekoek EP, Nastiti H, Ganesh K, de Bruijn MJ, Hockman S, van Nimwegen M, Braunstahl GJ, Boon L, Lambrecht BN, Manganiello VC, Hendriks RW, KleinJan A.

JCI Insight. 2018 Jan 25;3(2). pii: 94888. doi: 10.1172/jci.insight.94888. eCollection 2018 Jan 25.

42.

Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease.

Alissafi T, Kourepini E, Simoes DCM, Paschalidis N, Aggelakopoulou M, Sparwasser T, Boon L, Hammad H, Lambrecht BN, Panoutsakopoulou V.

J Immunol. 2018 Feb 15;200(4):1270-1282. doi: 10.4049/jimmunol.1701345. Epub 2018 Jan 12.

43.

Co-Activation of Glucocorticoid Receptor and Peroxisome Proliferator-Activated Receptor-γ in Murine Skin Prevents Worsening of Atopic March.

Deckers J, Bougarne N, Mylka V, Desmet S, Luypaert A, Devos M, Tanghe G, Van Moorleghem J, Vanheerswynghels M, De Cauwer L, Thommis J, Vuylsteke M, Tavernier J, Lambrecht BN, Hammad H, De Bosscher K.

J Invest Dermatol. 2018 Jun;138(6):1360-1370. doi: 10.1016/j.jid.2017.12.023. Epub 2017 Dec 27.

44.

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity.

Coccia M, Collignon C, Hervé C, Chalon A, Welsby I, Detienne S, van Helden MJ, Dutta S, Genito CJ, Waters NC, Deun KV, Smilde AK, Berg RAVD, Franco D, Bourguignon P, Morel S, Garçon N, Lambrecht BN, Goriely S, Most RV, Didierlaurent AM.

NPJ Vaccines. 2017 Sep 8;2:25. doi: 10.1038/s41541-017-0027-3. eCollection 2017. Erratum in: NPJ Vaccines. 2018 Mar 21;3:13.

45.

FcRn is mother's milk to allergen tolerance.

Lambrecht BN.

J Exp Med. 2018 Jan 2;215(1):1-3. doi: 10.1084/jem.20172022. Epub 2017 Dec 1.

46.

TGF-β Gives an Air of Exclusivity to Alveolar Macrophages.

Lambrecht BN.

Immunity. 2017 Nov 21;47(5):807-809. doi: 10.1016/j.immuni.2017.11.005.

47.

IL-21 Is Increased in Nasal Polyposis and after Stimulation with Staphylococcus aureus Enterotoxin B.

Calus L, Derycke L, Dullaers M, Van Zele T, De Ruyck N, Pérez-Novo C, Holtappels G, De Vos G, Lambrecht BN, Bachert C, Gevaert P.

Int Arch Allergy Immunol. 2017;174(3-4):161-169. doi: 10.1159/000481435. Epub 2017 Nov 9.

PMID:
29131072
48.

Personalized medicine with biologics for severe type 2 asthma: current status and future prospects.

Godar M, Blanchetot C, de Haard H, Lambrecht BN, Brusselle G.

MAbs. 2018 Jan;10(1):34-45. doi: 10.1080/19420862.2017.1392425. Epub 2017 Nov 14. Review.

49.

A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes.

Machiels B, Dourcy M, Xiao X, Javaux J, Mesnil C, Sabatel C, Desmecht D, Lallemand F, Martinive P, Hammad H, Guilliams M, Dewals B, Vanderplasschen A, Lambrecht BN, Bureau F, Gillet L.

Nat Immunol. 2017 Dec;18(12):1310-1320. doi: 10.1038/ni.3857. Epub 2017 Oct 16. Erratum in: Nat Immunol. 2018 Sep;19(9):1035.

PMID:
29035391
50.

The immunology of the allergy epidemic and the hygiene hypothesis.

Lambrecht BN, Hammad H.

Nat Immunol. 2017 Sep 19;18(10):1076-1083. doi: 10.1038/ni.3829. Review.

PMID:
28926539

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