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Items: 1 to 50 of 84

1.

Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.

Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C, Cifani C.

J Psychopharmacol. 2019 Jun 4:269881119845798. doi: 10.1177/0269881119845798. [Epub ahead of print]

PMID:
31161847
2.

Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Spinaci A, Marchenkova A, Abdelrahman A, Nistri A, Müller CE, Volpini R.

ACS Med Chem Lett. 2018 Dec 26;10(4):493-498. doi: 10.1021/acsmedchemlett.8b00524. eCollection 2019 Apr 11.

PMID:
30996785
3.

GPR17 receptor modulators and their therapeutic implications: review of recent patents.

Marucci G, Dal Ben D, Lambertucci C, Martí Navia A, Spinaci A, Volpini R, Buccioni M.

Expert Opin Ther Pat. 2019 Feb;29(2):85-95. doi: 10.1080/13543776.2019.1568990. Epub 2019 Jan 24. Review.

PMID:
30640576
4.

Biomarkers mapping of neuropathic pain in a nerve chronic constriction injury mice model.

Vincenzetti S, Pucciarelli S, Huang Y, Ricciutelli M, Lambertucci C, Volpini R, Scuppa G, Soverchia L, Ubaldi M, Polzonetti V.

Biochimie. 2019 Mar;158:172-179. doi: 10.1016/j.biochi.2019.01.005. Epub 2019 Jan 11.

PMID:
30639439
5.

Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia.

Martire A, Lambertucci C, Pepponi R, Ferrante A, Benati N, Buccioni M, Dal Ben D, Marucci G, Klotz KN, Volpini R, Popoli P.

J Neurochem. 2019 Apr;149(2):211-230. doi: 10.1111/jnc.14660. Epub 2019 Feb 11.

PMID:
30614535
6.

Anticancer activity study of A3 adenosine receptor agonists.

Marucci G, Santinelli C, Buccioni M, Navia AM, Lambertucci C, Zhurina A, Yli-Harja O, Volpini R, Kandhavelu M.

Life Sci. 2018 Jul 15;205:155-163. doi: 10.1016/j.lfs.2018.05.028. Epub 2018 May 13.

PMID:
29763615
7.

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

Lambertucci C, Marucci G, Dal Ben D, Buccioni M, Spinaci A, Kachler S, Klotz KN, Volpini R.

Eur J Med Chem. 2018 May 10;151:199-213. doi: 10.1016/j.ejmech.2018.03.067. Epub 2018 Mar 27.

PMID:
29614417
8.

Ex-vivo absorption study of lysine R-lipoate salt, a new pharmaceutical form of R-ALA.

Amenta F, Buccioni M, Ben DD, Lambertucci C, Navia AM, Ngouadjeu Ngnintedem MA, Ricciutelli M, Spinaci A, Volpini R, Marucci G.

Eur J Pharm Sci. 2018 Jun 15;118:200-207. doi: 10.1016/j.ejps.2018.03.025. Epub 2018 Mar 26.

PMID:
29597044
9.

Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases.

Dal Ben D, Antonioli L, Lambertucci C, Fornai M, Blandizzi C, Volpini R.

Front Pharmacol. 2018 Mar 14;9:212. doi: 10.3389/fphar.2018.00212. eCollection 2018. Review.

10.

The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor.

Betti M, Catarzi D, Varano F, Falsini M, Varani K, Vincenzi F, Dal Ben D, Lambertucci C, Colotta V.

Eur J Med Chem. 2018 Apr 25;150:127-139. doi: 10.1016/j.ejmech.2018.02.081. Epub 2018 Mar 6.

PMID:
29525433
11.

Fragment optimization for GPCRs by molecular dynamics free energy calculations: Probing druggable subpockets of the A 2A adenosine receptor binding site.

Matricon P, Ranganathan A, Warnick E, Gao ZG, Rudling A, Lambertucci C, Marucci G, Ezzati A, Jaiteh M, Dal Ben D, Jacobson KA, Carlsson J.

Sci Rep. 2017 Jul 25;7(1):6398. doi: 10.1038/s41598-017-04905-0.

12.

Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17).

Zhuo T, Zhou S, Zhang W, Lambertucci C, Volpini R.

Med Sci Monit. 2017 Feb 22;23:953-959.

13.

The G Protein-Coupled Receptor GPR17: Overview and Update.

Marucci G, Dal Ben D, Lambertucci C, Santinelli C, Spinaci A, Thomas A, Volpini R, Buccioni M.

ChemMedChem. 2016 Dec 6;11(23):2567-2574. doi: 10.1002/cmdc.201600453. Epub 2016 Nov 14. Review.

PMID:
27863043
14.

2',3'-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents.

Dal Ben D, Marchenkova A, Thomas A, Lambertucci C, Spinaci A, Marucci G, Nistri A, Volpini R.

Purinergic Signal. 2017 Mar;13(1):61-74. doi: 10.1007/s11302-016-9539-y. Epub 2016 Oct 18.

15.

Simulation and Comparative Analysis of Different Binding Modes of Non-nucleoside Agonists at the A2A Adenosine Receptor.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Santinelli C, Spinaci A, Thomas A, Volpini R.

Mol Inform. 2016 Sep;35(8-9):403-13. doi: 10.1002/minf.201501042. Epub 2016 Jun 28.

PMID:
27546044
16.

Overview on Radiolabel-Free in vitro Assays for GPCRs.

Buccioni M, Santinelli C, Angeli P, Dal Ben D, Lambertucci C, Thomas A, Volpini R, Marucci G.

Mini Rev Med Chem. 2017;17(1):3-14. Review.

PMID:
27515714
17.

Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.

Squarcialupi L, Falsini M, Catarzi D, Varano F, Betti M, Varani K, Vincenzi F, Dal Ben D, Lambertucci C, Volpini R, Colotta V.

Bioorg Med Chem. 2016 Jun 15;24(12):2794-808. doi: 10.1016/j.bmc.2016.04.048. Epub 2016 Apr 23.

PMID:
27161878
18.

The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor.

Thomas A, Buccioni M, Dal Ben D, Lambertucci C, Marucci G, Santinelli C, Spinaci A, Kachler S, Klotz KN, Volpini R.

ChemMedChem. 2016 Aug 19;11(16):1829-39. doi: 10.1002/cmdc.201500595. Epub 2016 Apr 1.

PMID:
27037522
19.

Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists.

Lambertucci C, Dal Ben D, Buccioni M, Marucci G, Thomas A, Volpini R.

Curr Med Chem. 2015;22(7):915-28. Review.

PMID:
25515515
20.

Purinergic P2X receptors: structural models and analysis of ligand-target interaction.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Thomas A, Volpini R.

Eur J Med Chem. 2015 Jan 7;89:561-80. doi: 10.1016/j.ejmech.2014.10.071. Epub 2014 Oct 25.

PMID:
25462266
21.

Probing ambiguous base-pairs by genetic transformation with XNA templates.

Pezo V, Schepers G, Lambertucci C, Marlière P, Herdewijn P.

Chembiochem. 2014 Oct 13;15(15):2255-8. doi: 10.1002/cbic.201402226. Epub 2014 Aug 26.

PMID:
25158283
22.

Antiproliferative evaluation of isofuranodiene on breast and prostate cancer cell lines.

Buccioni M, Dal Ben D, Lambertucci C, Maggi F, Papa F, Thomas A, Santinelli C, Marucci G.

ScientificWorldJournal. 2014;2014:264829. doi: 10.1155/2014/264829. Epub 2014 May 22.

23.

Pharmacological postconditioning of the rabbit heart with non-selective, A1 , A2A and A3 adenosine receptor agonists.

Bibli SI, Iliodromitis EK, Lambertucci C, Zoga A, Lougiakis N, Dagres N, Volpini R, Dal Ben D, Kremastinos DT, Tsantili Kakoulidou A, Cristalli G, Andreadou I.

J Pharm Pharmacol. 2014 Aug;66(8):1140-9. doi: 10.1111/jphp.12238. Epub 2014 Apr 27.

PMID:
24766266
24.

8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands.

Dal Ben D, Buccioni M, Lambertucci C, Thomas A, Klotz KN, Federico S, Cacciari B, Spalluto G, Volpini R.

Eur J Med Chem. 2013;70:525-35. doi: 10.1016/j.ejmech.2013.10.006. Epub 2013 Oct 17.

PMID:
24189496
25.

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch.

Dal Ben D, Buccioni M, Lambertucci C, Kachler S, Falgner N, Marucci G, Thomas A, Cristalli G, Volpini R, Klotz KN.

Biochem Pharmacol. 2014 Jan 15;87(2):321-31. doi: 10.1016/j.bcp.2013.10.011. Epub 2013 Oct 23.

PMID:
24161786
26.

Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists.

Lambertucci C, Sundukova M, Kachare DD, Panmand DS, Dal Ben D, Buccioni M, Marucci G, Marchenkova A, Thomas A, Nistri A, Cristalli G, Volpini R.

Eur J Med Chem. 2013 Jul;65:41-50. doi: 10.1016/j.ejmech.2013.04.037. Epub 2013 Apr 24.

PMID:
23688699
27.

Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A2B adenosine receptor.

Dal Ben D, Buccioni M, Lambertucci C, Thomas A, Volpini R.

In Silico Pharmacol. 2013 Dec 20;1:24. doi: 10.1186/2193-9616-1-24. eCollection 2013.

28.

Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.

Catarzi D, Colotta V, Varano F, Poli D, Squarcialupi L, Filacchioni G, Varani K, Vincenzi F, Borea PA, Dal Ben D, Lambertucci C, Cristalli G.

Bioorg Med Chem. 2013 Jan 1;21(1):283-94. doi: 10.1016/j.bmc.2012.10.031. Epub 2012 Oct 29.

PMID:
23171656
29.

Development of new chromatographic tools based on A2A adenosine receptor subtype for ligand characterization and screening by FAC-MS.

Temporini C, Massolini G, Marucci G, Lambertucci C, Buccioni M, Volpini R, Calleri E.

Anal Bioanal Chem. 2013 Jan;405(2-3):837-45. doi: 10.1007/s00216-012-6353-4. Epub 2012 Sep 8.

PMID:
22960794
30.

A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats.

Micioni Di Bonaventura MV, Cifani C, Lambertucci C, Volpini R, Cristalli G, Massi M.

Behav Pharmacol. 2012 Sep;23(5-6):567-74. doi: 10.1097/FBP.0b013e3283566a60.

PMID:
22743606
31.

In vitro antibacterial activity of different adenosine analogues.

Vitali LA, Petrelli D, Lambertucci C, Prenna M, Volpini R, Cristalli G.

J Med Microbiol. 2012 Apr;61(Pt 4):525-8. doi: 10.1099/jmm.0.038174-0. Epub 2011 Dec 8.

PMID:
22160314
32.

Effects of A₂A adenosine receptor blockade or stimulation on alcohol intake in alcohol-preferring rats.

Micioni Di Bonaventura MV, Cifani C, Lambertucci C, Volpini R, Cristalli G, Froldi R, Massi M.

Psychopharmacology (Berl). 2012 Feb;219(4):945-57. doi: 10.1007/s00213-011-2430-1. Epub 2011 Aug 11.

PMID:
21833502
33.

Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17.

Buccioni M, Marucci G, Dal Ben D, Giacobbe D, Lambertucci C, Soverchia L, Thomas A, Volpini R, Cristalli G.

Purinergic Signal. 2011 Dec;7(4):463-8. doi: 10.1007/s11302-011-9245-8. Epub 2011 Jul 20.

34.

Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.

Lenzi O, Colotta V, Catarzi D, Varano F, Squarcialupi L, Filacchioni G, Varani K, Vincenzi F, Borea PA, Dal Ben D, Lambertucci C, Cristalli G.

Bioorg Med Chem. 2011 Jun 15;19(12):3757-68. doi: 10.1016/j.bmc.2011.05.001. Epub 2011 May 6.

PMID:
21616671
35.

Evidence for the existence of a specific g protein-coupled receptor activated by guanosine.

Volpini R, Marucci G, Buccioni M, Dal Ben D, Lambertucci C, Lammi C, Mishra RC, Thomas A, Cristalli G.

ChemMedChem. 2011 Jun 6;6(6):1074-80. doi: 10.1002/cmdc.201100100. Epub 2011 Apr 15.

PMID:
21500353
36.

Neuropeptide S receptor: recent updates on nonpeptide antagonist discovery.

Dal Ben D, Antonini I, Buccioni M, Lambertucci C, Marucci G, Thomas A, Volpini R, Cristalli G.

ChemMedChem. 2011 Jul 4;6(7):1163-71. doi: 10.1002/cmdc.201100038. Epub 2011 Mar 30. Review.

PMID:
21452188
37.

The importance of alkynyl chain presence for the activity of adenine nucleosides/nucleotides on purinergic receptors.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Volpini R, Cristalli G.

Curr Med Chem. 2011;18(10):1444-63. Review.

PMID:
21428896
38.

Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.

Marucci G, Lammi C, Buccioni M, Dal Ben D, Lambertucci C, Amantini C, Santoni G, Kandhavelu M, Abbracchio MP, Lecca D, Volpini R, Cristalli G.

Anal Biochem. 2011 Jul 15;414(2):300-2. doi: 10.1016/j.ab.2011.02.028. Epub 2011 Feb 24.

PMID:
21354096
39.

Molecular modeling study on potent and selective adenosine A(3) receptor agonists.

Dal Ben D, Buccioni M, Lambertucci C, Marucci G, Thomas A, Volpini R, Cristalli G.

Bioorg Med Chem. 2010 Nov 15;18(22):7923-30. doi: 10.1016/j.bmc.2010.09.038. Epub 2010 Sep 22.

PMID:
20943397
40.

Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.

Calleri E, Ceruti S, Cristalli G, Martini C, Temporini C, Parravicini C, Volpini R, Daniele S, Caccialanza G, Lecca D, Lambertucci C, Trincavelli ML, Marucci G, Wainer IW, Ranghino G, Fantucci P, Abbracchio MP, Massolini G.

J Med Chem. 2010 May 13;53(9):3489-501. doi: 10.1021/jm901691y.

41.

Adenosine receptor modeling: what does the A2A crystal structure tell us?

Dal Ben D, Lambertucci C, Marucci G, Volpini R, Cristalli G.

Curr Top Med Chem. 2010;10(10):993-1018. Review.

PMID:
20370656
42.

Molecular modeling studies on the human neuropeptide S receptor and its antagonists.

Dal Ben D, Antonini I, Buccioni M, Lambertucci C, Marucci G, Vittori S, Volpini R, Cristalli G.

ChemMedChem. 2010 Mar 1;5(3):371-83. doi: 10.1002/cmdc.200900467.

PMID:
20087922
43.

Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.

Volpini R, Buccioni M, Dal Ben D, Lambertucci C, Lammi C, Marucci G, Ramadori AT, Klotz KN, Cristalli G.

J Med Chem. 2009 Dec 10;52(23):7897-900. doi: 10.1021/jm900754g.

PMID:
19839592
44.

Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.

Borrmann T, Abdelrahman A, Volpini R, Lambertucci C, Alksnis E, Gorzalka S, Knospe M, Schiedel AC, Cristalli G, Müller CE.

J Med Chem. 2009 Oct 8;52(19):5974-89. doi: 10.1021/jm9006356.

PMID:
19731917
45.

Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABA(A) receptors microtransplanted to Xenopus oocytes.

Roseti C, Palma E, Martinello K, Fucile S, Morace R, Esposito V, Cantore G, Arcella A, Giangaspero F, Aronica E, Mascia A, Di Gennaro G, Quarato PP, Manfredi M, Cristalli G, Lambertucci C, Marucci G, Volpini R, Limatola C, Eusebi F.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15927-31. doi: 10.1073/pnas.0907324106. Epub 2009 Aug 31.

46.

Adenine-based acyclic nucleotides as novel P2X3 receptor ligands.

Volpini R, Mishra RC, Kachare DD, Dal Ben D, Lambertucci C, Antonini I, Vittori S, Marucci G, Sokolova E, Nistri A, Cristalli G.

J Med Chem. 2009 Aug 13;52(15):4596-603. doi: 10.1021/jm900131v.

PMID:
19606867
47.

Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.

Volpini R, Dal Ben D, Lambertucci C, Marucci G, Mishra RC, Ramadori AT, Klotz KN, Trincavelli ML, Martini C, Cristalli G.

ChemMedChem. 2009 Jun;4(6):1010-9. doi: 10.1002/cmdc.200800434.

PMID:
19343763
48.

8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.

Lambertucci C, Antonini I, Buccioni M, Dal Ben D, Kachare DD, Volpini R, Klotz KN, Cristalli G.

Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. doi: 10.1016/j.bmc.2009.02.030. Epub 2009 Feb 23.

PMID:
19282184
49.

Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens.

Buccioni M, Kandhavelu M, Angeli P, Cristalli G, Dal Ben D, Giardinà D, Lambertucci C, Lammi C, Volpini R, Marucci G.

Eur J Pharmacol. 2009 Jan 14;602(2-3):388-94. doi: 10.1016/j.ejphar.2008.10.067. Epub 2008 Nov 14.

PMID:
19041301
50.

Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs.

Antonini I, Volpini R, Dal Ben D, Lambertucci C, Cristalli G.

Bioorg Med Chem. 2008 Sep 15;16(18):8440-6. doi: 10.1016/j.bmc.2008.08.027. Epub 2008 Aug 15.

PMID:
18774722

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