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Items: 35


In silico and in vitro immunogenicity assessment of B-domain-modified recombinant factor VIII molecules.

Bartholdy C, Reedtz-Runge SL, Wang J, Hjerrild Zeuthen L, Gruhler A, Gudme CN, Lamberth K.

Haemophilia. 2018 Sep;24(5):e354-e362. doi: 10.1111/hae.13555. Epub 2018 Jul 19.


The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides.

Schultz HS, Østergaard S, Sidney J, Lamberth K, Sette A.

PLoS One. 2018 May 14;13(5):e0197407. doi: 10.1371/journal.pone.0197407. eCollection 2018.


Engineering of a membrane-triggered activity switch in coagulation factor VIIa.

Nielsen AL, Sorensen AB, Holmberg HL, Gandhi PS, Karlsson J, Buchardt J, Lamberth K, Kjelgaard-Hansen M, Ley CD, Sørensen BB, Ruf W, Olsen OH, Østergaard H.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12454-12459. doi: 10.1073/pnas.1618713114. Epub 2017 Nov 6.


Quantitative analysis of the CD4+ T cell response to therapeutic antibodies in healthy donors using a novel T cell:PBMC assay.

Schultz HS, Reedtz-Runge SL, Bäckström BT, Lamberth K, Pedersen CR, Kvarnhammar AM; ABIRISK consortium.

PLoS One. 2017 May 31;12(5):e0178544. doi: 10.1371/journal.pone.0178544. eCollection 2017.


Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools.

Lamberth K, Reedtz-Runge SL, Simon J, Klementyeva K, Pandey GS, Padkjær SB, Pascal V, León IR, Gudme CN, Buus S, Sauna ZE.

Sci Transl Med. 2017 Jan 11;9(372). pii: eaag1286. doi: 10.1126/scitranslmed.aag1286.


Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function.

Cox JH, Hussell S, Søndergaard H, Roepstorff K, Bui JV, Deer JR, Zhang J, Li ZG, Lamberth K, Kvist PH, Padkjær S, Haase C, Zahn S, Odegard VH.

PLoS One. 2013 Dec 23;8(12):e82944. doi: 10.1371/journal.pone.0082944. eCollection 2013.


Human leukocyte antigen (HLA) class I restricted epitope discovery in yellow fewer and dengue viruses: importance of HLA binding strength.

Lund O, Nascimento EJ, Maciel M Jr, Nielsen M, Larsen MV, Lundegaard C, Harndahl M, Lamberth K, Buus S, Salmon J, August TJ, Marques ET Jr.

PLoS One. 2011;6(10):e26494. doi: 10.1371/journal.pone.0026494. Epub 2011 Oct 19. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/254c9f39-1c6b-4f48-a947-b4ed931642e7.


Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities.

Pedersen LE, Harndahl M, Rasmussen M, Lamberth K, Golde WT, Lund O, Nielsen M, Buus S.

Immunogenetics. 2011 Dec;63(12):821-34. doi: 10.1007/s00251-011-0555-3. Epub 2011 Jul 8.


Identification of CD8+ T cell epitopes in the West Nile virus polyprotein by reverse-immunology using NetCTL.

Larsen MV, Lelic A, Parsons R, Nielsen M, Hoof I, Lamberth K, Loeb MB, Buus S, Bramson J, Lund O.

PLoS One. 2010 Sep 14;5(9):e12697. doi: 10.1371/journal.pone.0012697.


Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential.

Riedl P, Wieland A, Lamberth K, Buus S, Lemonnier F, Reifenberg K, Reimann J, Schirmbeck R.

J Immunol. 2009 Jul 1;183(1):370-80. doi: 10.4049/jimmunol.0900505.


Functional recombinant MHC class II molecules and high-throughput peptide-binding assays.

Justesen S, Harndahl M, Lamberth K, Nielsen LL, Buus S.

Immunome Res. 2009 May 5;5:2. doi: 10.1186/1745-7580-5-2.


Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance.

Tenzer S, Wee E, Burgevin A, Stewart-Jones G, Friis L, Lamberth K, Chang CH, Harndahl M, Weimershaus M, Gerstoft J, Akkad N, Klenerman P, Fugger L, Jones EY, McMichael AJ, Buus S, Schild H, van Endert P, Iversen AK.

Nat Immunol. 2009 Jun;10(6):636-46. doi: 10.1038/ni.1728. Epub 2009 May 3.


Recombinant chymosin used for exact and complete removal of a prochymosin derived fusion tag releasing intact native target protein.

Justesen SF, Lamberth K, Nielsen LL, Schafer-Nielsen C, Buus S.

Protein Sci. 2009 May;18(5):1023-32. doi: 10.1002/pro.112.


Modified human beta 2-microglobulin (desLys(58)) displays decreased affinity for the heavy chain of MHC class I and induces nitric oxide production and apoptosis.

Wang M, Harhaji L, Lamberth K, Harndahl M, Buus S, Heegaard NH, Claesson MH, Nissen MH.

Scand J Immunol. 2009 Mar;69(3):203-12. doi: 10.1111/j.1365-3083.2008.02213.x.


Peptide binding to HLA class I molecules: homogenous, high-throughput screening, and affinity assays.

Harndahl M, Justesen S, Lamberth K, Røder G, Nielsen M, Buus S.

J Biomol Screen. 2009 Feb;14(2):173-80. doi: 10.1177/1087057108329453. Epub 2009 Feb 4.


MHC-I-restricted epitopes conserved among variola and other related orthopoxviruses are recognized by T cells 30 years after vaccination.

Tang ST, Wang M, Lamberth K, Harndahl M, Dziegiel MH, Claesson MH, Buus S, Lund O.

Arch Virol. 2008;153(10):1833-44. doi: 10.1007/s00705-008-0194-7. Epub 2008 Sep 12.


The peptide-binding specificity of HLA-A*3001 demonstrates membership of the HLA-A3 supertype.

Lamberth K, Røder G, Harndahl M, Nielsen M, Lundegaard C, Schafer-Nielsen C, Lund O, Buus S.

Immunogenetics. 2008 Nov;60(11):633-43. doi: 10.1007/s00251-008-0317-z. Epub 2008 Sep 4.


NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11.

Lundegaard C, Lamberth K, Harndahl M, Buus S, Lund O, Nielsen M.

Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W509-12. doi: 10.1093/nar/gkn202. Epub 2008 May 7.


One-pot, mix-and-read peptide-MHC tetramers.

Leisner C, Loeth N, Lamberth K, Justesen S, Sylvester-Hvid C, Schmidt EG, Claesson M, Buus S, Stryhn A.

PLoS One. 2008 Feb 27;3(2):e1678. doi: 10.1371/journal.pone.0001678.


HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D.

Chentoufi AA, Zhang X, Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A, Buus S, Wechsler SL, Nesburn AB, BenMohamed L.

J Immunol. 2008 Jan 1;180(1):426-37.


Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction.

Larsen MV, Lundegaard C, Lamberth K, Buus S, Lund O, Nielsen M.

BMC Bioinformatics. 2007 Oct 31;8:424.


NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence.

Nielsen M, Lundegaard C, Blicher T, Lamberth K, Harndahl M, Justesen S, Røder G, Peters B, Sette A, Lund O, Buus S.

PLoS One. 2007 Aug 29;2(8):e796.


CTL epitopes for influenza A including the H5N1 bird flu; genome-, pathogen-, and HLA-wide screening.

Wang M, Lamberth K, Harndahl M, Røder G, Stryhn A, Larsen MV, Nielsen M, Lundegaard C, Tang ST, Dziegiel MH, Rosenkvist J, Pedersen AE, Buus S, Claesson MH, Lund O.

Vaccine. 2007 Apr 12;25(15):2823-31. Epub 2006 Dec 29.


A community resource benchmarking predictions of peptide binding to MHC-I molecules.

Peters B, Bui HH, Frankild S, Nielson M, Lundegaard C, Kostem E, Basch D, Lamberth K, Harndahl M, Fleri W, Wilson SS, Sidney J, Lund O, Buus S, Sette A.

PLoS Comput Biol. 2006 Jun 9;2(6):e65. Epub 2006 Jun 9.


SARS CTL vaccine candidates; HLA supertype-, genome-wide scanning and biochemical validation.

Sylvester-Hvid C, Nielsen M, Lamberth K, Røder G, Justesen S, Lundegaard C, Worning P, Thomadsen H, Lund O, Brunak S, Buus S.

Tissue Antigens. 2004 May;63(5):395-400.


Definition of supertypes for HLA molecules using clustering of specificity matrices.

Lund O, Nielsen M, Kesmir C, Petersen AG, Lundegaard C, Worning P, Sylvester-Hvid C, Lamberth K, Røder G, Justesen S, Buus S, Brunak S.

Immunogenetics. 2004 Mar;55(12):797-810. Epub 2004 Feb 13.


Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach.

Nielsen M, Lundegaard C, Worning P, Hvid CS, Lamberth K, Buus S, Brunak S, Lund O.

Bioinformatics. 2004 Jun 12;20(9):1388-97. Epub 2004 Feb 12.


Breaking tolerance in hepatitis B surface antigen (HBsAg) transgenic mice by vaccination with cross-reactive, natural HBsAg variants.

Schirmbeck R, Dikopoulos N, Kwissa M, Leithäuser F, Lamberth K, Buus S, Melber K, Reimann J.

Eur J Immunol. 2003 Dec;33(12):3342-52.


Selecting informative data for developing peptide-MHC binding predictors using a query by committee approach.

Christensen JK, Lamberth K, Nielsen M, Lundegaard C, Worning P, Lauemøller SL, Buus S, Brunak S, Lund O.

Neural Comput. 2003 Dec;15(12):2931-42.


CCR3 expression induced by IL-2 and IL-4 functioning as a death receptor for B cells.

Jinquan T, Jacobi HH, Jing C, Millner A, Sten E, Hviid L, Anting L, Ryder LP, Glue C, Skov PS, Jarman E, Lamberth K, Malling HJ, Poulsen LK.

J Immunol. 2003 Aug 15;171(4):1722-31.


Reliable prediction of T-cell epitopes using neural networks with novel sequence representations.

Nielsen M, Lundegaard C, Worning P, Lauemøller SL, Lamberth K, Buus S, Brunak S, Lund O.

Protein Sci. 2003 May;12(5):1007-17.


Ca2+ response in neutrophils after exposure to bacterial N-formyl-methionyl-leucyl-phenylalanine: delayed response in ulcerative colitis.

Vainer B, Lamberth K, Brimnes J, Nielsen OH, Claësson MH.

Eur J Gastroenterol Hepatol. 2003 Mar;15(3):267-73.


Establishment of a quantitative ELISA capable of determining peptide - MHC class I interaction.

Sylvester-Hvid C, Kristensen N, Blicher T, Ferré H, Lauemøller SL, Wolf XA, Lamberth K, Nissen MH, Pedersen LØ, Buus S.

Tissue Antigens. 2002 Apr;59(4):251-8.


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