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Cancer stem cells-driven tumor growth and immune escape: the Janus face of neurotrophins.

Triaca V, Carito V, Fico E, Rosso P, Fiore M, Ralli M, Lambiase A, Greco A, Tirassa P.

Aging (Albany NY). 2019 Dec 7;11(23):11770-11792. doi: 10.18632/aging.102499. Epub 2019 Dec 7.


Ocular manifestations in Gorlin-Goltz syndrome.

Moramarco A, Himmelblau E, Miraglia E, Mallone F, Roberti V, Franzone F, Iacovino C, Giustini S, Lambiase A.

Orphanet J Rare Dis. 2019 Sep 18;14(1):218. doi: 10.1186/s13023-019-1190-6.


Amyotrophic Lateral Sclerosis: Autoimmune Pathogenic Mechanisms, Clinical Features, and Therapeutic Perspectives.

Ralli M, Lambiase A, Artico M, de Vincentiis M, Greco A.

Isr Med Assoc J. 2019 Jul;21(7):438-443. Review.


Evaluation of IL8 pathway on the ocular surface: new insights in patients with ocular mucous membrane pemphigoid.

Bruscolini A, Lambiase A, Segatto M, La Cava M, Nebbioso M, Sacchetti M.

Acta Ophthalmol. 2019 Sep 5. doi: 10.1111/aos.14240. [Epub ahead of print]


Controversies in the management of neuromyelitis optica spectrum disorder.

Bruscolini A, La Cava M, Mallone F, Marcelli M, Ralli M, Sagnelli P, Greco A, Lambiase A.

Expert Rev Neurother. 2019 Nov;19(11):1127-1133. doi: 10.1080/14737175.2019.1648210. Epub 2019 Aug 12.


Eye drop emulsion containing 0.1% cyclosporin (1 mg/mL) for the treatment of severe vernal keratoconjunctivitis: an evidence-based review and place in therapy.

Nebbioso M, Alisi L, Giovannetti F, Armentano M, Lambiase A.

Clin Ophthalmol. 2019 Jul 5;13:1147-1155. doi: 10.2147/OPTH.S181811. eCollection 2019.


Neurotrophic factors and nerve growth factor in ocular allergy.

Sacchetti M, Bruscolini A, Lambiase A.

Curr Opin Allergy Clin Immunol. 2019 Oct;19(5):510-516. doi: 10.1097/ACI.0000000000000555.


Therapeutic Approaches with Intravitreal Injections in Geographic Atrophy Secondary to Age-Related Macular Degeneration: Current Drugs and Potential Molecules.

Nebbioso M, Lambiase A, Cerini A, Limoli PG, La Cava M, Greco A.

Int J Mol Sci. 2019 Apr 4;20(7). pii: E1693. doi: 10.3390/ijms20071693. Review.


Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study.

Sacchetti M, Lambiase A, Schmidl D, Schmetterer L, Ferrari M, Mantelli F, Allegretti M, Garhoefer G.

Br J Ophthalmol. 2020 Jan;104(1):127-135. doi: 10.1136/bjophthalmol-2018-312470. Epub 2019 Apr 3.


VEGF inhibition alters neurotrophin signalling pathways and induces caspase-3 activation and autophagy in rabbit retina.

Segatto M, Fico E, Gharbiya M, Rosso P, Carito V, Tirassa P, Plateroti R, Lambiase A.

J Cell Physiol. 2019 Aug;234(10):18297-18307. doi: 10.1002/jcp.28462. Epub 2019 Mar 19.


A characteristic type of retinal microvascular abnormalities in a patient with Neurofibromatosis type 1.

Moramarco A, Lambiase A, Mallone F, Miraglia E, Giustini S.

Clin Ter. 2019 Jan-Feb;170(1):e4-e9. doi: 10.7417/CT.2019.2101.



Bonini S, Lambiase A.

Ophthalmology. 2019 Feb;126(2):e15-e16. doi: 10.1016/j.ophtha.2018.09.018. No abstract available.


Allergy screening in a schoolchildren-based population.

Sacchetti M, Regine V, Mantelli F, Chini L, Moschese V, Bonini M, Pugliese L, Suligoi B, Lambiase A.

Pediatr Allergy Immunol. 2019 May;30(3):289-295. doi: 10.1111/pai.13024. Epub 2019 Feb 11.


Autoimmune Diseases and the Anterior Segment of the Eye.

Sacchetti M, Mantelli F, Lambiase A.

J Ophthalmol. 2018 Nov 1;2018:6029460. doi: 10.1155/2018/6029460. eCollection 2018. No abstract available.


Radiological-Pathological Correlation in Plasmablastic Lymphoma in an Immunocompromised Patient.

Moramarco A, Marenco M, La Cava M, Lambiase A.

Case Rep Ophthalmol Med. 2018 Oct 21;2018:4746050. doi: 10.1155/2018/4746050. eCollection 2018.


Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients.

Nebbioso M, Sacchetti M, Bianchi G, Zicari AM, Duse M, Del Regno P, Lambiase A.

J Ophthalmol. 2018 Oct 14;2018:1061276. doi: 10.1155/2018/1061276. eCollection 2018.


Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives.

Sacchetti M, Rama P, Bruscolini A, Lambiase A.

Stem Cells Int. 2018 Oct 11;2018:8086269. doi: 10.1155/2018/8086269. eCollection 2018. Review.


Changes of NGF pathway in allergic rhinoconjunctivitis: A conjunctival allergen challenge study.

Sacchetti M, Segatto M, Bruscolini A, Abicca I, Cavaliere C, Lambiase A.

Allergy. 2019 Mar;74(3):605-607. doi: 10.1111/all.13641. Epub 2018 Nov 12. No abstract available.


Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms.

Russo FY, Ralli M, De Seta D, Mancini P, Lambiase A, Artico M, de Vincentiis M, Greco A.

Immunol Res. 2018 Dec;66(6):675-685. doi: 10.1007/s12026-018-9023-6. Review.


NGR-hTNF and Doxorubicin as Second-Line Treatment of Patients with Small Cell Lung Cancer.

Gregorc V, Cavina R, Novello S, Grossi F, Lazzari C, Capelletto E, Genova C, Salini G, Lambiase A, Santoro A.

Oncologist. 2018 Oct;23(10):1133-e112. doi: 10.1634/theoncologist.2018-0292. Epub 2018 Aug 3.


Nerve Growth Factor Role on Retinal Ganglion Cell Survival and Axon Regrowth: Effects of Ocular Administration in Experimental Model of Optic Nerve Injury.

Mesentier-Louro LA, Rosso P, Carito V, Mendez-Otero R, Santiago MF, Rama P, Lambiase A, Tirassa P.

Mol Neurobiol. 2019 Feb;56(2):1056-1069. doi: 10.1007/s12035-018-1154-1. Epub 2018 Jun 4.


In vivo antivascular endothelial growth factor treatment induces corneal endothelium apoptosis in rabbits through changes in p75NTR-proNGF pathway.

Gharbiya M, Bruscolini A, Sacchetti M, Rosso P, Carito V, Segatto M, Fico E, Tirassa P, Lambiase A.

J Cell Physiol. 2018 Nov;233(11):8874-8883. doi: 10.1002/jcp.26806. Epub 2018 Jun 1.


NGR-hTNF in combination with best investigator choice in previously treated malignant pleural mesothelioma (NGR015): a randomised, double-blind, placebo-controlled phase 3 trial.

Gregorc V, Gaafar RM, Favaretto A, Grossi F, Jassem J, Polychronis A, Bidoli P, Tiseo M, Shah R, Taylor P, Novello S, Muzio A, Bearz A, Greillier L, Fontana F, Salini G, Lambiase A, O'Brien M.

Lancet Oncol. 2018 Jun;19(6):799-811. doi: 10.1016/S1470-2045(18)30193-1. Epub 2018 May 9.


Quality of life and neuropsychiatric disorders in patients with Graves' Orbitopathy: Current concepts.

Bruscolini A, Sacchetti M, La Cava M, Nebbioso M, Iannitelli A, Quartini A, Lambiase A, Ralli M, de Virgilio A, Greco A.

Autoimmun Rev. 2018 Jul;17(7):639-643. doi: 10.1016/j.autrev.2017.12.012. Epub 2018 May 2. Review.


Management of Patients with Graves' Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography.

Bruscolini A, La Cava M, Gharbiya M, Sacchetti M, Restivo L, Nardella C, Marenco M, Lambiase A.

J Immunol Res. 2018 Feb 18;2018:1454616. doi: 10.1155/2018/1454616. eCollection 2018.


Phase I Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis.

Bonini S, Lambiase A, Rama P, Filatori I, Allegretti M, Chao W, Mantelli F; REPARO Study Group.

Ophthalmology. 2018 Sep;125(9):1468-1471. doi: 10.1016/j.ophtha.2018.03.004. Epub 2018 Apr 10. No abstract available.


Phase II Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis.

Bonini S, Lambiase A, Rama P, Sinigaglia F, Allegretti M, Chao W, Mantelli F; REPARO Study Group.

Ophthalmology. 2018 Sep;125(9):1332-1343. doi: 10.1016/j.ophtha.2018.02.022. Epub 2018 Apr 10.


Behçet's disease: New insights into pathophysiology, clinical features and treatment options.

Greco A, De Virgilio A, Ralli M, Ciofalo A, Mancini P, Attanasio G, de Vincentiis M, Lambiase A.

Autoimmun Rev. 2018 Jun;17(6):567-575. doi: 10.1016/j.autrev.2017.12.006. Epub 2018 Apr 6. Review.


Allergic conjunctivitis: current concepts on pathogenesis and management.

Sacchetti M, Abicca I, Bruscolini A, Cavaliere C, Nebbioso M, Lambiase A.

J Biol Regul Homeost Agents. 2018 Jan-Feb;32(1 Suppl. 1):49-60. Review.


Cenegermin for the treatment of neurotrophic keratitis.

Sacchetti M, Bruscolini A, Lambiase A.

Drugs Today (Barc). 2017 Nov;53(11):585-595. doi: 10.1358/dot.2017.53.11.2722395. Review.


Development and preliminary validation of a new screening questionnaire for identifying atopic children.

Sacchetti M, Baiardini I, Chini L, Moschese V, Bruscolini A, Lambiase A.

Pediatric Health Med Ther. 2017 Sep 21;8:99-105. doi: 10.2147/PHMT.S142271. eCollection 2017.


Diagnosis and management of neuromyelitis optica spectrum disorders - An update.

Bruscolini A, Sacchetti M, La Cava M, Gharbiya M, Ralli M, Lambiase A, De Virgilio A, Greco A.

Autoimmun Rev. 2018 Mar;17(3):195-200. doi: 10.1016/j.autrev.2018.01.001. Epub 2018 Jan 13. Review.


Near-infrared imaging: an in vivo, non-invasive diagnostic tool in neurofibromatosis type 1.

Moramarco A, Giustini S, Nofroni I, Mallone F, Miraglia E, Iacovino C, Calvieri S, Lambiase A.

Graefes Arch Clin Exp Ophthalmol. 2018 Feb;256(2):307-311. doi: 10.1007/s00417-017-3870-z. Epub 2017 Dec 30.


Neurotrophic factors and corneal nerve regeneration.

Sacchetti M, Lambiase A.

Neural Regen Res. 2017 Aug;12(8):1220-1224. doi: 10.4103/1673-5374.213534. Review.


Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders.

Nebbioso M, Del Regno P, Gharbiya M, Sacchetti M, Plateroti R, Lambiase A.

Int J Mol Sci. 2017 Aug 13;18(8). pii: E1764. doi: 10.3390/ijms18081764. Review.


Recombinant Human Nerve Growth Factor Treatment Promotes Photoreceptor Survival in the Retinas of Rats with Retinitis Pigmentosa.

Sacchetti M, Mantelli F, Rocco ML, Micera A, Brandolini L, Focareta L, Pisano C, Aloe L, Lambiase A.

Curr Eye Res. 2017 Jul;42(7):1064-1068. doi: 10.1080/02713683.2017.1279634. Epub 2017 Mar 1.


Clinical presentation and management of congenital ptosis.

Marenco M, Macchi I, Macchi I, Galassi E, Massaro-Giordano M, Lambiase A.

Clin Ophthalmol. 2017 Feb 27;11:453-463. doi: 10.2147/OPTH.S111118. eCollection 2017. Review.


Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells.

Mesentier-Louro LA, De Nicolò S, Rosso P, De Vitis LA, Castoldi V, Leocani L, Mendez-Otero R, Santiago MF, Tirassa P, Rama P, Lambiase A.

Int J Mol Sci. 2017 Jan 5;18(1). pii: E98. doi: 10.3390/ijms18010098.


Investigational drugs in dry eye disease.

Nebbioso M, Fameli V, Gharbiya M, Sacchetti M, Zicari AM, Lambiase A.

Expert Opin Investig Drugs. 2016 Dec;25(12):1437-1446. Epub 2016 Oct 28. Review.


A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease.

Lambiase A, Sullivan BD, Schmidt TA, Sullivan DA, Jay GD, Truitt ER 3rd, Bruscolini A, Sacchetti M, Mantelli F.

Ocul Surf. 2017 Jan;15(1):77-87. doi: 10.1016/j.jtos.2016.08.004. Epub 2016 Sep 8.


A review of the role of ultrasound biomicroscopy in glaucoma associated with rare diseases of the anterior segment.

Mannino G, Abdolrahimzadeh B, Calafiore S, Anselmi G, Mannino C, Lambiase A.

Clin Ophthalmol. 2016 Jul 29;10:1453-9. doi: 10.2147/OPTH.S112166. eCollection 2016. Review.


An Update on the Ophthalmologic Features in the Phakomatoses.

Abdolrahimzadeh S, Plateroti AM, Recupero SM, Lambiase A.

J Ophthalmol. 2016;2016:3043026. doi: 10.1155/2016/3043026. Epub 2016 Jul 17. Review.


Involvement of the Anterior Segment of the Eye in Patients with Mucopolysaccharidoses: A Review of Reported Cases and Updates on the Latest Diagnostic Instrumentation.

Bruscolini A, Amorelli GM, Rama P, Lambiase A, La Cava M, Abbouda A.

Semin Ophthalmol. 2017;32(6):707-714. doi: 10.3109/08820538.2016.1170160. Epub 2016 Jul 15. Review.


Ocular manifestations of Sturge-Weber syndrome: pathogenesis, diagnosis, and management.

Mantelli F, Bruscolini A, La Cava M, Abdolrahimzadeh S, Lambiase A.

Clin Ophthalmol. 2016 May 13;10:871-8. doi: 10.2147/OPTH.S101963. eCollection 2016. Review.


From discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU.

Pellegrini G, Lambiase A, Macaluso C, Pocobelli A, Deng S, Cavallini GM, Esteki R, Rama P.

Regen Med. 2016 Jun;11(4):407-20. doi: 10.2217/rme-2015-0051. Epub 2016 Apr 19. Review.


An Androgen Receptor-positive Carcinoma of the Lacrimal Drainage System Resembling Salivary Duct Carcinoma: Case Report and Review of the Literature.

Rahimi S, Lambiase A, Brennan PA, Abdolrahimzadeh S.

Appl Immunohistochem Mol Morphol. 2016 Sep;24(8):e69-71. doi: 10.1097/PAI.0000000000000313. Review.


Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory.

Oliveira G, Ruggiero E, Stanghellini MT, Cieri N, D'Agostino M, Fronza R, Lulay C, Dionisio F, Mastaglio S, Greco R, Peccatori J, Aiuti A, Ambrosi A, Biasco L, Bondanza A, Lambiase A, Traversari C, Vago L, von Kalle C, Schmidt M, Bordignon C, Ciceri F, Bonini C.

Sci Transl Med. 2015 Dec 9;7(317):317ra198. doi: 10.1126/scitranslmed.aac8265. Erratum in: Sci Transl Med. 2015 Dec 23;7(319):319er9. D'Agostino, Mattio [corrected to D'Agostino, Mattia].


NGF Modulates trkANGFR/p75NTR in αSMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP).

Micera A, Stampachiacchiere B, Di Zazzo A, Sgrulletta R, Cortes M, Normando EM, Lambiase A, Bonini S.

PLoS One. 2015 Nov 16;10(11):e0142737. doi: 10.1371/journal.pone.0142737. eCollection 2015.


Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned From Polycystic Ovary Syndrome.

Mantelli F, Moretti C, Macchi I, Massaro-Giordano G, Cozzupoli GM, Lambiase A, Bonini S.

J Cell Physiol. 2016 May;231(5):971-5. doi: 10.1002/jcp.25221. Epub 2015 Nov 10. Review.


Rare Diseases of the Anterior Segment of the Eye: Update on Diagnosis and Management.

Lambiase A, Mantelli F, Sacchetti M, Rahimi S, Massaro-Giordano G.

Biomed Res Int. 2015;2015:947326. doi: 10.1155/2015/947326. Epub 2015 Sep 27. No abstract available.

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